Effect of α-Glucosidase Inhibitor in Combination with Sulphonylurea Compounds on Lipid Profile in Patients with Non-Insulin-Dependent Diabetes Mellitus

Abstract

The effects of administration of an α-glucosidase inhibitor and a sulphonylurea compound on lipid profile were investigated in patients with non-insulin-dependent diabetes mellitus, (NIDDM) previously treated with sulphonylurea compounds alone, but in whom metabolic control was inadequate. A group of patients (n = 10) were treated with the α-glucosidase inhibitor at a dose of 0.2 mg, three times daily, for 4 weeks. Treatment significantly reduced the post-prandial glucose level and the serum total cholesterol level. In addition, there were non-significant reductions in the triglyceride and very low density lipoprotein levels. These preliminary results suggest that administration of α-glucosidase inhibitors might improve the lipid profile of patients with NIDDM.

Keywords

α-Glucosidase inhibitor Sulphonylurea compounds Noninsulin-dependent diabetes mellitus Lipid profile

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References

Baba

: α-glucosidase inhibitor. Med Prac 1993; 10: 189–194.

Okada

Ishii

Hamada

: J Int Med Res (in press).

Goto

Baba

Nakagawa

: Optimal dose finding study of AO-128 treated NIDDM (1). Jpn J Clin Exp Med 1992; 69: 1211–1236.

Goto

Baba

Nakagawa

: Optimal dose finding study of AO-128 treated NIDDM (2). Jpn J Clin Exp Med 1992; 69: 1237–1256.

WHO Study Group on Diabetes Mellitus : Diabetes Mellitus. Report No. 727. WHO Technical Report Series, Geneva: WHO, 1985.

Richmond

: Precipitation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 1973; 19: 1350–1356.

Fossati

Prencipe

: Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 1982; 28: 2077–2080.

Burstein

Scholnick

Morfin

: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970; 11: 583–595.

Kobatake

Matsuzawa

Tokunga

: Metabolic improvements associated with a reduction of abdominal visceral fat caused by a new α-glucosidase inhibitor, AO-128, in zucker fatty rats. Int J Obes 1989; 13: 147–154.

10.

Inui

Tokunaga

: Inhibitory effects of a new α-glucosidase inhibitor on fatty liver in Zucker fatty rats. J Hepatol 1990; 10: 62–68.

11.

Shinozaki

Ikebuchi

: Effect of α-glucosidase inhibitor on glucose and lipid metabolisms in patients with hyper-insulaemia. Proceedings of the 14th Congress of Japan Society for the Study of Obesity, 1993; pp 335–337.