Does Ritanserin,a Potent Serotonin-S 2 Antagonist,Restore Energetic Functions during the Night?

Loomis AL Harvey EN Hobart GA . Cerebral states during sleep as studied by human brain potentials. J Exp Psychol 1937; 21: 127–44

Rechtschaffen A Kales A , eds. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Bethesda: National Institutes of Health, 1968 (publication 204)

Adam K Oswald I . Sleep is for tissue restoration. J Roy Coll Physicians Lond 1977; 11: 376–88

Dement W . The effects of dream deprivation. Science 1960; 131: 1705–7

Agnew HW Webb WB Williams RL . The effects of stage four sleep deprivation. Electroencephalogr Clin Neurophysiol 1964; 17: 68–70

Berger RJ Oswald I . Effects of sleep deprivation on behaviour, subsequent sleep and dreaming. J Ment Sci 1962; 108: 457–65

Williams HL Hammack JT Daly RL Dement WC Lubin A . Responses to auditory stimulation, sleep loss and the EEG stages of sleep. Electroencephalogr Clin Neurophysiol 1964; 16: 269–79

Williams RL Karacan I Hursch CJ . Electroencephalography (EEG) of human sleep: clinical applications. New York: John Wiley, 1974

Gillin JC Duncan WC Murphy DL , Age-related changes in sleep in depressed and normal subjects. Psychiatry Res 1981; 4: 73–8

Hawkins DR Taub JM Van De Castle RL . Extended sleep (hypersomnia) in young depressed patients. Am J Psychiatry 1985; 142: 905–10

Mendels J Hawkins DR . Sleep and depression: Further consideration. Arch Gen Psychiatry 1968; 19: 445–52

Lairy GC Barte H Goldsteinas L Ridjanovic S . Sommeil de nuit de malades mentaux: étude des bouffées délirantes. In: Le sommeil de nuit normal et pathologique, études électroencéphalographiques. Paris: Masson et Cie, 1965: 353–81

Caldwell DF Domino EF . Electroencephalographic and eye-movement patterns during sleep in chronic schizophrenic patients. Electroencephalogr Clin Neurophysiol 1967; 22: 414–20

Feinberg I Hiatt JF . Sleep patterns in schizophrenia: A selective review. In: Williams RL Karacan I , eds. Sleep disorders: diagnosis and treatment. New York: John Wiley, 1978: 205–31

Hiatt JF Floyd TC Katz PH Feinberg I . Further evidence of abnormal non-rapid-eye-movement sleep in schizophrenia. Arch Gen Psychiatry 1985; 42: 797–802

Feinberg I . Changes in sleep cycle patterns with age. Journal of Psychiatric Research 1974; 10: 283–306

Wauquier A Gaillard JM Monti JM Radulovacki M , eds. Sleep: neurotransmitters and neuromodulators. New York: Raven Press, 1985: 344

Radulovacki M Miletich RS Green RD . N⁶ (L-Phenylisopropyl) adenosine (L-PIA) increases slow-wave (S₂) and decreases wakefulness in rats. Brain Res 1982; 246: 178–80

Nicholson AN Pascoe PA Stone BM . Histaminergic systems and sleep: Studies in man with H₁ and H₂ antagonists. Neuropharmacology 1985; 24: 245–50

Inoué S Borbély A , eds. Sleep substances: Their roles and evolution. In: Endogenous sleep substances and sleep regulation. Tokyo: Japan Scientific Societies Press, and Utrecht: VNU Science Press, 1985: 3–12

Koella WP . Serotonin and sleep. In: Wauquier A eds. Sleep: neurotransmitters and neuromodulators. New York: Raven Press, 1985: 185–96

Oswald I Ashcroft GW Berger RJ Eccleston D Evans JI Thacore VR . Some experiments in the chemistry of normal sleep. Br J Psychiatry 1966; 112: 391–9

Jouvet M . Biogenic amines and the stages of sleep. Science 1969; 163: 32–41

Wojcik WJ Fornal C Radulovacki M . Effect of tryptophan on sleep in the rat. Neuropharmacology 1980; 19: 163–7

Tatushi K Himwich HE . 5-Hydroxytryptophan and the sleep-wakefulness cycle in rabbits. Biol Psychiatry 1970; 2: 183–8

Wyatt RJ Kupfer DJ Sjoerdsma A Engelman K Fram DH Snyder F . Effects of L-tryptophan (a natural sedative) on human sleep. Lancet 1970; ii: 842–5

Ross CA Trulson ME Jacobs BL . Depletion of brain serotonin following intraventricular 5, 7-dihydroxytryptamine fails to disrupt sleep in the rat. Brain Res 1976; 114: 517–23

Nicholson AN Stone BM . L-Tryptophan and sleep in healthy man. Electroencephalogr Clin Neurophysiol 1979; 47: 539–45

Oswald I Adam K Spiegel R . Human EEG slow-wave sleep increased by a serotonin antagonist. Electroencephalogr Clin Neurophysiol 1982; 54: 583–6

Sallanon M Buda C Jamin M Jouvet M . Implication of serotonin in sleep mechanisms: Induction, facilitation? In: Wauquier A eds. Sleep: neurotransmitters and neuromodulators. New York: Raven Press, 1985: 135–40

Leysen JE Gommeren W Van Gompel P Wijnants J Janssen PFM Laduron PM . Receptor binding properties in vitro and in vivo of ritanserin: A very potent and long-acting serotonin-S₂ antagonist. Mol Pharmacol 1985; 27: 600–11

Idzikowski C Mills FJ Glennard R . 5-Hydroxytryptamine-2 antagonist increases human slow wave sleep. Brain Res 1986; 378: 164–8

Idzikowski C Mills FJ . 5-HT₂ Antagonist causes sustained increase in human slow wave sleep. Clin Sci 1986; 70 (13): 89