Isolated limb perfusion with urokinase was used in combination with balloon catheter embolectomy in three patients with extensive vascular thrombosis in the lower limbs after conventional methods of treatment failed to restore perfusion to the lower limb. The technique and its results are described and discussed. It is suggested that isolated limb perfusion with urokinase is safe and is worthy of further investigation in the treatment of critically ischaemic lower limbs.
Get full access to this article
View all access options for this article.
References
1.
Kroon Bbr.Regional isolated perfusion in melanoma of the limbs: accomplishments, unsolved problems, future. Eur J Surg Oncol1988; 14: 101-10.
2.
Lusby RJ, Wylie EJAcute lower limb ischaemia: pathinogenesis and management. World J Surg1983; 7:340-46.
3.
Thompson PLThrombolytic agents. Med J Aust1994; 160: 29-32.
4.
Seabrook GR, Mewissen MW, Schmitt DD et al. Percutaneous intra arterial thrombolysis in the treatment of thrombosis of lower extremity arterial reconstructions. J Vasc Surg1991; 13: 646-51.
5.
Quinones-Baldrich W.Proceedings Joint Annual Meeting of Society for Vascular Surgery/International Society for Cardiovascular Surgery, Boston, MA, 2-5 June 1991.
6.
Meryerovitz ME, Goldhaber SZ, Reagan K.Recombinant tissue type plasminogen activator vs. urokinase in peripheral arterial and graft occlusions: a randomised trial . Radiology1990; 175: 75-78.
