Effects of nonsteroidal anti-inflammatory meloxicam on stomach,kidney,and liver of rats

Abstract

Nonsteroidal anti-inflammatory (NSAI) drugs are the most commonly used group of drugs today. Increase in the use of standard NSAI for treating pain and inflammation was restricted by the fact that these drugs were proven to possibly cause gastrointestinal and renal toxicity. Meloxicam is a NSAI that has anti-inflammatory, analgesic, and antipyretic effects. This study aims to investigate the effects of meloxicam on stomach, kidney, and liver of rats under light microscopy level. Based on the light microscopic observations, mononuclear cell infiltration and pseudolobular formation was established in liver samples of animals in the experimental group. Metaplasia in surface and glandular epithelia and atrophy were observed in stomach samples. Glomerular stasis-related hypertrophy and focal interstitial nephritis were found in kidneys. It was concluded in this study that meloxicam might cause hepatotoxicity, nephrotoxicity, and gastric metaplasia in rats at a used dose and duration.

Keywords

Nonsteroidal anti-inflammatory (NSAI) drugs meloxicam stomach kidney liver rats

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References

Al-Rekabi

Abbas

Hadi

(2009) Effects of subchronic exposure to meloxicam on some hematological, biochemical and liver histopathological parameters in rats. Iraqi Journal of Veterinary Sciences 23: 249–254.

Baggaley

Nielsen

Marples

(2010) Dehydration-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs. American Journal of Physiology-Renal Physiology 4: 1051–1058.

Dudhgaonkar

Tandan

Bhat

. (2006) Synergistic anti-inflammatory interaction between meloxicam and aminoguanidine hydrochloride in carrageenan-induced acute inflammation in rats. Life Science 78: 1044–1048.

Gambero

Becker

Zago

. (2005) Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors. Inflammopharmacology 13: 441–454.

Gretzer

Maricic

Respondek

. (2001) Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge. British Journal of Pharmacology 132: 1565–1573.

Kunkel

Wiggins

Chensue

. (1986) Regulation of macrophage tumor necrosis factor production by prostaglandin E2. Biochemical and Biophysical Research Communications 137: 404–409.

Mahaprabhu

Bhandarkar

Jangir

. (2011) Ameliorative effect of ocimum sanctum on meloxicam induced toxicity in wistar rats. Toxicology International 18: 130–136.

Sturmer

Elseviers

De Broe

(2001) Nonsteroidal anti-inflammatory drugs and the kidney. Current Opinion in Nephrology and Hypertension 10: 161–163.

Tanaka

Hase

Miyazawa

. (2002) Up-regulation of COX-2 by inhibition of COX-1: a key to NSAID-induced intestinal damage. Journal of Pharmacology and Experimental Therapeutics 300: 754–761.

10.

Villegas

La Casa

de la Lastra

. (2004) Mucosal damage induced by preferential COX-1 and COX-2 inhibitors: role of prostaglandins and inflammatory response. Life Science 74: 873–884.

11.

Wallace

McKnight

Reuter

. (2000) NSAİİ-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 119: 706–714.