Human immunodeficiency virus (HIV) is likely to play a role in the onset of plasma cell tumors (PCT). In fact, HIV could be involved in plasmacytomagenesis in several ways: it has the ability to lessen the immunosurveillance to such a degree as to impair the immune response against tumor cell growth. This decreased immunosurveillance could further facilitate the transforming malignant role of possible Epstein-Barr virus (EBV) infection occurring in this setting. Lastly, a murine retrovirus has been shown to be able to accelerate plasmacytomagenesis in mice, thus indicating that these viruses may be directly involved in the onset of PCT. According to cases previously reported in the literature, the clinical features of this case of HIV-associated PCT were more aggressive and the survival was shorter than expected for PCT cases in the general population. Further, the pattern of alteration of gam-maglobulinemia differed in this setting. These alterations strongly suggest a direct role of HIV in PCT. Further in-depth investigations are therefore warranted to elucidate this issue.
AndreoniM., AccursoV., VeraniD.A., SalatinoA., GiudiciM.: Mieloma multiplo di tipo IgA in un paziente con AIDS.Giorn. Ital. AIDS, 5: 165–166, 1994.
2.
CarboneA., TirelliU., GloghiniA., VolpeR., BoiocchiM.: Human immunodeficiency virus-associated systemic lymphomas may be subdivided into two main groups according to Epstein-Barr viral latent gene expression.J. Clin. Oncol., 11: 1674–1681, 1993.
3.
ChenY.H., AndersonA.B.: Effector mechanism of tumor immunity in murine plasmacytoma.Cancer Res., 48: 1391–1401, 1988.
4.
GalieniP., CavoM., AvvisatiG., FalboR., BonelliM.A., RussoD., PetrucciM.T., BucalossiA., TuraS.: Solitary plasmacytoma of bone and extramedullary plasmacytoma: two different entities?Ann. Oncol., 6: 687–691, 1995.
5.
GastautJ.A., BouabdallahR., QuilichiniR., HorschowoskiN., TapkoJ.B., AubertL., CarcassonneJ.: Sarcomes plasmo-cytaires chez les malades par le VIH.Presse Med.,18: 586, 1989.
6.
GoldJ.E., SchwamL., CastellaA., PikeS.B., OpfellR., Za-luskyR.: Malignant plasma cell tumors in human immunodeficiency virus-infected patients.Cancer, 66: 363–368, 1990.
7.
HerndierB., KaplanL.D., McGrathM.S.: Pathogenesis of AIDS-lymphomas.AIDS, 8: 1025–1048, 1994.
8.
IsraelA.M., KozinerM.D., StreausD.J.: Plasmacytoma and the acquired immunodeficiency syndrome.Ann. Intern. Med., 99: 635–636, 1983.
9.
KaplanM.H., SusinM., PahwaS.G., FettenJ., AllenS.L., LichtmanS., SarngadharanM.G., GalloR.C.: Neoplastic complications of HTLV-III infection: lymphomas and solid tumors.Am. J. Med., 82: 389–396, 1987.
10.
KarnadA.B., MartinA.W., KohH.K., BrauerM.J., NovichM., WrightJ.: Nonsecretory multiple myeloma in a 26-year-old man with acquired immunodeficiency syndrome, presenting with multiple extramedullary plasmacytomas and osteolytic bone disease.Am. J. Hematol., 32: 305–310, 1989.
11.
KonradR.J., KrickaL.J., GoodmanD.B.P., GoldmanJ., SilbersteinL.E.: Myeloma-associated paraprotein directed against the HIV-p24 antigen in an HIV-1-seropositive patient.N. Engl. J. Med., 328: 1817–1819, 1993.
12.
KumarS., KumarD., SchnadigV., SelvanayagamP., SlaughterD.: Plasma cell myeloma in patients who are HIV-positive.Am. J. Clin. Pathol., 102: 633–639, 1994.
13.
NakajimaK., Martinez-MazaO., HiranoT., BreenE.C., Nis-hanianP.G., Salazar-GonzalezJ.F., FaheyJ.L., KishimotoT.: Induction of IL-6 (B-cell stimulatory factor-2/IFN-bi) production by HIV.J. Immunol., 142: 531–536, 1989.
NosariA.M., LandonioG., CantoniS., ErranteD., VolonterioA., MorraE.: Multiple myeloma associated to HIV infection: report of two patients.Eur. J. Hematol., 56: 98–99, 1996.
16.
PaglieroniT., CaggianoV., MacKenzieM.: Abnormalities in immune regulation precede the development of multiple myeloma.Am. J. Hematol., 40: 51–55, 1992.
17.
PathmanathanR., PrasadU., SadlerR., FlynnK., Raab-TraubN.: Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma.N. Engl. J. Med., 333: 693–698, 1995.
18.
PetersenJ., DrivsholmA., BrandtM., AmbjornsenA., Dick-meissE.: B-lymphocyte function in multiple myeloma: analysis of T-cell and monocyte-dependent antibody production.Eur. J. Hematol., 42: 193–201, 1989.
19.
PilarskiL., AndrewsJ., SerraH., LedbetterJ., RuetherB., MantM.: Abnormalities in lymphocyte profile and specificity repertoire of patients with Waldenstrom's macroglobuline-mia, multiple myeloma, and IgM monoclonal gammopathy of undetermined significance.Am. J. Hematol., 30: 53–60, 1989.
