Effect of 24 R,25-Dihydroxyvitamin D 3 in Experimental Diabetic Rats

Abstract

The results are presented of a controlled study in male Wistar rats into the effects of 24R,25-dihydroxyvitamin D₃ on blood glucose levels, bone calcium content and ADP-induced platelet aggregation in streptozocin-induced diabetes mellitus. Blood glucose levels were shown to be decreased by 10 μg/kg 24R,25-dihydroxyvitamin D₃. The reduced bone calcium content associated with diabetes mellitus was returned to normal levels with both 1 and 10 μg/kg 24R,25-dihydroxyvitamin D₃. It was also shown to exhibit dose-dependent anti-platelet activity. The data suggest that 24R,25-dihydroxyvitamin D₃ might have potential as a mild therapeutic agent in the treatment of osteoporosis and platelet hyperactivity associated with diabetes mellitus.

Keywords

streptozocin-induced diabetes bone calcium rats

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