1,3-Butadiene is classified as carcinogenic to humans by inhalation. This study aimed to assess cancer and non-cancer risk following occupational exposure to 1,3-butadiene. This cross-sectional study was conducted in a petrochemical plant producing acrylonitrile butadiene styrene copolymer in Iran. Occupational exposure to 1,3-butadiene was measured according to the National Institute for Occupational Safety and Health 1024 method. Cancer and non-cancer risk assessment were performed according to the United States Environmental Protection Agency method. The average occupational exposure to 1,3-butadiene during work shifts among all participants was 560.82 ± 811.36 µg m−3. The average lifetime cancer risk (LCR) in the present study was 2.71 × 10−3; 82.2% of all exposed workers were within the definite carcinogenic risk level. Also, the mean non-cancer risk (hazard quotient (HQ)) among all participants was 10.82 ± 14.76. The highest LCR and HQ were observed in the safety and fire-fighting station workers with values of 7.75 × 10−3 and 36.57, respectively. The findings revealed that values of carcinogenic and noncarcinogenic risk in the majority of participants were within the definitive and unacceptable risk levels. Therefore, corrective measures are necessary to protect these workers from non-cancer and cancer risks from 1,3-butadiene exposure.
AkerstromMAlmerudPAnderssonEM, et al. (2016) Personal exposure to benzene and 1,3-butadiene during petroleum refinery turnarounds and work in the oil harbour. International Archives of Occupational and Environmental Health89(8): 1289–1297.
2.
AlmerudPAkerstromMAnderssonEM, et al. (2017) Low personal exposure to benzene and 1,3-butadiene in the Swedish petroleum refinery industry. International Archives of Occupational and Environmental Health90(7): 713–724.
3.
Anttinen-KlemettiTVaaranrintaRMutanenP, et al. (2004) Personal exposure to 1,3-butadiene in a petrochemical plant, assessed by use of diffusive samplers. International Archives of Occupational and Environmental Health77(4): 288–292.
4.
ChanCCShieRHChangTY, et al. (2006) Workers’ exposures and potential health risks to air toxics in a petrochemical complex assessed by improved methodology. International Archives of Occupational and Environmental Health79(2): 135–142.
5.
ChenMJLinCHLaiCH, et al. (2016) Excess lifetime cancer risk assessment of volatile organic compounds emitted from a petrochemical industrial complex. Aerosol and Air Quality Research16: 1954–1966.
6.
DhainiHRSalamehTWakedA, et al. (2017) Quantitative cancer risk assessment and local mortality burden for ambient air pollution in an eastern Mediterranean City. Environmental Science and Pollution Research24(16): 14151–14162.
7.
DotsonGSMaierAParkerA, et al. (2016) Immediately dangerous to life or health (IDLH) value profile: 1,3-Butadiene. US Department of Health and Human Services, Centers for Disease Control and Prevention. National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication168. Available at: https://www.cdc.gov/niosh/docs/2016-171/pdfs/2016-171.pdf (accessed September 2016).
8.
DuZMoJZhangY (2014) Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China. Environment International73: 33–45.
9.
EdokpoloBYuQConnellD (2015) Health risk assessment for exposure to benzene in petroleum refinery environments. International Journal of Environmental Research and Public Health12(1): 595–610.
FabriziGFiorettiMRoccaLM (2013) Occupational exposure to complex mixtures of volatile organic compounds in ambient air: Desorption from activated charcoal using accelerated solvent extraction can replace carbon disulfide?Analytical and Bioanalytical Chemistry405(2–3): 961–976.
12.
GuoHLeeSCChanLY, et al. (2004) Risk assessment of exposure to volatile organic compounds in different indoor environments. Environmental Research94(1): 57–66.
13.
HeZLiGChenJ, et al. (2015) Pollution characteristics and health risk assessment of volatile organic compounds emitted from different plastic solid waste recycling workshops. Environment International77: 85–94.
14.
HuyLNLeeSCZhangZ (2018) Human cancer risk estimation for 1,3-butadiene: An assessment of personal exposure and different microenvironments. Science of the Total Environment616: 1599–15611.
15.
KampeerawipakornONavasumritPSettachanD, et al. (2017) Health risk evaluation in a population exposed to chemical releases from a petrochemical complex in Thailand. Environmental Research152: 207–213.
16.
KumarRPKashyapPKumarR, et al. (2019) Cancer and non-cancer health risk assessment associated with exposure to non-methane hydrocarbons among roadside vendors in Delhi. India. Human and Ecological Risk Assessment6: 1–5.
17.
MaranoKMLiuCFullerW, et al. (2018) Quantitative risk assessment of tobacco products: A potentially useful component of substantial equivalence evaluations. Regulatory Toxicology and Pharmacology95: 371–384.
18.
McDonaldBCDe GouwJAGilmanJB, et al. (2018) Volatile chemical products emerging as largest petrochemical source of urban organic emissions. Science1359(6377): 760–774.
19.
MillerGPFortneyTLThompsonM, et al. (1999) Exposure to hazardous air pollutants in the San Francisco Bay area. Atmospheric Environment19: 425–432.
20.
NRC, US (1983) Risk Assessment in the Federal Government: Managing the Process. Washington DC: National Research Council, vol. 11, p. 3. Available at: https://www.ncbi.nlm.nih.gov/pubmed/25032414.
21.
OrozcoJVan CaneghemLHensL, et al. (2019) Assessment of an ammonia incident in the industrial area of Matanzas. Journal of cleaner production222: 934–941.
22.
RahimnejadSBahramiAAssariM, et al. (2014) Quantitative risk assessment of occupational exposure to volatile organic compounds in the oil-dependent chemical industry. Journal of Sabzevar University of Medical Sciences21(4): 829–841.
23.
RamadanAYassinMFAlshammariBZ (2019) Health risk assessment associated with volatile organic compounds in a parking garage. International Journal of Environmental Science and Technology16(6): 2549–2564.
24.
Sadeghi-YarandiMGolbabaeiFKarimiA (2020) Evaluation of pulmonary function and respiratory symptoms among workers exposed to 1,3-butadiene in a petrochemical industry in Iran. Archives of Environmental & Occupational Health75: 1–8.
25.
ScarselliACorfiatiMDi MarzioD, et al. (2017) Appraisal of levels and patterns of occupational exposure to 1,3-butadiene. Scandinavian Journal of Work, Environment and Health1: 494–503.
26.
SunJWangJShenZ, et al. (2019) Volatile organic compounds from residential solid fuel burning in Guanzhong Plain, China: Source-related profiles and risks. Chemosphere221: 184–192.
27.
TanWDuHLiuT, et al. (2017) Experimental and numerical study of ammonia leakage and dispersion in a food factory. Journal of Loss Prevention in the Process Industries47: 129–139.
28.
TraumannATintPJärvikO, et al. (2013) Management of health hazards during shale oil handling. Agronomy Research11(2): 479–486.
29.
TulashieSAddaiKAnnanJ (2016) Exposure assessment, a preventive process in managing workplace safety and health, challenges in Ghana. Safety science84: 210–215.
YanYPengLChengN, et al. (2015) Health risk assessment of toxic VOCs species for the coal fire well drillers. Environmental Science and Pollution Research22(19): 15132–15144.
34.
ZhangZYanXGaoF, et al. (2018) Emission and health risk assessment of volatile organic compounds in various processes of a petroleum refinery in the Pearl River Delta, China. Environmental Pollution238: 452–461.
