Hepatocellular carcinoma (HCC) with portal thrombosis is usually regarded as a contraindication for surgery and for percutaneous alcohol injection (PAI). For palliative purposes we used PAI in 4 patients with infiltrative HCC and segmental portal thrombosis. Ethanol, injected directly into the thrombus, diffused mostly along it. No complications emerged after 20 injections. In the first patient, who later a liver transplant, the thrombus was completely necrotic. In the other patients, biopsies yielded only necrotic material: in two cases, progression of the thrombus was stopped at 4 and 12 months of follow-up, and in one case the thrombus shrank and remained as such 13 months later. This preliminary experience might broaden the scope of treatment for HCC.
LivraghiT., VettoriC.: Percutaneous ethanol injection therapy of hepatoma. Cardiovasc. Intervent. Radiol. (In press).
12.
NagaoT., InoueS., GotoS., KawahoN., MizutaT., MoriokaY., OmoriY.: Hepatic resection of hepatocellular carcinoma. Ann. Surg., 205: 33–40, 1987.
13.
NagasueN., YukayaN., ChangY.C., OgawaY., OtaM., KimuraN., NakamuraT.: Appraisal of hepatic resection in the treatment of minute hepatocellular carcinoma associated with liver cirrhosis. Br. J. Surg., 74: 836–838, 1987.
14.
OhtoM., EbaraM., WatanabeJ., SugiuraN., ShinagawaT., OkudaK.: Percutaneous ethanol injection therapy for small hepatocellular carcinoma: evaluation of its utility on the basis of tumor images and survival after therapy. Jpn. J. Med. Imaging, 7: 25–33, 1988.
15.
OkamotoE., YamanakaN., ToyosakaA., TamakaN., Ya-bukiK.: Current status of hepatic resection in the treatment of hepatocellular carcinoma. In: OkudaK., IshakK.G. (eds.), Neoplasms of the Liver. pp. 353–365, Springer-Verlag, Tokyo, 1987.
16.
OkudaK., KojroM.: Small hepatocellular carcinoma. In: OkudaK., IshakK.G. (eds.), Neoplasma of the Liver. pp. 215–226, Springer-Verlag, Tokyo, 1987.
17.
SheuJ.C., SungG.T., HuangD.S., ChenD.S., YamyP.M., LaiM.Y., WeitcsuC.T., TsangY.M., LeeC.Z., HsuM.C.: lntratumor injection of absolute ethanol under ultrasound guidance for the treatment of small hepatocellular carcinoma. Hepato-gastroenterol., 34: 255–261, 1987.
18.
ShiinaS., YasudaH., MutoH.: Percutaneous ethanol injection in the treatment of liver neoplasms. AJR, 149: 949–952, 1987.
19.
ShinagawaT., OhtoM., KimuraK., TsunetomiS., MoritaM., SaishoM., TsuchiyaY., SaotomeM., KarasawaE., MikiM., UemoT., OkudaK.: Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of real time ultrasonography. A study in 51 patients. Gastroenterology, 86: 495–502, 1984.
20.
TakayasuK., ShimaY., MuramatsuY., MoryamaM., YamadaT., MakuuchiM., MasegawaH., HirohashiS.: Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology, 162: 345–351, 1987.
21.
TangZ.: Surgical treatment of subclinical cases of hepatocellular carcinoma. In: Neoplasms of the Liver.OkudaK., IshakK.G. (eds.), pp. 367–374, Springer-Verlag, Tokyo, 1987.
