Neuroendocrine tumors of the larynx represent a rare group of neoplasms characterized by pathological and biological heterogeneity. The histological diagnosis is the most important step in the appropriate management of these tumors and the prognosis varies according to histological types. Here we report on a case of a laryngeal neuroendocrine tumor occurring in a 67-year-old man who underwent several locoregional and systemic treatments. Because of the very low incidence of neuroendocrine tumors in the larynx, a review of the literature has also been performed.
GoldmanN.C., HoodC.I., SingletonG.P.: Carcinoid of the larynx.Arch Otolaryngol, 90: 64–67, 1969.
2.
AlujevicA., JuricG., SeparovicR., KruslinB.: Unusual features of metastatic atypical carcinoid of the larynx.Eur Arch Otorhinolaryngol, 255: 318–321, 1998.
3.
SogaJ., OsakaM., YakuwaY.: Laryngeal endocrinomas (carcinoids and relevant neoplasms): analysis of 278 reported cases.J Exp Clin Cancer Res, 21: 5–13, 2002.
4.
MillsS.E.: Neuroendocrine tumors of the head and neck: a selected review with emphasis on terminology.Endocr Pathol, 7: 329–343, 1996.
5.
Vallejo ValdezateL.A., Menendez ArguellesM.E., Diaz SuarezI., Gil-Carcedo SanudoE., Cuetos AzconaM., Gil-Carcedo GarciaL.M., Sanz SantacruzC.: Small-cell laryngeal neuroendocrine carcinoma. A case report and review of literature.An Otorinolaringol Ibero Am, 29: 505–514, 2002.
6.
KasantikulV., KeelawatS., ManeesriS., PanichabhongseV.: Moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the larynx.J Med Assoc Thai, 80: 396–401, 1997.
7.
MachensA., HolzhausenH.J., DralleH.: Minimally invasive surgery for recurrent neuroendocrine carcinoma of the supraglottic larynx.Eur Arch Otorhinolaryngol, 256: 242–246, 1999.
8.
WenigM., GneppD.R.: The spectrum of neuroendocrine carcinomas of the larynx.Semin Diagn Pathol, 6: 329–350, 1989.
9.
WoodruffJ.M., SenieR.T.: Atypical carcinoid tumor of the larynx. A critical review of the literature.ORL J Otorhinolaryngol Relat Spec, 53: 194–209, 1991.
10.
FerlitoA., BarnesL., RinaldoA., GneppD.R., MilroyC.M.: A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment.J Laryngol Otol, 112: 827–834, 1998.
11.
FerlitoA., FriedmannI.: Review of neuroendocrine carcinomas of the larynx.Ann Otol Rhinol Laryngol, 98: 780–790, 1989.
12.
WenigB.M., HyamsV.J., HeffnerD.K.: Moderately differentiated neuroendocrine carcinoma of the larynx. A clinicopathologic study of 54 cases.Cancer, 62: 2658–2676, 1988.
13.
KimK.M., ChoiE.C., HongW.P., JeongH.J.: Primary carcinoid tumor of the larynx.Yonsey Med J, 30: 193–197, 1989.
14.
MillsS.E.: Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas.Mod Pathol, 15: 264–278, 2002.
GovaertsP.J., van den BroekP., CorstensF.H., PetersH.M.: Clinical oncology: case presentations from oncology centres-2. Carcinoid of the larynx.Eur J Cancer, 28: 1755–1758, 1992.
17.
KauR., ArnoldW.: Somatostatin receptor scintigraphy and therapy of neuroendocrine (APUD) tumors of the head and neck.Acta Otolaryngol, 116: 345–349, 1996.
18.
BrisigottiM., FabbrettiG., LanzanovaG., BrugnariE.R., Pre-suttiL., ArtoniS.: Atypical carcinoid of the larynx: case report.Tumori, 73: 417–421, 1987.
19.
DictorM., TennvallJ., AkermanM.: Moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the supraglottic larynx. A report of two cases including immunohisto-chemistry and aspiration cytology.Arch Pathol Lab Med, 116: 253–257, 1992.
20.
MoisaI.I.: Neuroendocrine tumors of the larynx.Head Neck, 13: 498–508, 1991.
21.
FerlitoA., ShahaA.R., RinaldoA.: Neuroendocrine neoplasms of the larynx: diagnosis, treatment and prognosis.ORL J Otorhinolaryngol Relat Spec, 64: 108–113, 2002.
22.
ShemenL., PetratosP., PatelS., HorowitzL.: Infiltrating, moderately differentiated neuroendocrine tumor of the larynx: a brief report.Ear Nose Throat J, 82: 205–207, 2003.
CatenaL., BajettaE., ProcopioG., FerrariL., Della TorreS., VerzoniE., BichisaoE., BuzzoniR., IacobelliS., FalconeG.: Oxaliplatin plus capecitabine in advanced neuroendocrine tumours (NETs): is the new WHO classification applicable to daily practice?Eur J Cancer, 1: 540 (abstract 117), 2003.
25.
BajettaE., ProcopioG., FerrariL., CatenaL., Del VecchioM., BombardieriE.: Update on the treatment of neuroendocrine tumors.Expert Rev Anticancer Ther, 3: 631–642, 2003.