Eight cases of abdominal carcinoids are reported, 5 males and 3 females, whose age ranged from 21 to 66 years. The site of the carcinoids was appendix in 3 cases, ileum in 3, cecum in 1 and the ovary in 1. Synchronous metastases were present at regional lymph nodes and liver in 5 of the 8 cases. Radical surgery was performed in 3 patients, whereas in 3 cases nonradical surgery, due to the presence of nodal or hepatic metastases, was followed by chemotherapy (2 cases) and radiotherapy (1 case). The patients radically operated on are alive and free of disease at 22, 27 and 27 months. Surgery should be resorted to, when possible, even in the presence of liver metastases, since the life expectancy for these patients is longer than that of patients with liver secondaries from tumors other than carcinoids. Chemotherapy and radiotherapy seem to play a complementary role, if any.
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References
1.
AnderssonA., BergdahlL.: Carcinoid tumors of the appendix in children. Acta Chir. Scand., 143: 173–175, 1977.
2.
BatesH.R.Jr.: Carcinoid tumors of the rectum. A statistical review. Dis. Colon Rectum, 9: 90–94, 1966.
3.
BersohnI., BlelochJ.: Right hemihepatectomy in secondary carcinoid of the liver: Clinical course and liver function tests. S. Afr. Med. J., 1: 271–274, 1967.
4.
BredisC., YoungG.: The blood supply of neoplasms in the liver. Am. J. Pathol., 30: 969–985, 1964.
5.
CaldarolaV.T., JackmanR.J., MoertelC.G., DockertyM.B.: Carcinoid tumors of the rectum. Am. J. Surg., 107: 844–850, 1964.
DilawariR.A., DouglassH.O.Jr.: Gastrointestinal carcinoid: Extrahepatic metastases and symptomatology following resection. J. Surg. Oncol., 11: 243–248, 1979.
8.
GodwinJ.D.: Carcinoid tumors - An analysis of 2837 cases. Cancer, 36: 560–569, 1975.
9.
HajduS.I., WinawerS.J., MyersW.P.L.: Carcinoid tumors - A study of 204 cases. Am. J. Clin. Pathol., 61: 521–528, 1974.
10.
JouanneauP., MalafosseM. cited in MazeauJ.C., BoulandJ., ValleyrandJ., CayotM.: Double localisation coecale et transverse droite d'un carcinoide colique avec métastases hépatiques et ovariennes. Lyon Chir., 75: 319–320, 1979.
11.
LanghansT.: Über einen Drusenpolyp im Ileum. Virchows Arch., 38: 559–560, 1867.
12.
LeghaS.S., ValdiviesoM., NelsonR.S., BenjaminR.S., BodeyG.P.: Chemotherapy for metastatic carcinoid tumors: Experiences with 32 patients and a review of the literature. Cancer Treat. Rep., 61: 1699–1703, 1977.
13.
LembeckF.: 5-Hydroxytryptamine in a carcinoid tumor. Nature, 172: 910–914, 1953.
14.
MaerpelF.Z., ModlinI.: Diagnosis and management of a gastric carcinoid tumor with hepatic metastases. Br. J. Surg., 65: 516–520, 1978.
15.
McDonaldR.A.: A study of 356 carcinoids of the gastrointestinal tract - Report of four new cases of the carcinoid syndrome. Am. J. Med., 21: 867–872, 1956.
16.
MoertelG.C., DockertyM.B., JuddE.S.: Carcinoid tumors of the vermiform appendix. Cancer, 21: 270–278, 1968.
17.
MoertelG.C., SaverW.G., DockertyM.B., BaggenstossA.H.: Life history of the carcinoid tumor of the small intestine. Cancer, 14: 901–908, 1961.
18.
Murray-LyonI., DawsonJ., ParsonsV.: Treatment of secondary hepatic tumors by ligation of hepatic artery and infusion of cytotoxic drugs. Lancet, 2: 172–175, 1970.
19.
OatesJ., SjoerdsmaA.: A unique syndrome associated with secretion of 5-hydroxytryptophane by metastatic gastric carcinoids. Am. J. Med., 32: 333–342, 1962.
SaltykowS.: Über die Genese der «Karzinoiden Tumoren », sowie der « Adenomyome » des Darmes. Beitr. Pathol. Anat., 54: 559–562, 1912.
22.
SandersR.J., AxtellH.K.: Carcinoids of the gastrointestinal tract. Surg. Gynecol. Obstet., 119: 369–375, 1964.
23.
StephensJ., Grahame-SmithD.: Treatment of carcinoid syndrome by local removal of hepatic metastases. Proc. R. Soc. Med., 15: 444–449, 1972.
24.
ThorsonA., BjorkG., BjorkmannG., WaldenstromJ.: Malignant carcinoid of the small intestine with metastases to liver, valvular disease of the right side of the heart (pulmonary stenosis and tricuspid regurgitation without septal defects), peripheral vasomotor symptoms, bronchoconstriction and an usual type of cyanosis. Am. Heart J., 44: 775–780, 1954.
25.
WelchJ.P., MaltR.A.: Management of carcinoid tumors of the gastrointestinal tract. Surg. Gynecol. Obstet., 145: 223–227, 1977.
