Eleven patients with chronic leukemia (7 with chronic lymphocytic leukemia and 4 with chronic myeloid leukemia) were evaluated with magnetic resonance (MR) imaging and T1 relaxation time measurements by use of a 1.5 tesla whole body MR scanner. Bone marrow biopsies were obtained from the posterior iliac crest (within 72 hours of the MR examination) in order to provide data on bone marrow cellularity and differential counts. The patients with chronic leukemia all showed a significant prolongation of the T1 relaxation times compared with the normal range for hemopoietic bone marrow.
JensenK. E.GrubeT.ThomsenC.: Prolonged bone marrow T1 relaxation in patients with polycythemia vera. Magn. Reson. Imag.6 (1988), 291.
2.
JensenK. E.NielsenH.ThomsenC.: In vivo measurements of the T1 relaxation processes in the bone marrow in patients with myelodysplastic syndrome. Acta Radiol.30 (1989), 365.
3.
JensenK. E.SørensenP. G.ThomsenC.ChristoffersenP.HenriksenO.KarleH.: Magnetic resonance imaging of the bone marrow in patients with acute leukemia during and after chemotherapeutic treatment. Changes in T1 relaxation. Acta Radiol.31 (1990), 362.
4.
JensenK. E.ThomsenC.HenriksenO.HertzH.JohansenH. K.YssingM.: Changes in T1 relaxation processes in the bone marrow following treatment in children with acute lymphoblastic leukemia. Pediat. Radiol.20 (1990), 464.
5.
LerskiR. A.McRobbieD. W.de CertainesJ. D.: IV. Protocols and test objects for the assessment of MRI equipment. EEC concerted research project. Magn. Reson. Imag.6 (1988), 195.
6.
LerskiR. A.McRobbieD. W.StraughanK.WalkerP. M.de CertainesJ. D.BernardA. M.: V. Multi center trial with protocols and prototype test objects for the assessment of MRI equipment. Magn. Reson. Imag.6 (1988), 201.
7.
LindenA.ZankovichR.TheissenP.DiehlV.SchichaH.: Malignant lymphoma. Bone marrow imaging versus biopsy. Radiology173 (1989), 335.
8.
McKinstryC. S.SteinerR. E.YoungA. T.JonesL.SwirskyD.AberV.: Bone marrow in leukemia and aplastic anemia. MR Imaging before, during and after treatment. Radiology162 (1987), 701.
9.
NymanR.RehnS.GlimeliusB.: Magnetic resonance imaging in diffuse malignant bone marrow diseases. Acta Radiol.28 (1987), 199.
10.
OlsonD. O.ShieldsA. F.ScheurichC. J.PorterB. A.MossA. A.: Magnetic resonance imaging of the bone marrow in patients with leukemia, aplastic anemia, and lymphoma. Invest. Radiol.21 (1986), 540.
11.
PodoF.: Tissue characterization by MRI. A multidisciplinary and multi-center challenge today. Editorial. Magn. Reson. Imag.6 (1988), 173.
12.
RanadeS. S.: Proton relaxation in vivo, in vitro and cellularity. Letter to the editor. Acta Radiol.29 (1988), 143.
13.
ShahS.RanadeS. S.KasturiS. R.PhadkeR. S.AdvaniS. H.: Distinction between normal and leukemic bone marrow by water protons nuclear magnetic resonance relaxation times. Magn. Reson. Imag.1 (1982), 23.
14.
SilingardiV.Davolio-MaraniS.FedericoM.: Bone marrow infiltration in hairy cell leukemia after interferon therapy detected by magnetic resonance imaging. Eur. J. Clin. Oncol.25 (1989), 209.
15.
SmithS. R.WilliamsC. E.DaviesJ. M.EdwardsR. H. T.: Bone marrow disorders. Characterization with quantitative MR imaging. Radiology172 (1989), 805.
16.
ThompsonJ. A.ShieldsA. F.PorterB. A.: Magnetic resonance imaging of bone marrow in hairy cell leukemia. Correlation with clinical response to alpha-interferon. Leukemia1(4) (1987), 315.
17.
ThomsenC.JensenK. E.JensenM.OlsenE. R.HenriksenO.: MR pulse sequences for selective relaxation time measurements. A phantom study. Magn. Reson. Imag.8 (1990), 43.
18.
ThomsenC.SørensenP. G.KarleH.ChristoffersenP.HenriksenO.: Prolonged bone marrow T1 relaxation in acute leukaemia. In vivo tissue characterization by magnetic resonance imaging. Magn. Reson. Imag.5 (1987), 251.
19.
VoglerJ. B.MurphyW. A.: Bone marrow imaging. Radiology168 (1988), 679.
