Abstract
Total extract of « Amanita phalloides » Fr., when used in the experimental conditions described in this study, determines a constant inhibitory activity on transplants of Yoshida tumor in the rat. An early and clear lytic effect on tumor cells has also been demonstrated in vitro. The antitumoral action takes effect in the phase of implantation. It is not related to the two well known toxins, alpha-amanitine and phalloidine, which do not possess the activity when used separately. The substance, in the extract that exerts the inhibiting activity on ascites tumor of Yoshida has yet to be identified. In rats in which tumor grafts with total extract of Amanita phalloides did not result in growth a further implantation of the same tumor without extract was unsuccessful. This behaviour is possibly explained by a phenomenon of active immunization. Some particular problems arise from these results. It might be of interest to extend the research to other experimental tumors.
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