A female American black bear (Euarctos ursus americanus) over 20 years old had shown epileptiform neurologic signs starting in March 1992 and was found dead unexpectedly 8 months later. At necropsy, pulmonary and intrabronchial hemorrhage was noted. In the brain, the leptomeninges exhibited slight thickening, and petechiae were evident in the hippocampus. Histopathologic examination of the brain revealed several senile changes: numerous senile plaques, amyloid deposition in cerebromeningeal arterioles, mineral deposition in the pallidum, and numerous corpora amylacea in the cerebellum.
AraiHLeeMY VOtvasLJrGreenbergBDLoweryDESharmaSKSchmidtMLTrojanowskiJQ:
Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer senile plaque.
Proc Natl Acad Sci USA87:
2249–2253,
1990.
2.
CorkLCPowersRESelkoeDJDaviesPGeyerJJPriceDL:
Neurofibrillary tangles and senile plaques in aged bears.
J Neuropathol Exp Neurol47:
629–641,
1988.
3.
InnesJRMSaundersLZ:
Pigmentations and depositions. In:
Comparative Neuropathology,
ed. InnesJRMSaundersLZ,
pp. 659–667.
Academic Press,
New York, NY,
1962.
4.
JoachimCLMorrisJHSelkoeDJ:
Diffuse plaques occur commonly in the cerebellum in Alzheimer's disease.
Am J Pathol135:
309–319,
1989.
5.
ScheibelMEScheibelAB:
Structural changes in the aging brain. In:
Aging,
ed. BrodyHHarmanDOrdyJM, vol. 1.Raven Press,
New York, NY1975.
6.
SelkoeDJBellDSPodlisnyMBPriceDICorkLC:
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Science235:
873–877,
1987.
7.
ShinRWIwakiTKitamotoTTateishiJ:
Hydrated autoclave treatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's brain tissues.
Lab Invest64:
693–702,
1990.
8.
UchidaKTaniYUetsukaKNakayamaHGotoN:
Immunohistochemical studies on canine cerebral amyloid angiopathy and senile plaques.
J Vet Med Sci54:
759–771,
1992.
9.
WisniewskiHMJonsonABRaineCSKayWJTerryRD:
Senile plaques and cerebral amyloidosis in aged dogs.
Lab Invest23:
287–296,
1970.
10.
WisniewskiHMWegielJMorysJBancherCSoltysiakZKimKS:
Aged dogs: an animal model to study beta-protein amyloidogenesis. In:
Alzheimer's Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics (Key topics in Brain Research),
ed. MaurerKRiedererPBecmannH,
pp. 151–168.
Springer-Verlag,
Wien, Germany,
1990.
