The effect of tobacco consumption on blood cholinesterase levels among workers exposed to organophosphorus pesticides

Abstract

This is a cross-sectional study of workers in the pesticide industry, engaged in the formulation and packaging of organophosphorus compounds. A detailed history was taken of all study participants. Investigations carried out were the measurement of haemoglobin levels and estimation of whole blood cholinesterase levels.

The prevalence of tobacco consumption in the industry is 76.09%. The mean age of employees was 42.8 years and the mean duration of service was 16.6 years. The study concludes that tobacco consumption increases the risk of toxicity due to organophosphorus pesticides, as indicated by a decrease in the blood cholinesterase levels. In this study, the age of employees and duration of service in the pesticide industry played no role in increasing the risk of toxic effects when exposed to organophosphorus pesticides. Toxicology and Industrial Health 2006; 22: 399-403.

Keywords

blood cholinesterase organophosphorus pesticide tobacco

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References

Drake, B. 2002: Chronic sublethal exposure. Retrieved from www.ktc.com/~bdrake/pest.html

Gan W. , Chen S. and Tao B. 2001: An epidemiological study on pesticide poisoning with mixed preparation . Zhonghua Yu Fang Yi Xue Za Zhi 35(1), 13-15 .

Garcia S.J. , Abu-Qare A.W. and Meeker-O'Connell W.A. et al. 2003: Methyl parathion: a review of health effects . Journal of Toxicology and Environmental Health B Critical Review 6(2), 185-210 .

GCxGC-TOFMS of pesticides in tobacco. Separation science application note. ww.leco.com/resources/application_ note_subs/pdf/separation_science/-292.pdf

Hayes A.L. , Wise R.A. and Weir F.W. 1980: Assessment of occupational exposure to organophosphates in pest control operators . American Industrial Hygiene Association Journal 41(8), 568-75 .

Hoffmann H. , Hogel J. and Speit G. 2005: The effect of smoking on DNA effects in the comet assay: a meta-analysis . Mutagenesis 20(6), 455-66 ; doi:10.1093/mutage/ gei064

Jaga K. and Dharmani C. 2003: Sources of exposure to and public health implications of organophosphate pesticides . Rev Panam Salud Publica 14(3), 171-185 .

Lakew K. and Mekonnen Y. 1998: The health status of northern Omo State Farm workers exposed to chlorpyrifos and profenofos . Ethiopian Medical Journal 36(3), 175-84 .

Limperos G. and Ranta K.E. A rapid screening test for determination of the approximate cholinesterase activity of human blood . Science 117(3043), 3-464 .

10.

Nordin R.B. , Araki S. and Sato H. et al. 2002: Effects of safety behaviours with pesticide use on occurrence of acute symptoms in male and female tobacco-growing Malaysian farmers . Industrial Health 40, 182-90 .

11.

Nordin R.B. , Araki S. and Sato H. et al. 2001: Gender difference in safe and unsafe practice of pesticide handling in tobacco farmers of Malaysia . Editorial. Malaysian Journal of Medical Sciences 8(1), 1-10 .

12.

Park K. Textbook of preventive and social medicine, seventeenth edition. Banarasidas Bhanot Publishers , 559.

13.

Slotkin T.A. 2004: Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates . Toxicology and Applied Pharmacology 198(2), 132-51 .

14.

Stefanidou M. , Athanaselis S. and Velonakis M. et al. 2003: Occupational exposure to cholinesterase inhibiting pesticides: a Greek case . International Journal of Environmental Health Research 13(1), 23-29 .

15.

Tolba M.K. , El-Kholy O.A. and El-Hinnawi E. et al. (editors) The world environment 1972- 1992: two decades of challenge. Ed Heldref Publications , Chapter 18. 529-67.

16.

Wadia RS Organophosphate poisoning. API textbook of medicine, seventh edition. Publishers: The Association of Physicians of India , 1271.