Morphologic and Biologic Correlation of Hyperplastic and Neoplastic Renal Lesions Occurring in Buffalo and Fischer Strain Rats Ingesting N-4-(4'-Fluorobiphenyl)Acetamide
Restricted accessResearch articleFirst published online November, 1977
Morphologic and Biologic Correlation of Hyperplastic and Neoplastic Renal Lesions Occurring in Buffalo and Fischer Strain Rats Ingesting N-4-(4'-Fluorobiphenyl)Acetamide
Hyperplastic and neoplastic lesions of the kidney induced in inbred Buffalo and Fischer strain rats with 0.04% N-4-(4'-fluorobiphenyl) acetamide were transplanted s.c. to rats of the same strain. Hyperplastic renal lesions (« areas » or' nodules) did not survive and grow. Carcinomas of the kidney grew and killed the animals. Growth was related to the size and the degree of differentiation of the carcinoma. It is concluded that the histologic pattern of hyperplastic and neoplastic lesions of the kidney can be correlated with the results obtained on transplantation.
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