Microscopic lesions in four cases of abortion caused by porcine reproductive and respiratory syndrome virus (PRRSV) were characterized by arteritis, myocarditis, and encephalitis. Fetal PRRSV infection was confirmed by virus isolation or immunohistochemistry and serology. Although fetal microscopic lesions in PRRSV abortions are rarely reported, diagnosticians should consider PRRSV when these lesions occur.
BautistaEMGoyalSMYoonIJJooHSCollinsJE:
Comparison of porcine alveolar macrophages and CL2621 for the detection of porcine reproductive and respiratory syndrome (PRRS) virus and anti-PRRS antibody.
J Vet Diagn Invest5:
163–165,
1993.
2.
ChristiansonWTCollinsJEBenfieldDAHarrisLGorcycaDEChaldekDWMorrisonRBJooHS:
Experimental reproduction of swine infertility and respiratory syndrome in pregnant sows.
Am J Vet Res53:
485–488,
1992.
3.
CollinsJEBenfieldDAChristiansonWTHarrisLChristopher-HenningsJShawDPGoyalSMMcCulloughSMorrisonRBJooHSGorcycaDChladekD:
Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs.
J Vet Diagn Invest4:
117–126,
1992.
4.
FaheyJLMcKelveyEM:
Quantitative determination of serum immunoglobulins in antibody-agar plates.
J Immunol94:
84–90,
1965.
5.
GoovaertsDVisserN:
Vascular lesions in pigs infected with PRRS.
Proc Congr Int Pig Vet Soc12:
129,
1992.
6.
GoyalSM:
Porcine reproductive and respiratory syndrome: a review.
J Vet Diagn Invest5:
656–664,
1993.
7.
LagerKMMengelingWLAckermannMR:
Pulmonary lesions in fetuses exposed in utero to porcine reproductive and respiratory syndrome virus.
J Vet Diagn Invest6:
480–483,
1994.
8.
MagarRLarochelleRRobinsonYDubucC:
Immunohistochemical detection of porcine reproductive and respiratory syndrome virus using colloidal gold.
Can J Vet Res57:
300–304,
1993.
9.
MengelingWL:
Maternal reproductive failure caused by porcine parvovirus. In:
Laboratory Diagnosis of Abortion,
ed. KirkbrideCE, 3rd ed.,
pp. 129–135.
Iowa State University Press,
Ames, IA,
1990.
10.
MengelingWLPaulPSLagerKM:
Virus-induced maternal reproductive failure of swine.
J Am Vet Med Assoc203:
1268–1272,
1993.
11.
NelsonEAChristopher-HenningsJDrewTWensvoortGCollinsJEBenfieldDA:
Differentiation of U.S. and European isolates of porcine reproductive and respiratory syndrome virus by monoclonal antibodies.
J Clin Microbiol34:
3184–3189,
1993.
12.
NortonAJJordanSYeomansP:
Brief, high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed tissues.
J Pathol173:
371–379,
1994.
13.
OnyekabaCBueonLKingPFahrmanJFGoyalSM:
Susceptibility of various cell culture systems to pseudorabies virus.
Comp Immunol Microbiol Infect Dis10:
163–166,
1987.
14.
PringleCR:
Committee pursues medley of virus taxonomic issues.
Am Soc Microbiol News58:
475–476,
1992.
15.
RossowKDCollinsJEGoyalSMNelsonEAChristopher-HenningsJBenfieldDA:
Pathogenesis of porcine reproductive and respiratory virus infection in gnotobiotic pigs.
Vet Pathol32:
361–373,
1995.
16.
SmithREReynoldsIMClarkGW:
Immunofluorescence in the diagnosis of bovine fetal leptospirosis.
Cornell Vet57:
517–526,
1967.
17.
ThompsonSWHuntRD:
Selected Histochemical and Histopathological Methods,
1st ed.,
p. 346.
Charles C Thomas,
Springfield, IL,
1966.
18.
Van AlstineWGKanitzCLStevensonGW:
Time and temperature survivability of PRRS virus in serum and tissues.
J Vet Diagn Invest5:
621–622,
1993.
19.
YoonIJJooHSChristiansonWTKimHSCollinsJEMorrisonRB:
An indirect fluorescent antibody test for the detection of antibody to swine infertility and respiratory syndrome virus in swine sera.
J Vet Diagn Invest4:
144–147,
1992.
