The aim of this study was to evaluate functional nerve recovery following reconstruction of a 1 cm gap in the sciatic nerve of a rat, using a new biodegradable p (DLLA-∊-CL) nerve guide. To evaluate both motor and sensory nerve recovery, walking track analysis and electrostimulation tests were carried out after implantation periods, ranging from 3 to 15 weeks post-operatively. The first signs of functional nerve recovery were observed after 3 weeks. After 15 weeks, 70% of the motor - and 90% of the sensory nerve function was re-established. Return of nerve function was better, in comparison with results from other studies. This study demonstrated successful functional nerve recovery after the reconstruction of a 1 cm nerve gap with a biodegradable p(DLLA-∊-CL) nerve guide.
KeeleyR.D., NguyenK.D., StephanidesM.J., PadillaJ., RosenJ.M.. The artificial nerve graft: A comparison of blended elastomerhydrogel with polyglycolic acid conduits.J Reconstr Microsurg1991; 7(2): 93–100.
6.
KuhnW.E., HallJ.L.. The repair of peripheral nerves using porous tubular protheses, in HausenerH.H., TaubenblatP.W. (eds): Modern Developments in Powder Metallurgy.Princeton NJ, American Powder Metallurgy Institute, 1977, pp 279–301.
7.
MackinnonS.E., DellonA.L., HudsonA.R., HunterD.A.. Chronic nerve compression: An experimental model in the rat.Ann Plast Surg1984; 13: 112–20.
8.
PeregoG., CellaG.D., AldiniN.N., FiniM., GiardinoR.. Preparation of a new nerve guide from a poly(L-lactide–∊–caprolactone).Biomaterials1994; 15(3): 189–93.
9.
Nicoli-AldiniN., PeregoG., CellaG.D., MaltarelloM.C., RoccaM., GiardinoR.. Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves.Biomaterials1996; 17(10): 959–62.
10.
GiardinoR., Nicoli-AldiniN., PeregoG.. Biological and synthetic conduits in peripheral nerve rapair: a comparative experimental study.Int J Artif Organs1995; 18: 225–30.
11.
Den DunnenW.F.A., van der LeiB., RobinsonP.H., HolwerdaA., PenningsA.J., SchakenraadJ.M.. Biological performance of a degradable poly (lactic acid–∊–caprolactone) nerve guide: Influence of tube dimensions.J Biomed Mat Res1995; 29: 757–66.
12.
Den DunnenW.F.A., StokroosI., BlaauwE.H., SchkenraadJ.M.. Light-microscopic and electron-microscopic evaluation of short-term nerve regeneration using a biodegradable poly(DL-lactide–∊–caprolacton) nerve guide.J Biomed Mat Res1996; 31: 105–15.
13.
Den DunnenW.F.A., van WesselR., PenningsA.J., RobinsonP.H., van LeeuwenM.B.M., SchakenraadJ.M.. Evaluation of degradation and foreign body reaction of subcutaneously implanted poly(lactide–∊–caprolacton) nerve guides.J Biomed Mat Res (in press. 1997).
14.
Den DunnenW.F.A., van der LeiB., SchakenraadJ.M., StokroosI., BlaauwE.H., BarelsH., PenningsA.J., RobinsonP.H.: Biodegradable poly(DL-lactide–∊–caprolacton) nerve guides perform better than autologous nerve grafts.Microsurg (in press, 1997).
15.
De MedinaceliL., FreedW.J., WyattR.J.. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks.Exp Neurol1982; 77: 634–43.
16.
BainJ.R., MackinnonS.E., HunterD.A.. Functional evaluation of complete sciatic, peroneal and posterior tibial nerve lesions in the rat.Plast Reconstr Surg831989; (1): 129–36.
17.
CarltonJ.M., GoldbergN.H.. Quantitating integrated muscle function following reinnervation.Surg Forum1986; 37: 611–2.
18.
DellonA.L., MackinnonS.E.. Sciatic nerve regeneration in the rat: Validity of walking track assessment in the presence of chronic.Contractures Microsurg1989; 10: 220–5.
19.
BrownC.J., MackinnonS.E., EvansP.J.. Self evaluation of walking-track measurement using a sciatic function index.Microsurg1989; 10: 226–35.
20.
HareG.M.T., EvansP.J., MackinnonS.E.. Walking track analysis: A long term assessment of peripheral nerve recovery.Plast Reconstr Surg1992; 89(2): 251–8.
21.
De MedinaceliL., WyattR.J., WilliamJ.F.. Peripheral nerve reconnection: mechanical, thermal, and ionic conditions that promote the return of function.Exp Neurol1983; 81: 469.
22.
BuehlerM.J., SeaberA.V., UrbaniakJ.R.. The relationship of functional return to varying methods of nerve repair.J Reconstr Microsurg1990; 6: 61.
23.
ShenaqJ.M., ShenaqS.M., SpiraM.. Reliability of sciatic function index in assessing nerve regeneration across a 1 cm gap.Microsurg1989; 10: 214.
24.
BainJ.R., MackinnonS.E., HudsonA.R., FalkR.E., FalkJ.A., HunterD.A.. The peripheral nerve allograft: an assessment of regeneration across nerve allografts in rats immunosuppressed with cyclosporin A.Plast Reconstr Surg1988; 82: 1052.
25.
BrownC.J., EvansP.J., MackinnonS.E.. Inter- and intraobserver reliability of walking-track analysis used to assess sciatic function in rats.Microsurg1991; 12: 76–9.
