Morphine sulphate 5 mg and placebo administered epidurally after caesarean section under epidural analgesia were compared in a double-blind fashion.
Morphine was significantly superior to placebo for pain relief, duration of pain relief, and reduction of parenteral narcotic requirements. Pruritis was the most commonly encountered side-effect. There was no statistical difference between morphine and placebo in the incidence of urinary catheterisation, vomiting, nausea, dizziness or drowsiness. No serious respiratory depression requiring treatment was observed.
BondM.R., PilowskyI.Subjective Assessment of pain and its relationship to the administration of analgesics in patients with advanced cancer. J Psychosomatic Res1966; 10: 203–208.
13.
BeecherH.K.The assessment of pain in man and animals. UFAW Symposium E & S Livingstone, Edin, London, 1961.
14.
BoasR.A.Hazards of epidural morphine. Anaesth Intens Care1980; 8: 377.
15.
TordaT.A., PybusD.A., LibermanH., ClarkeM., CrawfordM.Experimental comparison of extradural and IM morphine. Br J Anaesth1980; 52: 939.