Benign Prostatic Hypertrophy,Prostatic Cancer and Preneoplastic Lesions

Quite recently two dysplastic lesions have been found in prostatic tissue: atypical hyperplasia (AH), found in the periurethral zone, and prostatic intraepithelial neoplasia (PIN), present in the peripheral zone of the prostate. These lesions are likely to be considered as preneoplastic lesions. Theoretically they could be interpreted as the link between normal prostatic tissue and the cancer. It has also been suggested that BPH possibly contributes to the carcinogenetic process due to the demonstrated modifications occuring in the hyperplastic gland.