Influence of a Diet Low in Pyridoxine on Tumorigenesis in Rats Ingesting N-2-Fluorenylacetamide

Abstract

Italian

Early histological changes in the liver and cancer development in the liver and at other sites have been studied in male and female Buffalo-strain rats ingesting a diet containing N-2-Huorenylacetamide (2-FAA) and a low level of pyridoxine’ H'Cl, A month's delay in the appearance in the liver of mitotic figures in bile-duct cells and in the gradual increase in number of oval or ductal cells in the periportal areas were found in the low-pyridoxine groups when compared to previous studies with diets containing 2-FAA and high in pyridoxine (19).

The overall incidence of liver tumors in male and female rats induced by 2-FAA was not influenced by a low level of dietary pyridoxine, but there was a delayed appearance of tumors. Males fed the low pyridoxine-2-FAA diet developed a higher incidence of liver tumors than did females. The highest incidence of ear duct tumors developed in females. These females had the longest survival. The amount of 2-FAA ingested does not appear to have been a deciding factor in the development of tumors in this experiment.

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