Granulocyte Adherence after Intravenous and Intraarterial Injection of Ioxaglate or Iohexol

Abstract

The effect of iohexol and ioxaglate on granulocyte adherence to nylon fibers was investigated with blood from 15 patients undergoing angiography, and from 24 patients undergoing excretory urography. Decreased adherence and increased numbers of granulocytes in the circulation were observed soon after injection of iohexol or ioxaglate in the aorta, or injection of ioxaglate i.v. Increased adherence and decreased numbers of granulocytes in the circulation were observed soon after injection of iohexol i.v. The differences were small soon after the injection of contrast media (CM). More pronounced decreased adherence and increased numbers of granulocytes were detected 2 and 5 hours after injection in the aorta for both CM.

Keywords

Contrast media comparative studies effects;iohexol;ioxaglate

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References

Georgsen

Rasmussen

Pedersen

J. O.

: The effect of radiographic contrast media on the chemotaxis of granulocytes. Invest. Radiol. 23 (1988), 621.

Georgsen

Rasmussen

Pedersen

J. O.

: Granulocyte chemotaxis. Influence of radiographic contrast media on the chemoattractive properties of serum. Acta Radiol. 31 (1990), 531.

Halkola

Kormano

: Effect of iodinated contrast media on the phagocytic activity of human leukocytes. A new toxicity test. Invest. Radiol. Suppl. 1 (1988), S200.

Henon

Geroto

Palacios

: Functional abnormalities of neutrophils in cancer patients. Inefficient phagocytosis and reverse endocytosis. Biomedicine 7 (1977), 261.

Lang

E. V.

Lasser

E. C.

: Contrast medium induced changes in granulocyte adherence in vitro and during angiography. Acta Radiol. 29 (1988), 585.

MacFadden

D. K.

Saito

Pruzouski

: The effect of chemotherapeutic agents on chemotaxis and random migration of human leukocytes. J. Clin. Oncol. 3 (1985), 415.

MacGregor

R. R.

MacArek

E. J.

Kefalides

N. A.

: Comparative adherence of granulocyte to endothelium monolayers and nylon fibers. J. Clin. Invest. 61 (1978), 697.

MacGregor

R. R.

Spagnola

P. J.

Lentnek

A. L.

: Inhibition of granulocyte adherence by ethanol, prednisolone and aspirin measured with an assay system. N. Engl. J. Med. 291 (1974), 642.

Maderazo

E. G.

Anton

T. F.

Ward

P. A.

: Serum-associated inhibition of leukotaxis in humans with cancer. Clin. Immunol. Immunopathol. 9 (1978), 166.

10.

Mazzone

Ricevuti

Rossi

Rizo

S. C.

: Prognostic significance of functional defects of granulocytes in myeloproliferative disease. Oncology 43 (1986), 176.

11.

Rasmussen

Antonsen

Georgsen

: Granulocyte adherence is inhibited by radiographic contrast media in vitro. Acta Radiol. 33 (1992), 379.

12.

Rasmussen

Georgsen

Antonsen

Grunnet

: Phagocytic properties of granulocytes after intravenous injection of ioxaglate or iohexol. Acta Radiol. 33 (1992), 271.

13.

Rasmussen

Georgsen

Grunnet

: Influence of radiographic contrast media on phagocytosis. Acta Radiol. 29 (1988), 589.

14.

Rasmussen

Georgsen

Pedersen

J. O.

: Granulocyte chemotaxis. Chemoattractive properties of a synthetic tripeptide are inhibited by radiographic contrast media. Acta Radiol. 30 (1989), 93.

15.

Pruzouski

Saito

DeBoer

: Modulatory activity of chemotherapeutic agents on phagocytosis and intracellular bactericidal activity of human polymorphonuclear phagocytes. Cancer Res. 43 (1983), 1420.