51 patients with extensive inoperable head and neck cancer were treated with sequential continuous arterial infusion of anticancer agents. Mtx, 5 FUDR and Mitomycin C were administered in that order. At the end of the chemotherapy the patients were subjected to a full dose of external radiotherapy with the aim of destroying the residual cancer cells. Objective tumor regression was achieved in 27 patients lasting twice as long as in the same number of patients treated with external radiotherapy only. The study suggests that the idea of treating an extensive cancer with different drugs and therapeutic methods used sequentially with the aim of destroying the greatest number of cancer cells, is valid.
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