Editorial: A preamble to the pathology of humanized mouse models

Abdolahi S Ghazvinian Z Muhammadnejad S , et al. Patient-derived xenograft (PDX) models, applications and challenges in cancer research. J Transl Med. 2022;20(1):206.

Barro M Chen Q Armien AG , et al. Spontaneous IgM glomerulopathy in female athymic nude sentinel mice. Vet Pathol. 2026.

Bertani V Minoli L De Battisti A , et al. Spontaneous clinical and anatomical pathology findings in SDRG rats. Vet Pathol. 2026.

Bosma GC Custer RP Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 1983;301:527–530.

Brehm MA Shultz LD Greiner DL. Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes. 2010;17:120–125.

Brendel C Rio P Verhoeyen E. Humanized mice are precious tools for evaluation of hematopoietic gene therapies and preclinical modeling to move towards a clinical trial. Biochem Pharmacol. 2020;174:113711.

Casey KM Barouch-Bentov R Reineking W , et al. Clostridium cuniculi is associated with chronic high-morbidity low-mortality diarrhea in NSG and NSG-related mouse strains [published online ahead of print September 20, 2025]. Vet Pathol. doi:10.1177/03009858251372565.

Cómitre-Mariano B Martínez-García M García-Gálvez B , et al. Feto-maternal. iScience. 2021;25(1):103664.

Cox A Banerjee E Verrelle J , et al. Techniques to study chimerism at the tissue level in humanized mice [published online ahead of print November 21, 2025]. Vet Pathol. doi:10.1177/03009858251386916.

Finesso G Willis E Tarrant JC , et al. Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, NOG, and NXG mice. Vet Pathol. 2023;60:374–383.

Fujiwara S. Humanized mice: a brief overview on their diverse applications in biomedical research. J Cell Physiol. 2018;233:2889–2901.

Giusti AM Sam J Colombetti S , et al. Pathological insights of human CD34+ hematopoietic stem cell-engrafted NSG mice: implications for safety assessment of cancer immunotherapy drugs. Vet Pathol. 2026.

Homer. The Iliad. Rev ed. London, England: Penguin Classics; 2003.

Ito M Hiramatsu H Kobayashi K , et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100:3175–3182.

Jiang P Alam MM. Rise of the human-mouse chimeric brain models. Cell Regen. 2022;11(1):32.

Liu Y Wu W Cai C , et al. Patient-derived xenograft models in cancer therapy: technologies and applications. Signal Transduct Target Ther. 2023;8(1):160.

Mammone RM Willis E Ruivo P , et al. Pathology associated with human CAR T cell administration in NOD.Cg-Prkdc ^scid Il2rg ^tm1Wjl /SzJ (NSG) mice: a retrospective analysis [published online ahead of print January 27, 2026]. Vet Pathol. doi:10.1177/03009858251409216.

Mhaidly R Verhoeyen E. Humanized mice are precious tools for preclinical evaluation of CAR T and CAR NK cell therapies. Cancers (Basel). 2020;12(7):1915.

Miranda IC Kain ML Mitter AC , et al. Ultrastructural pathology and temporal patterns of viral replication and lesion development following mouse kidney parvovirus infection in B6, CD1, and NSG mice. Vet Pathol. 2026.

Pellegrini G Minoli L Degl’Innocenti S , et al. A comprehensive review of humanized mice applications in regulatory submissions for cell and gene therapy products [published online ahead of print January 26, 2026]. Vet Pathol. doi:10.1177/03009858251411297.

Radaelli E Hermans E Omodho L. Spontaneous post-transplant disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug/JicTac (NOG) mice engrafted with patient-derived metastatic melanomas. PLoS ONE. 2015;10(5):e0124974.

Roediger B Lee Q Tikoo S , et al. An atypical parvovirus drives chronic tubulointerstitial nephropathy and kidney fibrosis. Cell. 2018;175:530–543.

Ruivo P Mammone R Miranda IC , et al. Spontaneous and experimentally induced lesions in NOD-scid gamma and other NOD-derived mouse strains [published online ahead of print January 2, 2026]. Vet Pathol. doi:10.1177/03009858251403172.

Rygaard J Povlsen CO. Heterotransplantation of a human malignant tumour to “Nude” mice. Acta Pathol Microbiol Scand. 1969;77:758–760.

Santagostino SF Arbona RJR Nashat MA , et al. Pathology of aging in NOD scid gamma female mice. Vet Pathol. 2017;54:855–869.

Shirini K Ladowski JM Meier RPH . Xenotransplantation literature update: January-June 2025. Xenotransplantation. 2025;32(4):e70072.

Shultz LD Lyons BL Burzenski LM , et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol. 2005;174:6477–6489.

Shultz LD Schweitzer PA Christianson SW , et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol. 1995;154:180–191.

St Jean SC Ricart Arbona RJ Mishkin N , et al. Chlamydia muridarum infection causes bronchointerstitial pneumonia in NOD.Cg-Prkdc ^scid Il2rg ^tm1Wjl /SzJ (NSG) mice. Vet Pathol. 2024;61:145–156.

Tarrant JC Binder ZA Bugatti M , et al. Pathology of macrophage activation syndrome in humanized NSGS mice. Res Vet Sci. 2021;134:137–146.

Van Duyne R Pedati C Guendel I , et al. The utilization of humanized mouse models for the study of human retroviral infections. Retrovirology. 2009;6:76.

Walsh NC Kenney LL Jangalwe S , et al. Humanized mouse models of clinical disease. Annu Rev Pathol. 2017;12:187–215.

Willis E Banerjee E Verrelle J , et al. Characterization of host immune cell infiltrate in human CAR T cell-mediated xenogeneic graft versus host disease in NSG mice [published online ahead of print November 19, 2025]. Vet Pathol. doi:10.1177/03009858251391388.

Willis E Verrelle J Banerjee E , et al. Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice. Vet Pathol. 2024;61:664–674.

Willis E Verrelle J Secreto A. Diagnostic challenge in veterinary pathology: otitis in a humanized NOG-EXL mouse. Vet Pathol. 2025;62:113–116.