Blood transfusion is sometimes a necessary procedure during or following coronary artery bypass graft (CABG) surgery. However, transfusion-related acute lung injury (TRALI)/possible TRALI is a rare and fatal complication and characterized by acute hypoxemia and non-cardiogenic pulmonary edema that occurs within 6 hours following a transfusion. Anti-leukocyte antibodies or, possibly, other bioactive substances cause inflammation and capillary endothelial destruction in susceptible recipients’ lungs. Prompt diagnosis and mechanical ventilatory support are important. A successful treatment of two male patients following CABG surgery, compatible with TRALI/possible TRALI, is presented here.
ToyPPopovskyMAAbrahamE. Transfusion-related acute lung injury: definition and review. Crit Care Med2005; 33: 721–726.
2.
SillimanCCBoshkovLKMehdizadehkashiZ. Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors. Blood2003; 101: 454–462.
3.
VlaarAPBinnekadeJMPrinsD. Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med2010; 38: 771–778.
4.
Van SteinDBeckersEASintnicolaasK. Transfusion-related acute lung injury reports in the Netherlands: an observational study. Transfusion2010; 50: 213–220.
5.
EderAFHerronRMJrStruppA. Effective reduction of transfusion- related acute lung injury risk with male-predominant plasma strategy in the American Red Cross (2006–2008). Transfusion2010; 50: 1732–1742.
6.
FitzmauriceGJParissisHD. Platelet transfusion associated with acute lung injury after coronary artery bypass grafting. Ann Thorac Surg2011; 91: 1977–1979.
7.
GajicORanaRWintersJL. Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med2007; 176: 886–891.
