Abstract
Background: Long-term parenteral nutrition (PN) is a standardized treatment in many patients who are unable to use their gastrointestinal tract to absorb nutrients and water. Catheter-related thrombosis (CRT) is one of the most common complications of PN. Several factors predispose patients to CRT. The main objective of this study was to assess the platelet membrane glycoprotein (GP) activation and coagulopathy induced by PN. Methods: Fifteen patients with intestinal failure were given PN for 47.9 days (range, 30–92 days) and 15 oral-fed healthy volunteers served as controls. Complete blood counts and coagulation and biochemical parameters were determined. The platelet surface GPs, P-selectin and GPIIb/IIIa were measured by flow cytometry. Results: There was no significant difference between the control group and PN group in coagulation and biochemical parameters. Platelet P-selectin expression of the PN group was significantly higher than that of the control group (3.43% ± 1.22% and 1.99% ± 0.58%, respectively; P < .01). There was no significant difference in GPIIb/IIIa expression between the 2 groups. Conclusions: Long-term PN (>30 days) induced the activation of platelet membrane GPs, which may be a significant risk factor for the development of CRT in patients with intestinal failure who require PN.
Keywords
Get full access to this article
View all access options for this article.
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
