Lafora bodies (polyglucosan deposits) were identified in the brain of a young adult cat with neurologic signs characterized by intermittent but progressively worsening head and body tremors. The cerebellar cortex was the most severely affected area of brain, and the deposits were identified within Purkinje cell bodies and processes and throughout the neuropil. The association of Lafora bodies with neurologic signs, occurrence of deposits within neuronal perikarya, and distribution primarily within the cerebellar cortex are features distinct from the more commonly recognized situation in which Lafora bodies occur as incidental lesions in cats.
GhadiallyFN:
Ultrastructural Pathology of the Cell and Matrix. A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components,
3rd ed.,
vol. 2, pp. 970–973.
Butterworths, London, England,
1988
5.
HollandJMDavisWCPrieurDJCollinsGH:
Lafora's disease in the dog. A comparative study.
Am J Pathol58:509–529, 1970
6.
IannacconeSZucconiMQuattriniANemniRComolaMTaccagniLSmirneS:
Early detection of skin and muscular involvement in Lafora disease.
J Neurol238:217–220, 1991
7.
JianZAlleyMRCayzerJSwinneyGR:
Lafora's disease in an epileptic Basset hound.
NZ Vet J38:75–79, 1990
8.
KaiserEKrauserKSchwartz-PorscheD:
Lafora disease (progressive myoclonus epilepsy) in the Bassett Hound—possibility of early diagnosis using muscle biopsy?Tierärztl Prax19:290–295, 1991
9.
KamiyaSSuzukiY:
Polyglucosan bodies in the brain of the cat.
J Comp Pathol101:263–267, 1989
10.
KamiyaSSuzukiYDaigoM:
Immunoreactivity of canine and feline polyglucosan bodies for monoclonal antibody against human polyglucosan.
Acta Neuropathol Berl81:217–218, 1990
11.
KamiyaSSuzukiYDaigoM:
Polyglucosan bodies in the central nervous system of a fox.
J Comp Pathol105:467–470, 1991
12.
MackenzieCDJohnsonRP:
Lafora's disease in a dog.
Aust Vet J52:144, 1976
13.
OliverJEJrLorenzMDKornegayJN:
Handbook of Veterinary Neurology,
3rd ed., pp. 365–366.
WB Saunders, Philadelphia, PA,
1997
14.
SerratosaJMDelgado-EscuetaAVPosadaIShihSDruryIBercianoJZabalaJAAntunezMCSparkesRS:
The gene for progressive myoclonus epilepsy of the Lafora type maps to chromosome 6q.
Hum Mol Genet4:1657–1663, 1995
15.
SimmonsMM:
Lafora disease in the cow?J Comp Pathol110:389–401, 1994
16.
SummersBACummingsJFde LahuntaA:
Veterinary Neuropathology, pp. 326–327.
Mosby, St. Louis, MO,
1995
17.
YamanamiSIshiharaTTakahashiMUchinoF:
Comparative study of intraneuronal polyglucosan bodies in brain from patients with Lafora disease and aged dogs.
Acta Pathol Jpn42:787–792, 1992