Systematic Review of Randomized Controlled Trials Evaluating the Use of Platelet-Rich Plasma for Knee Osteoarthritis: Adherence to Minimum Information for Studies Evaluating Biologics in Orthopaedics
Restricted accessResearch articleFirst published online April, 2025
Systematic Review of Randomized Controlled Trials Evaluating the Use of Platelet-Rich Plasma for Knee Osteoarthritis: Adherence to Minimum Information for Studies Evaluating Biologics in Orthopaedics
The Minimum Information for Studies Evaluating Biologics in Orthopedics (MIBO) guidelines were developed in May 2017 to encourage improved reporting standards, promote increased transparency and reproducibility, and enhance clinical evaluation capabilities. The MIBO guidelines consist of 23 checklist items considered necessary to critically appraise clinical studies evaluating platelet-rich plasma (PRP).
Purpose:
To assess randomized controlled trials that evaluated PRP for the treatment of knee osteoarthritis in order to systematically review their adherence to the MIBO guidelines.
Study Design:
Systematic review. Level 1a.
Methods:
A search was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The inclusion criteria were randomized controlled trials reporting on knee osteoarthritis treated with intra-articular PRP. The studies were categorized into pre-, peri-, and post-MIBO groups based on the start date of data collection. The overall MIBO scores, defined as percentage of checklist items out of the 23 checklist items reported in 1 study, individual item scores, defined as percentage of studies reporting the checklist item within a specified group, and overall item score defined as the average of the individual item scores from all the included studies were calculated.
Results:
The review included 87 studies (7925 patients; 8118 knees). Of these, 51 studies were assigned to the pre-MIBO group, 19 studies to the peri-MIBO group, and 17 studies to the post-MIBO group. The overall MIBO score was 72%. No statistically significant differences in MIBO scores were found among the 3 MIBO groups (P = .345). The majority of the studies (62 studies; 71%) had MIBO scores <80%. MIBO items with particularly low item scores included reporting of whole-blood characteristics (20%), platelet recovery rate (22%), PRP analysis (30%), and PRP activation (47%). No significant difference among the 3 MIBO groups was found for the item scores except for the reporting of the recipient details (P = .012).
Conclusion:
This study highlights the deficiencies in adherence to the MIBO guidelines, particularly in reporting key variables such as whole-blood characteristics, platelet recovery rate, PRP analysis, and PRP activation. These findings suggest that the publication of the MIBO guidelines has not resulted in improved reporting practices in studies investigating intra-articular PRP for the treatment of knee osteoarthritis.
AakashVKumaranNAVigneshAVignesh SubashY.Comparison of functional outcome and pain relief between steroid injection and platelet rich plasma injection in early osteo arthritis knee. Int J Pharmaceut Sci Res. 2022;13(12):4985-4990.
2.
AhmadHSFarragSEOkashaAE, et al. Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis. Int J Rheum Dis. 2018;21(5):960-966.
3.
AkanOSarikayaNOKocyigitH.Efficacy of platelet-rich plasma administration in patients with severe knee osteoarthritis: can platelet-rich plasma administration delay arthroplasty in this patient population?Int J Clin Exper Med. 2018;11(9):9473-9483.
4.
AkedaKAnHSOkumaM, et al. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthritis Cartilage. 2006;14(12):1272-1280.
5.
AldemirHKiliçN.The effect of time of day and exercise on platelet functions and platelet-neutrophil aggregates in healthy male subjects. Mol Cell Biochem. 2005;280(1-2):119-124.
6.
AngooraniHMazaherinezhadAMarjomakiOYounespourS.Treatment of knee osteoarthritis with platelet-rich plasma in comparison with transcutaneous electrical nerve stimulation plus exercise: a randomized clinical trial. Med J Islamic Repub Iran. 2015;29:223.
7.
AnzAWPlummerHACohenA, et al. Bone marrow aspirate concentrate is equivalent to platelet-rich plasma for the treatment of knee osteoarthritis at 2 years: a prospective randomized trial. Am J Sports Med. 2022;50(3):618-629.
8.
AssirelliEFilardoGMarianiE, et al. Effect of two different preparations of platelet-rich plasma on synoviocytes. Knee Surg Sports Traumatol Arthrosc. 2015;23(9):2690-2703.
9.
AugestadKMBerntsenGLassenK, et al. Standards for reporting randomized controlled trials in medical informatics: a systematic review of CONSORT adherence in RCTs on clinical decision support. J Am Med Inform Assoc. 2012;19(1):13-21.
10.
AydoğanNHGülDİltarS, et al. The clinical effect of platelet-rich plasma prepared through different activation methods on patients with knee osteoarthritis. J Clin Analytic Med. 2016;7(6):767-771.
11.
AyeniFEsanOIkemICAdegbehingbeO.Early outcome of platelet rich plasma and non-steroidal anti-inflammatory agent alone and in combination on primary knee osteoarthritis. J Clin Diagn Res. 2019;(11):RC06-RC08p.
12.
BannuruRRNatovNSObadanIE, et al. Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis. Arthritis Rheum. 2009;61(12):1704-1711.
13.
BansalHLeonJPontJL, et al. Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: correct dose critical for long term clinical efficacy. Scientific Reports. 2021;11(1):3971.
14.
BariaMPedrozaAKaedingC, et al. Platelet-rich plasma versus microfragmented adipose tissue for knee osteoarthritis: a randomized controlled trial. Orthop J Sports Med. 2022;10(9):2325967122 1120678.
15.
BarmanABandyopadhyayDMohakudS, et al. Comparison of clinical outcome, cartilage turnover, and inflammatory activity following either intra-articular or a combination of intra-articular with intra-osseous platelet-rich plasma injections in osteoarthritis knee: a randomized, clinical trial. Injury. 2023;54(2):728-737.
16.
BarmanAPrakashSSahooJ, et al. Single intra-articular injection with or without intra-osseous injections of platelet-rich plasma in the treatment of osteoarthritis knee: a single-blind, randomized clinical trial. Injury. 2022;53(3):1247-1253.
17.
BasnaevUIKarakursakovNEMykhaylichenkoVYKriventsovMA.Platelet-rich plasma administering in osteoarthrosis treatment. Russian Open Medical Journal. 2021;10(1).
18.
BennellKLPatersonKLMetcalfBR, et al. Effect of intra-articular platelet-rich plasma vs placebo injection on pain and medial tibial cartilage volume in patients with knee osteoarthritis: the RESTORE randomized clinical trial. JAMA. 2021;326(20):2021-2030.
19.
BraunHJKimHJChuCRDragooJL.The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy. Am J Sports Med. 2014;42(5):1204-1210.
20.
BruyèreOCooperCPelletierJP, et al. A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis—from evidence-based medicine to the real-life setting. Semin Arthritis Rheum. 2016;45(4 suppl):S3-S11.
21.
Buendia-LopezDMedina-QuirosMMarnnM.Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial. J Orthop Traumatol. 2018;19(1):9.
22.
BugarinASchroederGShiBYJonesKJKremenTJJr.Assessment of characteristics and methodological quality of the top 50 most cited articles on platelet-rich plasma in musculoskeletal medicine. Orthop J Sports Med. 2022;10(5):23259671221093074.
23.
CampbellKASaltzmanBMMascarenhasR, et al. Does intra-articular platelet-rich plasma injection provide clinically superior outcomes compared with other therapies in the treatment of knee osteoarthritis? A systematic review of overlapping meta-analyses. Arthroscopy. 2015;31(11):2213-2221.
24.
CastilloTNPouliotMAKimHJDragooJL.Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. Am J Sports Med. 2011;39(2):266-271.
25.
CavalloCFilardoGMarianiE, et al. Comparison of platelet-rich plasma formulations for cartilage healing: an in vitro study. J Bone Joint Surg Am. 2014;96(5):423-429.
26.
CerzaFCarnìSCarcangiuA, et al. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med. 2012;40(12):2822-2827.
27.
ChahlaJCinqueMEPiuzziNS, et al. A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical orthopaedic literature. J Bone Joint Surg Am. 2017;99(20):1769-1779.
28.
ChuJBDuanWFYuZQ, et al. Intra-articular injections of platelet-rich plasma decrease pain and improve functional outcomes than sham saline in patients with knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2022;30(12):4063-4071.
29.
ColeBJKarasVHusseyKPilzKFortierLA.Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis. Am J Sports Med. 2017;45(2):339-346.
30.
CoppingerJACagneyGToomeyS, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004;103(6):2096-2104.
31.
DeClercqMGFiorentinoAMLengelHA, et al. Systematic review of platelet-rich plasma for rotator cuff repair: are we adhering to the minimum information for studies evaluating biologics in orthopaedics?Orthop J Sports Med. 2021;9(12):23259671211041971.
32.
DeekMSAbryDSEl SeedekHArweashA.Intra-articular injection of platelet rich plasma versus hyaluronic acid for moderate knee osteoarthritis: a prospective, double-blind randomized controlled trial on 189 patients with follow-up for three years. Acta Orthop Belg. 2021;87(4):729-734.
33.
DeLongJMRussellRPMazzoccaAD.Platelet-rich plasma: the PAW classification system. Arthroscopy. 2012;28(7):998-1009.
34.
Di MartinoABoffaAAndrioloL, et al. Leukocyte-rich versus leukocyte-poor platelet-rich plasma for the treatment of knee osteoarthritis: a double-blind randomized trial. Am J Sports Med. 2022;50(3):609-617.
35.
Dohan EhrenfestDMRasmussonLAlbrektssonT.Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158-167.
36.
DorioMPereiraRMRLuzAGB, et al. Efficacy of platelet-rich plasma and plasma for symptomatic treatment of knee osteoarthritis: a double-blinded placebo-controlled randomized clinical trial. BMC Musculoskelet Disord. 2021;22(1):822.
37.
DulicORasovicPLalicI, et al. Bone marrow aspirate concentrate versus platelet rich plasma or hyaluronic acid for the treatment of knee osteoarthritis. Medicina (Kaunas). 2021;57(11):1193.
38.
DuymusTMMutluSDernekB, et al. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc. 2017;25(2):485-492.
39.
El-TambolySMedhatMKhattabRDarwishHDeghadyA.Pulsed radiofrequency ablation of genicular nerve versus intra-articular radiofrequency ablation combined with platelets rich plasma for chronic knee osteoarthritis. Egyptian Journal of Anaesthesia. 2021;37(1):317-325.
40.
ElawamyAKamelEZMahranSAAbdellatifHHassanienM.Efficacy of genicular nerve radiofrequency ablation versus intra-articular platelet rich plasma in chronic knee osteoarthritis: a single-blind randomized clinical trial. Pain Physician. 2021;24(2):127-134.
41.
ElgendyMHElsamahySAMostafaMSEMHamzaMSK. Efficacy of shockwave therapy versus intra-articular platelet-rich plasma injection in management of knee osteoarthritis: a randomized controlled trial. Int J Pharmaceut Res. 2020;12(4):4283-4289.
42.
ElikHDoguBYilmazFBegogluFAKuranB.The efficiency of platelet-rich plasma treatment in patients with knee osteoarthritis. J Back Musculoskel Rehabil. 2020;33(1):127-138.
43.
Elksnins-FinogejevsAVidalLPeredistijsA.Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up. J Orthop Surg. 2020;15(1):257.
44.
EvertsPOnishiKJayaramPLanaJFMautnerK.Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020;21(20):7794.
45.
FilardoGDi MatteoBDi MartinoA, et al. Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial. Am J Sports Med. 2015;43(7):1575-1582.
46.
FilardoGKonEDi MartinoA, et al. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial. BMC Musculoskelet Disord. 2012;13:229.
47.
FilardoGKonEPereira RuizMT, et al. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach. Knee Surg Sports Traumatol Arthrosc. 2012;20(10):2082-2091.
48.
FitzpatrickJBulsaraMKMcCroryPRRichardsonMDZhengMH.Analysis of platelet-rich plasma extraction: variations in platelet and blood components between 4 common commercial kits. Orthop J Sports Med. 2017;5(1):2325967116675272.
49.
ForoghBMianehsazEShoaeeS, et al. Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial. J Sports Med Phys Fitness. 2016;56(7):901-908.
50.
FrazerABunningRAThavarajahMSeidJMRussellRG.Studies on type II collagen and aggrecan production in human articular chondrocytes in vitro and effects of transforming growth factor-beta and interleukin-1beta. Osteoarthritis Cartilage. 1994;2(4):235-245.
51.
FufaDShealyBJacobsonMKevySMurrayMM.Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008;66(4):684-690.
52.
GaballaNMMohammedYAKamelLMMahgoubHM.Therapeutic efficacy of intra-articular injection of platelet-rich plasma and ozone therapy in patients with primary knee osteoarthritis. Egypt Rheumatol. 2019;41(3):183-187.
53.
GobbiALadDKarnatzikosG.The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2015;23(8):2170-2177.
54.
GonzalesVKde MulderELde BoerT, et al. Platelet-rich plasma can replace fetal bovine serum in human meniscus cell cultures. Tissue Eng Part C Methods. 2013;19(11):892-899.
55.
GormeliGGormeliCAtaogluB, et al. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017;25(3):958-965.
56.
HahnOKiebMJonitz-HeinckeA, et al. Dose-dependent effects of platelet-rich plasma powder on chondrocytes in vitro. Am J Sports Med. 2020;48(7):1727-1734.
57.
HallMPBandPAMeislinRJJazrawiLMCardoneDA.Platelet-rich plasma: current concepts and application in sports medicine. J Am Acad Orthop Surg. 2009;17(10):602-608.
58.
HanBWoodell-MayJPonticielloMYangZNimniM.The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J Bone Joint Surg Am. 2009;91(6):1459-1470.
59.
HarrisonP.The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH. J Thromb Haemost. 2018;16(9):1895-1900.
60.
HartRSafiAKomzákM, et al. Platelet-rich plasma in patients with tibiofemoral cartilage degeneration. Arch Orthop Trauma Surg. 2013;133(9):1295-1301.
61.
HooiveldMRoosendaalGWentingM, et al. Short-term exposure of cartilage to blood results in chondrocyte apoptosis. Am J Pathol. 2003;162(3):943-951.
62.
HuangYLiuXXuXLiuJ.Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis: a prospective randomized controlled study. Orthopade. 2019;48(3):239-247.
63.
JacobGShettyVShettyS.A study assessing intra-articular PRP vs PRP with HMW HA vs PRP with LMW HA in early knee osteoarthritis. J Arthrosc Joint Surg. 2017;4(2):65-71.
64.
JafriSMVanRollinsMOzawaT, et al. Circadian variation in platelet function in healthy volunteers. Am J Cardiol. 1992;69(9):951-954.
65.
JiaoRZhangMSLiXPLiSQHuangWX.The effectiveness of single injection of platelet-rich plasma for knee osteoarthritis combined with meniscus injury: a randomized trial. J Biomater Tissue Engin. 2022;12(2):287-292.
66.
JubertNJRodriguezLReverte-VinaixaMMNavarroA.Platelet- rich plasma injections for advanced knee osteoarthritis: a prospective, randomized, double-blinded clinical trial. Orthop J Sports Med. 2017;5(2):2325967116689386.
67.
KaszynskiJBakowskiPKiedrowskiB, et al. Intra-articular injections of autologous adipose tissue or platelet-rich plasma comparably improve clinical and functional outcomes in patients with knee osteoarthritis. Biomedicines. 2022;10(3):16.
68.
KavadarGDemirciogluDTCelikMYEmreTY.Effectiveness of platelet-rich plasma in the treatment of moderate knee osteoarthritis: a randomized prospective study. J Phys Ther Sci. 2015;27(12):3863-3867.
69.
KesiktasFNDernekBSenEI, et al. Comparison of the short-term results of single-dose intra-articular peptide with hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized study. Clin Rheumatol. 2020;39(10):3057-3064.
70.
KhanAFGillaniSFUHSKhanAF.Role of intra-articular corticosteroid with xylocaine vs plate rich plasma for the treatment of early grade II knee osteoarthritis at Akhtar Saeed Teaching Hospital Lahore: a randomized controlled trial. Pakistan Journal of Medical & Health Sciences. 2018;12(4):1432-1435.
71.
KonEDi MatteoBDelgadoD, et al. Platelet-rich plasma for the treatment of knee osteoarthritis: an expert opinion and proposal for a novel classification and coding system. Expert Opin Biol Ther. 2020;20(12):1447-1460.
72.
KonEMandelbaumBBudaR, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Arthroscopy. 2011;27(11):1490-1501.
73.
KreuzPCKrügerJPMetzlaffS, et al. Platelet-rich plasma preparation types show impact on chondrogenic differentiation, migration, and proliferation of human subchondral mesenchymal progenitor cells. Arthroscopy. 2015;31(10):1951-1961.
74.
KurtzSOngKLauEMowatFHalpernM.Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89(4):780-785.
75.
Lamo-EspinosaJMBlancoJFSanchezM, et al. Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis. J Transl Med. 2020;18(1):356.
76.
LanaJPuritaJPaulusC, et al. Contributions for classification of platelet rich plasma—proposal of a new classification: MARSPILL. Regen Med. 2017;12(5):565-574.
77.
LanaJWegleinASampsonSE, et al. Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee. J Stem Cells Regen Med. 2016;(2):69-78.
78.
LawrenceRCFelsonDTHelmickCG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part II. Arthritis Rheum. 2008;58(1):26-35.
79.
LeADKEnwezeLDeBaunMRDragooJL. Current clinical recommendations for use of platelet-rich plasma. Curr Rev Musculoskelet Med. 2018;11(4):624-634.
LewisEMerghaniKRobertsonI, et al. The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial. Bone Joint J. 2022;104(6):663-671.
82.
LiMHuangZWangS, et al. Intra-articular injections of platelet-rich plasma vs. hyaluronic acid in patients with knee osteoarthritis: preliminary follow-up results at 6-months. Exp Ther Med. 2021;21(6): 598.
83.
LinKW.Treatment of knee osteoarthritis. Am Fam Physician. 2018;98(9):603-606.
84.
LinKYYangCCHsuCJYehMLRennJH.Intra-articular injection of platelet-rich plasma is superior to hyaluronic acid or saline solution in the treatment of mild to moderate knee osteoarthritis: a randomized, double-blind, triple-parallel, placebo-controlled clinical trial. Arthroscopy. 2019;35(1):106-117.
85.
LipprossSMoellerBHaasH, et al. Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint. Arthritis Rheum. 2011;63(11):3344-3353.
86.
LisiCPerottiCScudellerL, et al. Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid: a randomized controlled trial. Clin Rehabil. 2018;32(3):330-339.
87.
LouisMLDumonceauRGJouveE, et al. Intra-articular injection of autologous microfat and platelet-rich plasma in the treatment of knee osteoarthritis: a double-blind randomized comparative study. Arthroscopy. 2021;37(10):3125-3137.e3123.
88.
LouisMLMagalonJJouveE, et al. Growth factors levels determine efficacy of platelets rich plasma injection in knee osteoarthritis: a randomized double blind noninferiority trial compared with viscosupplementation. Arthroscopy. 2018;34(5):1530-1540.e1532.
89.
MagalonJBaussetOSerratriceN, et al. Characterization and comparison of 5 platelet-rich plasma preparations in a single-donor model. Arthroscopy. 2014;30(5):629-638.
90.
MagalonJBrandinTFrancoisP, et al. Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine. Platelets. 2021;32(2):200-208.
91.
MagalonJChateauALBertrandB, et al. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med. 2016;2(1):e000060.
92.
MarxRE.Platelet-rich plasma (PRP): what is PRP and what is not PRP?Implant Dent. 2001;10(4):225-228.
93.
MautnerKMalangaGASmithJ, et al. A call for a standard classification system for future biologic research: the rationale for new PRP nomenclature. PM R. 2015;7(4 suppl):S53-S59.
94.
MazzoccaADMcCarthyMBChowaniecDM, et al. Platelet-rich plasma differs according to preparation method and human variability. J Bone Joint Surg Am. 2012;94(4):308-316.
95.
MichaelJWSchlüter-BrustKUEyselP.The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Dtsch Arztebl Int. 2010;107(9):152-162.
96.
MishraAHarmonKWoodallJVieiraA.Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol. 2012;13(7):1185-1195.
97.
MoherDJonesALepageL.Use of the CONSORT statement and quality of reports of randomized trials: a comparative before-and-after evaluation. JAMA. 2001;285(15):1992-1995.
98.
Montanez-HerediaEIrizarSHuertasPJ, et al. Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the Spanish National Health Care System. Int J Mol Sci. 2016;17(7):1064.
99.
MousaviSAHermundstadBFleslandAKLlohnAHSaetherPC.Variation in platelet activation state in pre-donation whole blood: effect of time of day and abo blood group. J Blood Med. 2022;13:283-292.
100.
MukamalKJMassaroJMAultKA, et al. Alcohol consumption and platelet activation and aggregation among women and men: the Framingham Offspring Study. Alcohol Clin Exp Res. 2005;29(10):1906-1912.
101.
MurrayIRGeeslinAGGoudieEBPetriglianoFALaPradeRF.Minimum information for studies evaluating biologics in orthopaedics (MIBO): platelet-rich plasma and mesenchymal stem cells. J Bone Joint Surg Am. 2017;99(10):809-819.
102.
NabiBNSedighinejadAMardani-KiviM, et al. Comparing the effectiveness of intra-articular platelet-rich plasma and corticosteroid injection under ultrasound guidance on pain control of knee osteoarthritis. Iranian Red Crescent Medical Journal. 2018;20(3):9.
103.
NelsonAEAllenKDGolightlyYMGoodeAPJordanJM.A systematic review of recommendations and guidelines for the management of osteoarthritis: the chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum. 2014;43(6):701-712.
104.
NocellaCBiondi-ZoccaiGSciarrettaS, et al. Impact of tobacco versus electronic cigarette smoking on platelet function. Am J Cardiol. 2018;122(9):1477-1481.
105.
NöthURackwitzLHeymerA, et al. Chondrogenic differentiation of human mesenchymal stem cells in collagen type I hydrogels. J Biomed Mater Res A. 2007;83(3):626-635.
106.
Nunes-TamashiroJCNatourJRamuthFM, et al. Intra-articular injection with platelet-rich plasma compared to triamcinolone hexacetonide or saline solution in knee osteoarthritis: a double blinded randomized controlled trial with one year follow-up. Clin Rehabil. 2022;36(7):900-915.
107.
O’KeefeRJCrabbIDPuzasJERosierRN. Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I. J Orthop Res. 1994;12(3):299-310.
108.
PapaliaRZampognaBRussoF, et al. Comparing hybrid hyaluronic acid with PRP in end career athletes with degenerative cartilage lesions of the knee. J Biol Regul Homeost Agents. 2016;30(4):17-23.
109.
ParkYBKimJHHaCWLeeDH.Clinical efficacy of platelet-rich plasma injection and its association with growth factors in the treatment of mild to moderate knee osteoarthritis: a randomized double-blind controlled clinical trial as compared with hyaluronic acid. Am J Sports Med. 2021;49(2):487-496.
110.
PatelSDhillonMSAggarwalSMarwahaNJainA.Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013;41(2):356-364.
111.
PatersonKLNichollsMBennellKLBatesD.Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study. BMC Musculoskelet Disord. 2016;17:67.
112.
PerssonMSMSarmanovaADohertyMZhangW. Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials. Rheumatology (Oxford). 2018;57(10):1830-1837.
113.
PetreraMDe CroosJNIuJ, et al. Supplementation with platelet-rich plasma improves the in vitro formation of tissue-engineered cartilage with enhanced mechanical properties. Arthroscopy. 2013;29(10):1685-1692.
114.
PhulSHMobushirMJilaniRUA, et al. Comparison of intra-articular steroids injection versus platelets rich plasma injection in patients with osteoarthritic knee joints. Pakistan Journal of Medical & Health Sciences. 2018;12(3):931-934.
115.
PishgahiAAbolhasanRShakouriSK, et al. Effect of dextrose prolotherapy, platelet rich plasma and autologous conditioned serum on knee osteoarthritis: a randomized clinical trial. Iranian J Allergy Asthma Immunol. 2020;19(3):243-252.
116.
PretoriusJNematNAlsayedA, et al. Double-blind randomized controlled trial comparing platelet-rich plasma with intra-articular corticosteroid injections in patients with bilateral knee osteoarthritis. Cureus. 2022;14(9):e29744.
117.
QamarAMohsinSNSiddiquiUNNazSDanishS.Effectiveness of platelet rich plasma for the management of knee osteoarthritis: a randomized placebo controlled trial. Pakistan Journal of Medical & Health Sciences. 2021;15(7):1553-1556.
118.
RachulCRaskoJEJCaulfieldT.Implicit hype? Representations of platelet rich plasma in the news media. PLoS One. 2017;12(8):e0182496.
119.
RaeissadatSAGhazi HosseiniPBahramiMH, et al. The comparison effects of intra-articular injection of platelet rich plasma (PRP), plasma rich in growth factor (PRGF), hyaluronic acid (HA), and ozone in knee osteoarthritis: a one year randomized clinical trial. BMC Musculoskelet Disord. 2021;22(1):134.
120.
RaeissadatSARayeganiSMHassanabadiH, et al. Knee osteoarthritis injection choices: platelet-rich plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord. 2015;8:1-8.
121.
RahimzadehPFaizSHRAlebouyehMR.The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Pain Practice. 2018;18:72.
122.
RahimzadehPImaniFFaizSH, et al. Adding intra-articular growth hormone to platelet rich plasma under ultrasound guidance in knee osteoarthritis: a comparative double-blind clinical trial. Anesthesiol Pain Med. 2016;6(6):e41719.
123.
Reyes-SosaRLugo-RadilloACruz-SantiagoLGarcia-CruzCRMendoza-CanoO.Clinical comparison of platelet-rich plasma injection and daily celecoxib administration in the treatment of early knee osteoarthritis: a randomized clinical trial. J Appl Biomed. 2020;18(2):41-45.
124.
RikkersMLevatoRMaldaJVonkLA.Importance of timing of platelet lysate-supplementation in expanding or redifferentiating human chondrocytes for chondrogenesis. Front Bioeng Biotechnol. 2020;8:804.
125.
RoosendaalGVianenMEMarxJJ, et al. Blood-induced joint damage: a human in vitro study. Arthritis Rheum. 1999;42(5):1025-1032.
126.
RoussyYBertrand DuchesneMPGagnonG.Activation of human platelet-rich plasmas: effect on growth factors release, cell division and in vivo bone formation. Clin Oral Implants Res. 2007;18(5):639-648.
127.
SaqlainLHussainSSKeerioNH, et al. Effect of platelet rich plasma injection effect on knee osteoarthritis in elderly: single dose versus double dose randomized clinical trial. J Pharmaceut Res Int. 2021;33(6):84-89.
128.
SarafAHussainABishnoiSAzamGHabibH.Serial platelet-rich plasma intra-articular injections in Kellgren and Lawrence grade IV knee joint osteoarthritis: a prospective blinded placebo-controlled interventional study. Indian J Orthop. 2022;56(10):1722-1728.
129.
SchererSSTobalemMVigatoE, et al. Nonactivated versus thrombin-activated platelets on wound healing and fibroblast-to-myofibroblast differentiation in vivo and in vitro. Plast Reconstr Surg. 2012;129(1):46e-54e.
130.
SchmidtMBChenEHLynchSE.A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthritis Cartilage. 2006;14(5):403-412.
131.
SchulzKFAltmanDGMoherD.CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.
132.
ShomaFKChowdhuryZRHossainF, et al. Intra-articular injection of hyaluronic acid (HA) and platelet-rich plasma (PRP) in the treatment of mild and moderate osteoarthritis of knee. Bangladesh Med Res Counc Bull. 2021;47(1):62-69.
133.
SiddiqHPentapatiKCAcharyaS.Adherence of randomized controlled trials to consolidated standards of reporting trials 2010 guidelines: a survey of randomized controlled trials published in 2011-2016 in 3 periodontology journals. J Evid Based Dent Pract. 2019;19(3):260-272.
134.
Simental-MendíaMAcosta-OlivoCAHernández-RodríguezAN, et al. Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach: pilot study. Acta Reumatol Port. 2019;44(2):138-144.
135.
Simental-MendíaMVílchez-CavazosJFPeña-MartínezVMSaid-FernándezSLara-AriasJMartínez-RodríguezHG.Leukocyte-poor platelet-rich plasma is more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis. Arch Orthop Trauma Surg. 2016;136(12):1723-1732.
136.
SinghNTrivediVKumarV, et al. A comparative study of osteoarthritis knee arthroscopy versus intra-articular platelet rich plasma injection: a randomised study. Malay Orthop J. 2022;16(2):31-40.
137.
SmithPA.Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial. Am J Sports Med. 2016;44(4):884-891.
138.
SpreaficoAChelliniFFredianiB, et al. Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes. J Cell Biochem. 2009;108(5):1153-1165.
139.
SuKBaiYWangJ, et al. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. Clin Rheumatol. 2018;37(5):1341-1350.
140.
SubramanyamKAlguvellyRMundargiAKhanchandaniP.Single versus multi-dose intra-articular injection of platelet rich plasma in early stages of osteoarthritis of the knee: a single-blind, randomized, superiority trial. Arch Rheumatol. 2021;36(3):326-334.
141.
SunSFLinGCHsuCW, et al. Comparing efficacy of intraarticular single crosslinked hyaluronan (Hyajoint Plus) and platelet-rich plasma (PRP) versus PRP alone for treating knee osteoarthritis. Sci Rep. 2021;11(1):140.
142.
SzwedowskiDMobasheriAMoniuszkoAZabrzynskiJJekaS.Intra-articular injection of platelet-rich plasma is more effective than hyaluronic acid or steroid injection in the treatment of mild to moderate knee osteoarthritis: a prospective, randomized, triple-parallel clinical trial. Biomedicines. 2022;10(5):25.
143.
TavassoliMJanmohammadiNHosseiniAKhafriSEsmaeilnejad-GanjiSM.Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: a randomized controlled trial. World J Orthop. 2019;10(9):310-326.
144.
TuckerJDGoetzLLDuncanMB, et al. Randomized, placebo-controlled analysis of the knee synovial environment following platelet-rich plasma treatment for knee osteoarthritis. PM R. 2021;13(7):707-719.
145.
UggeriJBellettiSGuizzardiS, et al. Dose-dependent effects of platelet gel releasate on activities of human osteoblasts. J Periodontol. 2007;78(10):1985-1991.
Uslu GuvendiEAskinAGuvendiGKocyigitH. Comparison of efficiency between corticosteroid and platelet rich plasma injection therapies in patients with knee osteoarthritis. Arch Rheumatol. 2018;33(3):273-281.
148.
Vetri KumarMKNarayana ReddyM.A comparative study of functional outcome in patients with early osteoarthritis of knee treated with platelet-rich plasma with conventional treatment. Int J Pharmaceut Res. 2019;11(4):1012-1015.
149.
von ElmEAltmanDGEggerM, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453-1457.
150.
WangYCLeeCLChenYJ, et al. Comparing the efficacy of intra-articular single platelet-rich plasma (PRP) versus novel crosslinked hyaluronic acid for early-stage knee osteoarthritis: a prospective, double-blind, randomized controlled trial. Medicina (Kaunas). 2022;58(8):1028.
151.
WangZWangRXiangS, et al. Assessment of the effectiveness and satisfaction of platelet-rich plasma compared with hyaluronic acid in knee osteoarthritis at minimum 7-year follow-up: a post hoc analysis of a randomized controlled trial. Front Bioengin Biotechnol. 2022;10:1062371.
152.
WuYTHsuKCLiTYChangCKChenLC.Effects of platelet-rich plasma on pain and muscle strength in patients with knee osteoarthritis. Am J Phys Med Rehabil. 2018;97(4):248-254.
153.
WuYTLiTYLeeKC, et al. Efficacy of a novel intra-articular administration of platelet-rich plasma one-week prior to hyaluronic acid versus platelet-rich plasma alone in knee osteoarthritis: a prospective, randomized, double-blind, controlled trial. J Clin Med. 2022;11(11):3241.
154.
XuZHeZShuL, et al. Intra-articular platelet-rich plasma combined with hyaluronic acid injection for knee osteoarthritis is superior to platelet-rich plasma or hyaluronic acid alone in inhibiting inflammation and improving pain and function. Arthroscopy. 2021;37(3):903-915.
155.
YaradilmisYUDemirkaleISafa TagralA, et al. Comparison of two platelet rich plasma formulations with viscosupplementation in treatment of moderate grade gonarthrosis: a prospective randomized controlled study. J Orthop. 2020;20:240-246.
156.
YuWXuPHuangGLiuL.Clinical therapy of hyaluronic acid combined with platelet-rich plasma for the treatment of knee osteoarthritis. Exper Ther Med. 2018;16(3):2119-2125.
157.
YurtbayASayFÇinkaHErsoyA.Multiple platelet-rich plasma injections are superior to single PRP injections or saline in osteoarthritis of the knee: the 2-year results of a randomized, double-blind, placebo-controlled clinical trial. Arch Orthop Trauma Surg. 2022;142(10):2755-2768.
158.
ZaffagniniSAndrioloLBoffaA, et al. Microfragmented adipose tissue versus platelet-rich plasma for the treatment of knee osteoarthritis: a prospective randomized controlled trial at 2-year follow-up. Am J Sports Med. 2022;50(11):2881-2892.
159.
ZhangJZhangDGuoX, et al. Effects of advanced knee osteoarthritis treatment with autologous platelet-rich plasma intra-articular injection on pain, pain mediators and inflammatory factors. Int J Clin Exp Med. 2020;13(9):6850-6858.
160.
ZhangWMoskowitzRWNukiG, et al. OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage. 2007;15(9):981-1000.
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