The electron microscopic observation of 2 parathyroid adenomas led to detection, in addition to elements which can also be found in nonneoplastic cells and related to the functional state, of organelles more characteristically associated with neoplastic cells. Indeed, intracytoplasmic cilia and annulate lamellae are commonly (regarded as an expression of cellular atypia rather then distinctive of the adenoma cell. Moreover, our study seems to show that annulate lamellae are correlated with the hormonal synthesis more than with the rate of growth of the neoplastic tissue.
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References
1.
BhawanJ.CeccacciL.CranfordJ.: Annulate lamellae in a malignant mesenchymal tumor.Virchows Arch. B. Cell Pathol., 26: 261–365, 1978.
2.
BlackW.C.UtleyJ.R.: The differential diagnosis of parathyroid adenoma and chief cell hyperplasia.Am. J. Clin. Pathol., 49: 761–775, 1967.
3.
BlackW.C.: Correlative light and electron microscopy in primary hyperparathyroidism.Arch. Pathol., 88: 225–241, 1969.
4.
BlackW.C.HaffR.C.: The surgical pathology of parathyroid chief cell hyperplasia.Am. J. Clin. Pathol., 53: 565–579, 1970.
5.
BoquistL.: Anulate lamellae in human parathyroid adenoma.Virschows Arch. B. Cell Pathol., 6: 234–246, 1970.
6.
CopeO.KeynesW.M.RothS.I.CastelmanB.: Primary chief-cell hyperplasia of the parathyroid glands: A new entity in the surgery of hyperparathyroidism.Ann. Surg., 148: 375–388, 1958.
7.
ElliotR.L.ArhelgerR.B.JacksonJ.D.: Fine structure of parathyroid adenomas.Arch. Pathol., 81: 200–212, 1966.
8.
FacciniJ.M.: The ultrastructure of parathyroid glands removed from patients with primary hyperparathyroidism; a report of 40 including 4 carcinomata.J. Pathol., 102: 189–199, 1970.
9.
GhadiallyF.N.: Annulate lamellae - Chapter VI, pp. 283–289. In: Ultrastructural pathology of the cell.Butterworths, London and Boston, 1975.
10.
HrubanZ.SwiftM.DunnF.W.LewisD.E.: Effects of β-3-furylalanine on the ultrastructure of the hepatocyte and pancreatic acinar cells.Lab. Invest., 14: 70–80, 1965.
11.
KesselR.G.: Fine structure of annulate lamellae.J. Cell. Biol., 36: 658–664, 1968.
12.
MarshallR.B.RobertsD.K.TurnerA.R.: Adenomas of the human parathyroid.Cancer, 20: 512–524, 1967.
13.
MaulG.G.: On the relationship between the Golgi apparatus and annulate lamellae.J. Ultrastruct. Res., 30: 368–384, 1970.
14.
MerkowL.LeightonJ.: Increased numbers of annulate lamellae in myocardium of chick embryos incubated at abnormal temperatures.J. Cell. Biol., 28: 127–137, 1966.
15.
MerkowL.P.EpsteinM.S.SlifkinM.FarberE.PardoM.: The cellular analysis of liver carcinogenesis.V. Ultrastructural alterations within hepatocellular carcinoma induced by Ethyonine. Lab. Invest., 26: 300–305, 1972.
16.
NilssonO.: Studies on the ultrastructure of the human parathyroid glands in various pathological conditions.Acta Pathol. Microbiol. Scand. [A], 263: 1–88, 1977.
17.
PolyzonisM.B.: Ultrastructure study of human parathyroid adenoma and the occurrence of abnormal cilia in the adenoma cell.Pathol. Eur., 5: 454–469, 1970.
18.
PorterK.R.: The ground substance: Observation from electron microscopy. In: The Cell, Vol. II, p. 621. BrachetJ. and MirskyA.E. (eds.), Academic Press, New York, 1961.
19.
RothS.I.MungerB.L.: The cytology of the adenomatous, atrophic, and hyperplastic parathyroid glands of man.Virchows Arch. Pathol. Anat., 335: 389–410, 1962.
20.
SunC.N.WhiteH.J.: Annulate lamellae in human tumor cells.Tissue Cell, 11: 139–146, 1979.
21.
SwiftH.: The fine structure of annulate lamellae.J. Biophys. Biochem. Cytol., 2: 415–418, 1956.
22.
TandlerB.: Warthin's tumor electron microscopic studies.Arch. Otolaryngol., 84: 68–76, 1966.
