Macrophage (monocyte)-derived secretogogue (MMS) is a low molecular weight peptide released by activated macrophages. This substance can enhance incorporation of carbohydrates into protein and result in the production of glycoproteins. It is believed that increased glycoproteins lead to the increased tenaciousness of mucoid effusions. Sixteen of 28 middle ear effusions demonstrated significant amounts of MMS. It is suggested that MMS is produced by activated macrophages in MEE and may lead to the development of glycoprotein by secretory epithelial cells. This substance may lead to the development of the mucoid effusion in otitis media with effusion in children.
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GoswamiSKStathASMaromZ. Macrophage derived mucous secretagogue is released by peripheral blood monocytes from patients with pulmonary inflammation. Am Rev Respir Dis1987; 135: 367.
21.
LundgrenJDHirataFMaromZ, Dexamethasone inhibits respiratory glycoconjugate secretion from feline airways in vitro by the induction of lipocortin (lipomodulin) synthesis. Am Rev Respir Dis1988; 14: 353–7.
