Abstract
Sage and the Journal Editor hereby issue an expression of concern to the following articles:
Wakui S, Takahashi H, Mutou T, et al. Atypical Leydig Cell Hyperplasia in Adult Rats with Low T and High LH Induced by Prenatal Di(n-butyl) Phthalate Exposure. Toxicologic Pathology. 2013;41(3):480-486. doi:10.1177/0192623312457272
Shirai M, Wakui S, Wempe MF, et al. Male Sprague-Dawley Rats Exposed to In Utero Di(n-butyl) Phthalate: Dose Dependent and Age-related Morphological Changes in Leydig Cell Smooth Endoplasmic Reticulum. Toxicologic Pathology. 2013;41(7):984-991. doi:10.1177/0192623312474725
Wakui S, Shirai M, Motohashi M, et al. Effects of in Utero Exposure to Di(n-butyl) Phthalate for Estrogen Receptors α, β, and Androgen Receptor of Leydig Cell on Rats. Toxicologic Pathology. 2014;42(5):877-887. doi:10.1177/0192623313502879
Motohashi M, Wakui S, Takahashi H, et al. Adenocarcinoma of the Ampullary Glands of the Ductus Deferens in a Sprague-Dawley Rat. Toxicologic Pathology. 2015;43(4):593-599. doi:10.1177/0192623314554266
Okayama Y, Wakui S, Wempe MF, et al. In Utero Exposure to Di(n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty. Toxicologic Pathology. 2017;45(4):526-535. doi:10.1177/0192623317709091
Wakui S, Takahashi H, Muto T. In Utero Exposure to 3,3′,4,4′, 5-Pentachlorobiphenyl Dose-Dependently Induces N-butyl-4-(hydroxybutyl) Nitrosamine in Rats With Urinary Bladder Carcinoma. Toxicologic Pathology. 2022;50(3):366-380. doi:10.1177/01926233211064180
Toxicologic Pathology was contacted by the author, Shin Wakui, requesting retraction of these articles. Despite multiple attempts at gaining further information on the reasons for retraction, we have not received anymore communication regarding this case.
This expression of concern will remain in place until further evidence is provided to Sage.