Abstract
A 7-year-old mixed-breed cat presented with intermittent dry cough for 2 years. Histological examination of the lung biopsy revealed hyperplasia of bronchial and bronchiolar epithelium, and intraepithelial infiltration of globule leukocytes in many bronchi, bronchioles, and terminal bronchioles. Lymphoid aggregates cuffed airways, respiratory bronchioles, and alveolar ducts. Terminal airway inflammation was associated with type II pneumocyte hyperplasia within adjacent alveoli. Warthin-Starry stain revealed numerous argyrophilic and filamentous bacilli that were interspersed or clustered with cilia of the respiratory epithelium. The morphology, distribution, and gram (negative) and ultrastructural characteristics were consistent with cilia-associated respiratory (CAR) bacillus. Real-time polymerase chain reaction assays using paraffin-embedded lung tissue confirmed the presence of Filobacterium felis. Chronic bronchitis and bronchiolitis in a cat with F. felis share characteristics of diseases caused by species specific CAR bacilli in many species, but uniquely in this case, globule leukocytes were a prominent feature of the inflammatory response.
Get full access to this article
View all access options for this article.
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
