In 25 of 30 patients with bone metastases from prostatic carcinoma, red bone marrow extension was observed by scintigraphy of the reticuloendothelial system (RES). The degree of bone marrow extension in the lower extremities increased with increasing number of bone metastases. In 8 patients, 15 peripheral metastases were detected, all located in areas with extended red bone marrow. The distal level of bone marrow extension coincided with that of the most distal metastases. This is of importance for the detection of peripheral metastases at risk for fracture. Bone marrow extension was also seen in 5 of 8 patients with prostatic carcinoma without bone metastases and was interpreted as a paramalignant activation of RES.
BerettoniB. A.CarterJ. R.: Mechanisms of cancer metastasis to bone. J. Bone Joint Surg. 68-A (1986), 308.
2.
BourgeoisP.GassavelisC.MalarmeM.FeremansW.FrülingJ.: Bone marrow scintigraphy in breast cancer. Nucl. Med. Comm.10 (1989), 389.
3.
BremnerR. A.JeliffeA. M.: The management of pathological fracture of the major long bones from metastatic cancer. J. Bone Joint Surg. 40-B (1958), 652.
4.
DatzL.TaylorA.: The clinical use of radionuclide bone marrow imaging. Semin. Nucl. Med.3 (1985), 239.
5.
DunckerC. M.CarriI.EstorchM.: Radioimmune imaging of bone marrow in patients with suspected bone metastases from primary breast cancer. J. Nucl. Med.9 (1990), 1450.
6.
FordhamE. W.AliA.: Radionuclide imaging of bone marrow. Semin. Hematol.3 (1981), 222.
7.
FranksL. M.: The spread of prostatic carcinoma. J. Pathol.72 (1956), 603.
8.
FrimanL.: Distribution of the extrahepatic uptake in liver diseases as recorded by scintigraphy. Acta Radiol. Diagnosis22 (1981), 103.
9.
FrimanL.PerssonU.UdénR.: Recording of bone marrow activity in liver-spleen (RES) scintigraphy. Acta Radiol. Diagnosis25 (1984), 477.
10.
FritzP.AdolphJ.BubeckB.GeorgiP.zum VinkelK.: Knochenmarkszintigraphie mit Radiokolloiden bei Skelettmetastasen. RÖFO6 (1986), 689.
11.
GalaskoC. S. B.: Mechanisms of lytic and blastic metastatic disease of bone. Clin. Orthop. Rel. Res.169 (1982), 20.
12.
HaddockG.GrayH. W.McKillopJ. H.BessentR. G.KirkD.: 99mTc-nanocolloid bone marrow scintigraphy in prostatic cancer. Br. J. Urol.63 (1989), 497.
13.
HashimotoM.: Pathology of bone marrow. Acta Haematol.27 (1962), 13.
14.
HotzeA.MahlstedtJ.WolfF.: Bone marrow imaging. Technique, findings, interpretations. GIT Verlag, Darmstadt1984.
15.
ItoY.OkuyamaS.SuzukiM.SakuraiM.SatoT.TakagiH.: Bone marrow scintigraphy in the early diagnosis of experimental metastatic bone carcinoma. Cancer5 (1973), 1222.
16.
JacobsS. C.: Spread of prostatic cancer to bone. Urology4 (1983), 337.
KambyC.GuldhammerB.VejborgI.: The presence of tumor cells in bone marrow at the time of first recurrence of breast cancer. Cancer60 (1987), 1306.
19.
KociT. M.RensloR.MarcusC. S.: Incidental skeletal metastases from prostate cancer detected by sulfur colloid liver-spleen imaging. Clin. Nucl. Med.14 (1989), 225.
20.
KricunM. E.: Red-yellow marrow conversion. Its effect on the location of some solitary bone lesions. Skeletal Radiol.14 (1985), 10.
21.
LevyM. H.WheelockE. F.: The role of macrophages in defense against neoplastic disease. Adv. Cancer Res.20 (1974), 131.
22.
MargareyC. J.BaumM.: Reticulo-endothelial activity in humans with cancer. Br. J. Surg.10 (1970), 748.
23.
McKillopJ. H.: Radionuclide bone imaging for staging and follow-up of secondary malignancy. Clin. Oncol.5 (1986), 125.
24.
MunzD. L.: Bone marrow scintigraphy. Fundamental principles and clinical results. Nuclearmedizin7 (1984), 251.
25.
OehlbeckL. W. F.Robscheit-RobbinsF. S.WhippleG. H.: Marrow hyperplasia and hemoglobin reserve in experimental anemia due to bleeding. J. Exp. Med.56 (1932), 425.
26.
OmoriY.: The relation between the reticuloendothelial system and the spread of cancer, especially of gastric carcinoma. Tohoku J. Exp. Med.81 (1964), 315.
27.
OseasR. S.SiddiquiA. R.WellmanH. N.BaehnerR. L.: Usefulness of bone marrow imaging in childhood malignancies. J. Pediatr.2 (1982), 206.
28.
OtusakaN.FukunagaM.SoneT.: The usefulness of bone-marrow scintigraphy in the detection of bone metastasis from prostatic cancer. Eur. J. Nucl. Med.11 (1985), 319.
29.
PatersonA. H. G.: Bone metastases in breast cancer, prostate cancer and myeloma. Bone8 (1987), 17.
30.
ReskeS. N.KarstensJ. H.GloecknerW.: Radioimmunoimaging for diagnosis of bone marrow involvement in breast cancer and malignant lymphoma. Lancet (1989), 299.
31.
RubinP.LandmanS.MayerE.KellerB.CiccioS.: Bone marrow regeneration and extension after extended field irradiation in Hodgkin's disease. Cancer32 (1973), 699.
32.
RudbergU.AhlbäckS.-O.UdénR.: Bone marrow scintigraphy in Paget's disease of bone. Acta Radiol.31 (1990), 141.
33.
RudbergU.AhlbäckS.-O.UdénR.RydbergJ.: Radiocolloid uptake in spontaneous osteonecrosis of the knee. Clin. Orthop. Rel. Res. (1991).
34.
SacchiS.MariettaM.RinaldiG.PantusaM.RomaniF.ZaniolP.TorelliU.: Bone and bone marrow scintigraphy in the diagnosis of neoplastic involvement of skeletal system. A comparative analysis. J. Nucl. Med. Allied Sci.31 (1987), 255.
35.
SalkyN. K.Di LuzioN. R.LevinA. G.GoldsmithH. S.: Phagocytic activity of the reticuloendothelial system in neoplastic disease. J. Lab. Clin. Med.70 (1967), 393.
36.
ScherH. I.YagodaA.: Bone metastases. Pathogenesis, treatment, and rationale for use of resorption inhibitors. Am. J. Med.82 (1987), Suppl. 2A, p. 6.
37.
ShreinerD. P.HsuY.: Comparison of reticuloendothelial scans with bone scans in malignant disease. Clin. Nucl. Med.6 (1981), 101.
38.
VarenhorstE.ÅlundG.LindströmE.MånsonJ. C.: Bone marrow aspiration biopsy and bone scanning in the staging of prostatic cancer. Br. J. Urol.55 (1983), 534.
39.
VoglerJ. B.MurphyW. A.: Bone marrow imaging. Radiology168 (1988), 679.
40.
WeissL.: The structure of bone marrow. Functional interrelationships of vascular and hematopoietic compartments in experimental hemolytic anemia. An electron microscopic study. J. Morphol.117 (1965), 467.
