Choroidal metastasis from primaries other than breast or lung cancer is a rare event. There is no documented case in the literature of choroidal metastases in patients with hypopharynx carcinoma. Early treatment with radiation therapy provides effective palliation by preserving visual function and preventing the need for enucleation. Chemotherapy alone does not seem to be as effective as radiation therapy for patients with choroidal metastases. In this paper a case of choroidal metastasis arising from a primary hypopharynx carcinoma is presented.
BrinkleyJ.R.Jr.: Response of a choroidal metastasis to multiple-drug chemotherapy.Cancer, 45: 1538–1539, 1980.
5.
ChuF.C.H., HuhS.H., NisceL.Z., SimpsonL.D.: Radiation therapy of choroid metastases from breast cancer.Int. J. Radiat. Oncol. Biol. Phys., 2: 273–279, 1977.
6.
DobrowskyW.: Treatment of choroid metastases.Br. J. Radiology, 61: 140–142, 1988.
7.
FerryA.P., FontR.L.: Carcinoma metastatic to the eye and orbit.I. A clinicopathologic study of 227 cases. Arch. Ophthalmol., 92: 276–286, 1974.
8.
FreedmanM.I., FolkJ.C.: Metastatic tumors to the eye and orbit: patient survival and clinical characteristic.Arch. Ophthalmol., 105: 1215–1219, 1987.
9.
GodtfredsenE.: On the frequency of secondary carcinomas in the choroid.Acta Ophthalmol, 22: 394, 1944.
10.
HutchinsonD.S., SmithT.R.: Ocular and orbital metastatic carcinoma.Ann. Ophthalmol., 9: 615–658, 1966.
11.
JaegerE.A., FrayerW.C., SouthardM.E., KramerS.: Effect of radiation therapy on metastatic choroidal tumors.Trans. Am. Acad. Ophthalmol. Otol., 75: 94–101, 1971.
12.
LetsonA.D.F., DavidorfR.A., BruceR.A.: Chemotherapy for treatment of choroidal metastases from breast carcinoma.Am. J. Ophthalmol., 11: 869–873, 1979.
13.
MaorM., ChanR.C., YoungS.E.: Radiotherapy of choroidal metastases: breast cancer as a primary site.Cancer, 40: 2081–2086, 1977.
14.
McCormickB.: Ocular metastases from breast cancer. In: Diseases of the breast, HarrisJ.R., LippmanM.E., MorrowM., HellmanS. (Eds.), pp. 808–811, Lippincott-Raven, Philadelphia, 1996.
15.
MinatelE., TrovòM.G., FornerL., FranchinG., De PaoliA., RoncadinM., GobittiC., BassignanoG.: The efficacy of radiotherapy in the treatment of intraocular metastases.Br. J. Radiol., 66: 699–702, 1993.
16.
NelsonC.C., HertzbergB.S., KlinthworthG.K.: A histopathologic study of 716 unselected eyes in patients with cancer at the time of death.Am. J. Ophthalmol., 95: 788–793, 1983.
PanizzoniG.A., GaspariniG., Dal FiorS., PinnaV., MarchettiC., PozzaF.: Radiotherapeutic treatment for breast cancer choroidal metastases.Tumori, 76: 563–565, 1990.
20.
PerlsM.: Beitrage zur Pathologie der Geschwultse.Arch. Pathol. Anat., 56: 437, 1872.
21.
RatanatharathornV., PowersW.E., GrimmJ., SteversonN., HanI., AhmadK., LattinP.B.: Eye metastatis from carcinoma of the breast: diagnosis, radiation treatment and results.Cancer Treat. Rev., 18: 261–276, 1991.
22.
ReddyS., SaxenaV.S., HendricksonF., DeutschW.: Malignant metastatic disease of the eye: management of an uncommon complication.Cancer, 47: 810–812, 1981.
23.
RootmanJ., RagazJ., ClineR., LapointeJ.S.: Orbital metastases. In: Disease of the orbit. A multidisciplinary approach, RootmanJ. (Ed.), pp. 405–427, J.B. Lippincott, Philadelphia, 1988.
RudolerS.B., CornB.W., ShieldsC.L., De PotterP., HyslopT., ShieldsJ.A., CurranW.J.: External beam irradiation for choroid metastases: identification of factors predisposing to long-term sequelae.Int. J. Radiat. Oncol. Biol. Phys., 38: 251–256, 1997.
26.
ShieldsC.L., ShieldsJ.A., GrossN.E., SchwartzG.P., LallyS.E.: Survey of 520 eyes with uveal metastases.Ophthalmology, 104: 1265–1276, 1997.
27.
StephensR., SchieldsJ.A.: Diagnosis and management of cancer metastatic to the uvea: a study of 70 cases.Ophthalmology, 86: 1336–1349, 1979.
28.
TatcherN., ThomasP.R.M.: Choroidal metastases from breast carcinoma: a survey of 42 patients and the use of radiation therapy.Clin. Radiol., 26: 549–553, 1975.