Reduced cooperativeness and reward-dependence in depression with above-normal plasma vasopressin concentration

Abstract

The neuropeptide vasopressin is centrally involved in the regulation of social behaviour and response to stress. We previously found support for a subcategory of depression defined by above-normal plasma vasopressin (AVP) concentration. This subcategory is validated by a positive family history of depression and correlating plasma AVP and cortisol concentrations. The data support the validity of above-normal plasma AVP concentration as a genetically determined biological marker for a subcategory of depression. The aim of the present study was to test whether above-normal plasma AVP concentration in depression is related to personality characteristics reflecting a specific social behaviour style. The data of 78 patients from a previously investigated sample were reanalysed. Fifty-eight patients were available after 2 years, 15 of whom with initially above-normal plasma AVP. The dimensions of the Temperament and Character Inventory (TCI) were scored, with particular focus on the dimensions of Cooperativeness (CO) and Reward-dependence (RD). Normative subjects and other depressed subjects were used as controls. After full remission, patients with initially above-normal AVP had low CO compared with normal and patient controls. During depression, these patients had both low CO and low RD compared with normal controls and low RD compared with patient controls. Low CO is a presumably premorbid trait and reduced RD a state-dependent characteristic in depression with above-normal plasma AVP. The low CO further supports the validity of above-normal plasma AVP concentration as a genetically determined biological marker for a subcategory of depression.

Keywords

depression personality dimensions socialisation vasopressin

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References

American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, fourth ed . Washington DC: American Psychiatric Press.

Ando, J. , Ono, Y. , Yoshimura, K. , Onoda, N. , Shinohara, M. , Kanba, S. , et al. (2002) The genetic structure of cloninger’s seven-factor model of temperament and character in a Japanese sample. J Pers 70: 583-609PMID: 12322854.

Ando, J. , Suzuki, A. , Yamagata, S. , Kijima, N. , Maekawa, H. , Ono, Y. , et al. (2004) Genetic and environmental structure of cloninger’s temperament and character dimensions. J Personal Disord 18: 379- 393PMID: 15342324.

Antoni, FA ( 1993) Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age. Front Neuroendocrinol 14: 76- 122PMID: 8387436.

Åsberg, M. , Montgomery, SA , Perris, C. , Schalling, D. , Sedvall, G. ( 1978) A comprehensive psychopathological rating scale . Acta Psychiatr Scand 271(Suppl.): 5-27, PMID: 277059.

Bell, CJ , Nicholson, H. , Mulder, RT , Luty, SE , Joyce, PR ( 2006) Plasma oxytocin levels in depression and their correlation with the temperament dimension of reward dependence. J Psychopharmacol 20: 656-660, PMID: 16401658.

Cloninger, CR , Bayon, C. , Svrakic, DM ( 1998) Measurement of temperament and character in mood disorders: a model of fundamental states as personality types. J Affect Disord 51: 21-32PMID: 9879800.

Cloninger, CR , Svrakic, DM , Przybeck, TR ( 1993) A psychobiological model of temperament and character . Arch Gen Psychiatry 50: 975-990PMID: 8250684.

Cloninger, CR , Svrakic, NM , Svrakic, DM ( 1997) Role of personality self-organization in development of mental order and disorder. Dev Psychopathol 9: 881-906PMID: 9449010.

10.

De Winter, RF , Zwinderman, AH , Goekoop, JG ( 2004) Anxious-retarded depression: relation to family history of depression. Psychiatry Res 127: 111-119PMID: 15261710.

11.

De Winter, RFP , van Hemert, AM , De Rijk, RH , Zwinderman, AH , Frankhuijzen-Sierevogel, AC , Wiegant, VM , et al. (2003) Anxious-retarded depression. Relation to plasma vasopressin and cortisol. Neuropsychopharmacology 23: 140-147PMID: 12496950.

12.

De Winter, RFP , Wolterbeek, R. , Spinhoven, PH , Zitman, FG , Goekoop, JG ( 2007) Character and temperament in major depression and its highly anxious-retarded subtype. Compr Psychiatry 48: 426-435PMID: 17707250.

13.

De Winter, RFP , Zitman, FG , van Houwelingen, JC , Wolterbeek, R. , Goekoop, JG ( 2006) Anxious-retarded depression: relation to two-year outcome of major depressive disorder. J Affect Disord 90: 77- 81PMID: 16325260.

14.

Duijsens, IJ , Spinhoven, PH , Goekoop, JG , Spermon, A. , Eurelings-Bontekoe, EHM ( 2000) The Dutch temperament and character inventory (TCI): dimensional structure, reliability and validity in a normal and psychiatric outpatient sample. Pers Individ Dif 28: 487-499.

15.

Frank, E. , Prien, RF , Jarrett, RB , Keller, MB , Kupfer, DJ , Lavori, PW , et al. (1991) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48: 851- 855PMID: 1929776.

16.

Gillespie, N. , Cloninger, C. , Heath, A. , Martin, N. ( 2003) The genetic and environmental relationship between cloninger’s dimensions of temperament and character. Personality and individual differences 35: 1931-1946.

17.

Goekoop, JG , Hoeksema, T. Knoppert-Van der Klein, EA , Klinkhamer, RA , Van Gaalen, HA , Van Londen, L. , De Weme, R. , Zwinderman, AH ( 1992) Multidimensional ordering of psychopathology. A factor-analytic study using the Comprehensive psychopathological rating scale . Acta Psychiatr Scand 86: 306-312, PMID: 1456074.

18.

Goekoop, JG , de Winter, RFP , de Rijk, R. , Zwinderman, KH , Frankhuijzen-Sierevogel, A. , Wiegant, VM ( 2006) Depression with above-normal plasma vasopressin: validation by relations with family history of depression and mixed anxiety and retardation . Psychiatry Res 141: 201-211PMID: 16436301.

19.

Moleman, P. , Birkenhaeger, TK ( 1998) Praktische psychofarmacologie. Houten : Bohn Stafleu van Loghum.

20.

Momeni, N. , Nordstrom, B. , Avarsaji, H. , Joghataei, MT , Sivberg, B. , Persson, BL ( 2007) High plasma levels of arginine vasopressin (AVP) in children with autism spectrum disorders. In: Neumann, ID , Bosch, O , Landgraf, R , (eds), Advances in Vasopressin and Oxytocin - from Genes to Behaviour and Disease. Regensburg : VIIth World Congress on Neurohypophysial Hormones , pp. 108.

21.

Montgomery, SA , Asberg, M. ( 1979) A new depression scale designed to be sensitive to change . Br J Psychiatry 134: 382-389, PMID: 444788.

22.

Murgatroyd, C. , Wigger, A. , Frank, E. , Singewald, N. , Bunck, M. , Holsboer, F. , et al. (2004) Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety. J Neurosci 24: 7762-7770PMID: 15342744.

23.

Tse, WS , Bond, AJ ( 2005) The Application of the temperament and character inventory (TCI) in predicting general social adaptation and specific social behaviors in a dyadic interaction. J Appl Soc Psychol 35: 1571-1586.

24.

Volpi, S. , Rabadan-Diehl, C. , Aguilera, G. ( 2004) Vasopressinergic regulation of the hypothalamic pituitary adrenal axis and stress adaptation. Stress 7: 75-83PMID: 15512850.

25.

Watson, S. , Gallagher, P. , Ferrier, IN , Young, AH ( 2006) Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders. J Psychiatr Res 40: 353-359PMID: 16165159.

26.

Winokur, G. ( 1997) All roads lead to depression: clinically homogeneous, etiologically heterogeneous. J Affect Disord 45: 97- 108PMID: 9268779.

27.

Yirmiya, N. , Rosenberg, C. , Levi, S. , Salomon, S. , Shulman, C. , Nemanov, L. , et al. (2006) Association between the arginine vasopressin 1a receptor (AVPR1a) gene and autism in a family-based study: mediation by socialization skills. Mol Psychiatry 11: 488- 494PMID: 16520824.

28.

Young, LJ ( 2002) The neurobiology of social recognition, approach, and avoidance. Biol Psychiatry 51: 18-26PMID: 11801228.