Thymolipoma is an unusual benign tumor of the mediastinum, comprising 2%–9% of thymic neoplasms. Most presentations are atypical. Here we present the case of a 68-year-old man with effort intolerance and fatigue for 4 months. Computed tomography of the chest revealed a lipomatous mass in the anterior mediastinum and bilateral hemithoraces. There were atelectatic changes in both lungs. The tumor was resected via a midline sternotomy. The patient had to be ventilated for 3 days postoperatively. The histopathological diagnosis was pleomorphic thymolipoma.
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