Alfentanil and fentanyl were compared as supplements to thiopentone, nitrous oxide, relaxant anaesthesia in a randomised, double blind trial carried out on 55 adult patients undergoing elective surgery. The fentanyl-treated patients resumed spontaneous ventilation more rapidly at the end of anaesthesia (3 minutes) than the alfentanil-treated group (5.1 minutes, p < 0.02). In other respects the drugs appeared indistinguishable. A computer model is used to explain why, despite the shorter elimination half-life, the alfentanil-treated patients did not awaken more rapidly than those in the fentanyl group.
BovillJ.G., SebelP.S., BlackburnC.L., HeyekantsJ.The pharmacokinetics of alfentanil (R 39209): A new opioid analgesic. Anesthesiology1982; 57: 439–443.
4.
BowerS., HullC.J.Comparative pharmacokinetics of fentanyl and alfentanil. Br J Anaesth1982; 54: 871–877.
5.
van LeeuwenL., DeenL.Alfentanil, a new, potent and very short-acting morphinomimetic for minor operative procedures. Anaesthesist1981; 30: 115–117.
6.
CoeV., ShaferA., WhiteF.F.Techniques for administering alfentanil during outpatient anaesthesia — a comparison with fentanyl. Anesthesioloey1983; 59: A347.
7.
RosowC.E., LattaW.B., KeeganM.A., NozickD.L., MurphyA.L., KimballW.R., PhilbinD.M.Alfentanil and fentanil in short surgical procedures. Anesthesiology1983; 59: A345.
8.
American Society of Anesthesiologists, Handbook for Delegates1974; 416-3.2: 3.
9.
NieN.H., HullC.H., JenkinsJG., SteinbrennerK., BentD.H.Statistical package for the social sciences. 2nd ed. McGraw-Hill, New York1975.
ShaferA., CocV., WhiteP.F.Continuous intravenous infusion of alfentanil: Defining the therapeutic concentration range. Anesthesiology1983; 59: A348.
12.
PatrickM., EagarB., ToftD.F., SebelP.S.Alfentanil supplemented anesthesia for short procedures: A double blind comparison with fentanyl. Anesthesiology1983; 59: A346.
13.
GreenR., LongH.A., ElliottC.J., HowellsT.H.A method of studying recovery after anaesthesia. A critical assessment of recovery following methohexitone and thiopentone using a complex performance task. Anaesthesia1963; 18: 189.