Abstract
The leaves of the Qat plant (Catha edulis Forsk., Celastraceae) which contain amphetamine like compounds are widely chewed in Yemen and East Africa for their pleasurable stimulant properties. There are also a number of unwanted side-effects and this paper studies the effect on heart rate and blood pressure in 80 healthy volunteers. During a 3-h period of chewing fresh Qat leaves there was a significant and progressive rise in systolic and diastolic blood pressure and heart rate, and levels had not returned to baseline 1h after chewing had ceased. Further studies are needed on possible cardiovascular morbidity associated with regular Qat chewing.
References
1.
Kalix
P
. Cathinone, a natural amphetamine . Pharmacol Toxicol
1992 ;70 :77 –86 .
2.
Norusis
MJ
. SPSS/PC + Advanced Statistics, Vol. 2.02 . Chicago : SPSS , 1988 .
3.
Gendron
Y
Ch
Ardouin
Martine
J
. Accidents cardiovasculaires aigus declenches par le Kat . Med Trop
1977 ;37 :69 –72 .
4.
Brenneisen
R
Fisch
H-U
Koelbing
U
Geisshusler
S
Kalix
P
. Amphetamine-like effects in humans of the Khat alkaloid cathinone . Br J Clin Pharmacol
1990 ;30 :825 –8 .
5.
Widler
P
Mathys
K
Brenneisen
R
Kalix
P
Fisch
H-U
. Pharmacodynamics and pharmacokinetics of Khat: a controlled study . Clin Pharmacol Therapeut
1994 ;55 :556 –62 .
6.
Halket
JM
Karasu
Z
Murray-Lyon
IM
. Plasma carhinone levels following chewing Khat leaves (Catha edulis Forsk.)
J Ethnopharmacol
1995 ;49 :111 –13 .
7.
Nencini
P
Ahmed
AM
Amiconi
G
Elmi
AS
. Tolerance develops to sympathetic effects of Khat in humans . Pharmacology
1984 ;28 :150 –4 .
