Resistance to Moloney Murine Sarcoma Virus (M-MuSV) Tumor Induction is Associated with Natural Antibody Production to «Endogenous» Moloney Leukemia Virus (M-MuLV) in Balb/Mo Mice
Restricted accessResearch articleFirst published online December, 1981
Resistance to Moloney Murine Sarcoma Virus (M-MuSV) Tumor Induction is Associated with Natural Antibody Production to «Endogenous» Moloney Leukemia Virus (M-MuLV) in Balb/Mo Mice
BALB/Mo mice are characterized by early expression of « endogenized » M-MuLV and are resistant to M-MuSV tumor induction. Furthermore, compared to normal BALB/c mice, sera from BALB/Mo mice exhibit a significant reactivity which is specific for M-MuLV when tested in a 125I-labelled Staphylococcus protein A binding assay. The possible significance of this reactivity in conferring tumor resistance is explored.
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