Biocompatible chicken bone extracted dahllite/hydroxyapatite/collagen filler based polysulfone membrane for dialysis

Abstract

In the current study, dahllite/hydroxyapatite/collagen filler extracted via calcination of wasted chicken bone was blended with PSf polymer to obtain highly biocompatible, and antifoulant hemodialysis membranes. FTIR and Raman spectroscopic analysis was done to obtain information about the bonding chemistry of the obtained filler. The intermolecular interaction that existed between dahllite/hydroxyapatite/collagen filler and pristine PSf was confirmed by Raman spectroscopic study. The PSf polymer exhibited a sponge-like structure owing to its high thickness and slow exchange with non-solvent in coagulation bath whilst the instantaneous de-mixing course produced finger-like capillaries in dahllite/hydroxyapatite/collagen filler based PSf membranes as exposed by SEM photographs. The presence of different wt. % of filler composition in the PSf matrix improved the mechanical strength as revealed by fatigue analysis. The hydrophilic character improved by 78% while leaching consistency adjusted to 0%–4%. Pure water permeation (PWP) flux improved by nine times. The pore profile improved with the addition of filler as revealed by hydrophilicity experiment, PWP flux, and SEM micrographs. Fouling evaluation results disclosed that filler based membranes showed 36% less adsorption of protein (BSA) solution together with more than 84% flux recovery ratio. The biocompatibility valuation analysis unveiled that membranes composed of filler showed extended prothrombin and thrombin coagulation times, reduced activation of fibrinogen mass, and less adhesion of plasma proteins in comparison with pristine PSf membrane. The adsorption capacity of fabricated membranes for urea and creatinine improved by 31% (in the case of urea) and 34% (in the case of creatinine) in contrast with pristine PSf membrane. The overall results showed that the M-3 membrane was optimized in terms of surface properties, protein adhesion, anticoagulation activity, and adsorption amount of urea and creatinine.

Keywords

Polysulfone biocompatibility hemodialysis

Get full access to this article

View all access options for this article.

References

Gray

Tsuru

Cohen

, et al. Advanced materials for membrane fabrication and modification. New York, NY: CRC Press, 2018.

Daugirdas

Blake

Ing

TS.

Handbook of dialysis. Philadelphia, PA: Lippincott Williams & Wilkins, 2012.

NIoBIaB (NIBIB). Artificial kidney development advances, thanks to collaboration by NIBIB Quantum grantees. 2018.

Kim

Fissell

Humes

, et al. Current strategies and challenges in engineering a bioartificial kidney. Front Biosci 2015; 7: 215.

Medzhitov

Inflammation 2010: new adventures of an old flame. Cell 2010; 140: 771–776.

Ferrero-Miliani

Nielsen

Andersen

, et al. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol 2007; 147: 227–235.

Sugimoto

Sousa

Pinho

, et al. Resolution of inflammation: what controls its onset? Front Immunol 2016; 7: 160.

Hakim

RM.

Clinical implications of hemodialysis membrane biocompatibility. Kidney Int 1993; 44: 484–494.

Irfan

Idris

Yusof

, et al. Surface modification and performance enhancement of nano-hybrid f-MWCNT/PVP90/PES hemodialysis membranes. J Memb Sci 2014; 467: 73–84.

10.

Park

Acar

Akthakul

, et al. Polysulfone-graft-poly (ethylene glycol) graft copolymers for surface modification of polysulfone membranes. Biomaterials 2006; 27: 856–865.

11.

Gancarz

Poźniak

Bryjak

Modification of polysulfone membranes 1. CO2 plasma treatment. Eur Polym J 1999; 35: 1419–1428.

12.

Liu

Chen

, et al. Preparation of hydrophilic and antifouling polysulfone ultrafiltration membrane derived from phenolphthalin by copolymerization method. Appl Surf Sci 2017; 401: 69–78.

13.

Yang

Lin

WC.

Protein adsorption and platelet adhesion of polysulfone membrane immobilized with chitosan and heparin conjugate. Polym Adv Technol 2003; 14: 103–113.

14.

Hasegawa

Iwasaki

Ishihara

Preparation and performance of protein-adsorption-resistant asymmetric porous membrane composed of polysulfone/phospholipid polymer blend. Biomaterials 2001; 22: 243–251.

15.

Cowin

Van Buskirk

Ashman

Properties of bone. In: Skalak

Chien

(eds) Handbook of bioengineering. New York, NY: McGraw-Hill, 1987.

16.

Irfan

Basri

Irfan

, et al. An acid functionalized MWCNT/PVP nanocomposite as a new additive for fabrication of an ultrafiltration membrane with improved anti-fouling resistance. RSC Adv 2015; 5: 95421–95432.

17.

Irfan

Idris

, et al. Fabrication and performance evaluation of blood compatible hemodialysis membrane using carboxylic multiwall carbon nanotubes and low molecular weight polyvinylpyrrolidone based nanocomposites. J Biomed Mater Res A 2019; 107: 513–525.

18.

Irfan

Idris

Nasiri

, et al. Fabrication and evaluation of polymeric membranes for blood dialysis treatments using functionalized MWCNT based nanocomposite and sulphonated-PES. RSC Adv 2016; 6: 101513–101525.

19.

Figueiredo

Gamelas

Martins

Characterization of bone and bone-based graft materials using FTIR spectroscopy. Infrared Spectrosc Life Biomed Sci 2012; 315–338. DOI: 10.5772/36379

20.

Penel

Delfosse

Descamps

, et al. Composition of bone and apatitic biomaterials as revealed by intravital Raman microspectroscopy. Bone 2005; 36: 893–901.

21.

Szurkowska

Kolmas

Hydroxyapatites enriched in silicon–Bioceramic materials for biomedical and pharmaceutical applications. Prog Nat Sci: Mater Int 2017; 27: 401–409.

22.

Kim

Fouda

Jonasson

In situ study on kinetic behavior during asymmetric membrane formation via phase inversion process using Raman spectroscopy. J Appl Polym Sci 2000; 75: 135–141.

23.

Gordeyev

Nikolaeva

Prokhorov

, et al. Super-selective polysulfone hollow fibre membranes for gas separation: assessment of molecular orientation by Raman spectroscopy. Laser Phys 2001; 11: 82–85.

24.

Chowdhry

Jabeen

Alexander

Raman spectroscopy in pharmaceutical analysis. Eur Pharm Rev 2009; 5: 34–39.

25.

Rupiasih

Sumadiyasa

Ratnawati

, et al. Preparation, characterization and used of polysulfone membranes for the treatment of water solutions containing humic acids. J Mater Sci 2019; 13: 54–58.

26.

Shukla

Alam

Alhoshan

, et al. Development of a nanocomposite ultrafiltration membrane based on polyphenylsulfone blended with graphene oxide. Sci Rep 2017; 7: 41976.

27.

Rajesh

Hariharasubramanian

Ravichandran

YD.

Chicken bone as a bioresource for the bioceramic (hydroxyapatite). Phosphorus Sulfur Silicon Relat Elem 2012; 187: 914–925.

28.

Kumar

, et al. Development of sol–gel icephobic coatings: effect of surface roughness and surface energy. ACS Appl Mater Interfaces 2014; 6: 20685–20692.

29.

Zhao

Guo

, et al. The different N concentrations induced cytocompatibility and hemocompatibility of MWCNTs with CNx coatings. Surf Coat Technol 2013; 229: 90–96.

30.

Tian

Qiu

Y-R.

2-methoxyethylacrylate modified polysulfone membrane and its blood compatibility. Arch Biochem Biophys 2017; 631: 49–57.

31.

Yue

W-W

H-J

Xiang

, et al. Grafting of zwitterion from polysulfone membrane via surface-initiated ATRP with enhanced antifouling property and biocompatibility. J Memb Sci 2013; 446: 79–91.

32.

Wang

Y-X

Robertson

Spillman

, et al. Effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility. Pharm Res 2004; 21: 1362–1373.

33.

Sakai

Matsuda

. Solute removal efficiency and biocompatibility of the high-performance membrane–from engineering points of view. In: High-performance membrane dialyzers. Basel: Karger Publishers, 2011, pp.11–22.

34.

Yin

Janson

J-C

Liu

Characterization of protein adsorption on membrane surface by enzyme linked immunoassay. J Memb Sci 2000; 178: 99–105.

35.

Fujimori

Naito

Miyazaki

Adsorption of complement, cytokines, and proteins by different dialysis membrane materials: evaluation by confocal laser scanning fluorescence microscopy. Artif Organs 1998; 22: 1014–1017.

36.

Song

LIU

Photochemical surface modification of poly (arylsulfone) ultrafiltration membrane and covalent immobilization of enzyme. J Environ Sci 2004; 16: 392–396.

37.

Ishihara

Hasegawa

Watanabe

, et al. Protein adsorption–resistant hollow fibers for blood purification. Artif Organs 2002; 26: 1014–1019.

38.

Locatelli

Dose of dialysis, convection and haemodialysis patients outcome—what the HEMO study doesn’t tell us: the European viewpoint. Nephrol Dial Transplant 2003; 18: 1061–1065.

39.

Samarasekera

Yeow

JT.

Creatinine adsorption capacity of electrospun polyacrylonitrile (PAN)-zeolite nanofiber membranes for potential artificial kidney applications. J Appl Polym Sci 2015; 132. DOI: 10.1002/app.42418

40.

Yang

C-X

Liu

Cao

Y-M

, et al. Metal–organic framework MIL-100 (Fe) for artificial kidney application. RSC Adv 2014; 4: 40824–40827.