The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful neuropathy in rats. The intraperitoneal administration of acrylamide (30 mg/kg; for 24 consecutive days) has been employed for the induction of painful neuropathy. Acrylamide induced nociceptive pain sensitive changes, which have been assessed by hot plate, Von Frey Hair, and tail immersion tests at different time intervals, that is, 0, 6, 12, 18, and 24th day. Furthermore, the biochemical changes, that is, thiobarbituric acid-reactive substances, reduced glutathione, and total calcium levels have been estimated in sciatic nerve tissue on 24th day and histopathological changes have been observed in sciatic nerve tissue sample. MESM and pregabalin have been administered for 14 consecutive days before 1 h of the each acrylamide injection. Administration of acrylamide resulted in significant changes in behavioral and biochemical parameters. Pretreatment of MESM ameliorated acrylamide-induced behavioral, biochemical, and histopathological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. These findings suggested that the neuroprotective effect of S. mahagoni may be due to its potential of antioxidative, calcium channel modulatory, and neuroprotective action.
AhmedHHElmegeedGAel-Sayed elSM. (2010) Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats. European Journal of Medicinal Chemistry45: 5452–5459.
3.
AnnolaKKarttunenVKeski-RahkonenP. (2008) Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta. Toxicology Letters182: 50–56.
4.
BabbarSMarierJFMouksassiMS. (2009) Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain. Therapeutic Drug Monitoring31: 502–510.
5.
ChaplanSRBachFWPogrelJW. (1994) Quantitative assessment of tactile allodynia in the rat paw. Journal of Neuroscience Methods53: 55–63.
6.
ChenJHWuKYChiuIM. (2009) Acrylamide-induced astrogliotic and apoptotic responses in human astrocytoma cells. Toxicology in Vitro23: 855–861.
7.
CombesRGauntIBallsM (2006) A scientific and animal welfare assessment of the OECD health effects test guidelines for the safety testing of chemicals under the European union reach system. Alternatives to Laboratory Animals34: 77–122.
8.
ComblathDR (2004) Neuropathy in grout workers. Scandinavian Journal of Work, Environment and Health30: 253–254.
9.
DeDChatterjeeKAliKM. (2011) Antidiabetic Potentiality of the aqueous-methanolic extract of seed of Swietenia mahagoni (L.) Jacq. in streptozotocin-induced diabetic male albino rat: a correlative and evidence-based approach with antioxidative and antihyperlipidemic activities. Evidence-Based Complementary and Alternative Medicine2011: 892807.
10.
DworkinRHO’ConnorABAudetteJ. (2010) Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clinic Proceedings85: S3–S14.
11.
EddyNBTouchberryCFLiebermanJE (1950) Synthetic analgesics; methadone isomers and derivatives. Journal of Pharmacology and Experimental Therapeutics98: 121–137.
12.
EkimotoHIrieYArakiY. (1991) Platelet aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platelet-activating factor-induced effects of tetranortriterpenoids related to swietenine and swietenolide. Planta Medica57: 56–58.
13.
EllisRJToperoffWVaidaF. (2009) Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology34: 672–680.
14.
EllmanGL (1959) Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics82: 70–77.
15.
GlassJDCulverDGLeveyAI. (2002) Very early activation of m-calpain in peripheral nerve during Wallerian degeneration. Journal of the Neurological Sciences196: 9–20.
16.
GoldBGVodaJYuX. (2004) The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathy. Experimental Neurology187: 160–170.
17.
HammerslaMKapustinJF (2012) Peripheral neuropathy: evidence-based treatment of a complex disorder. Nurse Practitioner37: 32–39.
18.
JaggiASSinghN (2011) Therapeutic targets for the management of peripheral nerve injury-induced neuropathic pain. CNS and Neurological Disorders - Drug Targets10: 589–609.
19.
KimYSParkHJKimTK. (2009) The effects of Ginkgo biloba extract EGb 761 on mechanical and cold allodynia in a rat model of neuropathic pain. Anesthesia and Analgesia108: 1958–1963.
20.
LeeJNandiP (2010) Improving the management of neuropathic pain. Practitioner254: 27–30, 23.
21.
LehningEJBalabanCDRossJF. (2002) Acrylamide neuropathy. I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum. Neurotoxicology23: 397–414.
22.
LingBAuthierNBalayssacD. (2005) Assessment of nociception in acrylamide-induced neuropathy in rats. Pain119: 104–112.
23.
LowryOHRosebroughNJFarrAL. (1951) Protein measurement with the Folin phenol reagent. The Journal of Biological Chemistry193: 265–275.
24.
MacielENVercesiAECastilhoRF (2001) Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria. Journal of Neurochemistry79: 1237–1245.
25.
MaitiADewanjeeSSahuR. (2009) Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla seeds. Phytotherapy Research23: 1731–1733.
26.
MuthuramanADiwanVJaggiAS. (2008a) Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats. Journal of Ethnopharmacology120: 56–62.
27.
MuthuramanAJaggiASSinghN. (2008b) Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats. European Journal of Pharmacology587: 104–111.
28.
MuthuramanASinghN (2012) Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain. Journal of Ethnopharmacology142: 723–731.
29.
MuthuramanASinghNJaggiAS (2011a) Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity. Food and Chemical Toxicology49: 2557–2563.
30.
MuthuramanASinglaSKPetersA (2011b) Exploring the potential of flunarizine for cisplatin-induced painful uremic neuropathy in rats. International Neurourology Journal15: 127–134.
31.
MuthuramanASoodS (2010) Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats. Journal of Brachial Plexus and Peripheral Nerve Injury5: 13.
32.
MuthuramanARameshMSoodS (2012) Ameliorative potential of montelukast on ischemia-reperfusion injury induced vasculitic neuropathic pain in rat. Life Sciences90: 755–762.
33.
NeckerRHellonRF (1978) Noxious thermal input from the rat tail: modulation by descending inhibitory influences. Pain4: 231–242.
34.
OhkawaHOhishiNYagiK (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry95: 351–358.
35.
PerniceRHauderJKoehlerP. (2009) Effect of sulforaphane on glutathione-adduct formation and on glutathione-S-transferase-dependent detoxification of acrylamide in Caco-2 cells. Molecular Nutrition and Food Research53: 1540–1550.
36.
PinnenFSozioPCacciatoreI. (2011) Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease. Archiv der Pharmazie344: 139–148.
37.
RadhamaniSJeba SunilsonJGopinathR. (2009) Hypoglycemic activity of endocarp of Swietenia macrophylla King extracts in glucose loaded rats. Journal of Pharmacy Research2: 1203–1205.
38.
RahmanAKChowdhuryAKAliHA. (2009) Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains. Journal of Natural Medicines63: 41–45.
39.
SahgalGRamanathanSSasidharanS. (2009) In Vitro antioxidant and xanthine oxidase inhibitory activities of methanolic Swietenia mahagoni seed extracts. Molecules14: 4476–4485.
40.
SeveringhausJWFerrebeeJW (1950) Calcium determination by flame photometry: methods for serum, urine, and other fluids. The Journal of Biological Chemistry187: 621–630.
41.
ShenXLiHOuY. (2008) The secondary structure of calcineurin regulatory region and conformational change induced by calcium/calmodulin binding. The Journal of Biological Chemistry283: 11407–11413.
42.
SudohYDesaiSPHadererAE. (2004) Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline. Regional Anesthesia and Pain Medicine29: 434–440.
43.
TeepkerMAnthesNFischerS. (2007) Effects of oxidative challenge and calcium on ATP-levels in neuronal cells. Neurotoxicology28: 19–26.
44.
ThiagarajanVRShanmugamPKrishnanUM. (2012a) Ameliorative effect of Vernonia cinerea in vincristine-induced painful neuropathy in rats. Toxicology and Industrial Health. Epub ahead of print October 18, 2012. DOI:10.1177/0748233712463779
45.
ThiagarajanVRShanmugamPKrishnanUM. (2012b) Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats. Anais da Academia Brasileira de Ciências84: 1091–1104.
