Gonadoblastoma and mixed germ cell-sex cord stroma tumor have been widely recognized as two separate entities on the basis of both clinical and pathological features. The typical morphological pattern of both tumor types was found by us to coexist in the same gonadal tumor in a 14-year-old 46,XY phenotypically female subject who also had a contralateral dysgerminoma. A subserous implant showing the mixed germ cell-sex cord pattern of the primary tumor was detected in the uterine body. Following therapy the patient is alive and well after a 7-year follow-up. The distinction between gonadoblastoma and mixed germ cell-sex cord stroma tumor requires discussion.
BathenaD., HaningR.V.Jr., ShapiroS.: Coexistence of a gonadoblastoma and mixed germ cell-sex cord stroma tumor.Path. Res. Pract., 180: 203–206, 1985.
2.
BolenJ.W.: Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma.Am. J. Clin. Pathol., 75: 565–573, 1981.
3.
ChapmanW.H., PlymyerM.R., DresnerM.L.: Gonadoblastoma in an anatomically normal man: a case report and literature review.J. Urol., 144: 1472–1474, 1990.
GovanA.D.T., WoodcockA.S., GowingN.F.C., LangleyF.A., NevilleA.M., AndersonM.C.: A clinico-pathological study of gonadoblastoma.Br. J. Obstet. Gynaecol., 84: 222–228, 1977.
HughesdonP.E., KumarasamyT.: Mixed germ cell tumours (gonadoblastomas) in normal and dysgenetic gonads.Virch. Arch. A Pathol. Anat., 39: 258–280, 1970.
8.
HustinJ., GillerotY., ColletteJ., FranchimontP.: Placental alkaline phosphatase in developing normal and abnormal gonads and in germ-cell tumours.Virch. Arch. A Pathol. Anat., 417: 67–72, 1990.
9.
JacobsenG.K., BraendstrupO., TalermanA.: Bilateral mixed germ cell sex-cord stroma tumour in a young adult woman.APMIS Suppl., 23: 132–137, 1991.
10.
LacsonA.G., GillisD.A., ShawwaA.: Malignant mixed germ cell-sex cord stromal tumors of the ovary associated with isosexual precocious puberty.Cancer, 61: 2122–2133, 1988.
11.
MüllerJ., VisfeldtJ., PhilipJ., SkakkebaekN.E.: Carcinoma in situ, gonadoblastoma, and early invasive neoplasia in a nine-year-old girl with 46,XY gonadal dysgenesis.APMIS, 100: 170–174, 1992.
12.
ScullyR.E.: Gonadoblastoma. A review of 74 cases.Cancer, 25: 1340–1356, 1970.
13.
TalermanA.: A distinctive gonadal neoplasm related to gonadoblastoma.Cancer, 30: 1219–1224, 1972.
14.
TalermanA., Van Der HartenJ. J.: A mixed germ cell-sex cord stroma tumor of the ovary associated with isosexual precocious puberty in a normal girl.Cancer, 40: 889–894, 1977.
15.
TalermanA.: The pathology of gonadal neoplasms composed of germ cells and sex cord stroma derivates.Path. Res. Pract., 170: 24–38, 1980.
16.
TalermanA.: Germ cell tumors of the ovary. In: Blaustein's Pathology of the Female Genital Tract.KurmanR. (Ed.), pp. 659–721, Third ed., Springer-Verlag, New York, 1987.
17.
WilliamsonH.O., Pratt-ThomasH.R.: Bilateral gonadoblastoma with dysgerminoma. A case report.Obstet. Gynecol., 39: 263–268, 1972.
