The control of chronic inflammation has emerged as a target for improving the health of cancer survivors (CS).
Aim:
To examine differences in fitness and dietary characteristics of CS when grouped by low vs. moderate to high serum C-reactive protein (CRP).
Methods:
CS (N = 26, mean age = 68 ± 12 years) were evaluated for body mass index (BMI), body composition, cardiorespiratory fitness, dietary intake, dietary inflammatory index (DII), and serum CRP. Participants were assigned to one of two groups based on serum CRP concentrations: low CRP (≤1 mg/L) (LWC; n = 13) or moderate to high (CRP > 1 mg/L) (MHC; n = 13) and t-tests compared them. Data are presented as mean ± SD.
Results:
LWC had higher VO2peak values (mL/kg/min) (p = 0.0003), and lower visceral fat area (cm2) (p = 0.02) and body fat mass (kg) (p = 0.04). Secondary analysis using Pearson’s correlation coefficients, including all current study participant data, found significant negative relationships between CRP and total dietary fat intake (p = 0.02), saturated fat (p = 0.03), and polyunsaturated fat (p = 0.03).
Conclusion:
CS with moderate to high serum CRP concentrations had higher fat mass, visceral fat mass, and lower cardiorespiratory fitness. There was a significant negative relationship between dietary, fat, polyunsaturated and saturated fat, and CRP. However, these dietary fat related findings warrant further investigation. To summarize, improving cardiorespiratory fitness, maintaining lower body fat, may be helpful in altering chronic inflammation in CS.
AlemanBMMoserECNuverJ, et al. (2014) Cardiovascular disease after cancer therapy. European Journal of Cancer Supplements12(1): 18–28.
2.
AlfanoCMImayamaINeuhouserML, et al. (2012) Fatigue, inflammation, and omega-3 and omega-6 fatty acid intake among breast cancer survivors. Journal of Clinical Oncology30(12): 1280–1287.
3.
BabaeiZMoslemiDParsianH, et al. (2015) Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors. Journal of the Egyptian National Cancer Institute27(4): 223–229.
4.
BenjaminEJBlahaMJChiuveSE, et al. (2017) Heart disease and stroke statistics – 2017 update: a report from the American Heart Association. Circulation135(10): e146–e603.
5.
BonnSESjolanderALagerrosYT, et al. (2015) Physical activity and survival among men diagnosed with prostate cancer. Cancer Epidemiology, Biomarkers & Prevention24(1): 57–64.
6.
BosaeusIDanerydPSvanbergE, et al. (2001) Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. International Journal of Cancer93(3): 380–383.
7.
BrittonKAMassaroJMMurabitoJM, et al. (2013) Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. Journal of the American College of Cardiologists62(10): 921–925.
8.
CampbellPTCampbellKLWenerMH, et al. (2009) A yearlong exercise intervention decreases CRP among obese postmenopausal women. Medicine & Science in Sports & Exercise41(8): 1533–1539.
9.
CavicchiaPPSteckSEHurleyTG, et al. (2009) A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein. Journal of Nutrition139(12): 2365–2372.
10.
CoelhoMOliveiraTFernandesR (2013) Biochemistry of adipose tissue: an endocrine organ. Archives of Medical Science9(2): 191–200.
11.
CoussensLMWerbZ (2002) Inflammation and cancer. Nature420(6917): 860–867.
12.
ElliottLMolseedLMcCallumPD (2006) The Clinical Guide to Oncology Nutrition. Chicago, IL: Academy of Nutrition and Dietetics.
13.
EsmaillzadehAKimiagarMMehrabiY, et al. (2006) Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. American Journal of Clinical Nutrition84(6): 1489–1497.
14.
EspositoKMarfellaRCiotolaM, et al. (2004) Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA292(12): 1440–1446.
15.
FliserDBuchholzKHallerH, et al. (2004) Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation. Circulation110(9): 1103–1107.
16.
FordES (2002) Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology13(5): 561–568.
17.
FranciscoVPinoJGonzalez-GayMA, et al. (2018) Adipokines and inflammation: is it a question of weight?British Journal of Pharmacology175(10): 1569–1579.
18.
FriedSKBunkinDAGreenbergAS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology & Metabolism83(3): 847–850.
19.
FungTTRimmEBSpiegelmanD, et al. (2001) Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. American Journal of Clinical Nutrition73(1): 61–67.
20.
GeIRudolphAShivappaN, et al. (2015) Dietary inflammation potential and postmenopausal breast cancer risk in a German case-control study. Breast24(4): 491–496.
21.
GleesonMBishopNCStenselDJ, et al. (2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Reviews Immunology11(9): 607–615.
22.
HeflerLAConcinNHofstetterG, et al. (2008) Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer. Clinical Cancer Research14(3): 710–714.
23.
HicklingSHungJKnuimanM, et al. (2008) Are the associations between diet and C-reactive protein independent of obesity?Preventive Medicine47(1): 71–76.
24.
JohanssonGWikmanAAhrenAM, et al. (2001) Underreporting of energy intake in repeated 24-hour recalls related to gender, age, weight status, day of interview, educational level, reported food intake, smoking habits and area of living. Public Health Nutrition4(4): 919–927.
25.
KentSMFlahertyPJCoyleLC, et al. (2003) Effect of atorvastatin and pravastatin on serum C-reactive protein. American Heart Journal145(2): e8.
26.
KingDEEganBMGeeseyME. (2003) Relation of dietary fat and fiber to elevation of C-reactive protein. American Journal of Cardiology92: 1335–1339.
27.
LemieuxIPascotAPrud’hommeD, et al. (2001) Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arteriosclerosis, Thrombosis, and Vascular Biology21(6): 961–967.
28.
LeppinkJO’SullivanPWinstonK (2016) Effect size – large, medium, and small. Perspectives on Medical Education5(6): 347–349.
29.
LeySHSunQWillettWC, et al. (2014) Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. American Journal of Clinical Nutrition99(2): 352–360.
30.
Lopez-GarciaESchulzeMBMeigsJB, et al. (2005) Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. Journal of Nutrition135(3): 562–566.
31.
MariottoABYabroffKRShaoY, et al. (2011) Projections of the cost of cancer care in the United States: 2010–2020. Journal of the National Cancer Institute103(2): 117–128.
32.
MillerKDSiegelRLLinCC, et al. (2016) Cancer treatment and survivorship statistics, 2016. CA: A Cancer Journal for Clinicians66(4): 271–289.
33.
MozaffarianDPischonTHankinsonSE, et al. (2004) Dietary intake of trans fatty acids and systemic inflammation in women. American Journal of Clinical Nutrition79(4): 606–612.
34.
NozoeTMatsumataTKitamuraM, et al. (1998) Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosis in colorectal cancer. American Journal of Surgery176(4): 335–338.
35.
OgawaHFujitaniKTsujinakaT, et al. (2011) InBody 720 as a new method of evaluating visceral obesity. Hepatogastroenterology58(105): 42–44.
36.
OhtsukaT (2015) Different effect of oral cyclosporine therapy and oral antihistamine therapy on serum high-sensitivity C-reactive protein level and thymus and activation-regulated chemokine level in atopic dermatitis in older children and adulthood. International Journal of Dermatology54(6): 648–655.
37.
PearsonTAMensahGAAlexanderRW, et al. (2003) Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation107(3): 499–511.
38.
PierceBLBallard-BarbashRBernsteinL, et al. (2009) Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. Journal of Clinical Oncology27(21): 3437–3444.
39.
PrasadK. (2006) C-reactive protein (CRP)-lowering agents. Cardiovascular Drug Reviews24(1): 33–50.
40.
SantosSOliveiraACasalS, et al. (2013) Saturated fatty acids intake in relation to C-reactive protein, adiponectin, and leptin: a population-based study. Nutrition29(6): 892–897.
41.
SchneiderCMRepkaCPBrownJM, et al. (2014) Demonstration of the need for cardiovascular and pulmonary normative data for cancer survivors. International Journal of Sports Medicine35(13): 1134–1137.
42.
ShackelfordDYBrownJMPetersonBM, et al. (2017) The University of Northern Colorado Cancer Rehabilitation Institute treadmill protocol accurate measures VO2peak in cancer survivors. International Journal of Physical Medicine and Rehabilitation5(437): 2.
ShivappaNHebertJRRietzschelER, et al. (2015) Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study. British Journal of Nutrition113(4): 665–671.
45.
ShivappaNSteckSEHurleyTG, et al. (2014) Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutrition17(8): 1689–1696.
46.
SinDDLacyPYorkE, et al. (2004) Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine170(7): 760–765.
47.
SmithAWReeveBBBellizziKM, et al. (2008) Cancer, comorbidities, and health-related quality of life of older adults. Health Care Financing Review29(4): 41–56.
48.
StewartLKFlynnMGCampbellWW, et al. (2007) The influence of exercise training on inflammatory cytokines and C-reactive protein. Medicine & Science in Sports & Exercise39(10): 1714–1719.
49.
ThomasJRNelsonJKSilvermanSJ (2011) Research Methods in Physical Activity. Champaign, IL: Human Kinetics.
50.
VillasenorAAmbsABallard-BarbashR, et al. (2011) Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study. Breast Cancer Research and Treatment129(2): 485–494.
51.
VisserMBouterLMMcQuillanGM, et al. (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA282(22): 2131–2135.
52.
WirthMDBurchJShivappaN, et al. (2014) Association of a dietary inflammatory index with inflammatory indices and metabolic syndrome among police officers. Journal of Occupational and Environmental Medicine56(9): 986–989.
53.
YoneyamaSMiuraKSasakiS, et al. (2007) Dietary intake of fatty acids and serum C-reactive protein in Japanese. Journal of Epidemiology17(3): 86–92.
