There are several papers describing the rationale for using logarithmic transformation on concentration-dependent pharmacokinetic parameters before examination by analysis of variance in bioequivalence studies (1, 2). This paper focuses on the necessity of logarithmic transformation of plasma concentration of toxicokinetic studies.
WestlakeWJ. Bioavailability and bioequivalence of pharmaceutical formulations. In: PeaceKE, ed. Biopharmaceutical Statistics for Drug Development. New York: Marcel Dekker, Inc.; 1988:329–352.
2.
MidaKKOrmsbyEDHubbardJWMcKayGHauesEMGavalasLMcGilverayIJ. Logarithmic transformation in bioequivalence: Application with two formulations of perfenazine. J Pharma Sci. 1993;82(2):138–144.
3.
HubertJHBohidarNRPeaceKE. Assessment of pharmacological activity. In: PeaceKE, ed. Biopharmaceutical Statistics for Drug Development. New York: Marcel Dekker, Inc.'1988:105–117.
