Abstract
Li-Fraumeni syndrome is a rare cause of breast cancer. It should be considered in cancer cases where a genetic link is suspected. It impacts dramatically on treatment and has major implications for the patient and their family.
Keywords
References
1.Breast cancer in women. A national clinical guideline SIGN Guideline number 29 . http://www.sign.ac.uk/guidelines/fulltext/29/index.html.
2.
McPherson
K
Steel
C M
Dixon
JM
. Breast cancer-epidemiology, risk factors, and genetics . Br Med J , 2000 ; 321 , 624 –628 .
3.
Thull
DL
Vogel
VG
. Recognition and management of hereditary breast cancer syndromes . The Oncologist , 2004 ; 9 , 13 –24 .
4.
Schneider
KA
Li
F
. Li-Fraumeni Syndrome . http://www.geneclinics.org/profiles/li-fraumeni/details.html.
5.
Levine
AJ
. P53, the cellular gatekeeper for growth and division . Cell , 1997 ; 88 , 323 –331 .