La Radiochemioterapia Preoperatoria Del Carcinoma Pancreatico: Risultati Preliminari

Arbuck S.G. : Overview of chemotherapy for pancreatic cancer. Int. J. Pancreatol., 7: 209–222, 1990.

Ardalan B. , Ucar A. , Reddy R. , Livingstone A.S. , Markoe A. , Schwade J. , Richman S.P. , Donofrio K. : Phase I trial of low dose N-phosphonacetyl-L-aspartic acid and high dose 5-fluorouracil administered concomitantly with radiation therapy for unresectable localized adenocarcinoma of the pancreas. Cancer, 74: 1869–1873, 1994.

Bakkevold K.E. , Arnesjo B. , Dahl O. , Kambestad B. : Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater - results of a controlled, prospective randomized multicentre study. Eur. J. Cancer, 29A: 698–703, 1993.

Blackstock A.W. , Bernard S.A. , Richards F. , Savage P. , Tepper J.E. : Phase I study of concurrent radiation and twice-weekly gemcitabine in advanced/metastatic pancreatic cancer. Proc. Am. Soc. Clin. Oncol., 17: 1015, 1998.

Blanke C.D. , Choy H. , Beauchamp R.D. , Delbeke D. , Shyr Y. , Mertz H. , Washington M. , Johnson D.H. , Lrìeach S.D. : Phase I/II study of paclitaxel (P)-based neoadjuvant chemoradiation (CRT) for patients (PT) with potentially resectable adenocarcinoma of the pancreatic head (PHA). Proc. Am. Soc. Clin. Oncol., 17: 1103, 1998.

Bosset J.F. , Pavy J.J. , Gillet M. , Mantion G. , Pelissier E. , Schraub S. : Conventional external irradiation alone as adjuvant treatment in resectable pancreatic cancer: results of a prospective study. Radiother. Oncol., 24: 191–194, 1992.

Boz G. , De Paoli A. , Roncadin M. , Franchin G. , Galligioni E. , Arcicasa M. , Bortolus R. , Gobitti C. , Minatel E. , Innocente R. : Radiation therapy combined with chemotherapy for inoperable pancreatic carcinoma. Tumori, 77: 61–64, 1991.

Bronn D. , Franklin R. , Krishnan R. , Richardson R. , Conlin C. : Prolonged survival rates in pancreatic cancer with concurrent continous infusion 5-fluorouracil and cisplatin and hyperfractionated radiotherapy. Proc. Am. Soc. Clin. Oncol., 17: 1105, 1998.

Byfield J.E. , Chan Y.M. , Seagren S. : Radiosensitization by 5-fluorouracil (5-FU): molecular origins and clinical scheduling implication. Proc. AACR and ASCO; 74(294), 1977 (Abstract).

Cameron J.L. , Crist D.W. , Sitzmann J.V. , Hruban R.H. , Boit-nott J.K. , Seidler A.J. , Coleman J. : Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer. Am. J. Surg., 161: 120–124, 1991.

Cangemi V. , Volpino P. , Mingazzini P. , Fiori E. , Gentili S. , Ansali A. , Piat G. : Role of surgery in ductal carcinoma of the pancreas. Int. Surg., 77: 158–163, 1992.

Crucitti F. , Doglietto G.B. , Costamagna G. , Frontera D. , Ferrante A.M. , Montemaggi P. , Tradella L. , Dobelbower R.R. : Carcinoma of the pancreas: a personal experience with 100 cases. J. Surg. Oncol., 47: 141–146 IS, 1991.

Evans D.B. , Rich T.A. , Byrd D.R. , Ames F.C. : Adenocarcinoma of the pancreas: current management of resectable and locally advanced disease. South Med. J., 84: 566–570IS, 1991.

Foo M.L. , Gunderson L.L. , Nagorney D.M. , McIlrath D.C. , van Heerden J.A. , Robinow J.S. , Kvols L.K. , Garton G.R. , Martenson J.A. , Cha S.S. : Patterns of failure in grossly resected pancreatic ductal adenocarcinoma treated with adjuvant irradiation +/- 5-fluorouracil. Int. J. Radiat. Oncol. Biol. Phys., 26: 483–489, 1993.

Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer, 59: 2006–2010, 1987.

Griffin J.F. , Smalley S.R. , Jewell W. , Paraledo J.C. , Reymond R.D. , Hassanein R.E.S. , Evers B.M. : Patterns of failure after curative resection of pancreatic carcinoma. Cancer, 66: 56–61, 1990.

Heidelberger C. , Griesbach L. , Montag B.J. , Mooren D. , Cruz O. , Schnitzer R.J. , Grunberg E. : Studies on fluorinated pyrimidines. II. Effects on transplanted tumors. Cancer Research, 18: 305–317, 1958.

Hoffman J.P. , Lipsitz S. , Pisansky T. , Weese J.L. , Solin L. , Benson A.B. III : Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of pancreas: An Eastern Cooperative Oncology Group Study. J. Clin. Onc., 16: 317–323, 1998.

Hoffman J.P. , Weese J.L. , Solin L.J. , Agarwal P. , Engstrom P. , Scher R. , Paul A.R. , Litwin S. , Watts P. , Eisenberg B.L. : A single institutional experience with preoperative chemoradio-therapy for stage I-III pancreatic adenocarcinoma. Am. Surg., 59: 772–780, 1993.

Ishii H. , Okada S. , Tokuuye K. , Nose H. , Okusaka T. , Yoshi-mori M. , Nagahama H. , Sumi M. , Kagami Y. , Ikeda H. Protracted 5-fluorouracil infusion with concurrent radiotherapy as a treatment for locally advanced pancreatic carcinoma. Cancer, 15; 79: 1516–1520, 1997.

Ishikawa O. , Ohhigashi H. , Teshima T. , Chatani M. , Inoue T. , Tanaka S. , Kitamura T. , Wada A. , Sasaki Y. , Imaoka S. , Tamaka S. , Kitamura T. , Wada A. , Sasaki Y. , Imaoka S. : Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region. J. Surg. Oncol., 40: 143–151, 1989.

Ishikawa O. , Ohigashi H. , Imaoka S. , Teshima T. , Inoue T. , Sasaki Y. , Iwanaga T. , Nakaizumi A. : Concomitant benefit of preoperative irradiation in preventing pancreas fistula formation after pancreatoduodenectomy. Arch. Surg., 126: 885–889IS, 1991.

Jessup J.M. , Steele G.J. , Mayer R.J. , Posner M. , Busse P. , Cady B. , Stone M. , Jenkins R. , Osteen R. : Neoadjuvant therapy for unresectable pancreatic adenocarcinoma. Arch. Surg., 128: 559–564, 1993.

Johnstone P.A. , Sindelar W.F. : Patterns of disease recurrence following definitive therapy of adenocarcinoma of the pancreas using surgery and adjuvant radiotherapy: correlations of a clinical trial. Int. J. Radiat. Oncol. Biol. Phys., 27: 831–834, 1993.

Kaiser M.H. , Ellenberg S.S. : Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch. Surg., 120: 899–903, 1985.

Kamthan A.G. , Morris J.C. , Dalton J. , Mandeli J.P. , Chesser M.R. , Leben D. , Cooperman A. , Bruckner H.W. : Combined modality therapy for stage II and stage III pancreatic carcinoma. J. Clin. Oncol., 15: 2920–2927, 1997

Kawamura M. , Masaaki K. , Fujii T. , Itoh H. , Ishine M. , Hamamoto K. , Yokoyama S. , Takashima S. , Satoh M. , Inoue K. : Electron beam intraoperative radiation therapy (EBIORT) for localized pancreatic carcinoma. Int. J. Radiat. Oncol. Biol. Phys., 23: 751–757, 1992.

Marano P. , Brizi M.G. , Cellini N. , Montemaggi P. , Balducci M. , Morganti A.G. , Frontera D. , Fadda G. , De-Franco A. , Vecchioli A. : Esperienza di integrazione diagnostica e terapeutica del carcinoma duttale della testa del pancreas. Radiol. Med., 85: 615–624, 1993.

Matsuno S. , Sato T. : Surgical treatment for carcinoma of the pancreas. Experience in 272 patients. Am. J. Surg., 152: 499504, 1986.

McGinn C.J. , Smith D.C. , Szarka C.E. , Pinover W.H. , Loehrer P.J. , Morphis J.G. , Nicol S. , Shewach D.S. , Lawrence T.S. , o'Dwyer P.J. : A phase I study of gemcitabine (GEM) in combination with radiation therapy (RT) in patients with localized, unresectable pancreatic cancer. Proc. Am. Soc. Clin. Oncol., 17: 1014, 1998.

Miller A.B. , Hoogstraten B. , Staquet M. , Winkler A. : Reporting results of cancer treatment. Cancer, 47: 207–214, 1981.

Moertel C.G. , Childs D.S. , Reitemeier R.J. , Colby M.Y. , Holbrook M.A. : Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet, 25: 865–867, 1969.

Moertel C.G. , Frytak S. , Hanh R.G. , O'Connell M.J. , Reitemeier R.J. , Rubin J. , Schutt A.J. , Weiland L.H. , Childs D.S. , Holbrook M.A. , Lavin P.T. , Liustone E. , Spiro H. , Knowlton A. , Kaiser M. , Barkin J. , Lessner H. , Mann-Kaplan R. , Ramming K. , Douglas H.O. , Thomas P. , Nave H. , Bateman J. , Lokich J. , Brooks J. , Chaffey J. , Corson J.M. , Zamcheck N. , Novak J.W. : Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil) and high dose radiation + 5-fluorouracil. Cancer, 48: 1705–1710, 1981.

Montemaggi P. , Costamagna G. , Morganti A.G. , Cellini N. : Brachiterapia endoluminale in carcinomi non resecabili del pancreas esocrino e delle vie biliari extraepatiche. In: Atti dell'VIII Simposio Nazionale della Società Italiana di Endoscopia Digestiva, Taormina, 3-6 Novembre 1994, 99–104, Casa Editrice L'Antologia, Napoli, 1994.

Oken M.M. , Creech R.H. , Thormey D.C. , Horton J. , Davis T.E. , McFadden E.T. , Carbone P.P. : Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am. J. Clin. Oncol., 5: 649–655, 1982.

Ozaki H. , Kinoshita T. , Kosuge T. , Egawa S. , Kishi K. : Effectiveness of multimodality treatment for resectable pancreatic cancer. Int. J. Pancreatol., 7: 195–200, 1990.

Perez C.A. , Brady L.W. : Overview. In: Principles and practices of radiation oncology, Perez C.A. , Brady L.W. , (Eds.), pp. 1–63, Lippincott Co, Philadelphia, 1992.

Pilepich M.V. , Miller H.H. : Preoperative irradiation in carcinoma of the pancreas. Cancer, 46: 1945–1949, 1980.

Safran H. , King T.P. , Choy H. , Hesketh P.J. , Wolf B. , Altenhein E. , Sikov W. , Rosmarin A. , Akerley W. , Radie-Keane K. , Cicchetti G. , Lopez F. , Bland K. , Wanebo H.J. : Paclitaxel and concurrent radiation for locally advanced pancreatic and gastric cancer: a phase I study. J. Clin. Oncol., 15: 901–907, 1997.

Shibamoto Y. , Manabe T. , Baba N. , Sasai K. , Takahashi M. , Tobe T. , Abe M. : High dose, external beam and intraoperative radiotherapy in the treatment of resectable and unresectable pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys., 19: 605–611, 1990.

Sindelar W.F. , Kinsella T.J. : Randomized trial of intraoperative radiotherapy in resected carcinoma of the pancreas. Int. J. Radiat. Oncol. Biol. Phys., 12(Suppl. 1): 110, 1986 (Abstract).

Staley C.A. , Lee J.E. , Cleary K.R. , Abbruzzese J.L. , Fenoglio C.J. , Rich T.A. , Evans D.B. : Preoperative chemoradiation, pancreaticoduodenectomy and intraoperative radiation therapy for adenocarcinoma of the pancreatic head. Am. J. Surg., 171: 118–125, 1996.

Thomas C.R. Jr. , Weiden P.L. , Traverso L.W. , Thompson T. : Concomitant intraarterial cisplatin, intravenous 5-fluorouracil, and splitcourse radiation therapy for locally advanced unresectable pancreatic adenocarcinoma: a phase II study of the Puget Sound Oncology Consortium (PSOC-703). Am. J. Clin. Oncol., 20: 161–165, 1997.

Tradella L. , Crucitti F. , Doglietto G.B. , Frontera D. , Balducci M. , Morganti A.G. , Piermattei A. , Valentini V. , Cellini N. : Radioterapia intra- e postoperatoria nell'adenocarcinoma del pancreas esocrino: studio di fattibilità. Atti dell’ “International Congress on Advanced Diagnostic Modalities and New Irradiation Techniques in Radiotherapy”, pp. 347–354, Perugia, 9-11 marzo 1994.

Tsuchiya R. , Tsunoda T. , Yamaguchi T. : Operation of choise for resectable carcinoma of the head of the pancreas. Int. J. Pancreatol., 6: 295–306, 1990.

Vanhooser R. , Organ C.H. Jr. : Is the Whipple procedure a better palliative option for pancreatic cancer? J. Natl. Med. Assoc., 83: 405–408S, 1991.

Wanebo H. , Sliksman A. , Clark J. , Vezeridis M. : Preoperative chemotherapy (CT) and radiation therapy (RT) for locally advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol., 12: 225, 1993.

Weese J.L. , Nussbaum M.L. , Paul A.R. , Engstrom P.F. , Solin L.J. , Kowalyshyn M.J. , Hoffman J.P. : Increased resectability of locally advanced pancreatic and periampullary carcinoma with neoadjuvant chemoradiotherapy. Int. J. Pancreatol., 7: 177–185, 1990.

Willett C.G. , Lewandrowski K. , Warshaw A.L. , Efird J. , Compton C.C. : Resection margins in carcinoma of the head of the pancreas. Ann. Surg., 217: 144–148, 1993.

Wolff R.A. , Evans D.B. , Gravel D.M. , Lenzi R. , Pister P.W. , Lee J.E. , Janjan N.A. , Goswitz M.S. , Abbruzzese J.L. : Phase I trial of gemcitabine (GEM) combined with radiation (XRT) for the treatment of locally advanced pancreatic adenocarcinoma. Proc. Am. Soc. Clin. Oncol., 17: 1091, 1998.