Abstract
A detailed study has been made of the five hypertensive patients who received Minoxidil in Dumfries; four have been observed for over a year. Minoxidil was found to be highly effective, free from commonly encountered side effects and capable of achieving excellent control of blood pressure when given once daily. Its use led to simpler drug regimens, improved compliance and significant reduction in the length, or even need, of admission to hospital. A prolonged and clinically useful delay in the recurrence of hypertension following withdrawal of the drug was also observed.
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References
1.
Traub
YM
Redmond
DP
Rosenfeld
JB
McDonald
RH
Shapiro
AP
. Treatment of severe hypertension with Minoxidil. Israel J. Med . Sci
1975 ; 11 : 991 –998 .
2.
Devine
BL
Fife
R
Trust
PM
. Minoxidil for severe hypertension after failure of other hypotensive drugs . Br Med J
1977 ; 2 : 667 –669 .
3.
Dargie
HJ
Dollery
CT
Daniel
J
. Minoxidil in resistant hypertension . Lancet
1977 ; 2 : 515 –518 .
4.
Oka
M
Makela
M
. Minoxidil in severe hypertension . Acta Med Scand
1978 ; 203 : 43 –47 .
5.
Mitchell
HC
Pettinger
WA
. Long term treatment of refractory hypertensive patients with Minox idil . JAMA
1978 ; 239 : 2131 –2138 .
6.
Ambrosio
GB
. Minoxidil in resistant hypertension . Lancet
1977 ; 2 : 1087 .
7.
Marquez-Julio
A
Uldall
PR
. Pericardial effusions associated with Minoxidil . Lancet
1977 ; 2 : 816 –817 .
8.
Tarazi
RC
Dunstan
HP
Bravo
EL
Niarchos
AP
. Vasodilating drugs: contrasting haemodynamic effects . Clin Sci Mol Med
1976 ; 51 : 575 –578 .
9.
DuCharme
DW
Freyburger
WA
Graham
BE
Carlson
RG
. Pharmacologic properties of Minoxidil: a new hypotensive agent . J Pharmacol Exp Ther
1973 ; 184 : 662 –670 .
10.
Sleight
P
. Hypertension . In:
Hamer
J
Balcon
R
eds. Medicine 2nd Series : Medical Education (International) Ltd.
1977 ; 27 : 1431 –1457 .
11.
Mitnick
PD
Feig
PM
. Control of hypertension and reversal of renal failure in scleroderma . N Engl J Med
1978 ; 299 : 871 –872 .
12.
Fraser
HS
Carr
AC
. Propranolol psychosis . Br J Psychiatry
1976 ; 129 : 508 .
13.
Hall
D
Charocopos
F
Froer
K
Rudolph
W
. ECG changes during long term Minoxidil therapy for severe hypertension . Arch Intern Med
1979 ; 139 : 790 –794 .
14.
Alpert
MA
Baur
JH
Parker
BM
Brooks
CS
Freeman
JA
. The long term effect of Minoxidil on systemic and pulmonary haemodynamics . Prev Med
1978 ; 7 : 35 .
15.
Weir
EK
Chidsey
CA
Weil
JV
Grover
RF
. Minoxidil reduces pulmonary vascular resistance in dogs and cattle . J Lab Clin Med
1976 ; 6 : 885 –894 .
16.
Sobota
J
. Minoxidil-right atrial cardiac pathology in animals and man . Circulation
1980 (in press).
17.
Mehta
PK
Mamdani
B
Shansky
RM
Mahurkar
SD
Dunea
G
. Severe hypertension: treatment with Minoxidil . JAMA
1975 ; 233 : 249 –252 .
18.
Dunea
G
Mamdani
B
. Mahurkar SD. Treatment of severe and moderate hypertension with Minoxidil . Clin Sci Mol Med
1976 ; 51 : 583 –585 .
19.
Grim
CE
Luft
FC
Grim
CM
Klotman
PE
Van Huysse
JW
Weinberger
MH
. Rapid blood pressure control with Minoxidil . Arch Intern Med
1979 ; 139 : 529 –533 .
