Lack of Association between Eotaxin-1 Gene Polymorphisms and Nasal Polyposis

Abstract

Objective. To examine whether there is an association of eotaxin-1 gene polymorphisms with nasal polyposis (NP).

Study Design. Cross-sectional study.

Setting. Tertiary referral center.

Subjects and Methods. The study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin-1 (−384 A>G and +67 G>A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.

Results. The −384 A>G and +67 G>A single nucleotide polymorphisms were higher in patients with NP than in controls (P = .044 and P = .019, respectively). However, their relation was statistically poor (association coefficient = 0.18). Consistent with this result, comparisons of allele frequencies for both single nucleotide polymorphisms were not significantly different (−384 A>G, P = .164; +67 G>A, P = .144).

Conclusion. In this study, eotaxin-1 −384 A>G or 67 G>A genotypes were not associated with susceptibility to NP.

Keywords

eotaxin nasal polyposis genotype polymorphism

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