Polycyclic Aromatic Hydrocarbons (PAHs) are a group of chemicals that are formed during the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances, such as tobacco and charbroiled meat. There are more than 100 PAHs. PAHs generally occur as complex mixtures (for example, as part of products such as soot), not as single compounds. PAHs are found throughout the environment in the air, water, and soil. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals, including PAHs (ATSDR, 1995), found atfacilities on the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) and which pose the most significant potential threat to human health, as determined by ATSDR and the Environmental Protection Agency (EPA). These profiles include information on health effects of chemicals from different routes and durations of exposure, their potential for exposure, regulations and advisories, and the adequacy of the existing database. Assessing the health effects of PAHs is a major challenge because environmental exposures to these chemicals are usually to complex mixtures of PAHs with other chemicals. The biological consequences of human exposure to mixtures of PAHs depend on the toxicity, carcinogenic and noncarcinogenic, of the individual components of the mixture, the types of interactions among them, and confounding factors that are not thoroughly understood. Also identified are components of exposure and health effects research needed on PAHs that will allow estimation of realistic human health risks posed by exposures to PAHs. The exposure assessmentcomponent of research should focus on (1 ) development of reliable analytical methods for the determination of bioavailable PAHs following ingestion, (2) estimation of bioavailable PAHs from environmental media, particularly the determination of particle-bound PAHs, (3) data on ambient levels of PAHs metabolites in tissueslfluids of control populations, and (4) the need for a critical evaluation of current levels of PAHs found in environmental media including data from hazardous waste sites. The health effects component should focus on obtaining information on (1) the health effects of mixtures of PAHs particularly their noncarcinogenic effects in humans, and (2) their toxicokinetics. This report provides excerpts from the toxicological profile of PAHs (ATSDR, 1995) that contains more detailed information.
Aardema, M.J., Gibson, D.P., Kerckaert, G.A., et al. (1990). "Aneuploidy and nonrandom structural chromosome changes associated with early and late stages of benzo[a]pyrene-induced neoplastic transformation of syrian hamster embryo cells." Twenty-first Annual Meeting of the Environmental Mutagen Society. Environ, Mol. Mutagen Suppl. 15( 17):3.
2.
Abe, S., Nemoto, N., and Sasaki, M. ( 1983a). "Comparison of aryl hydrocarbon hydroxylase activity and inducibility of sister-chromatid exchanges by polycyclic aromatic hydrocarbons in mammalian cell lines." Mutat. Res.122:47-51.
3.
Abe, S., Nemoto, N., and Sasaki, M. (1983b). "Sister-chromatid exchange induction by indirect mutagens/carcinogens, aryl hydrocarbon hydroxylase activity and benzo[a]pyrene metabolism in cultured human hepatoma cells." Mutat. Res.109:83-90.
4.
Abe, S. and Sasaki, M. (1977). "Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals." J. Natl. Cancer Inst.58:1635-1641.
5.
Achard, S., Perderiset, M., and Jaurand, M.C. (1987). "Sister chromatid exchanges in rat pleural mesothelial cells treated with crocidolite, attapulgite, or benzo 3-4 pyrene." Br. J. Ind. Med.44:281-283.
6.
Adams, J.D., O'Mara-Adams, J., and Hoffmann, D. (1987). "Toxic and carcinogenic agents in undiluted mainstream smoke and sidestream smoke of different types of cigarettes." Carcinogenesis8:729-731.
7.
Adler, I.D. and Ingwersen, I. (1989). "Evaluation of chromosomal aberrations in bone marrow of lC3Fl mice." Mut. Res.224(3):343-345.
8.
Adler, I.D., Kliesch, U., and Kiefer, F. (1989). "Clastogenic effects of benzo[a]pyrene in postimplantation embryos with different genetic background." Teratogenesis Carcinog. Mutagen9(6):383-92.
9.
Agarwal, R., Medrano, E.E., Khan, I.U., et al. (1991). "Metabolism of benzo(a)pyrene by human melanocytes in culture." Carcinogenesis12( 10):1963-1966.
10.
Agency For Toxic Substances And Disease Registry (Atsdr) (1989). "Decision guide for identifying substance-specific data needs related to toxicological profiles." Atlanta, GA.
11.
Agency For Toxic Substances And Disease Registry (Atsdr) (1990). "Toxicological profile for creosote." Atlanta, GA.
12.
Agency For Toxic Substances And Disease Registry (Atsdr) (1994). "Materials submitted in support of comments on toxicological profile for PAHs, regulations and advisories." Atlanta, GA.
13.
Agency For Toxic Substances And Disease Registry (Atsdr) (1995). "Toxicological profile for polycyclic aromatic hydrocarbons (PAHs)." Atlanta, GA.
14.
Agrelo, C. and Amos, H. ( 1981 ). "DNA repair in human fibroblasts." In: Evaluation of Short-Term Tests for Carcinogens: Report of the International Collaborative Program. Prog. Mutat. Res.1:528-532.
15.
Akin, F.J., Snook, M.E., Severson, R.E., et al. (1976). "Identification of polynuclear aromatic hydrocarbons in cigarette smoke and their importance as tumorigens." J. Natl. Cancer Inst.57:191-195.
16.
Alarie, J.P. and Vo-Dinh, T. ( 1991). "Fibre-optic cyclodextrin-based sensor." Talanta 38(5): 529-534.
17.
Alben, K. (1980). "Gas chromatographic-mass spectrometric analysis of chlorination effects on commercial coal-tar leachate." Anal. Chem.52:1825-1828.
18.
Albert, R.E., Miller, M.L., Cody, T.E., et al. (1991a). "Benzo(a)pyrene-induced skin damage and tumor promotion in the mouse." Carcinogenesis12(7):1273-1280.
19.
Albert, R.E., Miller, M.L., Cody, T.E., et al. (1991b). "Cell kinetics and benzo[a]pyrene-DNA adducts in mouse skin tumorigenesis." Prog. Clin. Biol. Res.369:115-22.
20.
Aldrich (1986). Catalog Handbook of Fine Chemicals. Aldrich Chemical Company. Milwaukee, WI.
21.
Alexandrov, K., Rojas, M., Goldberg, M., et al. (1990). "A new sensitive fluorometric assay for the metabolism of (—)—7 8-dihydroxy-7 8-dihydrobenzo[a]pyrene by human hair follicles." Carcinogenesis11(12):2157-2161.
22.
Alexandrov, K. and Rojas-Moreno, M. (1990). "In vivo DNA adduct formation by benzo(a)pyrene in mouse and rat epidermal and dermal fibroblasts after topical application of an initiating dose of benzo(a)pyrene." Arch. Geschwulstforschung60(5):329-40.
23.
Alfheim, I. and Randahl, T. (1984). "Contribution of wood combustion to indoor air pollution as measured by mutagenicity in salmonella and polycyclic aromatic hydrocarbon concentration." Environ. Mutagen6:121-130.
24.
Allen-Hoffman, B.L. and Rheinwald, J.G. (1984). "Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture." Proceedings of Natl. Acad. Sci. USA81:7802-7806.
25.
Alzieu, P., Cassand P., Colin C., et al. (1987). "Effect of vitamins A, C and glutathione on the mutagenicity of benzo[a]pyrene mediated by S9 from vitamin A-deficient rats." Mutat. Res.192:227-231.
26.
Amacher, D.E. and Paillet, S.C. (1982). "Hamster hepatocyte-mediated activation of procarcinogens to mutagens in the L5178Y/TK mutation assay." Mutat. Res.106:305-316.
27.
Amacher, D.E. and Paillet, S.C. (1983). "The activation of procarcinogens to mutagens by cultured rat hepatocytes in the L5178Y/TK mutation assay." Mutat. Res.113:77-88.
28.
Amacher, D.E., Paillet, S.C., Turner, G.N., et al. (1980). "Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells: II. Test validation and interpretation ." Mutat. Res.72:447-474.
29.
Amacher, D.E. and Turner, G.N. (1980). "Promutagen activation by rodent-liver postmitochondrial fractions in the L5178Y/TK cell mutation assay." Mutat. Res.74:485-501.
30.
American Conference Of Governmental Industrial Hygienists (Acgih) (1986). Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. American Conference of Governmental Industrial Hygienists . Cincinnati, OH. p. 143.
31.
American Conference Of Governmental Industrial Hygienists (Acgih) (1991). Documentation of the Threshold Timit Values and Biological Exposure Indices. 6th ed. American Conference of Governmental Industrial Hygienists . Cincinnati, OH. p. 504-505.
32.
American Conference Of Governmental Industrial Hygienists (Acgih) (1992). 1993 Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists. Cincinnati, OH.
33.
American Conference Of Governmental Industrial Hygienists (Acgih) (1993). 1993-1994 Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices . American Conference of Governmental Industrial Hygienists. Cincinnati, OH. pp. 36-37.
34.
Amin, S., Huie, K. and Hecht, S. ( 1985a). "Mutagenicity and tumor-initiating activity of methylated benzo(b)fluoranthenes." Carcinogenesis6:1023-1025.
35.
Amin, S., Hussain, N., Balanikas, G., et al. ( 1985b). "Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes." Cancer Lett.26:343-347.
36.
Amin, S., Hussain, N., Brielmann, H., et al. (1984). "Synthesis and mutagenicity of dihydrodiol metabolites of benzo(b)fluoranthene." J. Org. Chem.49:1091-1095.
37.
Amin, S., Lavoie, E.J., and Hecht, S.S. (1982). "Identification of metabolites of benzo(b)fluoranthene ." Carcinogenesis3:171-174.
38.
Ampy, F.R., Saxena, S. and Verma, K. (1988). "Mutagenicity of benzo-a-pyrene in uninduced tissues from Balb-c mice and Sprague-Dawley rats as an index of possible health risks using the Salmonella mutagenicity assay." Cytobios.56(225):81-88.
39.
Andersson, K., Levin, J.O., and Nilsson, C.A. (1983). "Sampling and analysis of particulate and gaseous polycyclic aromatic hydrocarbons from coal tar sources in the working environment ." Chemosphere12:197-207.
40.
Andrews, A.W., Thibault, L.H. and Lijinsky, W. (1978). "The relationship between carcinogenicity and mutagenicity of some polynuclear hydrocarbons." Mutat. Res.51:311-318.
41.
Andrews, F.J., Halliday, G.M. and Muller, H.K. (1991a). "A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene but not dimethylbenz(a)anthracene-treated mice." Clin. Exp. Immunol.85( 1 ):9-13.
42.
Andrews, F.J., Halliday, G.M., Narkowicz, C.K., et al. (1991b). "Indomethacin inhibits the chemical carcinogen benzo(a)pyrene but not dimethylbenz(a)anthracene from altering Langerhans cell distribution and morphology." Br. J. Dermatol.124( 1 ):29-36.
43.
Antignac, E., Koch, B., Grolier, P., et al. ( 1990). "Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions." Toxicol. Lett.54(2-3):309-315.
44.
Arce, G.T., Allen, J.W., Doerr, C.L., et al. (1987). "Relationships between benzo(a)pyrene-DNA adduct levels and genotoxic effects in mammalian cells." Cancer Res.47:3388-3395.
45.
Arcos, J.C. and Argus, M.F. (1968). "Molecular geometry and carcinogenic activity of aromatic compounds." Adv. Cancer Res.11 :305-471.
46.
Armstrong, D.W. and Demond, W. (1984). "Cyclodextrin bonded phases for the liquid-chromatographic separation of optical geometrical and structural isomers." J. Chromatogr. Sci.22(9): 411-415.
47.
Asher, S.A. (1984). "UV resonance Raman spectrometry for detection and speciation of trace polycyclic aromatic hydrocarbons." Anal. Chem.56:720-724.
48.
Autrup, H., Harris, C.C., Stoner, G.D., et al. (1978). "Metabolism of [3H]benzo[a]pyrene by cultured human bronchus and cultured human pulmonary alveolar macrophages." Lab. Invest.38:217-224.
49.
Autrup, H. and Seremet, T. (1986). "Excretion of benzo[a]pyrene-Gua adduct in the urine of benzo[a]pyrene- treated rats." Chem. Biol. Interact.60:217-226.
50.
Avigdor, S., Zakheim, D. and Barnea, E.R. (1992). "Quinone reductase activity in the first trimester placenta: Effect of cigarette smoking and polycyclic aromatic hydrocarbons ." Reprod. Toxicol.6(4):363-336.
51.
Awogi, T. and Sato, T. (1989). "Micronucleus test with benzo[a]pyrene using a single peroral administration and intraperitoneal injection in males of the MS/Ae and CD-1 mouse strains." Mutat. Res.223(4):353-356.
52.
Ayrton, A.D., McFarlane, M., Walker, R., et al. (1990). "Induction of the P-450 I family of proteins by polycyclic aromatic hydrocarbons: Possible relationship to their carcinogenicity ." Toxicol.60( 1-2):173-186.
53.
Azuine, M.A., Kayal, J.J., and Bhide, S.V. (1992). "Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo [alpha] pyrene-induced genotoxicity and carcinogenicity." J. Cancer Res. Clin. Oncol.118(6):447-452.
54.
Babich, H., Sardana, M.K., and Borenfreund, E. (1988). "Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2 ." Cell Biol. Toxicol.4(3):295-309.
55.
Babson, J.R., Russo-Rodriquez, S.E., Rastetter, W.H., et al. (1986). "In vitro DNA-binding of microsomally-activated fluoranthene: Evidence that the major product is a fluoranthene N2-deoxyguanosine adduct." Carcinogenesis7:859-865.
56.
Badiali, D., Marcheggiano, A., Pallone, F., et al. (1985). "Melanosis of the rectum in patients with chronic constipation." Dis. Colon Rectum28:241-245.
57.
Baek, S.O., Field, R.A., Goldstone, M.E., et al. (1991). "A review of atmospheric polycyclic aromatic hydrocarbons: Sources fate and behavior." Water Air Soil Pollut.60(3-4):279-300.
58.
Baird, W.M., Salmon, C.P., and Diamond, L. (1984). "Benzo(e)pyrene-induced alterations in the metabolic activation of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene by hamster embryo cells." Cancer Res.44(4):1445-1452.
59.
Baker, J.E. and Eisenreich, S.J. (1990). "Concentrations and fluxes of polycyclic aromatic hydrocarbons and polychlorinated biphenyls across the air-water interface of Lake Superior (USA and Canada)." Environ. Sci. Technol.24(3):342-352.
60.
Barbieri, O., Ognio, E., Rossi, O., et al. (1986). "Embryotoxicity of benzo[a]pyrene and some of its synthetic derivatives in Swiss mice." Cancer Res.46:94-98.
61.
Barfknecht, T.R., Hites, R.A., Cavaliers, E.L., et al. (1982). "Human cell mutagenicity of polycyclic aromatic hydrocarbon components of diesel emissions." Dev. Toxicol. Environ . Sci.10:277-294.
62.
Barnea, E.R. and Shurtz-Swirski, R. (1992). "Modification of pulsatile human chorionic gonadotrophin secretion in first trimester placental explants induced by polycyclic aromatic hydrocarbons." Hum. Reprod.7(3):305-310.
63.
Barnes, D., Bellin, J., Derosa, C., et al. (1987). "Reference dose (RfD): Description and use in health risk assessments. Volume 1, Appendix A: Integrated risk information system supportive documentation." U.S. Environmental Protection Agency (EPA), Office of Health and Environmental Assessment, Cincinnati, OH. EPA 600/8-86/0322.
64.
Barnes, D.G. and Dourson, M. (1988). "Reference dose (RfD): Description and use in health risk assessments." Regul. Toxicol. Pharmacol.8:471-486.
65.
Barnsley, E. (1975). "The bacterial degradation of fluoranthene and benzo[a]pyrene." Can. J. Microbiol.21:1004-1008.
66.
Barratt, R.W. and Tatum, E.L. (1958). "Carcinogenic mutagens." Ann. NY Acad. Sci.71:1072-1084.
67.
Barrick, R.C. (1982). "Flux of aliphatic and polycyclic aromatic hydrocarbons to central Puget sound from Seattle (Westpoint) primary sewage effluent." Environ. Sci. Technol.16:682-692.
68.
Bartosek, I., Guaitani, A., Modica, R., et al. (1984). "Comparative kinetics of oral benz(a)anthracene, chrysene and triphenylene in rats: Study with hydrocarbon mixtures." Toxicol. Lett.23:333-339.
69.
Bassett, D.J.P., Bowen-Kelly, E., and Seed, J.L. (1988). "Rat lung benzo[a]pyrene metabolism following three days continuous exposure to 0.6 ppm ozone." Res. Commun. Chem. Pathol. Pharmacol.60:291-307.
70.
Basu, D.K. and Saxena, J. (1978a). "Monitoring of polynuclear aromatic hydrocarbons in water: II. Extraction and recovery of six representative compounds with polyurethane foams." Environ. Sci. Technol.12:791-795.
71.
Basu, D.K. and Saxena, J. (1978b). "Polynuclear aromatic hydrocarbons in selected U.S. drinking waters and their raw water sources." Environ. Sci. Technol.12:795-798.
72.
Bayer, U. (1978). "In vivo induction of sister chromatid exchanges by three polyaromatic hydrocarbons." Carcinogenesis3:423-428.
73.
Becher, G. (1986). Determination of Exposure to PAH by Analysis of Urine Samples. Banbury Report, pp. 33-44.
74.
Becher, G. and Bjørseth, A. (1983). "Determination of exposure to polycyclic aromatic hydrocarbons by analysis." Can. Lett.17:301-311.
75.
Becher, G. and Bjørseth, A. (1985). "A novel method for the determination of occupational exposure to polycyclic aromatic hydrocarbons by analysis of body fluids." In: Polynuclear Aromatic Hydrocarbons: Mechanisms, Methods and Metabolism . (M. Choke and A. Dennis, eds.) Batyl Press, Columbus, OH. pp. 145-155.
76.
Becher, G., Haugen, A., and Bjørseth, A. (1984). "Multimethod determination of occupational exposure to polycyclic aromatic hydrocarbons in an aluminum plant." Carcinogenesis5:647-651.
77.
Bechtold, W.E., Sun, J.D., Wolff, R.K., et al. (1991). "Globin adducts of benzo[a]pyrene: Markers of inhalation exposure as measured in F344/N rats." J. Appl. Toxicol.11 (2):115-118.
78.
Behymer, T.D. and Hites, R.A. (1988). "Photolysis of polycyclic aromatic hydrocarbons adsorbed on fly ash." Environ. Sci. Tech.22:1311-1319.
79.
Beniot, F.M., Lebel, G.L. and Williams, D.T. (1979). "The determination of polycyclic aromatic hydrocarbons at the ng/L level in Ottawa, Canada tap water." Int. J. Environ. Anal. Chem.6:277-288.
80.
Benjamin, H., Storkson, J., Tallas, P.G., et al. (1988). "Reduction of benzo[a]pyrene-induced forestomach neoplasms in mice given nitrite and dietary soy sauce." Food Chem. Toxicol.26(8):671-678.
81.
Benson, J.M., Royer, R.E., Galvin, J.B., et al. (1983). "Metabolism of phenanthridone to phenanthridone by rat lung and liver microsomes after induction with benzo(a)pyrene and Aroclor ." Toxicol. Appl. Pharmacol.68(1):36-42.
82.
Berenblum, I. and Haran, H. ( 1955). "The influence of croton oil and of polyethylene glycol-400 on carcinogenesis in the forestomach of the mouse." Cancer Res.15:510.
83.
Bevan, D.R. and Sadler, V.M. (1992). "Quinol diglucuronides are predominant conjugated metabolites found in bile of rats following intratracheal instillation of benzo[a]pyrene." Carcinogenesis13(3):403-407.
84.
Bevan, D.R. and Ulman, M.R. (1991). "Examination of factors that may influence disposition of benzo(a)pyrene in vivo: Vehicles and asbestos." Cancer Lett.57(2):173-180.
85.
Bevan, D.R. and Weyand, E.H. (1988). "Compartmental analysis of the disposition of benzo[a]pyrene in rats." Carcinogenesis9( 11 ):2027-2032.
86.
Bhatia, A.L., Tausch, H. and Stehlik, G. (1987). "Mutagenicity of chlorinated polycyclic aromatic compounds." Ecotoxicol. Environ. Safety14:48-55.
87.
Biancifiori, C. and Caschera, F. (1962). "The relation between pseudopregnancy and the chemical induction by four carcinogens of mammary and ovarian tumours in BALB/c mice." Br. J. Cancer16:722-730.
88.
Bieri, R., Hein, C., Huggett, R.J., et al. (1986). "Polycyclic aromatic hydrocarbons in surface sediments from the Elizabeth river subestuary." Intl. J. Environ. Anal. Chem.26:97-113.
89.
Bieri, R.H. and Greaves, J. (1987). "Characterization of benzo(a)pyrene metabolites by high performance liquid chromatography-mass spectrometry with a direct liquid introduction interface and using negative chemical ionization." Biomed. Environ. MassSpectrum14:555-561.
90.
Bingham, E. and Falk, H.L. (1969). "Environmental carcinogens: The modifying effect of carcinogens on the threshold response." Arch. Environ. Health19:779-783.
91.
Bjørseth, A., Bjørseth, O., and Fjedstad, P.E. (1978a). "Polycyclic aromatic hydrocarbons in the work atmosphere: I. Determination." Scand J. Work Environ. Health4:212-223.
92.
Bjørseth, A., Bjørseth, O., and Fjedstad, P.E. (1978b). "Polycyclic aromatic hydrocarbons in the work atmosphere: II. Determination in a coke plant." Scand. J. Work Environ. Health4:224-236.
93.
Bjørseth, A., Bjørseth, O., and Fjedstad, P.E. (1981). "Polycyclic aromatic hydrocarbons in the work atmosphere: Determination of area-specific concentrations and job-specific exposure in a vertical pin Soderberg aluminum plant." Scand. J. Environ. Health7:223-232.
94.
Bjørseth, A. and Olufsen, B.S. (1983). "Long-range transfer of polycyclic aromatic hydrocarbons ." In: Handbook of PAH. ( A. Bjørseth, ed.) M. Dekker, Inc., New York, NY. p. 507.
95.
Black, J.J., Dymerski, P.P., and Zapisek, W.F. (1979). "Routine liquid chromatographic method for assessing poly nuclear aromatic hydrocarbon pollution in fresh water environments." Bull. Environ. Contam. Toxicol.22:278-284.
96.
Black, W.V., Kosson, D.S., and Ahlert, R.C. (1989). "Characterization and evaluation of environmental hazards in a large metropolitan landfill." In: Proceedings of the Industrial Waste Conference. ( J.M. Bell, ed.) Lewis Publishers, Inc., Chelsea, MI. pp. 147-152.
97.
Blackburn, G.M. and Taussig, P.E. (1975). "The photocarcinogenicity of anthracene: Photochemical binding to deoxyribonucleic acid in tissue culture." Biochem. J.149:289-291.
98.
Blanton, R.H., Myers, M.J., and Bick, P.H. (1988). "Modulation of immunocompetent cell populations by benzo(a)pyrene." Toxicol. Appl. Pharmacol.93:267-274.
99.
Blanton, R.J., Lyte, M., Myers, M.J., et al. (1986). "Immunomodulation by polyaromatic hydrocarbons in mice and murine cells." Can. Res.46:2735-2739.
100.
Bock, F.G. and King, D.W. (1959). "A study of the sensitivity of the mouse forestomach toward certain polycyclic hydrocarbons." J. Natl. Cancer Inst.23:833.
101.
Bock, F.G. and Mund, R. (1958). "A survey of compounds for activity in the suppression of mouse sebaceous glands." Cancer Res.18:887-892.
102.
Bompart, G. (1990). "In vivo effect of molybdenum on benzo(a)pyrene metabolism in liver and lung rat microsomes." J. Toxicol. Clin. Exp.10(2):95-104.
103.
Bompart, G. and Claments, S. (1990). "In vitro and in vivo benzo(a)pyrene metabolism in rat liver and lung microsomes: Effect of sodium selenite." INSERM U 113-Faculté de Médicine, Toulouse. J. Toxicol. Clin. Exp.10(1):3-14.
104.
Bompart, G., Puig, P., Pipy, B., et al. (1989). "In vitro influence of molybdenum on benzo[a]pyrene metabolism in hepatic and pulmonary rat microsomes." J. Toxicol. Environ. Health26(4):459-468.
105.
Bond, J.A., Harkema, J.R., and Russell, V.I. (1988). "Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs." Drug Metab. Dispos.16:116-124.
106.
Bos, R.P., Prinsen, W.J., Van Rooy, J.G., et al. (1987). "Fluoranthene: A volatile mutagenic compound, present in creosote and coal tar." Mutat. Res.187:119-125.
107.
Bos, R.P., Theuws, J.L., Jongeneelen, F.J., et al. (1988). "Mutagenicity of bi-, tri-, and tetracylcic aromatic hydrocarbons in the "taped-plate assay" and in the conventional salmonella mutagenicity assay." Mutat. Res.204:203-206.
108.
Bossert, I.D. and Bartha, R. (1986). "Structure-biodegradability relationships of polycyclic aromatic hydrocarbons in soil." Bull. Environ. Contam. Toxicol.37:490-495.
109.
Bottomly, A.C. and Twort, C.C. (1934). "The carcinogenicity of chrysene and oleic acid ." Am. J. Cancer21:781-786.
110.
Boyland, E. (1986). "The metabolism of foreign compounds and the induction of cancer." Xenobiotica16:899-913.
111.
Boyland, E. and Sims, P. (1967). "The carcinogenic activities in mice of compounds related to benz(a)anthracene." Intl. J. Can.2:500-504.
112.
Bozicevic, Z., Cvitas, T., Curic, M., et al. (1987). "Airborne polycyclic aromatic hydrocarbons in the city of Zagreb, Yugoslavia." Sci. Total Environ.66:127-136.
113.
Brandys, J., Lipniak, M. and Piekoszewski, W. (1989). "Determination of polycyclic aromatic hydrocarbons in rat tissue by HPLC." Chem. Anal.34(3-6): 449-452.
114.
Brauze, D., Mikstacka, R. and Baer-Dubowska, W. (1991). "Formation and persistence of benzo[a]pyrene—DNA adducts in different tissues of C57BL/10 and DBA/2 mice." Carcinogenesis12(9):1607-1611.
115.
Breuer, G.M. (1984). "Solvents and techniques for the extraction of polynuclear aromatic hydrocarbons from filter samples of diesel exhaust." Anal. Lett.17:1293-1306.
116.
Broman, D., Naf, C., Lundbergh, I., et al. (1990). "An in situ study on the distribution biotransformation and flux of polycyclic aromatic hydrocarbons (PAHs) in an aquatic food chain (seston Mytilus edulis L and Somateria mollissima L) from the Baltic: An ecotoxicological perspective." Environ. Toxicol. Chem.9(4):429-442.
117.
Bronstein, A.C. and Currance, P.L. (1988). "Emergency care for hazardous materials exposure ." The C.V. Mosby Company, Washington, D.C. pp.221-222.
118.
Brown, R.A. and Weiss, F.T. (1978). "Fate and effects of polynuclear aromatic hydrocarbons in the aquatic environment." American Petroleum Institute , Washington, D.C., Publication no. 4297.
119.
Bruce, W.R. and Heddle, J.A. (1979). "The mutagenic activity of 61 agents as determined by the micronucleus, salmonella, and sperm abnormality assays." Can. J. Gen. Cytology21:319-334.
120.
Bruchlos, E., Dogra, S., Pauly, K., et al. (1989). "Formation of micronuclei in mouse bone marrow by benzo(a)pyrene and benzo(a)pyrene metabolites, and the role of induction of xenobiotic-metabolizing enzymes." Mutagenesis4:307.
121.
Brune, H., Deutsch-Wenzel, R.P., Habs, M., et al. (1981). "Investigation of the tumorigenic response to benzo(a)pyrene in aqueous carreine solution applied orally to Sprague-Dawley rats." J. Cancer Res. Clin. Oncology102(2):153-157.
122.
Brunnemann, K.D., Prokopczyk, B., Hoffmann, D., et al. (1986). Laboratory Studies on Oral Cancer and Smokeless Tobacco. Banbury Report23:197-213.
123.
Bryant, M.F., Erexson, G.L., Kwanyuen, P., et al. (1989). "Sister chromatid exchange and micronucleus analysis in rat peripheral blood lymphocytes after in vivo exposure to benzo(a)pyrene ." Environ. Mol. Mutagen14(suppl 15):30.
124.
Bryant, M.F., Kwanyuen, P., Atwater, A.L., et al. (1991). "Cytogenetic effects of benzo-b-fluoranthene in sprague-dawley rat peripheral blood lymphocytes after in vivo exposure ." Environ. Mol. Mutagen Suppl.0( 19):13.
125.
Buckley, T.J. and Lioy, P.J. (1992). "An examination of the time course from human dietary exposure to polycyclic aromatic hydrocarbons to urinary elimination of 1-hydroxypyrene." Br. J. Ind. Med. (England)49(2):113-124.
126.
Buening, M.K., Levin, W., Karle, J.M., et al. (1979a). "Tumorigenicity of bay region epoxides and other derivatives of chrysene and phenanthrene in newborn mice." Cancer Res.39:5063-5068.
127.
Buening, M.K., Levin, W., Wood, A., et al. (1979b). "Tumorigenicity of the dihydrodiols of dibenz(a,h)anthracene on mouse skin and in newborn mice." Cancer Res.39:1310-1314.
128.
Bui, Q.Q., Tran, M.B. and West, W.L. (1986). "A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat." Toxicol.42:195-204.
129.
Bulay, O.M. and Wattenberg, L.W. (1971). "Carcinogenic effects of polycyclic hydrocarbon carcinogen administration to mice during pregnancy on the progeny." J. Natl. Cancer Inst.46 :397-402.
130.
Buonicore, A. (1979). "Analyzing organics in air emissions." Environ. Sci. Technol.13:1340-1342.
131.
Burlinson, B. and Ashby, J. (1988). "Inactivity of benzo(a)pyrene in a weanling rat liver, unscheduled DNA synthesis assay." In: Evaluation of Short-Term Tests for Carcinogens: Report of the International Collaborative Program. Prog. Mutat. Res.1:389-390.
132.
Busbee, D.L., Norman, J.O., and Ziprin, R.L. (1990). "Comparative uptake, vascular transport and cellular internalization of aflatoxin B 1 and benzo(a)pyrene." Arch. Toxicol.64(4):285-290.
133.
Busby, W.F., Goldman, M.E., Newberne, P.M., et al. (1984). "Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay." Carcinogenesis5:1311-1316.
134.
Busby, W.F., JR., Stevens, E.K., Martin, C.N., et al. (1989). "Comparative lung tumorigenicity of parent and mononitro-polynuclear aromatic hydrocarbons in the BLU: Ha newborn mouse assay." Toxicol. Appl. Pharmacol.99(3):555-563.
135.
Butler, H.T., Coddens, M.E., and Poole, C.F. (1984a). "Qualitative identification of polycyclic aromatic hydrocarbons by high performance thin-layer chromatography and fluorescence scanning densitometry." J. Chromatogr.290:113-126.
136.
Butler, J.D., Butterworth, V., Kellow, C., et al. ( 1984b). "Some observations on the polycyclic aromatic hydrocarbon (PAH) content of surface soils in urban areas." Sci. Total Environ.38:75-85.
137.
Butler, J.D. and Crossley, P. (1981). "Reactivity of polycyclic aromatic hydrocarbons adsorbed on soot particles." Atmos. Environ.15:91-94.
138.
Byczkowski, J.Z. and Gessner, T. (1989). "Effects of inhibition of NADPH: cytochrome P-450 reductase on benzo(a)pyrene metabolism in mouse liver microsomes." Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, NY. Intl. J. Biochem.21(5):525-529.
139.
Calabrese, E. (1978). Pollutants and High Risk Groups: The Biological Basis of Increased Human Susceptibility to Environmental and Occupational Pollutants. John Wiley and Sons, New York, NY.
140.
Callahan, M.A., Slimak, M.W., Gabel, N.W., et al. (1979). "Water-related environmental fate of 129 priority pollutants, volume II." U.S. Environmental Protection Agency. EPA-440/4-79-029B. Washington, D.C.
141.
Carver, J.H., Machado, M.L., and Ma, J.A. (1986). "Application of modified salmonella/ microsome prescreen to petroleum-derived complex mixtures and polynuclear aromatic hydrocarbons (PAHs)." Mutat. Res.174:247-253.
142.
Casto, B.C. (1973). "Enhancement of adenovirus transformation by treatment of hamsters with ultraviolet irradiation, DNA base analogs, and dibenz(a,h)anthracene ." Cancer Res.33:402-407.
143.
Casto, B.C., Janosko N., and Dipaolo, J.A. (1977). "Development of a focus assay model for transformation of hamster cells in vitro by chemical carcinogens." Cancer Res.37:3508-3515.
144.
Casto, B.C., Pieczynski, W.J., and Dipaolo, J.A. (1973). "Enhancement of adenovirus transformation be pretreatment of hamster cells with carcinogenic polycyclic hydrocarbons." Cancer Res.33:819-824.
145.
Cavalieri, E.L., Devanesan, P.D., Cremonesi, P., et al. (1987). "Radical cations of polycyclic aromatic hydrocarbons (PAHs) in the binding." Proceedings of the American Association for Cancer Research Annual Meeting28:129.
146.
Cavalieri, E.L., Devanesan, P.D., and Rogan, E.G. (1988a). "Radical cations in the horseradish peroxidase and prostaglandin H synthase mediated metabolism and binding of benzo[a]pyrene to deoxyribonucleic acid." Biochem. Pharmacol.37:2183-2187.
147.
Cavalieri, E.L., Higginbotham, S., Ramakrishna, N.V.S., et al. (1991). "Comparative dose-response tumorigenicity studies of dibenzo(a,)pyrene versus 7,12-dimethylbenz(a)anthracene, benzo(a)pyrene and two dibenzo(a,)pyrene dihydrodiols in mouse skin and rat mammary gland ." Carcinogenesis12( 10):1939-1944.
148.
Cavalieri, E.L., Mailander, P., and Pelfrene, A. (1977). "Carcinogenic activity of anthanthrene on mouse skin." Z. Krebsforsch Klin.89:113-118.
149.
Cavalieri, E.L., Rogan, E., Cremonesi, P., et al. ( 1988b). "Tumorigenicity of 6-halogenated derivatives of benzo[a]pyrene in mouse skin and rat mammary gland." J. Cancer Res. Clin. Oncol.114:10-15.
150.
Cavalieri, E.L., Rogan, E., and Sinha, D. ( 1988c). "Carcinogenicity of aromatic hydrocarbons directly applied to rat mammary gland." J. Cancer Res. Clin. Oncol.114:3-9.
151.
Cerniglia, C.E. and Gibson, D.T. (1979). "Oxidation of benzo[a]pyrene by the filamentous fungus Cunninghamella elegans." J. Biol. Chem.254:12174-12180.
152.
Cervello, I., Lafuente, A., Giralt, M., et al. (1992). "Enhanced glutathione S-transferase (GST) activity in pregnant rats treated with benzo(a)pyrene." Department of Pharmacology, School of Medicine (Reus), University of Barcelona, Spain . Placenta (England)13(3):273-280.
153.
Chae, Y.H., Ho, D.K., Cassady, J.M., et al. (1992). "Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzo[a]pyrene in hamster embryo cell cultures." Chem. Biol. Interactions (Ireland)82(2):181-193.
154.
Chang, L.H. (1943). "The fecal excretion of polycyclic hydrocarbons following their administration to the rat." J. Biol. Chem.151:93-99.
155.
Chang, R.L., Levin, W., Wood, A.W., et al. (1981). "Tumorigenicity of the diastereomeric bay-region benzo(e)pyrene 9,10-diol-11,12-epoxides in newborn mice." Cancer Res.41:915-918. Chipman, J.K., Bhave, N.A., Hirom, P.C., et al. (1982 ). "Metabolism and excretion of benzo(a)pyrene in the rabbit ." Xenobiotica12:397-404.
156.
Christou, M., Moore, C.J., Gould, M.N., et al. (1987). "Induction of mammary cytochromes P-450 : An essential first step in the metabolism of 7,12-dimethylbenz[a]anthracene by rat mammary epithelial cells." Carcinogenesis8:73-80.
157.
Chu, E.W. and Malmgren, R.A. (1965). "An inhibitory effect of vitamin A on the induction of tumors in the forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons." Cancer Res.25:884-895.
158.
Chuang, J.C., Mack, G.A., Kuhlman, M.R., et al. (1991). "Polycyclic aromatic hydrocarbons and their derivatives in indoor and outdoor air in an eight-home study." Atmos. Environ. Part B UrbanAtmos.25(3):369-380.
159.
Clive, D., Johnson, K.O., Spector, J.F.S., et al. (1979). "Validation and characterization of the L5178Y/TK+/1- mouse lymphoma mutagen assay system." Mutat. Res.59:61-108.
160.
Clonfero, E., Jongeneelen, F., Zordan, M., et al. (1989). "Biological monitoring of human exposure to coal tar urinary mutagenicity assays and analytical determination of polycyclic aromatic hydrocarbon: Metabolites in urine." In: Complex Mixtures, No. 104. (H. Vainio, M. Sorsa, and J. McMichael , eds.) International Agency for Research on Cancer . Lyon, France. pp. 215-222.
161.
Contract Laboratory Program Statistical Database (Clpsd) (1988). U.S. Environmental Protection Agency, Contract Laboratory Program.
162.
Coccioli, F., Ronchetti, M., et al. (1986). "Determination of polycyclic aromatic hydrocarbons in natural waters by thin-layer chromatography and high-performance liquid chromatography." J. Chromatogr.370:157-163.
163.
Cohen, G.M. (1990). "Pulmonary metabolism of foreign compounds its role in metabolic activation." Symposium on Chemicals and Lung Toxicity: To Study the Agent or the Disease. Cardiff, Wales, UK, 1988. Environ. Health Perspect. 85(0):31-42.
164.
Cohen, G.M., Haws, S.M., Moore, B.P., et al. (1976). "Benzo(a)pyrene-3-yl hydrogen sulfate, a major ethyl acetate-extractable metabolite of B(a)P in human, hamster and rat lung cultures." Biochem. Pharmacol.25:2561-2570.
165.
Cole, R.H., Frederick, R.E., Nealy, R.P., et al. (1984). "Preliminary findings of the priority pollutant monitoring project of the nationwide urban runoff program journal." J. Water Pollut. Control. Fed.56:898-908.
166.
Collins, J.F., Brown, J.P., Dawson, S.V., et al. ( 1991 ). "Risk assessment for benzo(a)pyrene." Regul. Toxicol. Pharmacol.13(2):170-184.
167.
Computer-Aided Environmental Legislative Data Systems ( 1994). United States Army Corps of Engineers Environmental Technical Information systems, University of Illinois, Urbana, IL. September 1992.
168.
Coombs, M.M., Dixon, C., and Kissonerghis, A.M. ( 1976). "Evaluation of the mutagenicity of compounds of known carcinogenicity, belonging to the benz(a)anthracene, chrysene, and cyclopenta(a)phenanthrene series, using Ames' tests." Cancer Res.36:4525-2529.
169.
Coover, M.P. and Sims, R.C. (1987). "The effects of temperature on polycyclic aromatic hydrocarbon persistence". Haz. Waste Haz. Mat.4:69-82.
170.
Cosma, G.N., Jamasbi, R., and Marchok, A.C. (1988). "Growth inhibition and DNA damage induced by benzo[a]pyrene and formaldehyde in primary cultures of rat tracheal epithelial cells." Mutat. Res. Sep.201 ( 1 ):161-168.
171.
Cosma, G.N. and Marchok, A.C. (1988). "Benzo[a]pyrene- and formaldehyde-induced DNA damage and repair in rat tracheal epithelial cells." Toxicol.51 (2-3):309-320.
172.
Cottini, G.B. and Mazzone, G.B. (1939). "The effects of 3,4-benzpyrene on human skin." Am. J. Cancer37:186-195.
173.
Creasia, D.A., Poggenburg, J.K., and Nettesheim, P. (1976). "Elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice." J. Toxicol. Environ. Health1:967-975.
174.
Crespi, C.L., Liber, H.L., Behymer, T.D., et al. (1985). "A human cell line sensitive to mutation by particle-borne chemicals." Mutat. Res.157:71-75.
175.
Csaba, C. and Inczefi-Gonda, A. (1992). "Benzpyrene exposure at 15 days of prenatal life reduces the binding capacity of thymic glucocorticoid receptors in adulthood." Gen. Pharmacol.23(1):123-124.
176.
Csaba, G., Inczefi-Gonda, A., and Szeberenyi, S. ( 1991 ). "Lasting impact of a single benzpyrene treatment in pre-natal and growing age on the thymic glucocorticoid receptors of rats ." Gen. Pharmacol.22(5):815-818.
177.
Dahl, A.R., Coslett, D.C., Bond, J.A., et al. (1985). "Metabolism of benzo(a)pyrene on the nasal mucosa of Syrian hamsters: Comparison to by other extrahepatic tissues and possible role of nasally produced metabolites in carcinogenesis." J. Natl. Cancer Inst.75:135-139.
178.
Danheiser, S.L., Liber, H.L., and Thilly, W.G. (1989). "Long-term low-dose benzo-alpha-pyrene-induced mutation in human lymphoblasts competent in xenobiotic metabolism." Mutat. Res.210( 1 ):143-148.
179.
Daniel, P.M., Pratt, O.E., and Prichard, M.M.L. (1967). "Metabolism of labelled carcinogenic hydrocarbons in rats." Nature215:1142-1146.
180.
Dankovic, D.A., Wright, C.W., Zangar, R.C., et al. (1989). "Complex mixture effects on the dermal absorption of benzo[a]pyrene and other polycyclic aromatic hydrocarbons from mouse skin." J. Appl. Toxicol.9(4):239-244.
181.
Danz, M. and Brauer, R. (1988). "Carcinogenic and non-carcinogenic fluorene derivatives: Induction of thymocyte stimulating serum factors by 2-acetylaminofluorene (AAF) and their synergy with lymphocyte mitogens." Exp. Pathol.34(4):217-221.
182.
Danz, M., Hartmann, A., Otto, M., et al. (1991). "Hitherto unknown additive growth effects of fluorene and 2-acetylaminofluorene on bile duct epithelium and hepatocytes in rats." Arch. Toxicol. Suppl.14:71-74.
183.
Darby, F.W., Willis, A.F., and Winchester, R.V. (1986). "Occupational health hazards from road construction and sealing work." Ann. Occup. Hyg.30(4):445-454.
184.
Dasgupta, P.S. and Lahiri, T. (1992). "Alteration of brain catecholamines during growth of benzo(a)pyrene induced murine fibrosarcoma." Neoplasma39(3):163-165.
185.
Davidson, G.E. and Dawson, G.W.P. (1976). "Chemically induced presumed somatic mutations in the mouse." Mutat. Res.38:151-154.
186.
Davidson, G.E. and Dawson, G.W.P. (1977). "Induction of somatic mutations in mouse embryos by benzo[a]pyrene." Arch. Toxicol.38:99-103.
187.
Davis, B.R., Whitehead, J.K., Gill, M.E., et al. (1975). "Response of rat lung to 3,4-benzpyrene administered by intratracheal instillation in infusine with or without carbon black." Br. J. Cancer31:443-452.
188.
Day, B.W., Skipper, P.L., Wishnok, J.S., et al. (1990). "Identification of an in vivo chrysene diol epoxide adduct in human hemoglobin." Chem. Res. Toxicol.3(4):340-343.
189.
Debruin, A. (1976). "Metabolism of chemical carcinogens and their interactions with macromolecules." In: Biochemical Toxicology of Environmental Agents. Elsevier/North-Holland Biomedical Press, Amsterdam, The Netherlands, pp. 230-231.
190.
Deflora, S., D'Agostini, F., Izzotti, A., et al. ( 1991 ). "Prevention by N-acetylcysteine of benzo[a]pyrene clastogenicity and DNA adducts in rats." Mutat. Res.250(1-2):87-93.
191.
Devos, R.H., Vandokkum, W., and Schouten, A. (1990). "Polycyclic aromatic hydrocarbons in Dutch total diet samples (1984-1986)." Food Chem. Toxicol.28(4):263-268.
192.
Dean, B.J. ( 1981 ). "Activity of 27 coded compounds in the RL 1 chromosome assay." In: Evaluation of Short-Term Tests for Carcinogens: Report of the International Collaborative Program. Prog. Mutat. Res.1:570-579.
193.
Dean, J.H., Luster, M.I., Boorman, G.A., et al. (1983). "Selective immunosuppression resulting from exposure to the carcinogenic congener of benzopyrene in B6C3F 1 mice ." Clin. Exp. Immunol.52:199-206.
194.
Dean, R.G., Bynum, G., Jacobson-Kram, D., et al. ( 1983). "Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells." Mutat. Res.111:419-427.
195.
Delclos, K.B. and Heflich, R.H. (1992). "Mutation induction and DNA adduct formation in Chinese hamster ovary cells treated with 6-nitrochrysene, 6-aminochrysene and their metabolites." Mutat. Res.279(3):153-164.
196.
Deleon, I.R., Byrne, C.J., Peuler, E.L., et al. (1986). "Trace organic and heavy metal pollutants in the Mississippi River." Chemosphere15:795-805.
197.
Denhollander, H., Van De Meent, D., Van Noort, P., et al. (1986). "Wet deposition of polycyclic aromatic hydrocarbons in the Netherlands." Sci. Total Environ.52:211-219.
198.
Department Of Transportation ( 1990). Code of Federal Regulations. 49 CFR 172.101.
199.
Department Of Transportation (1991). Hazardous materials transport. Code of Federal Regulations . 49 CFR 171.2.
200.
Desiderie, P.G., Lepri, L., Heimler, D., et al. (1984). "Concentration, separation and determination of hydrocarbons in sea water." J. Chromatogr.284:167-178.
201.
Desilets, D.J., Kissinger, P.T., Lytle, F.E., et al. (1984). "Determination of polycyclic aromatic hydrocarbons in biomass gasifier effluents with liquid chromatography-diode array spectroscopy." Environ. Sci. Technol.18:386-391.
202.
Deutsch-Wenzel, R.P., Brune, H., Grimmer, G., et al. (1983). "Experimental studies in rat lungs on the carcinogenicity and dose-response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons." J. Natl. Cancer. Inst.71:539-544.
203.
Diamond, L., Kruszewski, F., Knowles, B.B., et al. (1980). "Metabolic activation of B[a]P by a human hepatoma cell line." Carcinogenesis1:871-875.
204.
Digiovanni J., Rymer, J., Slaga, T.J., et al. (1982). "Anticarcinogenic and cocarcinogenic effects of benzo[e]pyrene and dibenz[a,c]anthracene on skin tumor initiation by polycyclic hydrocarbons." Carcinogenesis3(4):371-375.
205.
Dipaolo, J.A. and Casto, B.C. (1976). "In vitro transformation—Interaction of chemical carcinogens with viruses and physical agents." Intl. Agency Res. CancerScientific Publications12:415-432.
206.
Dipaolo, J.A., Donovan, J.P., and Nelson, R.L. (1969). "Quantitative studies of in vitro transformation by chemical carcinogens." J. Natl. Cancer Inst.42:867-876.
207.
Dipaolo, J.A., Donovan, J.P., and Nelson, R.L. ( 1971 ). "Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity." Proc. Natl. Acad. Sci.68:2958-2961.
208.
Dipple, A. and Bigger, C.A.H. (1991). "Mechanism of action of food-associated polycyclic aromatic hydrocarbon." Carcinogens. Mutat. Res.259(3-4):263-276.
209.
Dock, L., Scheu, G., Jernstrom, B., et al. (1988). "Benzo[a]pyrene metabolism and induction of enzyme-altered foci in regenerating rat liver." Chem. Biol. Interact.67(3-4):243-253.
210.
Dorman, B.H., Genta, V.M., Mass, M.J., et al. ( 1981 ). "Benzo(a)pyrene binding to DNA in organ cultures of human endometrium." Cancer Res.41:2718-2722.
211.
Duncan, M.E. and Brookes, P. (1972). "Metabolism and macromolecular binding of dibenz(a,c)anthracene and dibenz(a,h)anthracene by mouse embryo cells in culture." Intl. J. Cancer9(2):349-352.
212.
Dunkel, V.C., Pienta, R.J., Sivak, A., et al. ( 1981 ). "Comparative neoplastic transformation responses of Balb 3T3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens ." J. Natl. Cancer Inst.67:1303-1315.
213.
Dunkel, V.C., Zeiger, E., Brusick, D., et al. (1984). "Reproducibility of microbial mutagenicity assays: 1. Tests with salmonella typhimurium and escherichia coli using a standardized protocol." Environ. Mutagen6:1-251.
214.
Eadie, B.J., Faust, W., Gardner, W.S., et al. (1982). "Polycyclic aromatic hydrocarbons in sediments and associated benthos in Lake Erie, USA." Chemosphere11:185-102.
215.
Eadie, B.J., Faust, W.R., Landrum, P.F., et al. (1983). "Bioconcentrations of PAH by some benthic organisms of the Great Lakes." In: Polynuclear Aromatic Hydrocarbons: Formation, Metabolism and Measurement. ( M. Choke, and A. Dennis, eds.) Batyl Press, Columbus, OH. pp. 437-449.
216.
Edwards, N.T. (1983). "Polycyclic aromatic hydrocarbons (PAHs) in the terrestrial environment - a review." J. Environ. Qual.12:427-441.
217.
Edwards, N.T. ( 1989). "Fate and effects of PAHs in the terrestrial environment: An overview." GRA&I, Issue 21. U.S. Department of Energy, Washington, DC. Contract Number CONF-890692-5, Contract AC05-840R21400.
218.
Ehrlich, G.G., Goerlitz, D.F., Godsy, E.M., et al. (1982). "Degradation of phenolic contaminants in ground water by anaerobic bacteria: St. Louis Park, MN." Ground Water20:703-710.
219.
Eiceman, G.A., Clement, R., and Karosek, F. (1979). "Analysis of fly ash from municipal incinerators for trace organic compounds." Anal. Chem.51:2343.
220.
Eisenberg, W.C. and Cunningham, D.L.B. (1985). "Analysis of polycyclic aromatic hydrocarbons in diesel emissions using high performance liquid chromatography: A methods development study" In: Polynuclear Aromatic Hydrocarbons: Mechanisms, Methods and Metabolism (M. Cook and A. Dennis, eds.) Batyl Press, Columbus, OH. pp. 379-393.
221.
Eisler, R. (1987). "Polycyclic aromatic hydrocarbon hazards to fish, wildlife, and invertebrates: A synoptic review." U.S. Fish and Wildlife Service Patuxent Wildlife Research Center, Laurel, MD.
222.
Elder, J.F. and Dresler, P.V. (1988). "Bioconcentration of polycyclic aromatic hydrocarbons in a nearshore estuarine environment near a Pensacola, Florida creosote contamination site." Environ. Pollut.49(2):117-132.
223.
Eldridge J.E., Shanmugam, K., Bobalek, E.G., et al. (1983). "PAH emissions from paving asphalt in laboratory simulation." In: Polynuclear Aromatic Hydrocarbons . (M. Choke and A. Dennis, eds.) Batyl Press, Columbus, OH. pp. 471-482.
224.
Elgjo, K. (1968). "Growth kinetics of the mouse epidermis after a single application of 3,4-benzpyrene, croton oil, or 1,2-benzpyrene." Acta Pathol. Microbiol. Scand.73:183-190.
225.
Eller, P.M. (1984). NIOSH manual of analytical methods. Vol. 2. U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, OH. 5506/7-5506/9, 5515/6-5515/7.
226.
Emura, M., Mohr, U., Riebe, M., et al. (1987). "Predisposition of cloned fetal hamster lung epithelial cells to transformation by a precarcinogen, benzo(a)pyrene, using growth hormone supplementation and collagen gel substratum." Cancer Res.47:1155-1160.
227.
Emura, M., Richter-Reichhelm, H.B., Schneider, P., et al. (1980). "Sensitivity of Syrian golden hamster fetal lung cells to benzo(a)pyrene and other polycyclic hydrocarbons in vitro ." Toxicol.17:149-155.
228.
Environment Canada (1991). " Toxic chemicals in the Great Lakes and associated effects: Vol. I. Contaminant levels and trends." Department of Fisheries and Oceans, Health and Welfare, Canada.
229.
Environment Canada (1991). " Toxic chemicals in the Great Lakes and associated effects: Volume II. Effects ." Environment Canada, Department of Fisheries and Oceans, Health and Welfare, Canada.
230.
Epstein, S. (1968). "Chemical mutagens in the human environment." Nature219:365.
231.
Fahmy, M. and Fahmy, O.G. (1980). "Altered control of gene activity in the soma by carcinogens." Mutat. Res.72:165-172.
232.
Faiderbe, S., Chagnaud, J.L., and Geffard, M. (1992). "Identification and characterization of a specific autoantiphosphatidylinositol immune response during the time course of benzo(a)pyrene-induced malignant tumors in female Sprague-Dawley rats." Cancer Res.52(10):2862-2865.
233.
Falk, H.L. and Kotin, P.T.S. (1964). "Inhibition of carcinogenesis: The effects of polycyclic hydrocarbons and related compounds." Arch. Environ. Health9:169-179.
234.
Falkson, G., Klein, B., and Falkson, H. (1985). "Hematological toxicity: Experience with anthracyclines and anthracenes." Exp. Hematol.13:64-71.
235.
Faoro, R.B. and Manning, J.A. (1981). "Trends in benzo[a]pyrene, 1966-77." J. Air Pollut. Control Assoc.31:62-64.
236.
Faulds, A., Waszczylo, Z., and Westaway, K.C. ( 1981 ). "Polynuclear aromatic hydrocarbons in the underground mine environment." CIM Bull. 74:84-90.
237.
Federal-State Toxicology And Regulatory Alliance Committee (1988). "Summary of state and federal drinking water standards and guidelines." Chemical Communication Subcommittee, Federal-State Toxicology and Regulatory Alliance Committee, Washington, D.C. March, 1988.
238.
Federal-State Toxicology And Regulatory Alliance Committee (1990). "Summary of state and federal drinking water standards and guidelines." Chemical Communication Subcommittee, Federal-State Toxicology and Regulatory Alliance Committee, Washington, D.C. February, 1990.
239.
Feron, V.J. (1972). "Respiratory tract tumors in hamsters after intratracheal installations of benzo[a]pyrene alone and with furfural." Cancer Res.32:28-36.
240.
Feron, V.J. (1973). "Dose-response correlation for the induction of respiratory-tract tumors in Syrian golden hamsters by intratracheal installations of benzo[a]pyrene." Eur. J. Cancer9:387.
241.
Feron, V.J. and Kruysse, A. (1978). "Effects of exposure to furfural vapor in hamsters simultaneously treated with benzo[a]pyrene and diethylnitrosamine." Toxicol.11:127-144.
242.
Ferrario, J.B., Deleon, H., and Tracy, R. (1985). "Evidence for toxic anthropogenic chemicals in human thrombogenic coronary plaques body burdens." Arch. Environ. Contam. Toxicol.14:529-534.
243.
Fielden, P.R. and Packham, A. (1989). "Selective determination of benzo(a)pyrene in petroleum-based products using multi-column liquid chromatography." J. Chromatogr.479(1): 117-124.
244.
Finch, M.A. (1990). "What is FT Raman spectroscopy and where can I use it?" Spectroscopy (Eugene, OR) 5(6):12, 14-16.
245.
Fiume, M., Guaitani, A., Modica, R., et al. (1983). "Effect of fasting, induction, sex and age on clearance of benz(a)anthracene and chrysene by isolated perfused rat liver." Toxicol. Lett.19:73-79.
246.
Forbes, P.D., Davies, R.E., and Urbach, F. (1976). "Phototoxicity and photocarcinogenesis: Comparative effects of anthracene and 8-methoxypsoralen in the skin of mice." Food Cosmet. Toxicol.14:303-306.
247.
Foreman, W.T. and Bidleman, T.F. (1990). "Semivolatile organic compounds in the ambient air of Denver, Colorado." Atmos. Environ.24(9):2405-2416.
248.
Foth, H., Kahl, R., and Kahl, G.F. (1988a). "Pharmacokinetics of low doses of benzo[a]pyrene in the rat." Food Chem. Toxicol.26( 1 ):45-51.
249.
Foth, H., Rudell, U., Ritter, G., et al. (1988b). "Inhibitory effect of nicotine on benzo(a)pyrene elimination and marked pulmonary metabolism of nicotine in isolated perfused rat lung." Klinische Wochenschrift66 (Suppl. 11 ):98-104.
250.
Fournier, J. and Pezerat, H. (1986). "Studies on surface properties of asbestos: III. Interactions between asbestos and polynuclear aromatic hydrocarbons." Environ. Res.41:276-295.
251.
Fox, M.A. and Staley, S.W. (1976). "Determination of polycyclic aromatic hydrocarbons in atmospheric particulate matter by high pressure liquid chromatography coupled with flourescene techniques." Anal. Chem.48:992-998.
252.
Franklin Associates (1984). " Composition and management of used oil generated in the United States." U.S. Environmental Protection Agency, Washington, D.C. NTIS PB 85-180-297.
253.
Fraumeni, J.R.(ed.) (1975). Persons at High Risk of Cancer: An Approach to Cancer Etiology and Control . Academic Press, Inc., New York, NY. pp. 172, 187-189.
254.
Freeman, D.J. and Cattell, C.R. (1990). "Woodburning as a source of atmospheric polycyclic aromatic hydrocarbons." Environ. Sci. Technol.24(10):1581-1585.
255.
Furman, G.M., Silverman, D.M., and Schatz, R.A. (1991). "The effect of toluene on rat lung benzo[a]pyrene metabolism and microsomal membrane lipids." Toxicol.68(1):75-87.
256.
Furuta, N. and Otsuki, A. (1983). "Time-resolved fluorometry in detection of ultratrace polycyclic aromatic hydrocarbons in lake waters by liquid chromatography ." Anal. Chem.55:2407-2413.
257.
Futoma, D.J., Smith, S.R., Tanaka, J., et al. (1981). "Chromatographic methods for the analysis of polycyclic aromatic hydrocarbons in water systems." Crit. Rev. Anal. Chem.12:69-153.
258.
Galle, B. and Grennfelt, P. (1983). "Instrument for polycyclic aromatic hydrocarbon analysis of airborne particles by capillary gas chromatography with laser induced fluorescence detection." J. Chromatogr.279:643-648.
259.
Gao, N., Aidoo, A., and Heflich, R.H. ( 1991 ). "Analysis of rat lymphocyte activation of benzo[a]pyrene, 2-acetylaminofluorene, and several of their metabolites to mutagenic and DNA-damaging species in vitro." Teratogenesis Carcinog. Mutagen.11 (2):65-76.
260.
Gardner, W.S., Lee, R.F., Tenore, K.R., et al. (1979). "Degradation of selected polycyclic aromatic hydrocarbons in coastal sediments: Importance of microbes and polychaete worms." Water Air Soil Pollut.11:339-348.
261.
Garner, R.C., Dvorackova, I., and Tursi, F. (1988). "Immunoassay procedures to detect exposure to aflatoxin B-l and benzo-a-pyrene in animals and man at the DNA level." Intl. Arch. Occup. Environ. Health60(3):145-150.
262.
Garrigues, P. and Ewald, M. (1987). "High resolution emission spectroscopy (Shpol'skii effect): A new analytical technique for the analysis of polycyclic aromatic hydrocarbons (PAH) in environmental samples." Chemosphere16:485-494.
263.
Gay, M.L., Belisle, A.A., and Patton, J.F. (1980). "Quantification of petroleum-type hydrocarbons in avian tissue." J. Chromatogr. 187:153-160.
264.
Generoso, W.M., Cain, K.T., Hellwig, C.S., et al. (1982). "Lack of association between induction of dominant-lethal mutations and induction of heritable translocations with benzo[a]pyrene in postmeiotic germ cells of male mice." Mutat. Res.94:155-163.
265.
Gensler, H.L. (1988). "Enhancement of chemical carcinogenesis in mice by systemic effects of ultraviolet irradiation." Cancer Res.48:620-623.
266.
Georgellis, A., Parvinen, M., and Rydstrom, J. (1989). "Inhibition of stage-specific DNA synthesis in rat spermatogenic cells by polycyclic aromatic hydrocarbons." Chem. Biol. Interact.72(1-2):79-92.
267.
Georgellis, A., Toppari, J., Veromaa, T., et al. (1990). "Inhibition of meiotic divisions of rat spermatocytes in vitro by polycyclic aromatic hydrocarbons." Mutat. Res.231(2):125-136.
268.
Gerde, P., Medinsky, M.A., and Bond, J.A. ( 1991 ). "The retention of polycyclic aromatic hydrocarbons in the bronchial airways and in the alveolar region: A theoretical comparison ." Toxicol. Appl. Pharmacol.107(2):239-252.
269.
Gerde, P. and Scholander, P. (1989). "An experimental study of the penetration of polycyclic aromatic hydrocarbons through a model of the bronchial lining layer." Environ. Res.48(2):287-295.
270.
Gershbein, L.L. (1975). "Liver regeneration as influenced by the structure of aromatic and heterocyclic compounds." Res. Commun. Chem. Pathol. Pharmacol.11:445-466.
271.
Gibson, T.L., Smart, V.B., and Smith, L.L. (1978). "Non-enzymatic activation of polycyclic aromatic hydrocarbons as mutagens." Mutat. Res.49:153-161.
272.
Giger, W. and Blumer M. (1974). "Polycyclic aromatic hydrocarbons in the environment: Isolation and characterization by chromatography visible, ultraviolet, and mass spectrometry." Anal. Chem.46:1163.
273.
Giger, W. and Schaffner, C. (1978). "Determination of polycyclic aromatic hydrocarbons in the environment by glass capillary gas chromatography." Anal. Chem.50:243-249.
274.
Gile, J.D., Collins, J.C., and Gillet, J.W. (1982). "Fate and impact of wood preservatives in a terrestrial microcosm." J. Agric. Food Chem.30:295-301.
275.
Ginsberg, G.L. and Atherholt, T.B. (1989). "Transport of DNA-adducting metabolites in mouse serum following benzo[a]pyrene administration." Carcinogenesis10(4):673-679.
276.
Ginsberg, G.L., Atherholt, T.B., and Butler, G.H. (1989). "Benzo[a]pyrene-induced immunotoxicity: Comparison to DNA adduct formation in vivo, in cultured splenocytes, and in microsomal systems." J. Toxicol. Environ. Health28(2):205-220.
277.
Glatt, H., Bucker, M., Platt, K.L., et al. ( 1985). "Host-mediated mutagenicity experiments with benzo[a]pyrene and two of its metabolites." Mutat. Res.156:163-169.
278.
Glatt, H., Seidel, A., Ribeiro, O., et al. (1987). "Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8- dihydrobenzo(a)pyrene, a secondary metabolite of benzo(a)pyrene." Carcinogenesis8:1621-1627.
279.
Goates, S.R., Sin, C.H., Simons, J.K., et al. (1989). "Supercritical-fluid chromatography - supersonic-Jet spectroscopy: Part 11. Capillary-column SFC with a sheath-flow nozzle." Microcolumn Sep.1 (4):207-211.
280.
Golden, C. and Sawicki, E. (1978). "Determination of benzo(a)pyrene and other polynuclear aromatic hydrocarbons in airborne particulates material by ultrasonic extraction and reverse phase pressure liquid chromatography." Anal. Lett.11:1051-1062.
281.
Gomes, M. and Santella, R.M. (1990). "Immunologic methods for the detection of benzo[a]pyrene metabolites in urine." Chem. Res. Toxicol.3(4):307-310.
282.
Gonzalez, B.L. and Rejthar, L. (1986). "Quantitative determination of trace concentration of organics in water by solvent extraction and fused silica capillary gas chromatography: aliphatic and polynuclear hydrocarbons." Intl. J. Environ . Anal. Chem.24:305-318.
283.
Gordon, R.J. (1976). "Distribution of airborne polycyclic aromatic hydrocarbons throughout Los Angeles." Env. Sci. Tech.10:370-373.
284.
Gorelick, N.J. and Wogan, G.N. (1989). "Fluoranthene - DNA adducts: identification and quantification by an HPLC - phosphorus-32 post-labelling method." Carcinogenesis10(9):1567-1577.
285.
Govindwar, S.P., Kachole, M.S., and Pawar, S.S. (1988). "Effect of caffeine on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo[a]pyrene treatment in rats." Toxicol. Lett.42(2):109-115.
286.
Grant, G.A. and Roe, F.J.C. (1963). "The effect of phenanthrene on tumor induction by 3,4-benzpyrene administered to newly born mice." Br. J. Cancer17:261-265.
287.
Grayson, M. (ed.) (1978). Kirk-OthmerEncyclopedia of Chemical Technology. Vol. 21.
288.
Greb, W., Strobel, R., and Roehrborn, G. (1980). "Transformation of BHK 21/CL 13 cells by various polycyclic aromatic hydrocarbons using the method of styles." Toxicol. Lett. (Amst.)7:143-148.
289.
Greenberg, A., Darack, F., Harkov, R., et al. (1985). "Polycyclic aromatic hydrocarbons in New Jersey (USA): A comparison of winter and summer concentrations over a two-year period." Atmos. Environ.19:1325-1340.
290.
Grimmer, G., Brune, H., Dettbarn, G., et al. (1988). "Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application." Arch. Toxicol.62(6):401-405.
291.
Grimmer, G., Jacob, J., Schmoldt, A., et al. (1985). "Metabolism of benz(a)anthracene in hamster lung cells in culture in comparison to rat liver microsomes." In: Polynuclear Aromatic Hydrocarbons: Mechanisms, Methods and Metabolism (M. Choke and A. Dennis, eds.) Batyl Press, Columbus, OH. pp. 521-532.
292.
Grolier, P., Cassand, P., Antignac, E., et al. (1989). "Effects of prototypic PCBs on benzo-alpha-pyrene mutagenic activity related to vitamin A intake." Mutat. Res.211(1):139-146.
293.
Grover, P.L., Sims, P., Huberman, E., et al. ( 1971 ). "In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons." Proc. Nat. Acad. Sci. (USA)68:1098-1101.
294.
Grover, P.L., Sims, P., Mitchley, B.C.U., et al. (1975). "The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice." Br. J. Cancer31:182-188.
295.
Guerin, M.R. (1978). "Energy sources of polycyclic aromatic hydrocarbons ." In: Polycyclic Hydrocarbons and Cancer. Vol. 1. (H.V. Gelboin and P.O.P. Ts'o, eds.) Academic Press , New York, NY. pp. 3-55.
296.
Gunnison, A.F., Sellakumar, A., Snyder, E.A., et al. (1988). "The effect of inhaled sulfur dioxide and systemic sulfite on the induction of lung carcinoma in rats by benzo[a]pyrene ." Environ. Res.46(1):59-73.
297.
Gupta, M.P., Khanduja, K.L., Koul, I.B., et al. (1990). "Effect of cigarette smoke inhalation on benzo[a]pyrene-induced lung carcinogenesis in vitamin A deficiency in the rat." Cancer Lett.55(2):83-88.
298.
Gupta, M.P., Khanduja, K.L., and Sharma, R.R. (1987). "Effect of cigarette smoke inhalation on (3H)benzo(a)pyrene binding to lung DNA of vitamin A-deficient rats." Med. Sci. Res.15:1323-1324.
299.
Gupta, P.H., Mehta, S., and Mehta, S.K. (1989). "Effects of dietary benzo(a)pyrene on intestinal phase I and phase II drug metabolizing systems in normal and vitamin A-deficient rats." Biochem. Intl.19(4):709-722.
300.
Gupta, R.S. and Goldstein, S. (1981). "Mutagen testing in the human fibroblast diphtheria toxin resistance (HF Dipr.) system." Prog. Mutat. Res.1:614-625.
301.
Gupta, R.S. and Singh, B. (1982). "Mutagenic responses of five independent genetic loci in CHO cells to a variety of mutagens: Development and characteristics of a mutagen screening system based on selection for multiple drug-resistant markers." Mutat. Res.94:449-466.
302.
Gurka, D.F. and Pyle, S.M. (1988). "Qualitative and quantitative environmental analysis by capillary column gas chromatography/lightpipe Fourier-transforms infrared spectrometry." Environ. Sci. Technol.22:963-967.
303.
Gurka, D.F., Titus, R., Giffiths, P.R., et al. (1987). "Evaluation of an improved single-beam gas chromatography/Fourier transform infrared interface for environmental analysis." Anal. Chem.59:2362-2369.
304.
Guyda, H.J. (1991). "Metabolic effects of growth factors and polycyclic aromatic hydrocarbons on cultured human placental cells of early and late gestation." J. Clin. Endocrinol. Metab.72(3):718-723.
305.
Guyda, H.J., MATHIEU, L., LAI, W., et al. (1990). "Benzo(a)pyrene inhibits epidermal growth factor binding and receptor autophosphorylation in human placental cell cultures." Mol. Pharmacol.37(2):137-143.
306.
Ha, M. and Grover, P.L. (1988). "Stereoselective aspects of the metabolic activation of benzo[a]pyrene by human skin in vitro." Chem. Biol. Interact.64(3):281-296.
307.
Haas, J.W.I., Buchanan, M.V., and Wise, M.B. (1988). "Differentiation of polycyclic aromatic hydrocarbons using a multimode ionization gas chromatographic detector." J. Chromatogr. Sci.26:49-54.
308.
Habs, M., Jahn, S.A., and Schmahi, D. (1984). "Carcinogenic activity of condensate from coloquint seeds (Citrullus colocynthis) after chronic epicutaneous administration to mice." J. Cancer Res. Clin. Oncol.108:154-156.
309.
Habs, M., Schmahl, D., and Misfeld, J. (1980). "Local carcinogenicity of some environmentally elevant polycyclic aromatic hydrocarbons after lifelong topical application to mouse skin." Arch. Geschwulstforschung50:266-274.
310.
Hahon, N. and Booth, J.A. (1986). "Coinhibition of viral interferon induction by benzo[a]pyrene and chrysolite asbestos." Environ. Res.40(1): 103-109.
311.
Hahon, N. and Booth, J.A. (1988). "Benzo[a]pyrene: Kinetics of in vitro bioactivation in relation to inhibition of viral interferon induction." J. Interferon Res.8(2):151-167.
312.
Hall, M. and Grover, P.L. (1987). "Differential stereoselectivity in the metabolism of benzo(a)pyrene and anthracene by rabbit epidermal and hepatic microsomes ." Cancer Lett.38:57-64.
313.
Hall, M., Parker, D.K., Grover, P.L., et al. (1990). "Effects of l-ethynylpyrene and related inhibitors of P450 isozymes upon benzo[a]pyrene metabolism by liver microsomes ." Chem. Biol. Interact.76(2):181-192.
314.
Hammond, E.D., Selikoff, I.J., Lawther, P.O., et al. (1976). "Inhalation of B[a]P and cancer in man ." Ann. N.Y. Acad. Sci.271:116-124.
315.
Hampel, C.A. and Hawley, G.G. (eds.) (1973). The Encyclopedia of Chemistry . Third edition. Van Nostrand Reinhold Company, New York, NY.
316.
Harper, B.L., Ramanujam, V.M.S., and Legator, M.S. (1989). "Micronucleus formation by benzene, cyclophosphamide, benzo(a)pyrene, and benzidine in male, female, pregnant female, and fetal mice." Teratogenesis Carcinogen. Mutagen.9(4):239-252.
317.
Harris, C.C. and Autrup, H. (1983). Human Carcinogenesis. Academic Press, New York, NY.
318.
Harris, C.C., Autrup, H., Stoner, G.D., et al. (1979). "Metabolism of B[a]P, N-nitrosodimethylamine, and N-nitrosopyrrolidine and identification of the major carcinogen-DNA adducts formed in cultured human esophagus." Cancer Res.39:4401-4406.
319.
Harris, C.C., Grafstom, R.C., Shamsuddin, A.M., et al. (1984). "Carcinogen metabolism and carcinogenic DNA adducts in human tissues and cells." In: Biochemical Basis of Chemical Carcinogenesis. (H. Marquardt and F. Oesch, eds.) Raven Press, New York, NY. pp. 123-135.
320.
Harris, C.C., Sporn, M.B., Kaufman, D.G., et al. (1971). "Acute ultrastructural effects of benzo(a)pyrene and ferric oxide on the hamster tracheobronchial epithelium." Cancer Res.31:1977-1981.
321.
Harris J., Perwak J., and Coons, S. (1985). Exposure and risk assessment for benzo(a)pyrene and other polycyclic aromatic hydrocarbons. Volume 1. Summary: pp. 123-135.
322.
Harrison, R.M., Perry, R., and Wellings, R.A. (1976a). "Chemical kinetics of chlorination of some polynuclear aromatic hydrocarbons under conditions of water treatment processes." Environ. Sci. Technol.10:1156-1160.
323.
Harrison, R.M., Perry, R., and Wellings, R.A. (1976b). "Effect of water chlorination upon levels of some polynuclear aromatic hydrocarbons in water." Environ. Sci. Technol.10:1151-1156.
324.
Hartwell, J.L. (1951). Survey of Compounds Which Have Been Tested for Carcinogenic Activity. Public Health Series Publication No. 149.
325.
Harvath, P.V. (1983). "Quantitative analysis of multiple polycyclic aromatic hydrocarbons in the coal conversion atmosphere." Am. Ind. Hyg. Assoc. J.44:739-745.
326.
Hass, B.S., Brooks, E.E., Schumann, K.E., et al. (1981). "Synergistic, additive, and antagonistic mutagenic responses to binary mixtures of benzo(a)pyrene and benzo(e)pyrene as detected by strains TA98 and TA 100 in the Salmonella/microsome assay ." Environ. Mutagen.3(2):159-166.
327.
Haugen, A., Becher, G., Benestad, C., et al. (1986). "Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amount of polycyclic aromatic hydrocarbons in the work atmosphere ." Cancer Res.46:4178-4183.
328.
Haugen, D.A. and Zegar, I.S. (1990). "Formation of hemoglobin-benzo[a]pyrene adducts in human erythrocytes incubated with benzo[a]pyrene and hamster embryo cells ." Toxicol. 65( 1-2):109-122.
329.
Hawley, G.G. (1987). "The Condensed Chemical Dictionary." Van Nostrand Reinhold Company, New York, NY.
330.
Hawthorne, S.B. and Miller, D.J. (1987a). "Directly coupled supercritical fluid extraction-gas chromatographic analysis of polycyclic aromatic hydrocarbons and polychlorinated biphenyls environmental from solids." J. Chromatogr.403:63-76.
331.
Hawthorne, S.B. and Miller, D.J. (1987b). "Extraction and recovery of polycyclic aromatic hydrocarbons from environmental solids using supercritical fluids." Anal. Chem.59:1705-1708.
332.
Hazardous Substance Data Bank (1988). National Library of Medicine, National Toxicology Program , Bethesda, MD. December, 1988.
333.
Hazardous Substance Data Bank (1992). National Library of Medicine, National Toxicology Information Program, Bethesda, MD. April 27, 1992.
334.
Hazardous Substance Release/Health Effects Database (Hazdat) (1993). Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, G.A. March 9, 1993.
335.
He, S.L. and Baker, R. (1991). "Micronuclei in mouse skin cells following in vivo exposure to benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene, chrysene, pyrene and urethane." Environ. Mol. Mutagen.17(3):163-168.
336.
Hecht, S.S., Bondinell, W.E., and Hoffman, D. (1974). "Chrysene and methylchrysenes: Presence on tobacco smoke and carcinogenicity." J. Natl. Cancer Inst.53:1121-1133.
337.
Hecht, S.S., Grabowski, W., and Groth, K. (1979). "Analysis of faeces for B[a]P after consumption of charcoal-broiled beef by rats and humans." Food Cosmet. Toxicol.17:223-227.
338.
Hecht, S.S., Lavoie, E., Amin, S., et al. (1980). "On the metabolic activation of the benzofluoranthenes ." In: Polynuclear Aromatic Hydrocarbons: Chemistry and Biological Effects. 4th National Symposium1980. pp. 417-433.
339.
Heinrich, U., Pott, F., Mohr, U., et al. (1986). "Lung tumors in rats and mice after inhalation of PAH-rich emissions." Exp. Pathol.29:29-34.
340.
Heit, M., Tan, Y., Klusek, C., et al. (1981). "Anthropogenic trace elements and polycyclic aromatic hydrocarbon levels in sediment cores from two lakes in the Adirondack acid lake region." Water Air Soil Pollut.15:441-464.
341.
Henry, M.C., Port, D.C., and Kaufman, D.G. (1975). "Importance of physical properties of benzo[a]pyrene - ferric oxide mixtures." Cancer Res.35:207-217.
342.
Henry, M.C., Port, D.C., Bates, R.R., et al. (1973). "Respiratory tract tumors in hamsters induced by benzo[a]pyrene." Cancer Res.33:1585-1592.
343.
Herberg, R., Marcus, M., Wolff, M.S., et al. (1990). "A pilot study of detection of DNA adducts in white blood cells of roofers by 32P-postlabelling." IARC Sci. Publ. (104):205-14.
344.
Hermann, M. (1981). "Synergistic effects of individual polycyclic aromatic hydrocarbons on the mutagenicity of their mixtures." Mutat. Res.90:399-409.
345.
Hess, G.G., Mckenzie, D.E., and Hughes, B.M. (1986). "Selective preconcentration of polycyclic aromatic hydrocarbons and polychlorinated biphenyls by in situ metal hydroxide precipitation ." J. Chromatogr.366:197-203.
346.
Heston, W.E. and Schneiderman, M.A. (1953). "Analysis of dose-response in relation to mechanisms of pulmonary induction." Science117:109.
347.
Hinga, K.R. and Pilson, M.E.Q. (1987). "Persistence of benz(a)anthracene degradation products in an enclosed marine ecosystem." Env. Sci. Technol.21:648-653.
348.
Hinoshita, F., Hardin, J.A., and Sherr, D.H. (1992). "Fluoranthene induces programmed cell death and alters growth of immature B cell populations in bone marrow cultures." Toxicol.73(2):203-218.
349.
Hirakawa, T., Ishikawa, T., Nimoto, N., et al. (1979). "Induction of enzyme-altered islands in rat liver by a single treatment with B[a]P after partial hepatectomy." GANN.70:373-394.
350.
Hites, R.A., Laflamme, R.E., and Windson, J.J. (1980). "Polycyclic aromatic hydrocarbons in an anoxic sediment core from the Pettaquamscutt River (Rhode Island, U.S.A.)." Geochimica et Cosmochimica Acta44:873-878.
351.
Hluchan, E., Jenik, M., and Maly, E. (19??) "Determination of airborne polycyclic hydrocarbons by paper chromatography." J. Chromatogr.91:531-538.
352.
Hoch-Ligeti, C. (1941). "Studies on the changes in the lymphoid tissue of mice treated with carcinogenic and non-carcinogenic hydrocarbons." Cancer Res.1:484-488.
353.
Hoffmann, D., Rathkamp, G., Nesnow, S., et al. (1972). "Fluoranthenes: Quantitative determination in cigarette smoke, formation by pyrolysis and tumor initiating activity." J. Natl. Cancer Inst.49:1165-1175.
354.
Hogue, C., JR. and Brewster, M.A. ( 1991 ). "The potential of exposure biomarkers in epidemiologic studies of reproductive health." Seventh Symposium on Environmental Epidemiology: Methods for Environmental Quantitative Risk Assessment. Environ. Health Perspect. 90(0):261-270.
355.
Holloway, M.P., Biaglow, M.C., McCoy, E.C., et al. (1987). "Photochemical instability of 1-nitropyrene, 3-nitrofluoranthene, 1,8-dinitropyrene and their parent polycyclic aromatic hydrocarbons." Mutat. Res.187:199-207.
356.
Horikawa, K., Sera, N., Otofuji, T., et al. (1991). "Pulmonary carcinogenicity of 3,9-dinitrofluoranthene 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo(alpha)pyrene in F344 rats." Carcinogenesis12(6):1003-1008.
357.
Horton, A.W. and Christian, G.M. (1974). "Cocarcinogenic versus incomplete carcinogenic activity among aromatic hydrocarbons: Contrast between chrysenes and benzo[b]triphenylene ." J. Natl. Cancer Inst.53:1017-1020.
358.
Horton, J.K., Rosenior, J.C., Bend, et al. (1985). "Quantitation of B[a]P metabolite: DNA adducts in selected hepatic and pulmonary cell types isolated from [3H]benzo[a]pyrene-treated rabbits ." Cancer Res.45:3477-3481.
359.
Hoshino, K., Hyashi, Y., Takehira, Y., et al. (1981). "Influences of genetic factors on the teratogenicity of environmental pollutants: Teratogenic susceptibility to benzo[a]pyrene and Ah locus in mice." Congenital Anomalies pp. 97-103.
360.
Howard, A.G. and Mills, G.A. (1983). "Identification of polynuclear aromatic hydrocarbons in diesel particulate emissions." Intl. J. Environ. Anal. Chem.14:43-54.
361.
Howard, J. (1979). "Analysis of B[a]P and other polycyclic aromatic hydrocarbons in food." In: Environmental Carcinogens: Selected Methods of Analysis: Vol. 3. (H. Egan, ed.) Analysis of Polyaromatic Hydrocarbons in Environmental Samples. International Agency for Research on Cancer, Lyon, France, pp. 175-191.
362.
Huberman, E. (1975). "Mammalian cell transformation and cell-mediated mutagenesis by carcinogenic polycyclic hydrocarbons." Mutat. Res.29:285-291.
363.
Hueper, W.C. (1949). "Occupational cancer hazards found in industry." Industrial HygieneNewsletter9:7-9.
364.
Huggett, R.J., Defur, P.O., and Bieri, R.H. (1988). "Organic compounds in Chesapeake Bay sediments ." Mar. Pollut. Bull.19(9):454-458.
365.
Huggins, C. and Yang, N.C. (1962). "Induction and extinction of mammary cancer." Science137:257-262.
366.
Hughes, N.C., Pfau, W., Hewer, A., Jacob, J., Grimmer, G., and Phillips, D.H. (1993). "Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin." Carcinogenesis14:135-144.
367.
Hughes, N.C. and Phillips, D.H. (1990). "Covalent binding of dibenzpyrenes and benzo(a)pyrene to DNA: Evidence for synergistic and inhibitory interactions when applied in combination to mouse skin." Carcinogenesis (Eynsham)11(9):1611-1620.
368.
Huh, N., Nemoto, N., and Utakoji, T. (1982). "Metabolic activation of benzo[a]pyrene, aflatoxin B 1, and dimethylnitrosamine by a human hepatoma cell line." Mutat. Res.94:339-348.
369.
Hunt, D.F., Shabanowitz, F., Harvey, T.M., et al. (1983). "Analysis of organics in the environment by functional group using a triple quadrupole mass spectrometer." J. Chromatogr.271:93-105.
370.
Husgafvel-Pursiainen, K., Sorsa, M., Miller, M., et al. (1986). "Genotoxicity and polycyclic aromatic hydrocarbon analysis of environmental tobacco smoke samples from restaurants ." Mutagenesis1:287-292.
371.
Imaizumi, N., Hayakawa, K., Suzuki, Y., et al. (1990). "Determination of nitrated pyrenes and their derivatives by high performance liquid chromatography with chemiluminescence detection after online electrochemical reduction." J. Biomed. Chromatogr.4(3):108-112.
372.
Integrated Risk Information System (1994). U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH.
373.
International Agency For Research On Cancer (Iarc) (1973). Monographs on the Evaluation of Carcinogenic Risk of the Chemical to Man. Vol. 3. Certain Polycyclic Aromatic Hydrocarbons and Heterocyclic Compounds. World Health Organization. Lyon, France.
374.
International Agency For Research On Cancer (Iarc) (1983). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 32: Polynuclear Aromatic Compounds. Part 1. Chemical, Environmental and Experimental Data. World Health Organization, Lyon, France. pp. 155-161, 225-237.
375.
International Agency For Research On Cancer (Iarc) (1984). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 33: Polynuclear Aromatic Hydrocarbons. Part 2. Carbon blacks, mineral oils and some nitroarenes. World Health Organization. Lyon, France.
376.
International Agency For Research On Cancer ( 1985). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Vol. 35: Polynuclear Aromatic Compounds. Part 4. Bitumens, coal-tars and derived products, shale oils and soots. World Health Organization. Lyon, France. pp. 104-140.
377.
International Agency For Research On Cancer (Iarc) (1987). Monographs on the Evaluation of Carcinogenic Risks to Humans: An Updating of IARC Monographs. Vols. 1-42. Supplement 7. World Health Organization. Lyon, France. 7:56-71.
378.
International Agency For Research On Cancer (Iarc) (1987b). Monographs on the evaluation of the carcinogenic risk of chemicals to humans: an updating of IARC monographs. Vols. 1-42. Supplement 7. World Health Organization. Lyon , France. 7:252-254.
379.
International Agency For Research On Cancer (Iarc) (1989). IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Vol. 45: Occupational exposures in petroleum refining: crude oil and major petroleum fuels. World Health Organization, Lyon, France.
380.
International Technical Information Institute ( 1982). Toxic and Hazardous Industrial Chemicals Safety Manual . International Technical Information Institute. Tokyo, Japan.
381.
Ishidate, M. and Odashima, S. (1977). "Chromosome tests with 134 compounds on Chinese hamster cells in vitro: A screening for chemical carcinogens." Mutat. Res.48:337-354.
382.
Iwagawa, M., Maeda, T., Izumi, K., et al. (1989). "Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo(a)pyrene in F344 rats." Carcinogenesis10(7):1285-1290.
383.
Iwata, K., Inui, N., and Takeuchi, T. (1981). "Induction of active melanocytes in mouse skin by carcinogens: A new method for detection of skin carcinogens." Carcinogenesis (London)2:589-594.
384.
Jacob J., Schmoldt, A., and Grimmer, G. (1983a). "Benzo[e]pyrene metabolism in rat liver microsomes: Dependence of the metabolite profile on the pretreatment of rats with various monooxygenase inducers." Carcinogenesis4(7):905-910.
385.
Jacob J., Schmoldt, A., Hamann, M., et al. (1987). "Monooxygenase induction by various xenobiotics and its influence on rat liver microsomal metabolism of chrysene in comparison to benz(a)anthracene." Cancer Lett.34:91-102.
386.
Jacob J., Schmoldt, A., Raab, G., et al. (1983b). "Induction of specific monooxygenases by isosteric heterocyclic compounds of benz(a)anthracene, benzo(c)phenanthrene and chrysene." Cancer Lett.20:341-348.
387.
Jacob J., Schmoldt, A., Raab, G., et al. (1985). "Monooxygenase induction by various xenobiotics and its influence on the rat liver microsomal metabolite profile of benz[a]anthracene ." Cancer Lett.27:105-113.
388.
Jarvholm, B. and Easton, D. (1990). "Models for skin tumour risks in workers exposed to mineral oils." Br. J. Cancer62:1039-1041.
389.
Jensen, K. (1984). "Benzo(a)pyrene input and occurrence in a marine area affected by refinery effluent." Water Air Soil Pollut.22:57-65.
390.
Jerina, D.M., Lehr, R.E., Yagi, H., et al. (1976). "Mutagenicity of B[a]P derivatives and the description of a quantum mechanical model which predicts the ease of carbonium ion formation from diol epoxides." In: In Vitro Metabolic Activation In Mutagenesis Testing. ( F.J. de Serres, J.R. Fouts, J.R. Bend, et al., eds.). Elsevier, Amsterdam, The Netherlands. pp. 159-178.
391.
Jerina, D.M., Sayer, J.M., Thakker, D.R., et al. (1980). "Carcinogenicity of polycyclic aromatic hydrocarbons: The bay-region theory." In: Carcinogenesis: Fundamental Mechanisms and Environmental Effects. ( B. Pullman, P.O.P. Ts'O, H. Gelboin, eds.). D. Reidel Publishing Co., Hingham, MA. pp. 1-12.
392.
Joe, F.L.J., Salemme, J., and Fazio, T. (1982). "High performance liquid chromatography with fluorescence and UV detection of polynuclear aromatic hydrocarbons in barley malt." J. Assoc. Off. Anal. Chem.65:1395-1402.
393.
Joe, F.L.J., Salemme, J., and Fazio, T. (1984). "Liquid chromatographic determination of trace residues of polynuclear aromatic hydrocarbons in smoked foods." J. Assoc. Off. Anal. Chem.67:1076-1082.
394.
John, E.D. and Nickless, G. (1977). "Gas chromatographic method for the analysis of major polynuclear aromatics in particulate matter." J. Chromatogr.138:399-412.
395.
Johnson, J.H. (1988). "Automotive emissions." In: Air Pollution: The Automobile and Public Health ( A.Y. Watson, R.R. Bates, and D. Kennedy, eds.). National Academy Press . Washington, DC. pp. 39-76.
396.
Jones, B.T., Glick, M.R., Mignardi, M.A., et al. (1988). "Determination of polycyclic aromatic hydrocarbons in cooked beef by low-temperature molecular luminescence spectrometry using a moving sample cooling belt." Appl. Spectrosc.42(5):850-853.
397.
Jones, K.C., Stratford, J.A., Waterhouse, K., et al. (1987). "Polynuclear aromatic hydrocarbons in U.K. soils: Long-term temporal trends and current levels." Trace Subst. Environ . Health2:140-148.
398.
Jongeneelen, F.J., Anzion, B.M., Scheepers, P.T.J., et al. (1988). "1-Hydroxypyrene in urine as a biological indicator of exposure to polycyclic aromatic hydrocarbons in several work environments." Am. Ind. Hyg.32:35-43.
399.
Jongeneelen, F.J., Bos, R.P., Anzion, R., et al. (1986). "Biological monitoring of polycyclic aromatic hydrocarbons - metabolites in urine." Scand. J. Work Environ. Health12:137-143.
400.
Jongeneelen, F.J., LEIJDEKKERS, C.M., BOS, R.P., et al. (1985). "Excretion of 3-hydroxy-benzo(o)pyrene and mutagenicity in rat urine after exposure to benzo(a)pyrene." J. Appl. Toxicol.5:277-282.
401.
Kagan, J., Tuveson, R.W., and Gong, H.H. (1989). "The light-dependent cytotoxicity of benzo[a]pyrene: Effect on human erythrocytes, Escherichia coli cells, and Haemophilus influenzae transforming DNA" Mutat. Res.216(5):231-242.
402.
Kamens, R.M., Fulcher, J.N., and Zhishi, G. (1986). "Effects of temperature on wood soot: PAH decay in atmospheres with sunlight and low NOx." Atmos. Environ.20:1579-1587.
403.
Kanoh, T., Fukuda, M., Hayami, E., et al. (1990). "Nitro reaction in mice injected with pyrene during exposure to nitrogen dioxide." Mutat. Res.245(1):1-4.
404.
Kao, J.K., Patterson, F.K., and Hall, J. (1985). "Skin penetration and metabolism of topically applied chemicals in six mammalian species, including man: An in vitro study with benzo[a]pyrene and testosterone." Toxicol. Appl. Pharmacol.81:502-516.
405.
Kapitulnik, J., LEVIN, W., LU, A.Y.H., et al. (1977). "Hydration of arene and alkene oxides by epoxide hydrase in human liver microsomes." Clin. Pharmacol. Ther.21:158-165.
406.
Karasek, F.W., Denney, D.W., Chan, K.W., et al. (1978). "Analysis of complex organic mixtures on airborne particulate matter." Anal. Chem.50:82-87.
407.
Karickhoff, S.W., Brown, D.S., and Scott, T.A. (1979). "Sorption of hydrophobic pollutants on natural sediments." Water Res.13:241-248.
408.
Karlesky, D.L., Ramelow, G., Ueno, Y., et al. (1987). "Survey of polynuclear aromatic compounds in oil refining areas." Environ. Poll.43:195-207.
409.
Katz, M. and Pierce, R.C. (1976). "Quantitative distribution of polynuclear aromatic hydrocarbons in relation." In: Carcinogenesis: Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism, and Carcinogenesis. (R.I. Freudenthal and P.W. Jones, eds.) Vol. 1. Raven Press, New York, NY. pp. 413-429
410.
Kawamura, Y., Kamata, E., Ogawa, Y., et al. (1988). "The effect of various foods on the intestinal absorption of benzo-a-pyrene in rats." J. Food Hyg. Soc. Jpn.29(1):21-25.
411.
Keller, G.M., Christou, M., Pottenger, L.H., et al. (1987). "Product inhibition of benzo(a)pyrene metabolism in uninduced rat liver microsomes: Effect of diol epoxide formation ." Chem. Biol. Interact.61:159—175.
412.
Kemena, A., Norpoth, K.H., and Jacob, J. (1988). "Differential induction of the monooxygenase isoenzymes in mouse liver microsomes by polycyclic aromatic hydrocarbons." In: Polynuclear Aromatic Hydrocarbons: A Decade of Progress. Proceedings of the Tenth International Symposium. (M. Choke and A. Dennis, eds.). Batyl Press, Columbus, OH. pp. 449-460.
413.
Kenneway, E.L. (1924). "On cancer-producing tars and tar-fractions." J. Ind. Hyg.5:462-490.
414.
Kentucky Natural Resources And Environmental Protection Cabinet (Nrepc) (1991). "Acceptable ambient limits and significant emission levels of toxic air pollutants." (Frankfurt, KY) . Bureau of National Affairs, Inc.Washington, DC. 401 KAR 63:022.
415.
Kertesz-Saringer, M. and Morlin, Z. (1975). "On the occurrence of polycyclic aromatic hydrocarbons in the urban area of Budapest." Atmos. Environ.9:831-834.
416.
Ketkar, M., Green, V., Schnieder, P., et al. (1979). "Investigations on the carcinogenic burden by air pollution in man: Intratracheal instillation studies with benzo[a]pyrene in a mixture of Tris buffer and saline in Syrian golden hamsters." Cancer Lett.6:279-284.
417.
Ketkar, M., Resnick, G., Schneider, P., et al. (1978). "Investigations on the carcinogenic burden by air pollution in man: Intratracheal instillation studies with benzo[a]pyrene in bovine serum albumin." Cancer Lett.4:235-239.
418.
Kiefer, F., Cumpelik, O., and Wiebel, F.J. (1988). "Metabolism and cytotoxicity of benzo(a)pyrene in the human lung tumour cell line NCI-H322." Xenobiotica18:747-755.
419.
King, L.C., George, M., Gallagher, J.E., et al. (1994). "Separation of 32P-postlabeled DNA adducts of polycyclic aromatic hydrocarbons and nitrated polycyclic aromatic hydrocarbons by HPLC." Chem. Res. Toxicol.7:503-510.
420.
Kirso, U., Belykh, L., Stom, D., et al. (1983). "Oxidation of benzo[a]pyrene by plant enzymes ." In: Polynuclear Aromatic Hydrocarbons: Formation, Metabolism and Measurement. (M. Choke and A. Dennis, eds.) Batyl Press , Columbus, OH. pp. 679-687.
421.
Klein, M. (1952). "Effect of croton oil on induction of tumors by 1,2-benzanthracene, deoxychloric or low doses of 20-methylcholanthrene in mice." J. Natl. Cancer Inst.13:333-341.
422.
Klein, M. (1960). "A comparison of the initiating and promoting actions of 9,10-dimethyl-1,2-benzanthracene and 1,2,5,6-dibenzanthracene in skin tumorigenesis." Cancer Res.20:1179.
423.
Klein, M. (1963). "Susceptibility of strain B6AF/J. hybrid infant mice to tumorigenesis with 1,2-benzanthracene, deoxycholic acid and 3-methylcholanthrene ." Cancer Res.23:1701-1707.
424.
Klemme, J.C., Mukhtar, H., and Elmets, C.A. (1987). "Induction of contact hypersensitivity to dimethylbenz(a)anthracene and benzo(a)pyrene in C3H/HeN mice." Cancer Res.47:6074-6078.
425.
Knecht, U., Elliehausen, H.J., Jusas, W., et al. (1987). "Polycyclic aromatic hydrocarbons (PAH) in abraded particles of brake and clutch linings." Intl. J. Environ. Occup. Soc. Med.28:227-236.
426.
Knobloch, K., Szendzikowski, S., and Slusarczyk-Zalobna, A. (1969). "On the acute and sub-acute toxic effects of acenapthene and acenapthylene." Occup. Med.20:210-220.
427.
Kolarovic, L. and Traitler, H. (1982). "Determination of polycyclic aromatic hydrocarbons in vegetable oils by caffeine complexation and glass capillary gas chromatography ." J. Chromatogr.237:263-272.
428.
Konash, P.L., Wise, S.A., and May, W.E. (1981). "Selective quenchofluorimetric detection of fluoranthenic polycyclic aromatic hydrocarbons in high-performance liquid chromatography ." J. Liq. Chromatogr.4(8):1339-1349.
429.
Korfmacher, W.A., Wehry, E.L., Mamantov, G., et al. (1980). "Resistance to photochemical decomposition of polycyclic aromatic hydrocarbons vapor-adsorbed on coal fly ash." Environ. Sci. Technol.14:1094-1099.
430.
Kouri, R.E., Rude, T.H., Joglekar, R., et al. (1978). "2,3,7,8-Tetrachloro-dibenzo-p-dioxin as cocarcinogen causing 3- methylcholanthrene initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus." Cancer Res.38:2777-2783.
431.
Krahn, M. and Malins, D.C. (1982). "Gas chromatographic-mass spectrometric determination of aromatic hydrocarbon metabolites from livers of fish exposed to fuel oil ." J. Chromatogr.248:99-107.
432.
Krahn, M.M., Moore, L.K., Bogar, R.G., et al. (1988). "High-performance liquid chromatographic method for isolating organic contaminants from tissue and sediment extracts ." J. Chromatogr.437:161-175.
433.
Kraybill, H.F. (1983). "Assessment of human exposure and health risk to environmental contaminants in the atmosphere and water with special reference to cancer." J. Environ. Sci. HealthC1(2): 175-232.
434.
Kunstler, K. (1983). "Failure to induce tumors by intratracheal instillation of automobile exhaust condensate and fractions thereof in Syrian golden hamsters ." Cancer Let. 18:105-108.
435.
Kushwaha, S.C., Clarkson, S.G., and Mehkeri, K.A. (1985). "Polycyclic aromatic hydrocarbons in barbecue briquettes." J. Food Saf.7:177-201.
436.
Ladics, G.S., Kawabata, T.T., and White K.L., JR. (1991). "Suppression of the in vitro humoral immune response of mouse splenocytes by 7,12-dimethylbenz(a)anthracene metabolites and inhibition of immunosuppression by alpha-naphthoflavone." Toxicol. Appl. Pharmacol.110(1):31-44.
437.
Laher, J.M. and Barrowman, J.A. (1987). "Role of the lymphatic system in the transport of absorbed 7,12- dimethylbenzanthracene in the rat." Lipids22:152-155.
438.
Lai, L.K., Filseth, S.V., Sadowski, C.M., et al. (1990). "Direct determination of benzo(a)pyrene and pyrene in solid environmental samples by jet-cooled spectroscopy." Intl. J. Environ. Anal. Chem.40(1-4):99-109.
439.
Lamotte, M., Rima, J., Garrigues, P., et al. (1985). "Quantitative analysis of PAH (polynuclear aromatic hydrocarbons) in environmental samples by fluorometry in Shpol'skii matrices at low temperature." Polynuclear Aromatic Hydrocarbons :785-798.
440.
Laskin, S., Kuscher, M., and Drew, R.T. (1970). "Studies in pulmonary carcinogenesis." In: Inhalation Carcinogenesis. ( M.G. Hanna, , P. Nettesheim and J. Gilbert, eds.) AEC Symposium Series No. 18. U.S. Atomic Energy Commission, Oak Ridge Division of Technical Information, Oak Ridge, TN. pp. 321-351.
441.
Lasnitzki, A. and Woodhouse, D.L. (1944). "The effect of 1,2,5,6-dibenzanthracene on the lymph nodes of the rat." J. Anat.78 :121.
442.
Lau, H.H. and Baird, W.M. ( 1991 ). "Detection and identification of benzo[a]pyrene-DNA adducts by [35S]phosphorothioate labeling and HPLC" Carcinogenesis12(5):885-893.
443.
Lau, H.H. and Baird, W.M. (1992). "The co-carcinogen benzo[e]pyrene increases the binding of a low dose of the carcinogen benzo[a]pyrene to DNA in Sencar mouse epidermis." Purdue University, School of Pharmacy and Pharmacal Sciences, Department of Medicinal Chemistry and Pharmacognosy, West Lafayette, IN. Cancer Lett. (Ireland)63(3):229-236.
444.
Lavoie, E.J., Bedenko, V., Hirota, N., et al. (1979). "A comparison of the mutagenicity, tumor initiating activity and complete carcinogenicity of polynuclear aromatic hydrocarbons." In: Polynuclear Aromatic Hydrocarbons. (P.W. Jones and P. Leber, eds.) Science Publishers, Inc. Ann Arbor, MI.
445.
Lavoie, E.J., Amin, S., Hecht, S.S., et al. (1982). "Tumor initiating activity of dihydrodiols of benzo(b)fluoranthene, benzo(j)fluoranthene and benzo(k)fluoranthene." Carcinogenesis3:49-52.
446.
Lavoie, E.J., Braley, J., Rice, J.E., et al. (1987). "Tumorigenic activity of non-alternate polynuclear aromatic hydrocarbons in newborn mice." Cancer Lett.34:15-20.
447.
Lavoie, E.J., Coleman, D.T., Rice, J.E., et al. (1985). "Tumor-initiating activity, mutagenicity, and metabolism of methylated anthracenes." Carcinogenesis (London)6:1483-1488.
448.
Lavoie, E.J., Coleman, D.T., Tonne, R.L., et al. ( 1983a). "Mutagenicity, tumor initiating activity and metabolism of methylated anthracenes." In: Proceedings of the Seventh International Symposium ( M. Choke and A, Dennis, eds.). Batyl Press, Columbus, OH. pp. 785-798.
449.
Lavoie, E.J., He, Z.M., Meegalla, R.L., et al. ( 1993a). "Exceptional tumor-initiating activity of 4-fluorobenzo(j)fluoranthene on mouse skin: Comparison with benzo(j)fluoranthene, 10-fluorobenzo(j)fluoranthene, benzo(a)pyrene, dibenzo(a,l)pyrene, and 7,12-dimethylbenzo(a)anthracene ." Cancer Lett. (in press).
450.
Lavoie, E.J., He, Z.M., Rice, J.E., et al. ( 1993b). "On the metabolic activation of benzo(j)fluoranthene ." In: Polycyclic Aromatic Compounds, Synthesis, Properties, Analytical Measurements, Occurrence, and Biological Effects. Proceedings of the Thirteenth International Symposium on Polynuclear Aromatic Hydrocarbons. (P. Garriques and M. Lamotte, eds.) Gordon and Breach, Philadelphia, PA.
451.
Lavoie, E.J., Hecht, S.S., Amin, S., et al. (1980a). "Identification of mutagenic dihydrodiols as metabolites of benzo(j)fluoranthene and benzo(k)fluoranthene." Cancer Res.40:4528-4532.
452.
Lavoie, E.J., Tulley, L., Bedenko, V., et al. ( 1980b). "Mutagenicity, tumor-initiating activity, and metabolism of tricyclic polynuclear aromatic hydrocarbons." In: Polynuclear Aromatic Hydrocarbons:Chemistry and Biological Effects . (A. Bjørseth and A. Dennis, eds.) Batelle Press, Columbus, OH.
453.
Lavoie, E.J., Tulley, L., Bedenko, V., et al. (1981a). "Mutagenicity of methylated fluorenes and benzofluorenes." Mutat. Res.91 (3):167-176.
454.
Lavoie, E.J., Tulley, L., Bedenko, V., et al. ( 1981 b). "Mutagenicity, tumor-initiating activity and metabolism of methylphenanthrenes." Cancer Res.41:3441-3447.
455.
Lavoie, E.J., Tulley, L., Bedenko, V., et al. (1983b). "Mutagenicity of substituted phenanthrenes in Salmonella typhimurium." Mutat. Res.116:91-102.
456.
Lawrence, J.F. and Das, B.S. ( 1986). "Determination of nanogram/kilogram levels of polycyclic aromatic hydrocarbons in foods by HPLC with fluorescence detection ." Intl. J. Environ. Anal. Chem.24(2):113-131.
457.
Lawrence, J.F. and Weber, D.F. ( 1984). "Determination of polycyclic aromatic hydrocarbons in some Canadian commercial fish, shellfish and meat products by liquid chromatography with confirmation by capillary gas chromatography-mass spectrometry." J. Agric. Food Chem.32:789-794.
458.
Leadon, S.A., Stampfer, M.R., and Bartley, J. (1988). "Production of oxidative DNA damage during the metabolic activation of benzo(a)pyrene in human mammary epithelial cells correlates with cell killing." Proc. Natl. Acad. Sci.85:4365-4368.
459.
Lecoq, S., Chalvet, O., Strapelias, H., et al. (1991a). "Microsomal metabolism of dibenz(a,c)anthracene, dibenz(a,h)anthracene and dibenz(a,j)anthracene to bisdihydrodiols and polyhydroxylated products." Chem-Biol. Interact.80(3):261-280.
460.
Lecoq, S., Ni She, M., Grover, P.L., et al. (1991b). "The in vitro metabolic activation of dibenz[a,h]anthracene, catalyzed by rat liver microsomes and examined by 32P-postlabelling." Cancer Lett.57(3):261-269.
461.
Lecoq, S., Perin, F., Plessis, M.J., et al. (1989). "Comparison of the in vitro metabolisms and mutagenicities of dibenzo[a,c]anthracene, dibenzo[a,h]anthracene and dibenzo[a,j]anthracene: Influence of norharman." Carcinogenesis10(3):461-469. 0143-3334.
462.
Lee, B.M. and Santella, R.M. (1988). "Quantitation of protein adducts as a marker of genotoxic exposure: Immunologic detection of benzo[a]pyrene—globin adducts in mice." Carcinogenesis9( 10):1773-1777.
463.
Lee, H. and Lin, J.Y. (1988). "Antimutagenic activity of extracts from anticancer drugs in Chinese medicine." Mutat. Res.204:229-234.
464.
Legraverend, C., Guenther, T.M., and Nebert, D.W. (1984). "Importance of the route of administration for genetic differences in benzo[a]pyrene-induced in utero toxicity and teratogenicity ." Teratology29:35-47.
465.
Legraverend, C., Harrison, D.E., Ruscetti, W., et al. (1983). "Bone marrow toxicity induced by oral benzo(a)pyrene: Protection resides at the level of the intestine and liver ." Toxicol. Appl. Pharmacol.70:390-401.
466.
Lesage, J., Perrault, G., and Durand, P. (1987). "Evaluation of worker exposure to polycyclic aromatic hydrocarbons." Am. Ind. Hyg. Assoc. J.48:753-759.
467.
Leung, H.W., Henderson, R.F., Bond, J.A., et al. (1988). "Studies on the ability of rat lung and liver microsomes to facilitate transfer and metabolism of benzo(a)pyrene from diesel particles." Toxicol.51:1-9.
468.
Levin, W., Chang, R.L., Wood, A.W., et al. (1984). "High stereoselectivity among the optical isomers of the diastereomeric bay-region diol-epoxides of benz(a)anthracene in the expression of tumorigenic activity in murine tumor models." Cancer Res.44:929-933.
469.
Levin, W., Wood, A., Chang, R., et al. (1982). "Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens." Drug Metab. Rev.13:555-580.
470.
Levin, W., Wood, A.W., Chang, R.L., et al. (1978). "Evidence for bay region activation of chrysene 1,2-dihydrodiol to an ultimate carcinogen." Cancer Res.38 :1831.
471.
Levin, W., Wood, A.W., Yagi, H., et al. (1976). "Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, 9 and 10-oxides on mouse skin." Proc. Natl. Acad. Sci. USA73:243-247.
472.
Liao, W., Smith, W.D., Chiang, T.C., et al. (1988). "Rapid, low-cost cleanup procedure for determination of semivolatile organic compounds in human and bovine adipose tissues." J. Assoc. Off. Anal. Chem.71:742-747.
473.
Lijinsky, W.H., Garcia, B., and Terracini, B. (1965). "Tumorigenic activity of hydrogenated derivatives of dibenz(a,h)anthracene." J. Natl. Cancer Inst.34 : 1.
474.
Likhachev, A., Beniashvili, D. Sh., Bykov, V.J., et al. (1992). "Relevance of quantitation of benzo(a)pyrene metabolites in animal excretes to evaluate individual human cancer risk." Prog. Clin. Biol. Res.374:435-452.
475.
Lin, C.H., Fukii, H., Imasaka, T., et al. (1991). "Synchronous scan luminescence techniques monitoring resonance and non-resonance fluorescence in supersonic jet spectrometry applied to anthracene derivatives." Anal. Chem.63( 14):1433-1440.
476.
Lindemann, R.A. and Park, N-H. (1989). "The effects of benzo-a-pyrene nicotine and tobacco-specific nitrosamines on the generation of human lymphokine-activated killer cells ." Arch. Oral. Biol.34(4):283-288.
477.
Liotti, F.S., Bodo, M., Mariucci, G., et al. (1989). "The role of antioxidant enzymes in benzo(a)pyrene-induced carcinogenesis." Bull. Cancer76( 1 ):43-50.
478.
Liotti, F.S., Pelliccia, C., and Pezzetti, F. (1988). "Different response of chicken embryo fibroblasts and hepatocytes to the interference of certain antioxidants on the binding of [G-3H] benzo[a]pyrene to DNA." Cancer Lett.41:235-242.
479.
Lioy, P.J. (1989). "Exposure analysis and assessment for low-risk cancer agents." Intl. J. Epidemiol.19(3 Suppl. 1):53-61.
480.
Lioy, P.J. and Greenberg, A. (1990). "Factors associated with human exposures to polycyclic aromatic hydrocarbons." Toxicol. Ind. Health6(2):209-224.
481.
Lioy, PL, Waldman, J.M., Greenberg, A., et al. (1988). "The total human environmental exposure study (THEES) to benzo(a)pyrene: Comparison of the inhalation and food pathways ." Arch. Environ. Health43:304-312.
482.
Lipniak, M. and Brandys, J. (1993). "Toxicokinetics of fluoranthene, pyrene and benz(a)anthracene in the rat." Polycyclic Aromatic Hydrocarbons3:111-119.
483.
Little, J.B. and Vetroys, H. (1988). "Studies of ionizing radiation as a promoter of neoplastic transformation in vitro." Intl. J. Radiat. Biol.53:661-666.
484.
Lloyd, J.W. (1971). "Long-term mortality study of steelworkers: V. Respiratory cancer in coke plant workers." J. Occup. Med.13:53-68.
485.
Lo, J., Jacono, F., Stecca, C., and Duverger, M. (1992). "Mutagenic activation ofbenzo[a]pyrene by human red blood cells." Mutat. Res.268(1):21-26.
486.
Lorenz, E. and Stewart, H.L. (1948). "Tumors of alimentary tract in mice fed carcinogenic hydrocarbons in mineral oil emulsions." J. Natl. Cancer Inst.9:173.
487.
Lorenz, L.F. and Gjovik, L.R. (1972). "Analyzing creosote by gas chromatography: Relationship to creosote specifications." Proceedings of the American Wood-Preservers' Association68:32-42.
488.
Low, G.K-C., Batley, G.E., Lidgard, R.O., et al. (1986). "Determination of polycyclic aromatic hydrocarbons in coal fly ash using gas chromatography/negative ion chemical ionization mass spectrometry." Biomed. Environ. Mass Spectrom . 13:95-104.
489.
Lubet, R.A., Brunda, M.J., Lemaire, B., et al. (1984). "Polycyclic hydrocarbon: Induced immunotoxicity in mice: Role of the Ah locus." In: Mechanisms, Methods and Metabolism: Polynuclear Aromatic Hydrocarbons. ( M. Choke and A. Dennis, eds.) 8th International Symposium. Batyl Press, Columbus, OH. pp. 843-855.
490.
Lubet, R.A., Connelly, G.M., Nebert, D.W., et al. (1983a). "Dibenz[a,h]anthracene-induced subcutaneous tumors in mice. Strain sensitivity and the role of carcinogen metabolism." Carcinogenesis4:513-517.
491.
Lubet, R.A., Kiss, E., Gallagher, M.M., et al. (1983b). "Induction of neoplastic transformation and DNA single-strand breaks in C3H/10T1/2 clone 8 cells by polycyclic hydrocarbons and alkylating agents." J. Natl. Cancer Inst.71:991-998.
492.
Lunde, G. and Bjørseth, A. (1977). "Polycyclic aromatic hydrocarbons in long-range transported aerosols." Nature268:518.
493.
Luster, M.I. and Rosenthal, G.J. (1993). "Chemical agents and the immune response." Environ. Health Perspect.100:219-226.
494.
Lyman, W., Reehl, W.F., and Rosenblatt, D.H. (1982). Handbook of Chemical Property Estimation Methods. McGraw Hill, Inc., New York, NY. pp. 15/10-15/21.
495.
Lyte, M. and Bick, P.H. (1985). "Differential immunotoxic effects of the environmental chemical benzo[a]pyrene in young and aged mice." Mech. Aging Dev.30:333-341.
496.
Lyte, M., Blanton, R.H., Myers, M.J., et al. (1987). "Effect of in vivo administration of the carcinogen benzo(a)pyrene on interleukin-2 and interleukin-3 production." Intl. J. Immunopharmacol. 9:307-312.
497.
Mabey, W.R., Smith, J.H., Podoll, R.T., et al. (1982). "Aquatic fate process data for organic priority pollutants." U.S. Environmental Protection Agency, Office of Water Regulations and Standards. Washington, D.C. EPA 440/4-81-014.
498.
Mackenzie, K.M. and Angevine, D.M. ( 1981 ). "Infertility in mice exposed in utero to benzo[a]pyrene ." Biol. Reprod.24:183-191.
499.
Mackenzie, M.J. and Hunter, J.V. (1979). "Sources and fates of aromatic compounds in urban stormwater runoff." Environ. Sci. Technol.13:179-183.
500.
Ma, K.M. and Ma, B. (1980). "An epidemiologic perspective of environmental carcinogenesis." Epidemiol. Rev.2:19-48.
501.
Macnicoll, A.D., Grover, P.L., and Sims, P. (1980). "The metabolism of a series of polycyclic hydrocarbons by mouse skin maintained in short-term organ culture." Chem. Biol. Interact.29(2):169-188.
502.
Mager, R., Huberman, E., Yang, S.K., et al. (1977). "Transformation of normal hamster cells by benzo(a)pyrene diol-epoxide." Intl. J. Cancer19:814-817.
503.
Majer, J.R., Perry, R., and Reade, M.J. (1970). "The use of thin-layer chromatography and mass spectrometry for the rapid estimation of trace quantities of air pollutants ." J. Chromatogr.48:328-333.
504.
Malmgren, R.A. (1952). "Reduced antibody titers in mice treated with carcinogenic and cancer chemotherapeutic agents." Proc. Soc. Biol. Med.79:484.
505.
Mamber, S.W., Bryson, V., and Katz, S.E. (1983). "The Esherichia coli WP2/WP100 rec assay for detection of potential chemical carcinogens." Mutat. Res.119:135-144.
506.
Mane, S.S., Purnell, D.M., and Hsu, I.C. (1990). "Genotoxic effects of five polycyclic aromatic hydrocarbons in human and rat mammary epithelial cells." Environ. Mol. Mutagen15(2):78-82.
507.
Manilal, V.B. and Alexander, M. (1991). "Factors affecting the microbial degradation of phenanthrene in soil." Appl. Microbiol. Biotechnol.35(3):401-405.
508.
Marcomini, A., Sfriso, A., and Pavoni, B. (1987). "Variable wavelength absorption in detecting environmentally relevant PAHs by high-performance liquid chromatography." Mar. Chem.21:15-24.
509.
Marcus, J.M., Swearingen, G.R., Williams, A.D., et al. (1988). "Polynuclear aromatic hydrocarbon and heavy metal concentrations in sediments at coastal South Carolina marinas ." Arch. Environ. Contam. Toxicol.17(1):103-114.
510.
Marino, D.J. (1987). "Evaluation of pluronic polyol F127 as a vehicle for petroleum hydrocarbons." Environ. Mutagen9:307-316.
511.
Marquardt, H., Kuroki, T., Huberman, E., et al. (1972). "Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons ." Cancer Res.32:716-720.
512.
Marshall, M.V., He, Z-H., Rice, J.E., et al. (1993). "Mutagenic activity of the syn- and anti-dihydrodiol epoxides of 4,5- and 9,10-dihydrodiol of benzo(j)fluoranthene in Salmonella typhimurium." Accepted for publication by Environ. Mol. Mutagen .
513.
Marshall, M.V., He, Z.M., Weyand, E.H., et al. (1992). "Mutagenic activity of the 4,5- and 9,10-dihydrodiols of benzo[j]fluoranthene and their syn- and anti-dihydrodiol epoxides in Salmonella typhimurium." Environ. Mol. Mutagen (In press).
514.
Martin, C.N., McDermid, A.C., and Garner, R.C. (1978). "Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells." Cancer Res.38:2621-2627.
515.
Masclet, P., Pistikopoulos, P., Beyne, S., et al. (1988). "Long-range transport and gas/particle distribution of polycyclic aromatic hydrocarbons at a remote site in the Mediterranean sea." Atmos. Environ.22:639-650.
516.
Masento, M.S., Hewer, A., Grover, P.L., et al. (1989). "Enzyme-mediated phosphorylation of polycyclic hydrocarbon metabolites: Detection of non-adduct compounds in the phosphorus-32 post-labelling assay." Carcinogenesis10(8):1557-1559.
517.
Matsumoto, H. and Kashimoto, T. (1985). "Average daily respiratory intake of polycyclic aromatic hydrocarbons in ambient air determined by capillary gas chromatography ." Bull. Environ. Contam. Toxicol.34:17-23.
518.
Matsuoka, A., Hayashi, M., and Ishidate, M.J. (1979). "Chromosomal aberration tests on 29 chemicals combined with S9 mix in vitro." Mut. Res.66:277-290.
519.
Matsuoka, A., Sofuni, T., Miyata, N., et al. (1991). "Clastogenicity of 1-nitropyrene, dinitropyrenes, fluorene and mononitrofluorenes in cultured Chinese hamster cells." Mutat. Res.259(1):103-110.
520.
Mattison, D.R., Singh, H., Takizawa, K., et al. (1989). "Ovarian toxicity of benzo(a)pyrene and metabolites in mice." Reprod. Toxicol.3(2):115-126.
521.
Matzner, E. (1984). "Annual rates of deposition of polycyclic aromatic hydrocarbons in different forest ecosystems." Water Air Soil Poll.21:425-434.
522.
May, W.E., Chesler, S.N., Hertz, H.S., et al. (1982). "Analytical standards and methods for the determination of polynuclear aromatic hydrocarbons in environmental samples ." Intl. J. Environ. Anal. Chem.12:259-275.
523.
Mazumdar, S., Redmond, C.K., Sollecito, W., et al. (1975). "An epidemiological study of exposure to coal tar pitch volatiles among coke oven workers." J. Air Pollut. Control Assoc.25:382-389.
524.
McCabe, D.P. and Flynn, E.J. (1990). "Deposition of low dose benzo(a)pyrene into fetal tissue: Influence of protein binding." Teratology41(1):85-95.
525.
McCarthy D.J., Lindamood, C.I., and Hill, D.L. (1987). "Effects of retinoids on metabolizing enzymes and on binding on benzo(a)pyrene to rat tissue DNA." Cancer Res.47:5014-5020.
526.
McCormick, D.L., Burns, F.J., and Alberg, R.E. (1981). "Inhibition of benzo[a]pyrene-induced mammary carcinogenesis by retinyl acetate." J. Natl. Cancer Inst.66:559-564.
527.
McIntyre, A.E., Perry, R., and Lester, J.N. (1981). "Analysis of polynuclear aromatic hydrocarbons in sewage sludges." Anal. Lett.14:291-309.
528.
McVeety, B.D. and Hites, R.D. (1988). "Atmospheric deposition of polycyclic aromatic hydrocarbons to water surfaces a mass balance approach." Atmos. Environ.22(3):511-536.
529.
Melikian, A.A., Bagheri, K., and Hecht, S.S. (1987). "Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in Mouse Epidermis in vivo." Cancer Res.47:5354-5360.
530.
Melikian, A.A., Bagheri, K., Hecht, S.S., et al. (1989). "Metabolism of benzo[a]pyrene and 7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice." Chem. Biol. Interact.69(2-3):245-257.
531.
Menzie, C.A., Potocki, B.B., and Santodonato, J. (1992). "Ambient concentrations and exposure to carcinogenic pahs in the environment." Environ. Sci. Technol.26(7):1278-1284.
532.
Merk, H.F., Mukhtar, H., Kaufmann, I., et al. (1987). "Human hair follicle benzo(a)pyrene and benzo(a)pyrene 7,8-diol metabolism: Effect of exposure to a coal tar-containing shampoo." J. Invest. Dermatol.88:71-76.
533.
Mersch-Sundermann, V., Mochayedi, S., and Kevekordes, S. (1992a). "Genotoxicity of polycyclic aromatic hydrocarbons in Escherichia coli." Mutat. Res.278(1):1-9.
534.
Mersch-Sundermann, V., Rosenkranz, H.S., and Klopman, G. (1992b). "Structural basis of the genotoxicity of polycyclic aromatic hydrocarbons." Mutagenesis7(3):211-218.
535.
Metivier, H., Wahrendorf, J., and Masse, R. (1984). "Multiplicative effect of inhaled plutonium oxide and benzo[a]pyrene on lung carcinogenesis in rats." Br. J. Cancer50:215-221.
536.
Miguel, A.H. and Deandrade, J.B. (1989). "Rapid quantitation of ten polycyclic aromatic hydrocarbons in atmospheric aerosols by direct HPLC separation after ultrasonic acetonitrile extraction." Intl. J. Environ. Anal. Chem.35(1):35-41.
537.
Miller, M.M., Plowchalk, D.R., Weitzman, G.A., et al. (1992). "The effect of benzo(a)pyrene on murine ovarian and corpora lutea volumes." Am. J. Obstet. Gynecol.166(5):1535-1541.
538.
Milo, G.E., Blakeslee, J., Yohn, D.S., et al. (1978). "Biochemical activation of aryl hydrocarbon hydroxylase activity, cellular distribution of polynuclear hydrocarbon metabolites, and DNA damage by polynuclear hydrocarbon products in human cells in vitro ." Cancer Res.38:1638-1644.
539.
Miralis, J.C., Tyson, C.K., and Butterworth, B.E. (1982). "Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay. Environ. Mutagen4:553-562.
540.
Misfeld, J. (1980). "The tumor-producing effects of automobile exhaust condensate and of diesel exhaust condensate: Health effects of diesel engine emissions" Proceedings of an International Symposium . U.S. Environmental Protection Agency. Cincinnati, OH. EPA 600/9-80-057b., pp. 1012-1025.
541.
Mishra, N.K., Wilson, C.M., Pant, KJ, et al. (1978). "Simultaneous determination of cellular mutagenesis and transformation by chemical carcinogens in Fischer rat embryo cells." J. Toxicol. Environ. Health4:79-91.
542.
Mitchell, C.E. (1979). "A method for the determination of polycyclic aromatic hydrocarbons in animal tissue." Bull. Environ. Contam. Toxicol.23:669-676.
543.
Mitchell, C.E., Fischer, J.P., and Dahl, A.R. (1987). "Differential induction of cytochrome P-450 catalyzed activities by polychlorinated biphenyls and benzo[a]pyrene in B6C3F1 mouse liver and lung." Toxicol.43:315-323.
544.
Modica, R., Fiume, M., and Bartosek, Z. (1982). "Gas-liquid chromatographic assay of polycyclic aromatic hydrocarbon mixtures: Specifically modified method for rat tissues ." J. Chromatogr.24:352-355.
545.
Molliere, M., Foth, H., Kahl, R., et al. (1987). "Metabolism of benzo(a)pyrene in the combined rat liver-lung perfusion system." Toxicol.45:143-154.
546.
Monarca, S. and Fagioli, F. (1981). "Evaluation of the potential carcinogenicity of paraffins for medicinal and cosmetic uses - determination of polycyclic aromatic hydrocarbons." Sci. Total Environ.17:83-93.
547.
Monarca, S., Sforzolini, G.S., and Fagioli, F. (1982). "Presence of benzo(a)pyrene and other polycyclic aromatic hydrocarbons in suntan oils." Food Chem. Toxicol.20:183-187.
548.
Monteith, D.K., Novotny, A., Michalopoulos, G., et al. (1987). "Metabolism of benzo(a)pyrene in primary cultures of human hepatocytes: Dose-response over a four-log range." Carcinogenesis8:983-988.
549.
Moore, B.P., Hicks, R.M., Knowles, M.A., et al. (1982). "Metabolism and binding of benzo[a]pyrene and 2 acetylamino fluorene by short-term organ cultures of human and rat bladder ." Cancer Res.42:642-648.
550.
Moore, C.J., Pruess-Schwartz, D., Mauthe, R.J., et al. (1987). "Interspecies differences in the major DNA adducts formed from benzo(a)pyrene but not 7,12-dimethylbenz(a)anthracene in rat and human mammary cell cultures." Cancer Res.47:4402-4406.
551.
Morel, G., Samhan, 0., Literathy, P., et al. (1991). "Evaluation of chromatographic and spectroscopic methods for the analysis of petroleum-derived compounds in the environment ." Fresenius J. Anal. Chem.339(10):699-715.
552.
Morris, D.L. and Ward, J.B. (1992a). "Coumarin inhibits micronuclei formation induced by benzo(a)pyrene in male but not female ICR mice." Environ. Mol. Mutagen19(2):132-138.
553.
Morris, H.P., Velat, C.A., Wagner, B.P., et al. (1960). "Studies of carcinogenicity in the rat of derivatives of aromatic amines related to O-2-fluorenylacetamide." J. Natl. Cancer Inst.24:149-180.
554.
Morris, J.J. and Seifter, E. (1992b). "The role of aromatic hydrocarbons in the genesis of breast cancer." Med. Hypotheses38(3):177-184.
555.
Morse, M.A., Baird, W.M., and Carlson, G.P. (1987). "Distribution, covalent binding, and DNA adduct formation of 7,12- dimethylbenz(a)anthracene in Sencar and Balb/c mice following topical and oral administration." Cancer Res.47:4571-4575.
556.
Morse, M.A. and Carlson, G.P. (1985). "Distribution and macromolecular binding of benzo[a]pyrene in sencar and balb/c mice following topical and oral administration." J. Toxicol. Environ. Health16:263-276.
557.
Morselli, L. and Zappoli, S. (1988). "PAH determination in samples of environmental interest." Sci. Total Environ.73:257-266.
558.
Mossanda, K., Poncelet, F., Fouassin, A., et al. (1979). "Detection of mutagenic polycyclic aromatic hydrocarbons in African smoked fish." Food CosmetToxicol.17:141-143.
559.
Moyer, S.R. and Jurs, P.C. (1990). "An SRA study of the mutagenicity of PAH compounds in Salmonella typhimurium." In: Progress in Clinical and Biological Research: Vol. 340. Mutation and the Environment: Part B. Metabolism, Testing Methods, and Chromosomes. (M.L. Mendelsohn and J. Albertini, eds.) Wiley-Liss, New York, NY. pp. 1-10.
560.
Mukhtar, H., Asokan, P., Das, M., et al. (1986). "Benzo(a)pyrene diol epoxide-I-DNA adduct formation in the epidermis and lung of sencar mice following topical application of crude coal tar" Cancer Letters33:287-394.
561.
Mukhtar, H., Das, M., Khan, W.A., et al. (1988). "Exceptional activity in tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo[a]pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice." Cancer Res.48:2361-2365.
562.
Mulik, C.M., Guyer, M.F., Semeniuk, G.M., et al. (1975). "A gas liquid chromatographic fluorescent procedure for the analysis of benzo(a)pyrene in 24 hour atmospheric particulate samples." Anal. Lett.8:511-524.
563.
Mullaart, E., Buytenhek, M., Brouwer, A., et al. (1989). "Genotoxic effects of intragastrically administered benzo[a]pyrene in rat liver and intestinal cells." Carcinogenesis10(2):393-395.
564.
Muller, J. and Rohbock, E. (1980). "Method for measurement of polycyclic aromatic hydrocarbons in particulate matter in ambient air." Talanta27:673-675.
565.
Mumford, J.L., Williams, R.W., Walsh, D.B., et al. (1991). "Indoor air pollutants from unvented kerosene heater emissions in mobile homes: Studies on particles, semivolatile organics, carbon monoxide, and mutagenicity." Environ. Sci. Technol.25:1732-1738.
566.
Myers, M.J., Blanton, R.H., and Bick, P.H. (1988). "Inhibition of IL-2 responsiveness following exposure to benzo(a)pyrene is due to alterations in accessory cell function ." Intl. J. Immunopharmacol. 10:177-186.
567.
Myers, M.J., Schook, L.B., and Bick, P.H. (1987). "Mechanisms of benzo[a]pyrene-induced modulation of antigen presentation." J. Pharmacol. Exp. Ther.242:399-404.
568.
Myers, S.R. and Flesher, J.W. ( 1991 a). "Characterization of hemoglobin (hb) adducts with polynuclear aromatic hydrocarbons." Proceedings of the Annual Meeting of the American Association for Cancer Research 32:A532.
569.
Myers, S.R. and Flesher, J.W. ( 1991 b). "Metabolism of chrysene, 5-methylchrysene, 6-methylchrysene and 5,6-dimethylchrysene in rat liver cytosol, in vitro, and in rat subcutaneous tissue, in vivo." Chem. Biol. Interact.77(2):203-221.
570.
Nagabhushan, M., Ng, Y.K., Elias, R., et al. (1990). "Acute inhibition of DNA synthesis in hamster buccal pouch epithelium exposed to indirect acting carcinogens" Cancer Lett.53(2-3):163-173.
571.
Nagata, S. and Kondo, G. (1977). "Photo-oxidation of crude oils." Proceedings of the 1977 Oil Spill Conference (prevention, behavior, cleanup, control). pp. 617-620.
572.
Naikwadi, K.P., Charbonneau, G.M., Karasek, F.W., et al. (1987). "Separation and identification of organic compounds in air particulate extracts by high-performance liquid chromatography and gas chromatography-mass spectrometry." J. Chromatogr.398:227-238.
573.
Naslund, I., Rubio, C.A., and Auer, G.U. (1987). "Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice." Anal. Quant. Cytol. Histol.9:411-418.
574.
National Academy Of Sciences (1972). "Particulate polycyclic organic matter." National Research Council, Division of Medical Science, Washington, D.C. pp. 28-81.
575.
National Academy Of Sciences (1986). "Drinking Water and Health" Vol. 6. Washington, D.C. pp. 139-145.
576.
National Academy Of Sciences/National Research Council (1989). "Biologic Markers in Reproductive Toxicology ." National Academy Press, Washington, D.C. pp. 15-35.
577.
National Air Toxics Information Clearinghouse (Natich) (1988). Report on State, Local, and EPA Air Toxics Activities . U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC . July, 1988.
578.
National Air Toxics Information Clearinghouse (Natich) (1992). Report on State, Local, and EPA Air Toxics Activities . U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC . December 1992.
579.
National Institute For Occupational Safety And Health (Niosh) (1976). "National Occupational Hazard Survey (1970)." U.S. Department of Health and Human Services, Cincinnati, OH.
580.
National Institute For Occupational Safety And Health (Niosh) (1977). "Criteria for a Recommended Standard: Occupational Exposure to Coal Tar Products." U.S. Department of Health and Human Services, Department of Health and National Institute for Occupational Safety and Health, Cincinnati, OH .
581.
National Institute For Occupational Safety And Health (Niosh) (1984). National Occupational Hazard Survey (1980-1983). U.S. Department of Health and Human Services , Cincinnati, OH.
582.
National Institute For Occupational Safety And Health (Niosh) (1985). Pocket Guide to Chemical Hazards . U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Washington, D.C. p. 84.
583.
National Institute For Occupational Safety And Health (Niosh) (1990). NIOSH Pocket Guide to Chemical Hazards. National Institute of Occupational Safety and Health, Cincinnati, OH, pp. 170-171.
584.
National Institute For Occupational Safety And Health (Niosh) (1992). NIOSH Recommendations for Occupational Safety and Health: Compendium of policy documents and statements. U.S. Department of Health and Human Services, Cincinnati, OH. p. 64.
585.
National Research Council (Nrc) (1983). Polycyclic Aromatic Hydrocarbons: Evaluation of Sources and Effects . National Academy Press, Washington, D.C. ES/1-ES/7.
586.
National Research Council (Nrc) (1989). Biologic Markers in Pulmonary Toxicology. National Academy Press, Washington, DC.
587.
National Research Council (Nrc) (1992). Biologic Markers in Immunotoxicology. National Academy Press, Washington, DC.
588.
Neal, J. and Rigdon, R.H. (1967). "Gastric tumors in mice fed benzo[a]pyrene: A quantitative study." Tex. Rep. Biol. Med.25:553-557.
589.
Neff, J.M. (1979). "Polycyclic aromatic hydrocarbons in the aquatic environment - sources, fates and biological effects." Applied Science Publishers, Ltd.London, England.
590.
Neff, J.M. (1982). "Accumulation and release of polycyclic aromatic hydrocarbons from water, food, and sediment by marine animals." Symposium: Carcinogenic Polynuclear Aromatic Hydrocarbons in the Marine Environment. U.S. Environmental Protection Agency , Washington, D.C. Report no. 600/9-82-013.
591.
Nettesheim, P., Griesemer, R.A., Martin, D.H., et al. (1977). "Induction of preneoplastic and neoplastic lesions in grafted rat tracheas continuously exposed to benzo(a)pyrene." Cancer Res.37:1272-1278.
592.
Neubert, D. and Tapken, S. (1988). "Transfer of benzo(a)pyrene into mouse embryos and fetuses." Arch. Toxicol.62(2-3):236-239.
593.
Newman, M.J., Light, B.A., Weston, A., et al. (1988). "Detection and characterization of human serum antibodies to polycyclic aromatic hydrocarbon diol-epoxide DNA adducts ." J. Clin. Invest. (United States)82:145-153.
594.
Newman, M.J., Weston, A., Carver, D.C., et al. (1990). "Serological characterization of polycyclic aromatic hydrocarbon diolepoxide-DNA adducts using monoclonal antibodies " Carcinogenesis11(11): 1903-1907.
595.
New York State Department Of Environmental Conservation (1994). "Water quality standards: surface waters and groundwaters." Albany, NY. Chapter X, Section 703.5.
596.
Ng, K.M., Chu, I., Bronaugh, R.L., et al. (1991). "Percutaneous absorption/metabolism of phenanthrene in the hairless guinea pig: Comparison of in vitro and in vivo results." Fundam. Appl. Toxicol.16(3):517-524.
597.
Ng, K.M., Chu, I., Bronaugh, R.L., et al. (1992). "Percutaneous absorption and metabolism of pyrene, benzo[a]pyrene, and di(2-ethylhexyl) phthalate: comparison of in vitro and in vivo results in the hairless guinea pig." Toxicol. Appl. Pharmacol.115(2):216-223.
598.
Nielsen, T. (1979). "Determination of polycyclic aromatic hydrocarbons in automobile exhaust by means of high-performance liquid chromatography with fluorescence detection." J. Chromatogr.170:147-156.
599.
Niimi, A. (1987). Biological Half-Lives of Chemicals in Fishes. Rev. Environ. Contam. Toxicol. Vol. 99. Springer-Verlag, New York, NY . pp. 1-46.
600.
Nikonova, T.V. (1977). "The transplacental effect of benzo(a)pyrene and pyrene." Byull. Eksp. Biol. Med.84:1025-1027.
601.
Nirmalakhandan, N.N. and Speece, R.E. (1988). "QSAR model for predicting Henry's constant." Environ. Sci. Technol.22:1349-1357.
602.
Nisbet, I.C.T. and Lagoy, P.K. (1992). "Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs)." Reg. Toxicol. Pharmacol.16:290-300.
603.
New Jersey Department Of Environmental Protection (1991). "State primary drinking water regulations." Trenton, NJ. Chapter 10, Subchapter 5,7:10-5.1.
604.
Norpoth, K., Kemena, A., Jacob, J., et al. (1984). "The influence of 18 environmentally relevant polycyclic aromatic hydrocarbons and Clophen A50, as liver monooxygenase inducers, on the mutagenic activity of benz(a)anthracene in the Ames test ." Carcinogenesis5:747-752.
605.
Nousiainen, U., Torronen, R., and Hanninen, O. (1984). "Differential induction of various carboxylesterases by certain polycyclic aromatic hydrocarbons in the rat." Toxicol.32:243-251.
606.
Nowak, D., Meyer, A., Schmidt-Preuss, U., et al. (1992). "Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer." J. Cancer Res. Clin. Oncol.118(1):67-71.
607.
O'Donovan, M.R. (1990). "Mutation assays of ethyl methanesulphonate, benzidine and benzo[a]pyrene using Chinese hamster V79 cells." Mutagenesis5:9-13.
608.
O'Gara, R.W., Kelly, M.G., Brown, J., et al. (1965). "Induction of tumors in mice given a minute single dose of dibenz[a,h]anthracene or 3-methylcholanthrene as newborns: A dose-response study." J. Natl. Cancer Inst.35(6):1027-1042.
609.
O'Neill, I.K., Bingham, S., Povey, A.C., et al. (1990a). "Modulating effects in human diets of dietary fibre and beef, and of time and dose on the reactive microcapsule trapping of benzo[a]pyrene metabolites in the rat gastrointestinal tract ." Carcinogenesis11(4):599-607.
610.
O'Neill, I.K., Goldberg, M.T., El Ghissassi, F., et al. (1991). "Dietary fiber, fat and beef modulation of colonic nuclear aberrations and microcapsule-trapped gastrointestinal metabolites of benzo(a)pyrene-treated C57/B6 mice consuming human diets." Carcinogenesis12(2):175-180.
611.
O'Neill, I.K., Povey, A.C., Bingham, S., et al. (1990b). "Systematic modulation by human diet levels of dietary fibre and beef on metabolism and disposition of benzo[a]pyrene in the gastrointestinal tract of Fischer F344 rats." Carcinogenesis11 (4):609-616.
612.
Obana, H., Hori, S., Kashimoto, T., et al. (1981). "Polycyclic aromatic hydrocarbons in human fat and liver." Bull. Environ. Contam. Toxicol.27:23-27.
613.
Occupational Safety And Health Administration (Osha) (1974). Code of Federal Regulations. 29 CFR 1910.1000.
614.
Occupational Safety And Health Administration (Osha) (1983). Code of Federal Regulations. 29 CFR 1910.1002.
615.
Occupational Safety And Health Administration (Osha) (1985). Coal Tar Pitch Volatiles; Interpretation of Term . U.S. Code of Federal Regulations. 29 CFR 1910.1002.
616.
Occupational Safety And Health Administration (Osha) (1990). Code of Federal Regulations. 29 CFR 1910.1450.
617.
Oehme, M. (1983). "Determination of isomeric polycyclic aromatic hydrocarbons in air particulate matter by high-resolution gas chromatography negative ion chemical ionization mass spectrometry." Anal. Chem.55:2290-2295.
618.
Oesch, F., Bucker, M., and Glatt, H.R. (1981). "Activation of phenanthrene to mutagenic metabolites and evidence for at least two different activation pathways." Mut. Res.81:1-10.
619.
Oesch, F. and Golan, M. (1980). "Specificity of mouse liver cytosolic epoxide hydrolase for K-region epoxides derived from polycyclic aromatic hydrocarbons ." Cancer Lett.9:169-175.
620.
Office Of Technology Assessment (Ota) (1990 ). "Neurotoxicity: identifying and controlling poisons of the nervous system." OTA, U.S. Congress, Washington, DC . OTA-BA-438, April 1990.
621.
Ogan, K., Katz, E., and Slavin, W. (1979). "Determination of polycyclic aromatic hydrocarbons in aqueous samples by reversed-phase liquid chromatography." Anal. Chem.51:1315-1320.
622.
Ogawa, I., Junk, G.A., and Svec, H.J. (1982). "Degradation of aromatic compounds in groundwater, and methods of sample preparation." Talanta28:725-730.
623.
Old, L.J., Benacerraf, B., and Carswell, E. (1963). "Contact reactivity to carcinogenic polycyclic hydrocarbons." Nature198:1215-1216.
624.
Ostman, C.E., Colmsjo, A.L., and Zebuehr, Y. (1986). "Polycyclic aromatic compounds in lubricating oil: A study of gasoline, gasoline/methanol, gas and diesel fueled engines ." In: Polycyclic Aromatic Hydrocarbons: Chemistry, Characterization, and Carcinogenesis. (M. Choke and A. Dennis, eds.) Proceedings of the Ninth International Symposium. Batyl Press, Columbus, OH. pp. 729-744.
625.
Oueslati, R., Alexandrov, K., Chouikha, M., et al. ( 1992). "Formation and persistence of DNA adducts in epidermal and dermal mouse skin exposed to benzo(a)pyrene in vivo." In Vivo6(2):231-235.
626.
Oyler, A.R., Bodenner, D.L., Welch, K.J., et al. (1978). "Determination of aqueous chlorination reaction products of polynuclear aromatic hydrocarbons by reversed phase high performance liquid chromatography-gas chromatography." Anal. Chem.50:837-842.
627.
Pahlman, R. and Pelkonen, O. (1987). "Mutagenicity studies of different polycyclic aromatic hydrocarbons: The significance of enzymatic factors and molecular structure." Carcinogenesis8:773-778.
628.
Palitti, F., Cozzi, R., Fiore, M., et al. (1986). "An in vitro and in vivo study on mutagenic activity of fluoranthene: Comparison between cytogenetic studies and HPLC analysis." Mutat. Res.174:125-130.
629.
Pallardy, M., Mishal, Z., Lebrec, H., et al. (1992). "Immune modification due to chemical interference with transmembrane signalling: Application to polycyclic aromatic hydrocarbons ." Intl. J. Immunopharmacol. 14(3):377-382.
630.
Panthanickal, A. and Marnett, L.J. (1981). "Arachidonic acid-dependent metabolism of (+/-)-7,8-dihydroxy-7,8- dihydrobenzo[a]pyrene to polyguanylic acid-binding derivatives." Chem. Biol. Interact.33:239-252.
631.
Park, J.K. and Park, S.D. (1988). "Effects of benzo(a)pyrene on DNA strand breaks and replication in the presence of metabolic activation system in mammalian cells." Korean J. Genetics10(4):279-287.
632.
Park, K.S., Sims, R.C., Dupont, R.R., et al. (1990). "The fate of PAH compounds in two soil types influence of volatilization abiotic loss and biological activity." Environ. Toxicol. Chem.9(2):187-196.
633.
Pavanello, S. and Levis, A.G. (1992). "Coal tar therapy does not influence in vitro benzo[a]pyrene metabolism and DNA adduct formation in peripheral blood lymphocytes of psoriatic patients." Carcinogenesis13:1569-1573.
634.
Payne (1958). " The pathological effects of the intraperitoneal injection of 3:4-benzopyrene into rats and mice." Br. J. Cancer12:65-74.
635.
Penn, A. and Snyder, C. (1988). "Arteriosclerotic plaque development is 'promoted' by polynuclear aromatic hydrocarbons." Carcinogenesis9( 12):2185-2189.
636.
Perera, F.P., Hemminki, K., Young, T.L., et al. (1988). "Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers." Cancer Res.48:2288-2291.
637.
Pershagen, G.G., Nordberg, G., and Bjorklund, N.E. (1984). "Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo[a]pyrene by the pulmonary route." Environ. Res.34:227-241.
638.
Perwak, J., Byrne, M., Coons, S., et al. (1982). "An exposure and risk assessment for benzo[a]pyrene and other polycyclic aromatic hydrocarbons." Volume IV. Benzo[a]pyrene, acenaphthylene, benz[a]anthracene, benzo[b]fluoranthene, benzo[k]fluroanthene, benzo[g,h,i]perylene, chrysene, dibenz[a,h]anthracene, and indeno[ 1,2,3-c,d]pyrene. U.S. Environmental Protection Agency, Office of Water Regulations and Standards , Washington, D.C. EPA 440/4-85-020-V4.
639.
Peterson, A.R., Landolph, J.R., Peterson, H., et al. (1981). "Oncogenic transformation and mutation of C3H/10T1/2 clone 8 mouse embryofibroblasts by alkylating agents." Cancer Res.41:3095-3099.
640.
Petridou-Fischer, J., Whaley, S.L., and Dahl, A.R. (1988). "In vivo metabolism of nasally instilled benzo(a)pyrene in dogs and monkeys." Toxicol.48(1):31-40.
641.
Pfeiffer, E.H. (1977). "Oncogenic interaction of carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons in mice." In: IARC Scientific Publication No. 16. Air Pollution and Cancer in ManInternational Agency for Research on Cancer, Lyon, France. pp. 69-77.
642.
Phillips, D.H., Hemminki, K., Alhonen, A., et al. (1988). "Monitoring occupational exposure to carcinogens: Detection by 32P-postlabelling of aromatic DNA adducts in white blood cells from iron foundry workers." Mutat. Res.204:531-541.
643.
Phillips, D.H., Hewer, A., and Grover, P.E. (1987). "Formation of DNA adducts in mouse skin treated with metabolites of chrysene." Cancer Res.35:207-214.
644.
Phillips, D.H., Hewer, A., Seidel, A., et al. (1991). "Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons" Chem. Biol. Interact.199180(2):177-186.
645.
Phillipson, C.E. and Ioannides, C. (1989). "Metabolic activation of polycyclic aromatic hydrocarbons to mutagens in the Ames test by various animal species including man." Mutat. Res. Mar. 211(1):147-151.
646.
Platt, K.L., Pfeiffer, E., Petrovic, P., et al. (1990). "Comparative tumorigenicity of picene and dibenz[a,h]anthracene in the mouse." Carcinogenesis11(10):1721-1726.
647.
Pollia, J.A. (1941). "Investigation on the possible carcinogenic effect of anthracene and chrysene and some of their compounds: II. The effect of subcutaneous injection in rats." J. Ind. Hyg. Toxicol.223:449-451.
648.
Poole, S.K., Dean, T.A., and Poole, C.F. (1987). "Preparation of environmental samples for the determination of polycyclic aromatic hydrocarbons by thin-layer chromatography ." J. Chromatogr.400:323-341.
649.
Popescu, N.C., Turnbull, D., and Dipaolo, J.A. (1977). "Sister chromatid exchange and chromosome aberration analysis with the use of several carcinogens and noncarcinogens." J. Natl. Cancer Inst.59:289-293.
650.
Popl, M., Stejskal, M., and Mostecky, J. (1975). "Determination of polycyclic aromatic hydrocarbons in white petroleum products." Anal. Chem.47:1947-1950.
651.
Pott, F., Tomingas, R., and Misfeld, J. (1977). "Tumors in mice after subcutaneous injection of automobile exhaust condensates." In: IARC Scientific Publication No. 16: Air Pollution and Cancer in Man. (U. Mohr, D. Schmaehl, and L. Tomatis , eds.) Scientific Publications, Hannover , West Germany. pp. 79-87.
652.
Pott, P. (1975). "Surgical observations relative to the cancer of the scrotum." Reprinted in Natl. Cancer Institute Monographs . London, UK. 10:7-13. 1973.
653.
Prahl, F.G., Crecellus, E., and Carpenter, R. (1984). "Polycyclic aromatic hydrocarbons in Washington (USA) coastal sediments: An evaluation of atmospheric and riverine routes of introduction." Environ. Sci. Technol.18:687-693.
654.
Prasanna, P., Jacobs, M.M., and Yang, S.K. (1987). "Selenium inhibition of benzo(a)pyrene, 3-methylcholanthrene, and 3-methylcholanthrylene mutagenicity in Salmonella typhimurium strains TA98 and TA100." Mutat. Res.190:101-105.
655.
Propper, R. (1988). Polycyclic Aromatic Hydrocarbons (PAH): A Candidate Toxic Air Contaminant. Stationary Source Div, California State Air Resources Board, Sacramento, CA.
656.
Pucknat, A.W., (ed.) (1981). Characteristics of PNA in the Environment: Health Impacts of Polynuclear Aromatic Hydrocarbons. Noyes Data Corporation, Park Ridge, NJ. pp. 78-122.
657.
Purde, M. and Etlin, S. (1980). Cancer Cases Among Workers in the Estonia Oil Shale Processing Industry: Health Implications of New Energy Technologies . Ann Arbor Science, Ann Arbor, MI. pp. 527-528.
658.
Quarles, J.M., Sega, M.W., Schenley, C.K., et al. (1979). "Transformation of hamster fetal cells by nitrosated pesticides in a transplacental assay." Cancer Res.39:4525-4533.
659.
Quilliam, M.A. and Sim, P.G. (1988). "Determination of polycyclic aromatic compounds by high-performance liquid chromatography with simultaneous mass spectrometry and ultraviolet diode array detection." J. Chromatogr. Sci.26:160-167.
660.
Radding, S.B., Mill, T., Gould, C.W., et al. (1976). "The environmental fate of selected polynuclear aromatic hydrocarbons." U.S. Environmental Protection Agency, Office of Toxic Substances, Washington, D.C. EPA 560/5-75-009.
661.
Rahimtula, A.D. (1977). "The effects of antioxidants of the metabolism and mutagenicity of benzo[a]pyrene in vitro." Biochem. J.164:473-475.
662.
Rahman, A., Barrowman, J.A., and Rahimtula, A. (1986). "The influence of bile on the bioavailability of polynuclear aromatic hydrocarbons from the rat intestine." Can. J. Physiol. Pharmacol.64:1214-1218.
663.
Ramdahl, T., Alfheim, I., and Bjørseth, A. (1982). "Nitrated polycyclic aromatic-hydrocarbons in urban air particles." Environ. Sci. Technol.16:861-865.
664.
Ramdahl, T., Alfheim, I., Rustad, S., et al. (1982). "Chemical and biological characterization of emissions from small residential stoves burning wood and charcoal." Chemosphere11:501-611.
665.
Ranadine, K.J. and Karande, K.A. (1963). "Studies on 1,2,5,6-dibenzanthracene-induced mammary carcinogenesis in mice." Br. J. Cancer17:272.
666.
Rao, K.P. and Nandan, B.D. (1990). "Modification of benzo(a)pyrene induced chromosomal damage in mouse bone marrow by vitamin A." Bull. Environ. Contam. Toxicol.45(6):829-832.
667.
Rao, K.P., Ramadevi, G., and Das, U.N. (1986). "Vitamin A can prevent genetic damage induced by benzo(a)pyrene to the bone marrow cells of mice." Intl. J. Tissue React.8:219-223.
668.
Rastetter, W.H., Nachbar, R.B.J., Russo-Rodriguez, S., et al. (1982). "Fluoranthene: Synthesis and mutagenicity of 4 diol epoxides." J. Org. Chem.47:4873-4878.
669.
Readman, J.W., Mantourar, R.F.C., Rhead, M.M., et al. (1982). "Aquatic distribution and heterotrophic degradation and polycyclic aromatic hydrocarbons in the Tamar Estuary, England, UK." Estuarine Coastal ShelfSci.14:369-389.
670.
Redmond, E., Strobino, B., and Cypress, R. (1976). "Cancer experience among coke by-product workers ." Ann. N.Y. Acad. Sci.2-7:102-115.
671.
Rees, E.D., Mandelstan, P., Lowry, J.Q., et al. (1971). "A study of the mechanism of intestinal absorption of benzo[a]pyrene." Biochim. Biophys. Acta.225:96-107
672.
Research Triangle Institute (Rti) (1993). National Listing of State Fish and Shellfish Consumption Advisories and Bans . Technical Report for U.S. EPA Office of Water, Office of Science and Technology, Fish Contamination Section , Washington, DC. Research Triangle Park, NC.
673.
Reynders, J.B.J., Immel, H.R., Scherrenberg, P.M., et al. (1985). "Respiratory tract tumors in hamsters after severe focal injury to the trachea and intratracheal instillation of benzo(a)pyrene." Cancer Lett.29:93-99.
674.
Rhodes, G., Opsal, R.B., Meek, J.T., et al. (1983). "Analysis of polycyclic aromatic hydrocarbon mixtures with laser ionization gas chromatography/mass spectrometry." Anal. Chem.55:280-286.
675.
Rice, J.E., Coleman, D.T., Hosted, T.J.J., et al. (1985a). "Identification of mutagenic metabolites of indeno[ 1,2,3-cd]pyrene formed in vitro with rat liver enzymes." Cancer Res.45:5421-5425.
676.
Rice, J.E., Coleman, D.T., Hosted, T.J.J., et al. (1985b). "On the metabolism, mutagenicity, and tumor-initiating activity of indeno(1,2,3-cd)pyrene." In: Polynuclear Aromatic Hydrocarbons: Metabolisms, methods and metabolism. Proceedings of the Eighth International Symposium. (M. Choke and A. Dennis, eds.) Batyl Press, Columbus, OH. pp. 1097-1109.
677.
Rice J.E., Defloria, M.C., Sensenhauser, C., et al. (1988). "The influence of fluoranthene on the metabolism and DNA binding of benzo[a]pyrene in vivo in mouse skin." Chem. Biol. Interact. (1988) 68(1-2):127-136.
678.
Rice, J.E., Geddie, N.G., and Lavoie, E.J. (1987a). "Identification of metabolites of benzo[j]fluoranthene formed in vitro in rat liver homogenate." Chem. Biol. Interact.198763(3):227-237.
679.
Rice J.E., Hosted, T.J., Defloria, M.C., et al. (1986). "Tumor-initiating activity of major in vivo metabolites of indeno- 2 3 -cd-pyrene on mouse skin." Carcinogenesis7(10):1761-1764.
680.
Rice, J.E., Hosted, T.J.J., and Lavoie, E.J. (1984). "Fluoranthene and pyrene enhance benzo(a)pyrene-DNA adduct formation in vivo in mouse skin." Cancer Lett.24:327-333.
681.
Rice, J.E., Weyand, E.H., Geddie, N.G., et al. ( 1987b). "Identification of tumorigenic metabolites of benzo[j]fluoranthene formed in vivo in mouse skin." Cancer Res.47(23):6166-6170.
682.
Rice, J.W., Weyand, E.H., Burrill, C., et al. (1990). "Fluorine probes for investigating the mechanism of activation of indeno(1,2,3-cd)pyrene to a tumorigenic agent ." Carcinogenesis11( 11 ):1971-1974.
683.
Richardson, J.H. and Ando, M.E. (1977). "Sub-part-per-trillion detection of polycyclic aromatic hydrocarbons by laser induced molecular fluorescence." Anal. Chem.49:955-959.
684.
Richter-Reichhelm, H.B., Emura, M., and Althoff, J. (1985). "Scanning electron microscopical investigations on the respiratory epithelium of the Syrian golden hamster: VI. In vitro effects of different polycyclic aromatic hydrocarbons." Zentralbl. Bakteriol. Mikrobiol. Hyg. [B]181(3-5):272-280.
685.
Riegel, B., Watman, W.B., and Hill, W.T. (1951). "Delay of methylcholanthrene skin carcinogenesis in mice by 1,2,5,6- dibenzofluorene." Cancer Res.11:301-306.
686.
Rigdon, R.H. and Giannukos, N.J. (1964). "Effect of carcinogenic hydrocarbons on growth of mice." Arch. Pathol.77:198-204.
687.
Rigdon, R.H. and Neal, J. (1965). "Effects of feeding benzo[a]pyrene on fertility, embryos, and young mice." J. Natl. Cancer Inst.34:297-305.
688.
Rigdon, R.H. and Neal, J. (1966). "Gastric carcinomas and pulmonary adenomas in mice fed benzo[a]pyrene." Tex. Rep. Biol. Med.24:195-207.
689.
Rigdon, R.H. and Neal, J. (1969). "Relationship of leukemia to lung and stomach tumors in mice fed benzo[a]pyrene." Proc. Soc. Exp. Biol. Med.130:146-148.
690.
Rigdon, R.H. and Rennels, E.G. (1964). "Effect of feeding benzpyrene on reproduction in the rat." Experimentia20:224-226.
691.
Risner, C.H. (1988). "The determination of benzo(a)pyrene in the total particulate matter of cigarette smoke." J. Chromatogr. Sci.26:113-125.
692.
Robinson, D.E. and Mitchell, A.D. (1981). Unscheduled DNA Synthesis Response of Human Fibroblasts, WI-38 Cells, to 20 Coded Chemicals: Evaluation of Short-term Tests for carcinogenesis. Report of the International Collaborative Program. Prog. Mutat. Res.1:517-527.
693.
Robinson, J.R., Felton J.S., Levitt, R.C., et al. (1975). "Relationship between 'aromatic hydrocarbon responsiveness' and the survival times in mice treated with various drugs and environmental compounds." Mol. Pharmacol.11:850-865.
694.
Rocchi, P., Ferreri, A.M., Borgia, R., et al. (1980). "Polycyclic hydrocarbons induction of diptheria toxin-resistant mutants in human cells." Carcinogenesis1:765-767.
695.
Roe, F.J.C. (1962). "Effect of phenanthrene on tumour-initiation by 3,4-benzpyrene." Br. J. Cancer16:503-506.
696.
Rogan, E.G., Ramakrishna, N.V.S., Higginbotham, S., et al. (1990). "Identification and quantitation of 7-(benzo(a)pyren-6-yl)guanine in the urine and feces of rats treated with benzo(a)pyrene." Chem. Res. Toxicol.3(5):441-444.
697.
Rosenfeld, J.K. and Plumb, R.H. ( 1991 ). "Ground water contamination at wood treatment facilities." Ground Water Monit. Rev.11 ( 1 ):133-140.
698.
Rosenkranz, H.S. and Poirier, L.A. (1979). "Evaluation of the mutagenicity and DNA-modifying activity of carcinogens and noncarcinogens in microbial systems." J. Natl. Cancer Inst.62:873-892.
699.
Ross, J., Nelson, G., Erexson, G., et al. (1991). "DNA adducts in rat lung, liver and peripheral blood lymphocytes produced by i.p. administration of benzo[a]pyrene metabolites and derivatives." Carcinogenesis12(10):1953-1955.
700.
Ross, J., Nelson, G., Kligerman, A., et al. (1990). "Formation and persistence of novel benzo(a)pyrene adducts in rat lung, liver, and peripheral blood lymphocyte DNA." Cancer Res.50(16):5088-5094.
701.
Ross, J.A., Nelson, G.B., Holden, K.L., et al. (1992). "DNA adducts and induction of sister chromatid exchanges in the rat following benzo[b]fluoranthene administration." Carcinogenesis13:1731-1734.
702.
Rossi, L., Barbieri, O., Sanguineti, M., et al. (1983). "Carcinogenic activity of benzo(a)pyrene and some of its synthetic derivatives by direct injection into the mouse fetus." Carcinogenesis4:153-156.
703.
Roszinsky-Kocher, G., Basler, A., and Rohrborn, G. (1979). "Mutagenicity of polycyclic hydrocarbons: V. Induction of sister-chromatid exchanges in vivo." Mutat. Res.66( 1 ):65-67.
704.
Ruby, J.C., Halliday, G.M., and Muller, H.K. (1989). "Differential effects of benzo[a]pyrene and dimethylbenz[a]-anthracene on Langerhans cell distribution and contact sensitization in murine epidermis ." J. Invest. Dermatol.92(2):150-155.
705.
Rudo, K.M., Dauterman, W.C., and Langenbach, R. (1989). "Human and rat kidney cell metabolism of 2-acetylaminofluorene and benzo(a)pyrene." Cancer Res.49(5):1187-1192.
706.
Rugen, P.J., Stern, C.D., and Lamm, S.H. (1989). "Comparative carcinogenicity of the pahs as a basis for acceptable exposure levels in drinking water." Regul. Toxicol. Pharmacol.9(3):273-283.
707.
Russell, L.B. (1977). "Validation of the in vivo somatic mutation method in the mouse as a prescreen for germinal point mutations." Arch. Toxicol.38:75-85.
708.
Saber, A., Morel, G., Paturel, L., et al. (1991). "Application of the high-resolution low temperature spectrofluorometry to analysis of PAHs in lake sediments marine intertidal sediments and organisms." Fresenius' J. Anal. Chem.339( 10):716-721.
709.
Saboori, A.M. and Newcombe, D.S. (1992). "Environmental chemicals with immunotoxic properties ." In: Clinical Immunotoxicology ( D.S. Newcombe, N. Rose, and J.C. Bloom, eds.). Raven Press, New York. pp. 365-400.
710.
Sadhana, A.S., Rao, A.R., Kucheria, K., et al. (1988). "Inhibitory action of garlic oil on the initiation of benzo(a)pyrene-induced skin carcinogenesis in mice." Cancer Lett.40:193-197.
711.
Saffiotti, U., Montesane, R., Sellakumar, A.R., et al. (1972). "Respiratory tract carcinogenesis induced in hamsters by different dose levels of benzo[a]pyrene and ferric oxide." J. Natl. Cancer Inst.49:1199-1204.
712.
Sajewicz, M., Rzepa, J., and Sliwiok, J. (1988). "Determination of benzo(a)pyrene in coke tars ." J. Chromatogr.456( 1 ):227-231.
713.
Sakai, M., Yoshida, D., and Mizusaki, S. (1985). "Mutagenicity of polycyclic aromatic hydrocarbons and quinones on salmonella typhimurium TA97." Mutat. Res.156:61-67.
714.
Salaman, M.H. and Roe, F.J.C. (1956). "Further tests for tumour-initiating activity: N,N-di(2-chloroethyl)-p- aminophenylbutic acid (CB 1348) as an initiator of skin tumour formation in the mouse." Br. J. Cancer10:363-378 (Retrieval in progress).
715.
Salamone, M.F. (1981). "Toxicity of 41 carcinogens and noncarcinogenic analogs." Prog. Mutat. Res.1:682-685.
716.
Salamone, M.F., Chiu, S., and Logan, D.M. (1988). Abnormal Sperm Test Results for Benzo(a)pyrene, Pyrene, 2-acetylaminofluorene, and 4-acetylaminofluorene Using Both Hybrid and Outbred Mice. Part 2. Gavage Treatment: Evaluation of Short-Term Tests for Carcinogenicity. Report of the International Program for Chemical Safety's Collaborative Study2:243-250.
717.
Salhab, A.S., James, M.O., Wang, S.L., et al. (1987). "Formation of benzo(a)pyrene-DNA adducts by microsomal enzymes: Comparison of maternal and fetal liver, fetal hematopoietic cells and placenta." Chem. Biol. Interact. (Ireland)61:203-214.
718.
Sanders, C.L., Skinner, C., and Gelman, R.A. (1986). "Percutaneous absorption of 7,10 14C-benzo[a]pyrene and 7,12 14C- dimethylbenz[a]anthracene in mice." J. Environ. Pathol. Toxicol. Oncol.7:25-34.
719.
Santodonato, J. (1981). "Polycyclic organic matter." J. Environ. Pathol . Toxicol.5:1-364.
720.
Sawicki, E. (1962). "Analysis for airborne particulate hydrocarbons: Their relative proportions as affected by different types of pollution" National Cancer Institute Monograph No. 9, Bethesda, MD. pp.201-220.
721.
Sax, N.I. and Lewis, R.S. (1989). "Dangerous Properties of Industrial Materials ." 7th ed. Van Nostrand Reinhold , New York, NY
722.
Schimberg, R.W. (1981). "Polycyclic aromatic hydrocarbons (PAH) in the work environment." Kem- Kemi.8 :537-541.
723.
Schnizlein, C.T., Munson, A.E., and Rhoades, R.A. (1987). "Immunomodulation of local and systemic immunity after subchronic pulmonary exposure of mice to benzo(a)pyrene." Intl. J. Immunopharmacol. 9:99-106.
724.
Sega, G.A. (1979). "Unscheduled DNA synthesis (DNA repair) in the germ cells of male mice - its role in the study of mammalian mutagenesis ." Genetics92:49-58.
725.
Selkirk, J.K., Huberman, E., and Heidelberger, C. (1971). "An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene ." Biochem. Biophys. Res. Commun.43(5):1010-1016.
726.
Sellakumar, A. and Shubik, P. (1974). "Carcinogenicity of different polycyclic hydrocarbons in the respiratory tract of hamsters." J. Natl. Cancer Inst.53:1713-1719.
727.
Sellakumar, A., Stenback, F., and Rowland, J. (1976). "Effects of different dusts on respiratory carcinogenesis in hamsters induced by benzo[a]pyrene and diethylnitrosamine." Europ. J. Cancer12:313-319.
728.
Severson, R.F., Snook, M.E., Arrendale, R.F., et al. (1976). "Gas chromatographic quantitation of polynuclear aromatic hydrocarbons in tobacco smoke: Analytic laboratory methods." Anal. Chem.48:1866-1872.
729.
Shah, G.M. and Bhattacharya, R.K. (1989). "Alteration in hepatic nuclear RNA polymerase activity following benzo[a]pyrene administration in rats." In Vivo3(2):125-127.
730.
Shamsuddin, A.K. and Gan, R. (1988). "Immunocytochemical localization of benzo(a)pyrene-DNA adducts in human tissue." Human Pathol.19(3):309-315.
731.
Shamsuddin, A.K.M., Sinopoli, N.T., Hemminki, K., et al. (1985). "Detection of benzo(a)pyrene DNA adducts in human white blood cells." Cancer Res.45:66-68.
732.
Shane, B.S., Henry, C.B., Hotchkiss, J.H., et al. (1990). "Organic toxicants and mutagens in ashes from eighteen municipal refuse incinerators." Arch. Environ. Contam. Toxicol.19(5):665-673.
733.
Shear, M.J. and Luter, J. (1941). "Studies in carcinogenesis: XVI. Production of subcutaneous tumors in mice by miscellaneous polycyclic compounds." J. Natl. Cancer Inst.2:241-258.
734.
Shendrikova, I.A. and Aleksandrov, V.A. (1974). "Comparative penetration of polycyclic hydrocarbons through the rat placenta into the fetus." Bull. Exp. Biol. Med.77:169-171.
735.
Sherson, D., Sabro, P., Sigsgaard, T., et al. (1990). "Biological monitoring of foundry workers exposed to polycyclic aromatic hydrocarbons." Br. J. Ind. Med.47(7):448-453.
736.
Shiba, M., Marchok, A.C., Klein-Szanto, A., et al. (1987). "Pathological changes induced by formaldehyde in open-ended rat tracheal implants preexposed to benzo(a)pyrene." Toxicol. Pathol.15:401-408.
737.
Shimada, H., Satake, S., Itoh, S., et al. (1990). "Multiple-dosing effects of benzo[a]pyrene in the mouse bone marrow micronucleus test." Mutat. Res.234(3-4):179-181.
738.
Shimada, H., Suzuki, H., Itoh, S., et al. (1992). "The micronucleus test of benzo[a]pyrene with mouse and rat peripheral blood reticulocytes." Mutat. Res.278(2-3):165-168.
739.
Shimkin, M.B. and Stoner, G.D. (1975). "Lung tumors in mice: Application to carcinogenesis bioassay." In: Advances in Cancer Research, (G. Klein and S. Weinhouse , eds.). Vol. 12. Raven Press , New York, NY. p. I.
740.
Shiraishi, H., Pilkington, N.H., Otsuki, A., et al. (1985). "Occurrence of chlorinated polynuclear aromatic hydrocarbons in tap water." Environ. Sci. Technol.19:585-590.
741.
Shmahl, D., Schmidt, K.G., and Habs, M.K. (1977). "Syncarcinogenic action of polycyclic aromatic hydrocarbons in automobile exhause gas condensates." In: Air Pollution and Cancer in Man. IARC Publication 16. (U. Mohr, D. Schmahl, and L. Tomatis, eds.). World Health Organization. Lyon France, pp. 53-59.
742.
Shubik, P. and Hartwell, J.L. (1957). Survey of Compounds Which Have Been Tested for Carcinogenic Activity. Government Printing Office, Washington, D.C. Public Health Service publication no. 149, supplement I.
743.
Shubik, P. and Hartwell, J.L. (1969). Survey of Compounds Which Have Been Tested for Carcinogenic Activity. Government Printing Office, Washington, D.C. Public Health Service publication no. 149, supplement 1.
744.
Shubik, P., Pietra, G., and Della Porta, G. (1960). "Studies of skin carcinogenesis in the Syrian golden hamster." Cancer Res.20:100.
745.
Shubik, P. and Porta, G.D. (1957). "Carcinogenesis and acute intoxication with large doses of polycyclic hydrocarbons." Am. Med. Assoc. Arch. Pathol.64:691-703.
746.
Shugart, L. (1986). "Quantifying adductive modification of hemoglobin from mice exposed to benzo(a)pyrene." Anal. Biochem.152:365-369.
747.
Shugart, L., Holland, J.M., and Rahn, R.O. (1983). "Dosimetry of polycyclic aromatic hydrocarbon skin carcinogenesis: Covalent binding of benzo(a)pyrene to mouse epidermal DNA." Carcinogenesis4:195-198.
748.
Shum, S., Jensen, N.M., and Nebert, D.W. (1979). "The murine - HA- Hh locus: In utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism ." Teratology20:365-376.
749.
Siebert, D., Marquardt, H., Friesel, H., et al. (1981). "Polycyclic aromatic hydrocarbons and possible metabolites: Convertogenic activity in yeast and tumor initiating activity in mouse skin." J. Cancer Res. Clin. Oncol.102:127-139.
750.
Simmon, V.F. (1979a). "In vitro assays for recombinogenic activity of chemical carcinogens and related compounds with Saccharomyces cerevisiae D3." J. Natl. Cancer Inst.62:901-910.
751.
Simmon, V.F. (1979b). "In vitro mutagenicity assays of chemical carcinogens and related compounds with Salmonella typhimurium." J. Natl. Cancer Inst.62:893-900.
752.
Simmon, V.F., Rosenkranz, H.S." Zeiger, E., et al. (1979). "Mutagenic activity of chemical carcinogens and related compounds in the intraperitoneal host-mediated assay." J. Natl. Cancer Inst.62:911-918.
753.
Simonsick, W.J.J. and Hites, R.A. (1985). "Charge exchange chemical ionization mass spectrometry: A tool for PAH isomer differentiation." In: Polynuclear Aromatic Hydrocarbons: Mechanisms, Methods and Metabolism. ( M. Choke and A. Dennis, eds.) Batyl Press, Columbus, OH, pp. 1227-1237.
754.
Sims, P. (1982). "The metabolic activation of some polycyclic hydrocarbons: The role of dihydrodiols and diol-epoxides." Adv. Exp. Med. Biol.136:487-500.
755.
Sims, R.C. and Overcash, M.R. (1983). "Fate of polynuclear aromatic compounds (PNAs) in soil-plant systems." Res. Rev.88:1-68.
756.
Singer, B. and Grunberger. ( 1983). "Metabolic activation of carcinogens and mutagens." In: Molecular Biology of Mutagens and Carcinogens. Plenum Press, New York, NY. pp. 97-141.
757.
Singh, R. and Weyand, E.H. (1994). "Studies on the binding of various polycyclic aromatic hydrocarbons to mouse hemoglobin and serum proteins." Polycyclic Aromatic Hydrocarbons6:135-142.
758.
Sinsheimer, J.E., Giri, A.K., Hooberman, B.H., et al. (1991). "Mutagenicity in Salmonella and sister chromatid exchange in mice for 1,4-dimethylphenanthrenes 1,3-,2,4-dimethylphenanthrenes and 3,4-dimethylphenanthrenes." Environ. Mol. Mutagen17(2):93-97.
759.
Sirianni, S.R. and Huang, C.C. (1978). "Sister chromatid exchange induced by promutagens/carcinogens in Chinese hamster cells cultured in diffusion chambers in mice." Proceedings of the Society for Experimental Biology and Medicine158:269-274.
760.
Sisovic, A. and Fugas, M. (1991). "Comparative evaluation of procedures for the determination of PAH in low-volume samples." Environ. Monit. Assess18(3):235-241.
761.
Slaga, T.J. and Digiovanni, J. (1984). "Inhibition of chemical carcinogenesis." In: Chemical Carcinogens. ACS Monograph No. 182, (C.E. Searle, ed.). Vol. 2, 2nd ed. American Chemical Society, Washington, D.C.
762.
Slaga, T.J., Gleason, G.L., and Wells, G. ( 1980a). "Comparison of the skin tumor-initiating activities of dihydrodiols and diol-epoxides of various polycyclic aromatic hydrocarbons ." Cancer Res.40:1981-1984.
763.
Slaga, T.J., Jecker, L., Bracken, W.M., et al. (1979). "The effects of weak or non-carcinogenic polycyclic hydrocarbons on 7,12- dimethylbenz(a)anthracene and benzo(a)pyrene skin tumor-initiation." Cancer Lett.7:51-59.
764.
Slaga, T.J., Triplett, L.L., and Nesnow, S. ( 1980b). "Mutagenic and carcinogenic potency of extracts of diesel and related environmental emissions: Two-stage carcinogenesis in skin tumor sensitive mice (SENCAR): Health effects of diesel engine emissions ." Proceedings of An International Symposium . U.S. Environmental Protection Agency, Cincinnati, OH . EPA 600/9-80-057b, 874-897.
765.
Smolarek, T.A. and Baird, W.M. (1984). "Benzo[e]pyrene-induced alterations in the binding of benzo[a]pyrene to DNA in hamster embryo cell cultures." Carcinogenesis5(8): 1065-1069.
766.
Smolarek, T.A., Baird, W.M., Fisher, E.P., et al. (1987). "Benzo(e)pyrene-induced alterations in the binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene to DNA in Sencar mouse epidermis." Cancer Res.47(14):3701-3706.
767.
Smolarek, T.A., Moynihan, C., Salmon, C.P., et al. (1986). "Benz(a)anthracene-induced alterations in the metabolic activation of benzo[a]pyrene by hamster embryo cell cultures ." Cancer Lett.30:243-249.
768.
Snell, K.C. and Stewart, H.L. (1962). "Pulmonary adenomatosis induced in DBA/2 mice by oral administration of dibenz[a,h]anthracene." J. Natl. Cancer Inst.28:1043.
769.
Snell, K.C. and Stewart, H.L. (1963). "Induction of pulmonary adenomatoses in DBA/2 mice by the oral administration of dibenz[a,h]anthracene." Acta Unio Internationale Contra Cancrum19: 692-694.
770.
Snider, E.H. and Manning, F.S. (1982). "A survey of pollutant emission levels in waste waters and residuals from the petroleum refining industry." Environment International7:237-258.
771.
Solt, D.B., Polverini, P.J., and Calderon, L. (1987). "Carcinogenic response of hamster buccal pouch epithelium to 4 polycyclic aromatic hydrocarbons." J. Oral Pathol.16:294-302.
772.
Sorrel, R.K., Brass, H.J., and Reding, R. (1980). "A review of occurrences and treatment of polynuclear aromatic hydrocarbons." EPA-600/D-81-066.
773.
Southworth, G.R. (1979). "The role of volatilization on removing polycyclic aromatic hydrocarbons from aquatic environments." Bull. Environ. Contam. Toxicol.21:507-514.
774.
Southworth, G.R., Beauchamp, J.J., and Schmeider, P.K. (1978). "Bioaccumulation potential of polycyclic aromatic hydrocarbons in Daphnia pulex." Water Res.12:973-977.
775.
Soyka, L.F. (1980). "Hepatic drug metabolizing enzyme activity and tumorigenesis in mice following perinatal exposure to benzo(a)pyrene." Pediatr . Pharmacol.1:85-96.
776.
Spacie, A., Landruff, P.F., and Leversee, G.J. (1983). "Uptake, depuration and biotransformation of anthracene and benzo[a]pyrene." Ecotoxicol. Environ. Safety7:330.
777.
Sparnins, V.L., Mott, A.W., Baraney, G., et al. (1986). "Effects of allyl methyl trisulfide on glutathione-S-transferase activity." Nutr. Cancer8:211-215.
778.
StanfordRESEARCH INSTITUTE (SRI) (1992). SRI International. Directory of Chemical Producers. United States of America. Menlo Park, CA.
779.
Srivastava, V., Chauhan, W., Srivastava, P., et al. (1986). "Fetal translocation and metabolism of PAH obtained form coal fly ash given intratracheally to pregnant rats." J. Toxicol. Environ. Health18:459-469.
780.
Stahl, R.G., Liehr, J.G., and Davis, E.M. (1984). "Characterization of organic compounds in simulated rainfall runoffs from model coal piles." Arch. Environ. Contam. Toxicol.13:179-190.
781.
Stanton, M.F., Miller, E., Wrench, C., et al. (1972). "Experimental induction of epidermoid carcinoma in the lungs of rats by cigarette smoke condensate." J. Natl. Cancer Inst.49:867-877.
782.
Stavenow, L. and Pessah-Rasmussen, H. (1988). "Effects of polycyclic aromatic hydrocarbons on proliferation, collagen secretion and viability of arterial smooth muscle cells in culture." Artery15:94-108.
783.
Steiner, P.E. (1955). "Carcinogenicity of multiple chemicals simultaneously administered." Cancer Res.15:632-635.
784.
Steiner, P.E. and Edgecomb, J.H. (1952). "Carcinogenicity of 1,2-benzanthracene." Cancer Res.12:657-659.
785.
Steiner, P.E. and Falk, H.L. (1951). "Summation and inhibition effects of weak and strong carcinogenic hydrocarbons: 1,2-Benzanthracene, chrysene, 1,2,5,6-dibenzanthracene and 20-methylcholanthrene." Cancer Res.11: 56-63.
786.
Stenback, F. and Rowland, J. (1979). "Experimental respiratory carcinogenesis in hamsters: Environmental, physiochemical and biological aspects." Oncol.36:63-71.
787.
Stenback, F., Rowland, J., and Sellakumar, A. (1976). "Carcinogenicity of benzo[a]pyrene and dusts in the hamster lung (instilled intratracheally with titanium oxide, aluminum oxide, carbon and ferric oxide)." Oncol. 33:29-34.
788.
Stenback, F., Sellakumar, A., and Shubik, P. (1975). "Magnesium oxide as carrier dust in benzo[a]pyrene-induced lung carcinogenesis in Syrian hamsters." J. Natl. Cancer Inst.54:861-867.
789.
Stora, C. (1980). "Comparative study of the cellular localization of three polycyclic hydrocarbons differing in their carcinogenicity." Oncol. 37( 1 ):23-26.
790.
Storer, J.S., Deleon, I., Millikan, L.E., et al. (1984). "Human absorption of crude coal tar products ." Arch. Dermatol.120:874-877.
791.
Stutz, D.R. and Janusz, S.J. (1988). Hazardous Materials Injuries: A Handbook for Pre-Hospital Care. 2nd ed. Bradford Communications Corp., Beltsville, MD. pp. 298-299.
792.
Su, S.Y., Lai, E.P.C., and Winefordner, J.D. (1982). "Determination of polynuclear aromatic hydrocarbons by a spiked mobile fluorescence HPLC detector." Anal. Lett.15:439-450.
793.
Sullivan, P.D., Calle, L.M., Shafer, K., et al. (1978). "Effects of antioxidants of benzo[a]pyrene free radicals." In: Polynuclear Aromatic Hydrocarbons: 2nd International Symposium on Analysis, Chemistry, and Biology (Carcinogenesis — a comprehensive survey). Vol. 3. (R.I. Freudenthal and P.W. Jones, eds.) Raven Press, New York, NY. pp. 1-3.
794.
Sullivan, T.J. and Mix, M.C. (1985). "Persistence and fate of polynuclear aromatic hydrocarbons deposited on slash burn sites in the Cascade Mountains and Coast Range of Oregon (USA)." Arch. Environ. Contam. Toxicol.14:187-192.
795.
Sun, J.D., Wolff, R.K., and Kanapilly, G.M. (1982). "Deposition, retention, and biological fate of inhaled benzo[a]pyrene adsorbed onto ultrafine particles as a pure aerosol ." Toxicol. Appl. Pharmacol.65:231-244.
796.
Swartz, W.J. and Mattison, D.R. (1985). "Benzo[a]pyrene inhibits ovulation in C57BL/6N mice." Anatomical Record212:268-276.
797.
Symons, R.K. and Crick, I. (1983). "Determination of polynuclear aromatic hydrocarbons in refinery effluent by high-performance liquid chromatography." Anal. Chim. Acta151:237-243.
798.
Szepesy, L., Lakszner, K., Akermann, L., et al. (1981). "Rapid method for the determination of polycyclic aromatic hydrocarbons in environmental samples by combined liquid chromatography and gas chromatography." J. Chromatogr.206:611-616.
799.
Tan, Y.L. (1988). "Analysis of polynuclear aromatic hydrocarbons in shale oil and diesel particulates." Anal. Lett.21:553-562.
800.
Tanaka, K. and Saito, M. (1988). "High-performance liquid chromatographic separation and synchronous fluorimetric determination of polycyclic aromatic hydrocarbons in soils." The Analyst113:509-510.
801.
Teranishi, K., Hamada, K., and Watanabe, H. (1975). "Quantitative relationship between carcinogenicity and mutagenicity of polyaromatic hydrocarbons in Salmonella typhimurium mutants ." Mutat. Res.31(2):97-102.
802.
Thomas, D.H. and Delfino, J.J. (1991). "A gas chromatographic/chemical indicator approach to assessing ground water contamination by petroleum products." Ground Water Monit. Rev.11(4):90-100.
803.
Thomas, J.F., Mukai, M., Tebbens, et al. (1968). "Fate of airborne benzo[a]pyrene." Env. Sci. Technol.2:33-39.
804.
Thomas, W. (1986). "Accumulation of airborne trace pollutants by arctic plants and soil." Water Sci. Technol.18:47-57.
805.
Thomas, W., Ruehling, A., and Simon, H. (1984). "Accumulation of airborne pollutants (polycyclic aromatic hydrocarbons, chlorinated hydrocarbons, heavy metals) in various plant species and humus." Environ. Poll. (Series A) 36:295-310.
806.
Thompson, J.I. (1971). "Survey of compounds which have been tested for carcinogenic activity." Government Printing Office, Washington, D.C. Public Health Service Publication no. 149, 1968-1969.
807.
Thrane, K.E., Makalsen, A., and Stray, H. (1985). "Monitoring method for airborne polycyclic aromatic hydrocarbons." Intl. J. Environ. Anal. Chem.23:111-134.
808.
Thruston, A.D.J. (1978). "High pressure liquid chromatography techniques for the isolation and identification of organics in drinking water extracts ." J. Chromatogr. Sci.16:254-259.
809.
Thyssen, J., Althoff, J.K.G., and Mohr, U. (1981). "Inhalation studies with benzo[a]pyrene in Syrian golden hamsters." J. Natl. Cancer Inst.66:575-577.
810.
Tolos, W.P., Shaw, P.B., Lowry, L.K., et al. (1990). "I-Pyrenol: A biomarker for occupational exposure to polycyclic aromatic hydrocarbons." Appl. Occup. Environ. Hyg.5(5):303-309.
811.
Tomingas, R., Pott, F., and Dehnen, W. (1976). "Polycyclic aromatic hydrocarbons in human bronchial carcinoma." Cancer Lett.1:189-195.
812.
Tomkins, B.A., Buchanan, M.V., Reagan, R.R., et al. (1986). "The isolation, identification, and quantitation of the four- and five-ring dermal tumorigen PAH in petroleum crude oils and distillate fractions using normal-phase isolation HPLC and GC/MS in the single-ion monitoring mode." In: Polynuclear Aromatic Hydrocarbons, Chemistry, Characterization, and Carcinogenesis. (M. Choke and A. Dennis, eds.) Proceedings of the Ninth International Symposium. Batyl Press, Columbus, OH. pp. 917-932.
813.
Tomkins, B.A. and Griest, W.H. (1987). "Liquid chromatographic determination of benzo(a)pyrene at part-per-billion concentrations in highly refined coal- and petroleum-derived fuels." J. Chromatogr. (Netherlands)386:103-110.
814.
Tomkins, B.A., Griest, W.H., Caton, J.E., et al. (1982). "Multicomponent isolation and analysis of polynuclear aromatics." In: Polynuclear Aromatic Hydrocarbons: Physical and Biological Chemistry. (M. Choke , A. Dennis, and G. L. Fisher, eds.) Springer-Verlag, New York, NY. pp. 813-824.
815.
Tong, C., Brat, S.V., and Williams, G.M. (1981). "Sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in an intact cell system of adult rat-liver epithelial cells." Mutat. Res.91:467-473.
816.
Topham, J.C. (1980). "Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens?" Mutat. Res.74:379-387.
817.
Topping, D.C., Martin, D.H., and Nettesheim, P. (1981). "Determination of cocarcinogenic activity of benzo[e]pyrene for respiratory tract mucosa." Cancer Lett.11(4):315-321.
818.
Topping, D.C., Pal, B.C., Martin, D.H., et al. (1978). "Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity ." Am. J. Pathol.93(2):311-324.
819.
Torronen, R., Nousiainen, U., and Hanninen, O. (1981). "Induction of aldehyde dehydrogenase by polycyclic aromatic hydrocarbons in rats." Chem.-Biol. Interact.36:33-44.
820.
Toussaint, G. and Walker, E.A. (1979). "Use of high-performance liquid chromatography as a cleanup procedure in analysis of polycyclic aromatic hydrocarbons in alcoholic beverages." J. Chromatogr.171:448-452.
821.
Tracor-Jitco (1973a). Survey of Compounds Which Have Been Tested for Carcinogenic Activity . Government Printing Office, Washington, D.C. Public Health Service Publication no. 149, 1961- 1967.
822.
Tracor-Jitco ( 1973b). Survey of Compounds Which Have Been Tested for Carcinogenic Activity . Government Printing Office, Washington, D.C. Public Health Service Publication no. 149, 1970- 1971.
823.
Traynor, G.W., Apte, M.G., Sokol, H.A., et al. (1990). "Selected organic pollutant emissions from unvented kerosene space heaters." Environ. Sci. Technol.24(8):1265-1270.
824.
Tromberg, B.J., Sepaniak,M.J., Alarie, J.P., et al. (1988). "Development of antibody-based fibre-optic sensors for detection of a benzo(a)pyrene metabolite." Anal. Chem.60(18): 1901-1908.
825.
Tsuda, H. and Farber, E. (1980). "Resistant hepatocytes as early changes in liver induced by polycyclic aromatic hydrocarbons." Intl. J. Cancer25:137-139.
826.
Tsuge, S., Nishimura, K., Suzuki, M., et al. (1988). "Determination of benzo(a)pyrene in airborne particulates by automated thermal-desorption gas chromatography." Anal. Sci.4(1): 115-116.
827.
Ttan, Y., Quanci, J.F., Borys, R.D., et al. (1992). "Polycyclic aromatic hydrocarbons in smoke particles from wood and duff burning." Atmos. Environ.26(6):1177-1181.
828.
Tuominen, J., Pyysalo, H., Laurikko, J., et al. (1987). "Application of GLC-selected ion monitoring (SIM)-technique in analyzing polycyclic organic compounds in vehicle emissions ." Sci. Total Environ.59:207-210.
829.
Tuominen, J.P., Pyysalo, H.S., and Sauri, M. (1988). "Cereal products as a source of polycyclic aromatic hydrocarbons." J. Agric. Food Chem.36(1):118-120.
830.
Turney, G.L., and Goerlitz, D.F. (1990). "Organic contamination of ground water at Gas Works Park, Seattle, Washington." Ground Water Monit. Rev.19(3):187-198.
831.
Turusov, V.S., Nikonova, T.V., and Parfenov, Y.U.D. (1990). "Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant." Cancer Lett.55(3):227-231.
832.
Tweats, D.J. (1981). Activity of 42 Coded Compounds in a Differential Killing Test Using Escherichia Coli Strains WP2, WP67 (uvrA polA), and CM871 (uvrA lexA recA): Evaluation of Short-Term Tests for Carcinogens. Report of the International Collaborative Program. Prog. Mutat. Res.1:199-209.
833.
U.S. Department Of Agriculture (1980). "The biologic and economic assessment of pentachlorophenol, inorganic arsenicals, creosote. Volume 1: Wood preservatives." U.S. Department of Agriculture, Washington, D.C. Technical bulletin no. 1658-1, 193-227.
834.
U.S. Department Of Commerce (1985). U.S. Imports for Consumption and General Imports. TSUSA Commodity by Country of Origin. FT246/Annual 1985. U.S. Department of Commerce , Washington, D.C.
835.
U.S. Environmental Protection Agency (1975 ). Code of Federal Regulations. 40 CFR 141.24.
836.
U.S. Environmental Protection Agency (1979 a). Code of Federal Regulations. 40 CFR 141.6.
837.
U.S. Environmental Protection Agency (1979 b). Code of Federal Regulations. 40 CFR 401.15.
838.
U.S. Environmental Protection Agency ( 1980 a). "Ambient water quality criteria document for polynuclear aromatic hydrocarbons." U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office. Cincinnati, OH. EPA 440/5-8-069.
839.
U.S. Environmental Protection Agency (1980 b). Code of Federal Regulations. 40 CFR 261.33.
840.
U.S. Environmental Protection Agency ( 1981 a). Engineering Handbook for Hazardous Waste Incineration . U.S. Environmental Protection Agency, Office of Solid Waste. Washington, DC. EPA/SW-889.
841.
U.S. Environmental Protection Agency ( 1981 b). Toxic pollutants/effluent standards. U.S. Environmental Protection Agency. Code of Federal Regulations. 40 CFR 401.15.
842.
U.S. Environmental Protection Agency ( 1981 c). Code of Federal Regulations. 40 CFR 261 App. VII.
843.
U.S. Environmental Protection Agency (1981 d). Code of Federal Regulations. 40 CFR 413.02.
844.
U.S. Environmental Protection Agency ( 1982 a). Code of Federal Regulations. 40 CFR 420.02.
845.
U.S. Environmental Protection Agency ( 1982 b). Code of Federal Regulations. 40 CFR 420.13.
846.
U.S. Environmental Protection Agency ( 1982 c). Code of Federal Regulations. 40 CFR 420.14.
847.
U.S. Environmental Protection Agency (1982 d). Code of Federal Regulations. 40 CFR 465.02.
848.
U.S. Environmental Protection Agency (1982 e). Code of Federal Regulations. 40 CFR 423.
849.
U.S. Environmental Protection Agency ( 1982 f). "Test methods. Methods for organic chemical analysis of municipal and industrial wastewater." U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory, Cincinnati, OH.
850.
U.S. Environmental Protection Agency ( 1983 a). Code of Federal Regulations. 40 CFR 271.1.
851.
U.S. Environmental Protection Agency ( 1983 b). Code of Federal Regulations. 40 CFR 122.
852.
U.S. Environmental Protection Agency (1983 c). Code of Federal Regulations. 40 CFR 433.11.
853.
U.S. Environmental Protection Agency (1983 d). Code of Federal Regulations. 40 CFR 467.02.
854.
U.S. Environmental Protection Agency (1983 e). Code of Federal Regulations. 40 CFR 468.02.
855.
U.S. Environmental Protection Agency (1984 a). "Health effects assessment for polynuclear aromatic hydrocarbons (PAH)." First Draft. U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office. Cincinnati, OH. ECAO-CIN-H013.
856.
U.S. Environmental Protection Agency (1984 b). Code of Federal Regulations. 40 CFR 261 App. IX.
857.
U.S. Environmental Protection Agency (1984 c). Code of Federal Regulations. 40 CFR 136.
858.
U.S. Environmental Protection Agency (1984 d). Code of Federal Regulations. 40 CFR 421.21.
859.
U.S. Environmental Protection Agency (1984 e). Code of Federal Regulations. 40 CFR 421.23.
860.
U.S. Environmental Protection Agency (1984 f). Code of Federal Regulations. 40 CFR 421.24.
861.
U.S. Environmental Protection Agency ( 1984 g). Code of Federal Regulations. 40 CFR 421.26.
862.
U.S. Environmental Protection Agency (1985 a). Code of Federal Regulations. 40 CFR 464.11.
863.
U.S. Environmental Protection Agency (1985 b). Code of Federal Regulations. 40 CFR 464.21.
864.
U.S. Environmental Protection Agency (1985 c). Code of Federal Regulations. 40 CFR 464.31.
865.
U.S. Environmental Protection Agency (1985 d). Code of Federal Regulations. 40 CFR 464.41.
866.
U.S. Environmental Protection Agency (1985 e). Code of Federal Regulations. 40 CFR 141.50.
867.
U.S. Environmental Protection Agency (1986 a). "Test methods for evaluating solid waste. Volume 1B: Laboratory manual, physical/chemical methods." U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, D.C. SW-846.
868.
U.S. Environmental Protection Agency (1986 b). Code of Federal Regulations. 40 CFR 268.10.
869.
U.S. Environmental Protection Agency (1986 c). Code of Federal Regulations. 40 CFR 268.12.
870.
U.S. ENVIRONMENTAL PROTECTION AGENCY (1986d). Code of Federal Regulations. 40 CFR 403.
871.
U.S. Environmental Protection Agency (1987 a). Code of Federal Regulations. 40 CFR 246, Appendix XI.
872.
U.S. Environmental Protection Agency (1987 b). Code of Federal Regulations. 40 CFR 302.
873.
U.S. Environmental Protection Agency (1987 c). Code of Federal Regulations. 40 CFR 264 App. IX.
874.
U.S. Environmental Protection Agency (1987 d). Code of Federal Regulations. 40 CFR 355.
875.
U.S. Environmental Protection Agency (1987 e). Code of Federal Regulations. 40 CFR 141.32.
876.
U.S. Environmental Protection Agency (1987 f). Code of Federal Regulations. 40 CFR 141.40
877.
U.S. Environmental Protection Agency ( 1987 g). Code of Federal Regulations. 40 CFR 414.91.
878.
U.S. Environmental Protection Agency ( 1988 a). "Drinking water criteria document for polycyclic aromatic hydrocarbons (PAHs)." U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH. ECAO-CIN-DO10.
879.
U.S. Environmental Protection Agency (1988 b). "Recommendations for and documentation of biological values for use in risk assessment." U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH. EPA/600/6-87/008.
880.
U.S. Environmental Protection Agency (1988 c). Code of Federal Regulations. 40 CFR 261 App. VIII.
881.
U.S. Environmental Protection Agency (1988 d). Code of Federal Regulations. 40 CFR 268.43.
882.
U.S. Environmental Protection Agency (1988 e). Code of Federal Regulations. 40 CFR 372.65.
883.
U.S. Environmental Protection Agency (1988 f). Code of Federal Regulations. 40 CFR 704.225.
884.
U.S. Environmental Protection Agency (1988 g). Code of Federal Regulations. 40 CFR 716.120.
885.
U.S. Environmental Protection Agency (1988 h). Code of Federal Regulations. 40 CFR 795.54.
886.
U.S. Environmental Protection Agency ( 1989 a). "Interim methods for development of inhalation reference doses." U.S. Environmental Protection Agency. EPA/600/8-90/066F.
887.
U.S. Environmental Protection Agency (1989 b). "Health and environmental effects profile for benzo(g,h,i)perylene ." U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office. Cincinnati, OH. Contract Number EPA-600-X-87-395.
888.
U.S. Environmental Protection Agency (1989 c). Code of Federal Regulations. 40 CFR 302.4.
889.
U.S. Environmental Protection Agency (1989 d). "Designation, reportable quantities, and notification." U.S. Environmental Protection Agency. Code of federal regulations. 40 CFR 302.4
890.
U.S. Environmental Protection Agency (1990 ). "Interim methods for development of inhalation reference doses." U.S. Environmental Protection Agency. Washington, DC. EPA/600/8-90/066A.
891.
U.S. Environmental Protection Agency (1991 a). "Ambient water quality criteria document: Addendum for acenaphthene." U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office. Cincinnati, OH. Contract Number ECAO-CIN-613.
892.
U.S. Environmental Protection Agency (1991 b). "EPA toxic pollutant effluent standards." U.S. Environmental Protection Agency. Code of Federal Regulations. 40 CFR 129.
893.
U.S. Environmental Protection Agency (1991 C). Code of Federal Regulations. 40 CFR 258.
894.
U.S. Environmental Protection Agency (1991 d). Code of Federal Regulations. 40 CFR 265 App. VII.
895.
U.S. Environmental Protection Agency (1991 e). Code of Federal Regulations. 40 CFR 141.61.
896.
U.S. Environmental Protection Agency (1992 ), Toxic Chemical Release Inventory90, Office of Toxic Substances , Washington, DC.
897.
U.S. Environmental Protection Agency (1992 a). Code of Federal Regulations. 40 CFR 721.3764.
898.
U.S. Environmental Protection Agency (1992 b). Federal Register 57 FR 60848.
899.
U.S. Environmental Protection Agency (1993 a). "Provisional guidance for quantitative risk assessment of polycyclic aromatic hydrocarbons." Final Draft. Environmental Criteria and Assessment Office. Cincinnati, OH. ECAO-CIN-842. March 1993.
900.
U.S. Environmental Protection Agency (1993 b). Federal Register. 58 FR 48092.
901.
U.S. Environmental Protection Agency (1993 c). Federal Register. 58 FR 54702.
902.
U.S. Environmental Protection Agency (1993 d). Federal Register. 58 FR 65622.
903.
U.S. Environmental Protection Agency (1993 e). Federal Register. 58 FR 36872.
904.
U.S. Environmental Protection Agency (1994 ), Toxic Chemical Release Inventory92, Office of Toxic Substances, Washington, DC.
905.
U.S. Environmental Protection Agency (1994 a). Federal Register. 59 FR 15504
906.
U.S. Environmental Protection Agency (1994 b). Federal Register. 59 FR 9808.
907.
U.S. Environmental Protection Agency (1994 c). Federal Register. 59 FR 1788.
908.
Urso, P. and Gengozian, N. (1980). "Depressed humoral immunity and increased tumor incidence in mice following in utero exposure to benzo[a]pyrene." J. Toxicol. Environ. Health6:569-576.
909.
Urso, P., Gengozian, N., Rossi, R.M., et al. (1986). "Suppression of humoral and cell-mediated immune responses in vitro by benzo(a)pyrene." J. Immunopharmacol . 1986, 8(2):223-241.
910.
Urso, P. and Johnson, R.A. (1987). "Early changes in T lymphocytes and subsets of mouse progeny defective as adults in controlling growth of a syngeneic tumor after in utero insult with benzo(a)pyrene." Immunopharmacol . 14:1-10.
911.
Urso, P. and Johnson, R.A. (1988). "Quantitative and functional change in T cells of primiparous mice following injection of benzo(a)pyrene at the second trimester of pregnancy." Immunopharmacol. Immunotoxicol.10:195-217.
912.
Urso, P., Ryan, M.C., and Bennett, J.S. (1988). "Changes in peripheral blood cells in mice after injection with benzo[a]pyrene during pregnancy." Immunopharmacol. Immunotoxicol.10:179-193.
913.
Urso, P., Zhang, W., and Cobb, J.R. (1992). "Immunological consequences from exposure to benzo(a)pyrene during pregnancy." Scand. J. Immunol.36(Suppl. 11):203-206.
914.
Uziel, M., Ward, R.J., and Vo-Dinh, T. (1987). "Synchronous fluorescence measurement of benzo(a)pyrene metabolites in human and animal urine." Anal. Lett.20:761-776.
915.
Vahakangas, K., Trivers, G., Rowe, M., et al. (1985). "Benzo[a]pyrene diolepoxide-DNA adducts detected by synchronous fluorescence spectrophotometry." Environ. Health Perspect.62:101-104.
916.
Valencia, R. and Houtchens, K. (1981). Mutagenic Activity of 10 Coded Compounds in the Drosophila Sex-Linked Recessive Lethal Test. Evaluation of Short-Term Tests for Carcinogens. Report of the International Collaborative Program. Prog . Mutat. Res.1:652-659.
917.
Van Duuren, B.L., Langseth, L., and Goldschmidt, B.M. (1967). "Carcinogenicity of epoxides, lactones and peroxy compounds: VI. Structure and carcinogenic activity." J. Natl. Cancer Inst.39:1217-1227.
918.
Van Duuren, B.L., Sivak, A., Segal, A., et al. (1966). "The tumor producing agents of tobacco leaf and tobacco smoke condensate." J. Natl. Cancer Inst.37:519.
919.
Van Heddeghem, A., Huyghebaert, A., and De Moor, H. (1980). "Determination of polycyclic aromatic hydrocarbons in fat products by high-performance liquid chromatography." Zeitschrift für Lebensmittel-Untersuchungs-Forschung171(1):9-13.
920.
Van Schooten, F.J., Hillebrand, M.J.X., Scherer, E., et al. (1991). "Immunocytochemical visualization of DNA adducts in mouse tissues and human white blood cells following treatment with benzo(a)pyrene or its diol epoxide: A quantitative approach." Carcinogenesis12(3):427-434.
921.
Van Schooten, F.J., Hillebrand, M.J.X., Van Leeuwen, F.F., et al. (1992). "Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from lung cancer patients: No correlation with adduct levels in lung." Carcinogenesis13(6):987-993.
922.
Vanio (1976). " The fate of intratracheally installed benzo[a]pyrene in the isolated perfused rat lung of both control and 20-methylcholanthrene pretreated rats." Res. Commun. Chem. Pathol. Pharmacol.13:259-272.
923.
Varanasi, U. and Gmur, D.J. (1980). "Metabolic activation and covalent binding of benzo[a]pyrene to deoxyribonucleic acid catalyzed by liver enzymes of marine fish." Biochem. Pharmacol.29:753-762.
924.
Varanasi, U. and Gmur, D.J. (1981). "In vivo metabolism of naphthalene and benzo[a]pyrene of flatfish." In: Chemical Analysis and Biological Fate: Polynuclear Aromatic Hydrocarbons, (M. Choke and A. Dennis, eds.). Fifth International Symposium. Batyl Press, Columbus, OH. pp. 367-376.
925.
Varanasi, U., Reichert, W.L., Stein, J.E., et al. (1985). "Bioavailability and biotransformation of aromatic hydrocarbons in benthic organisms exposed to sediment from an urban estuary." Environ. Sci. Technol.19:836-841.
926.
Vassilaros, D.L., Stoker, P.W., Booth, G.M., et al. (1982). "Capillary gas chromatographic determination of polycyclic aromatic compounds in vertebrate fish tissue." Anal. Chem.54:106-112.
927.
Vaughan, B.E. (1984). "State of research: Environmental pathways and food chain transfer." Environ. Health Perspect., pp. 353-371.
928.
Veith, G.D., Kuehl, D.W., Leonard, E.N., et al. (1981). "Polychlorinated biphenyls and other organic chemical residues in fish from major United States watersheds near the great lakes, 1978." Pestic. Monit. J.15:1-8.
929.
Verschueren, K. (1983). Handbook of Data on Organic Chemicals. 2nd ed. Van Nostrand Reinhold Co., New York, NY.
930.
View (1989). Agency of Toxic Substances and Disease Registry (ATSDR), Office of External Affairs, Exposure and Disease Registry Branch, Atlanta, GA. June 20, 1989.
931.
Vo-Dinh, T. (1981). "A new passive dosimeter for monitoring personnel exposure to polycyclic aromatic vapors." 182nd American Chemical Society National Meeting, New York, NY , August 23-28.
932.
Vo-Dinh T. and Abbott, D.W. (1984). "A ranking index to characterize polynuclear aromatic pollutants in environmental samples." Environ. Intl.10:299-304.
933.
Vo-Dinh, T., Alarie, J.P., and Johnson, R.W. (1991). "Evaluation on the fiber-optic antibody-based fluoroimmunosensor for DNA adducts in human placenta samples." Clin. Chem.37(4):532-535.
934.
Vo-Dinh, T., Bruewer, T.J., Colovos, G.C., et al. (1984). "Field evaluation of a cost-effective screening procedure for polynuclear aromatic pollutants in ambient air samples ." Environ. Sci. Technol.18:477-482.
935.
Vogel, E.W., Zijlstra, J.S., and Blijleven, W.G.H. (1983). "Mutagenic activity of selected aromatic amines and polycyclic hydrocarbons in Drosophila melanogaster ." Mutat. Res.107(1):53-78.
936.
Vogt, N.B., Brakstad, F., Thrane, K., et al. (1987). "Polycyclic aromatic hydrocarbons in soil and air: Statistical analysis and classification by the SIMCA method." Environ. Sci. Technol.21:35-44.
937.
Vreuls, J.J., De Jong, G.G., and Brinkman, U. (1991). "On-line coupling of liquid chromatography capillary gas chromatography and mass spectrometry for the determination and identification of polycyclic aromatic hydrocarbons in vegetable oils." Chromatographia31(3-4)113-122.
938.
Wachter, R.A. and Blackwood, T.R. (1979). "Water pollutants from coal storage areas." Coal Technol. (Houston) 2:234-239.
939.
Wadler, S., Fuks, J.Z., and Wiernik, P.H. (1986). "Phase I and II agents in cancer therapy: Part I. Anthracyclines and related compounds." J. Clin. Pharmacol.26:491-509.
940.
Wallace, W.E., Keane, M.J., Hill, C.A., et al. (1987). "Mutagenicity of diesel exhaust particles and oil shale particles dispersed." J. Toxicol. Environ. Health21 :163-171.
941.
Wang, D.T. and Meresz, O. (1982). "Occurrence and potential uptake of polynuclear aromatic hydrocarbons of highway traffic origin by proximally grown food crops." In: Polynuclear Aromatic Hydrocarbons: Physical and Biological Chemistry. (M. Choke and A. Dennis, eds.) Batyl Press , Columbus, OH. pp. 885-896.
942.
Warshawsky, D. and Barkley, W. (1987). "Comparative carcinogenic potencies of 7 H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo(a)pyrene in mouse skin." Cancer Lett.37:337-344.
943.
Warshawsky, D.T., Cody, M., Raidke, B.A., et al. (1983). "Toxicity and metabolism of benzo[a]pyrene in the green alga Selenastrum capricontum." In: Polynuclear Aromatic Hydrocarbons: Formation, Metabolism and Measurement, (M. Choke and A. Dennis, eds.). Batyl Press, Columbus, OH. pp. 1235-1245.
944.
Wattenberg, L.W. and Bueding, E. (1986). "Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard." Carcinogenesis7:1379-1381.
945.
Wattenberg, L.W. and Leong, J.L. (1970). "Inhibition of the carcinogenic action of benzo[a]pyrene by flavones." Cancer Res.30:1922-1925.
946.
Weast, R.C., Astle, M.J. , and Beyer, W.H., (eds). ( 1988). Handbook of Chemistry and Physics. CRC Press, Inc.Boca Raton, FL.
947.
Weast, R.C., ed. (1987). CRC Handbook of Chemistry and Physics. 68th ed. CRC Press, Boca Raton, FL.
948.
Weibel, F.J. (1980). "Activation and inactivation of carcinogens by microsomal nonoxooxygenases: Modification by benzoflavones and polycyclic aromatic hydrocarbons." Carcinogenesis5: Modifiers of chemical carcinogenesis.
949.
Weinberg, C.R., Wilcox, A., and Baird, D.D. (1989). "Reduced fecundability in women with prenatal exposure to cigarette smoking." Am. J. Epidemiol.129:1072-1078.
950.
Weinstein, D., Katz, M.L., and Kazmer, S. (1977). "Chromosomal effects of carcinogens and noncarcinogens on WI-38 after short term exposures with and without metabolic activation ." Mutat. Res.46:297-304.
951.
Weissenfels, W.D., Klewer, H.L., and Langhoff, J. (1992). "Adsorption of polycyclic aromatic hydrocarbons (PAHs) by soil particles: Influence on biodegradability and biotoxicity." Appl. Microbiol. Biotechnol.36(5):689-696.
952.
Wenzel-Hartung, R., Brune, H., Grimmer, G., et al. (1990). "Evaluation of the carcinogenic potency of 4 environmental polycyclic aromatic compounds following intrapulmonary application in rats." Exp. Pathol.40(4):221-227.
953.
Wester, R.C., Maibach, H.I., Bucks, D.A.W., et al. (1990). "Percutaneous absorption of carbon-14 labelled DDT and carbon-14 labelled benzo(a)pyrene from soil." Fundam. Appl. Toxicol.15(3):510-516.
954.
Weston, A. (1985). "Comparative studies of the metabolic activation of chrysene in rodent and human skin." Chem. Biol. Interact.54:223-242.
955.
Weston, A. and Bowman, E.D. (1991). "Fluorescence detection of benzo(a)pyrene-DNA adducts in human lung." Carcinogenesis12(8):1445-1450.
956.
Weston, A., Rowe, M., Poirier, M., et al. (1988). "The application of immunoassays and fluorometry to the detection of polycyclic hydrocarbon-macromolecular adducts and anti-adduct antibodies in humans." Intl. Arch. Occup. Environ. Health . 60(3):157-162.
957.
Weyand, E.H., Amin, S., Huie, K., et al. (1992). "Effects of fluorine substitution on the DNA binding and tumorigenicity of benzo[b]fluoranthene in mouse epidermis ." Chem. Biol. Interactions71:279-290.
958.
Weyand, E.H., Amin, S., Sodhi, R., et al. (1991). "Effects of methyl substitution on the metabolism and binding of benz[e]acephenanthrylene." In: Polycyclic Aromatic Compounds. Synthesis, Properties, Analytical Measurements, Occurrence, and Biological Effects. (P. Garriques and M. Lamotte, eds.) Proceedings of the Thirteenth International Symposium on Polynuclear Aromatic Hydrocarbons. Gordon and Breach, Philadelphia, PA.
959.
Weyand, E.H. and Wu, Y. (1994). "Genotoxicity of manufactured gas plant residue (MPG) in skin and lung of mice following ingestion or topical administration ." Polycyclic Aromatic Hydrocarbons6:35-42.
960.
Weyand, E.H. and Bevan, D.R. (1986). "Benzo(a)pyrene disposition and metabolism in rats following intratracheal instillation." Cancer Res.46:5655-5661.
961.
Weyand, E.H. and Bevan, D.R. (1987a). "Covalent binding of benzo(a)pyrene to macromolecules in lung and liver of rats following intratracheal instillation." Cancer Lett.36:149-159.
962.
Weyand, E.H. and Bevan, D.R. (1987b). "Species differences in disposition of benzo(a)pyrene ." Drug Metab. Dispos.15:442-448.
963.
Weyand, E.H. and Bevan, D.R. (1988). "Benzo(a)pyrene metabolism in vivo following intratracheal administration." In: Polynuclear Aromatic Hydrocarbons: A Decade of Progress, (M. Choke and Dennis, A., eds.) Batyl Press , Columbus, OH. pp. 913-923.
964.
Weyand, E.H., BRYLA, P., WU, Y., et al. (1993a). "Detection of the major DNA adducts of benzo(j)fluoranthene in mouse skin: Nonclassical dihydrodiol epoxides." Chem. Res. Toxicol.6:117-124.
965.
Weyand, E.H., Cai, Z.-W., Wy, Y., et al. (1993b). "Detection of the major DNA adducts of benzo(b)fluoranthene on mouse skin: Role of phenolic dihydrodiols." Accepted for publication by Chem. Res. Toxicol.
966.
Weyand, E.H., Geddie, N., Rice, J.E., et al. (1988). "Metabolism and mutagenic activity of benzo[k]fluoranthene and 3-, 8- and 9-fluorobenzo[k]fluoranthene." Carcinogenesis9(7):1277-1281.
967.
Weyand, E.H., He, Z.-H., Ghodrati, Y., et al. (1992). "Effect of fluorine substitution on benzo(j)fluoranthene genotoxicity." Chem. Biol. Interact.84:37-53.
968.
Weyand, E.H. and Lavoie, E.J. (1988). "Comparison of PAH: DNA adduct formation and tumor initiating activity in newborn mice (meeting abstract)." Proceedings of the Annual Meeting of the American Association for Cancer Res. 29:A390.
969.
Weyand, E.H., Patel, S., Lavoie, E.J., et al. (1990). "Relative tumor initiating activity of benzo(a)fluoranthene, benzo(b)fluoranthene, naphthol( 1,2-b)fluoranthene and naphtho(2,1-a)fluoranthene on mouse skin." Cancer Lett.52(3):229-234.
970.
Weyand, E.H., Rice, J.E., and Lavoie, E.J. (1987). "32P-postlabeling analysis of DNA adducts from non-alternant PAH using thin-layer and high performance liquid chromatography ." Cancer Lett.37:257-266.
971.
Weyand, E.H., Wu, Y., and Patel, S. (1994). "Biochemical effects of manufactured gas plant residue following ingestion by B6C3F, mice." J. Toxicol. Environ. Health42:89-107.
972.
Weyand, EH, Wu, Y., Patel, S., et al. (1991). "Biochemical effects of coal tar in mice following ingestion." In: Polycyclic Aromatic Compounds. Synthesis, Properties, Analytical Measurements, Occurrence, and Biological Effects. Proceedings of the Thirteenth International Symposium on Polynuclear Aromatic Hydrocarbons. (P. Garriques, M. Lamotte, eds.) Gordon and Breach. Philadelphia, PA.
973.
White, C.M. and Lee, M.L. (1980). "Identification and geochemical significance of some aromatic components of coal." Geochim. Cosmochim. Acta44:1825-1832.
974.
White, J. and White, A. (1939). "Inhibition of growth of the rat by oral administration of methylcholanthrene, benzpyrene, or pyrene and the effects of various dietary supplements." J. Biol. Chem.131:149-161.
975.
White, J.B. and Vanderslice, RR (1980). POM Source and Ambient Concentration Data: Review and Analysis. U.S. Environmental Protection Agency, Office of Research and Development, Washington, D.C. EPA-600/7-80-044.
976.
White, K.J. and Holsapple, M.P. (1984). "Direct suppression of in vitro antibody production by mouse spleen cells by the carcinogen benzo[a]pyrene but not by the congener benzo[e]pyrene." Cancer Res.44:3388-3393.
977.
White, K.J., Lysy, H.H., and Holsapple, M.P. (1985). "Immunosuppression by polycyclic aromatic hydrocarbons: A structure-activity relationship in B6C3F and DBA/2 mice." Immunopharmacol. 9:155-164.
978.
Wielgosz, S.M., Brauze, D., and Pawlak, A.L. (1991). "Ah locus-associated differences in induction of sister-chromatid exchanges and in DNA adducts by benzo[a]pyrene in mice ." Mutat. Res.246(1): 129-137.
979.
Wiencke, J.K., McDowell, M.L., and Bodell, W.J. (1990). "Molecular dosimetry of DNA adducts and sister chromatid exchanges in human lymphocytes treated with benzo(a)pyrene." Carcinogenesis11(9):1497-1502.
980.
Wilcox, A., Baird, D.D., and Weinberg, C.R. (1989). "Do women with childhood exposure to cigarette smoking have increased fecundability?" Am. J. Epidemiol.129:1079-1083.
981.
Wild, S.R., Berrow, M.L., McGrath, S.P., et al. (1992). "Polynuclear aromatic hydrocarbons in crops from long-term field experiments amended with sewage sludge." Environ. Poll.76( 1 ):25-32.
982.
Wild, S.R. and Jones, K.C. (1993). "Biological and abiotic losses of polynuclear aromatic hydrocarbons (PAHs) from soils freshly amended with sewage sludge ." Environ. Toxicol. Chem.12:5-12.
983.
Wild, S.R., Mitchell, D.J., Yelland, C.M., et al. (1992). "Wasted municipal solid waste incinerator fly ash as a source of polynuclear aromatic hydrocarbons (PAHs) to the environment ." Waste Manag. Res.10(1):99-111.
984.
Willems, M.I., Roggeband, R., Baan, R.A., et al. (1991). "Monitoring the exposure of rats to benzo(a)pyrene by the determination of mutagenic activity in excreta, chromosome aberrations and sister chromatid exchanges in peripheral blood cells, and DNA adducts in peripheral blood lymphocytes and liver." Mutagenesis6(2):151-158.
985.
Williams, G.M., Laspia, M.F., and Dunkel, V.C. (1982). "Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and noncarcinogens." Mutat. Res.97 :359-370.
986.
Wilson, J.S. and Holland, L.M. (1988). "Periodic response difference in mouse epidermis chronically exposed to crude-oils or b(a)p males vs. females." Toxicol.50( 1 ):83-94.
987.
Wilson, J.T., Mcnabb, J.F., Cochran, J.W., et al. (1986). "Influence of microbial adaptation on the fate of organic pollutants in ground water." Environ. Toxicol. Chem.721-726.
988.
Wilson, R.H., Deeds, F., and Cox, A. (1947). "The carcinogenic activity of 2-acetaminofluorene: IV. Action of related compounds." Cancer Res.7:453-458.
989.
Windholz, M. (1983). The Merck index. 10th ed. Merck and Co., Rahway, NJ .
990.
Windsor, J.G. and Hites, R.A. ( 1979). "Polycyclic aromatic hydrocarbons in Gulf of Maine sediments and Nova Scotia soils." Geochim. Cosmochim. Acta43:27-33.
991.
Wise, S.A., Chesler, S.N., Hilpert, L.R., et al. (1985). "Characterization of polycyclic aromatic hydrocarbon mixtures from air particulate samples using liquid chromatography, gas chromatography, and mass spectrometry." In: Polynuclear Aromatic Hydrocarbons: Mechanisms, Methods and Metabolism. Batyl Press, Columbus, OH. pp. 1413-1427.
992.
Withey, J.R., Law, F.C.P., and Endrenyi, L. (1991). "Pharmacokinetics and bioavailability of pyrene in the rat." J. Toxicol. Environ. Health32(4):429-447.
993.
Withey, J.R., SHEDDEN, J., LAW, F.P., et al. (1992). "Distribution to the fetus and major organs of the rat following inhalation exposure to pyrene." J. Appl. Toxicol.12(3):223-231.
994.
Wojciechowski, J.P., Kaur, P., and Sabharwal, P.S. (1981). "Comparison of metabolic systems required to activate pro-mutagens/carcinogens in vitro for sister-chromatid exchange studies ." Mutat. Res.88:89-97.
995.
Wojdani, A. and Alfred, L.J. (1984). "Alterations in cell-mediated immune functions induced in mouse splenic lymphocytes by polycyclic aromatic hydrocarbons ." Cancer Res. Mar.44(3):942-945. Wojdani, A.M., Attarzadeh , G., Wolde-Tsadik, et al. (1984). "Immunocytotoxicity effects of polycyclic aromatic hydrocarbons on mouse lymphocytes." Toxicol.31:181-189.
996.
Wolfe, J.M. and Bryan, W.R. (1939). "Effects induced in pregnant rats by injection of chemically pure carcinogenic agents." Am. J. Cancer36:359-368.
997.
Wolff, M.S., Herbert, R., Marcus, M., et al. (1989). "Polycyclic aromatic hydrocarbon (PAH) residues on skin in relation to air levels among roofers." Arch. Environ. Health44(3):157-163.
998.
Wolff, R.K., Griffith, W.C., Henderson, R.F., et al. (1989a). "Effects of repeated inhalation exposures to 1-nitropyrene, benzo(a)pyrene, Ga2O3 particles, and SO2 alone and in combinations on particle clearance, bronchoalveolar lavage fluid composition, and histopathology." J. Toxicol. Environ. Health27(1): 123-138.
999.
Wolff, R.K., Sun, J.D., Bond, J.A., et al. (1989b). "Repeated inhalation exposures to 1-nitropyrene (NP) or benzo(a)pyrene (BaP) in association with Ga2O3 particles and SO2: Tissue distribution, binding, and metabolism of ( 14C)NP and (14C)BaP." Inhal. Toxicol.1(1):79-94.
1000.
Woo, C.S., D'Silva, A.P., and Fassel, V.A. (1980). "Characterization of environmental samples for polynuclear aromatic hydrocarbons by an x-ray excited optical luminescence technique." Anal. Chem.52:159-164.
1001.
Wood, A.W., Chang, R.L., Huang, M.T., et al. (1980). "Mutagenicity of benzo(e)pyrene and triphenylene tetrahydroepoxides and diol-epoxides in bacterial and mammalian cells." Cancer Res.40:1985-1989.
1002.
Wood, A.W., Chang, R.L., Levin, W., et al. (1979a). "Mutagenicity and tumorigenicity of phenanthrene and chrysene epoxides and diol epoxides." Cancer Res.39:4069-4077.
1003.
Wood, A.W., Levin, W., and Chang, R.L. (1980). "Mutagenicity and tumor-initiating activity of cyclobenz(C,A)pyrene and structurally-related compounds." Cancer Res.40:642-649.
1004.
Wood, A.W., Levin, W., Ryan D., et al. (1977). "High mutagenecity of metabolically activated chrysene 1,2-dihydrodiol: Evidence for bay region activation of chrysene." Biochem. Biosphys. Res. Comm. 78:847.
1005.
Wood, A.W., Levin, W., Thakker, D.R., et al. (1979b). "Biological activity of benzo[e]pyrene: An assessment based on mutagenic activities and metabolic profiles of the polycyclic hydrocarbon and its derivatives." J. Biol. Chem.254(11):4408-4415.
1006.
Wood, A.W., Levin, W., Thomas, P.E., et al. (1978). "Metabolic activation of dibenz(a,h)anthracene and its dihydrodiols to bacterial mutagens." Cancer Res.38:1967-1973.
1007.
World Health Organization (Who) (1971). International Standards for Drinking-Water. 3rd ed. World Health Organization, Geneva, Switzerland. p 37.
1008.
World Health Organization (Who) (1977). International Standards for Drinking-Water. 3rd ed.World Health Organization, Geneva, Switzerland.
1009.
Wu, R.M., Jiang, YM, Ge, N.C., et al. (1985). "Determination of trace amounts of organic pollutants in the Yellow River by capillary column gas chromatography-mass spectrometry." Intl. J. Environ. Anal. Chem.22:115-126.
1010.
Wu, Y., Kim, S.J., and Weyand, E.H. (1994). "Bioavailability of manufactured gas plant residue (MPG) components in mice following ingestion: comparison of adulterated powder and gel diets." Polycyclic Aromatic Hydrocarbons7:175-182.
1011.
Wynder, E.L. and Hoffmann, D. (1959a). "A study of tobacco carcinogenesis: VII. The role of higher polycyclic hydrocarbons." Cancer12:1079-1086.
1012.
Wynder, E.L. and Hoffmann, D. (1959b). "The carcinogenicity of benzofluoranthene." Cancer12:1194.
1013.
Wynder, E.L. and Hoffmann, D. (1967). Tobacco and Tobacco Smoke. Academic Press. New York, NY
1014.
Wynder, E.L. and Ritz, L.F.N. (1957). "Effect of concentrations of benzopyrene in skin carcinogenesis." J. Natl. Cancer Inst.19:361-370.
1015.
Wynder, E.L., Spranger, J.W., and Fark, M.M. (1960). "Dose-response studies with benzo[a]pyrene." J. Natl. Cancer Inst.13:106-110.
1016.
Xu, B.X. and Fang, Y.Z. (1988). "Determination of polynuclear aromatic hydrocarbons in water by flotation enrichment and HPLC." Talanta35(11):891-894.
1017.
Yakhesina, A., Shcherback, N.P., Shabad, L.M., et al. (1969). "Benzpyrene breakdown by the soil microflora ." Bull. Exp. Biol. Med.68:70.
1018.
Yamagiwa, K. and Ichikawa, K. (1981). "Experimental study of the pathogenesis of carcinoma ." J. Cancer Res.3:1-29.
1019.
Yamazaki, H., Imamura, E., Kamei, S., et al. (1990). "Polycyclic aromatic hydrocarbons affect the calcium ionophore induced activation of rabbit platelet." Chemosphere21(1/2):21-28.
1020.
Yamazaki, H. and Kakiuchi, Y. (1989). "The uptake and distribution of benzo(a)pyrene in rat after continuous oral administration." Toxicol. Environ. Chem.24(1/2):95-104.
1021.
Yamazaki, H., Terada, M., Tsuboi, A., et al. (1987). "Distribution and binding pattern of benzo(a)pyrene in rat liver, lung and kidney constituents after oral administration." Toxicol . Environ. Chem.15:71-81.
1022.
Yang, J.J., Roy, T.A., Krueger, A., ET AL. (1989). "In vitro and in vivo percutaneous absorption of benzo-a-pyrene from petroleum crude-fortified soil in the rat." Bull. Environ. Contam. Toxicol.43(2):207-214.
1023.
Yang, J.J., Roy, T.A., and Mackerer, C.R. (1986). "Percutaneous absorption of anthracene in the rat: Comparison of in vivo and in vitro results." Toxicol. Ind. Health2:79-84.
1024.
Yang, S.K. (1988). "Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbons ." Biochem. Pharmacol.37(1):61-70.
1025.
Yang, S.Y.N., Connell, D.W., Hawker, D.W., et al. (1991). "Polycyclic aromatic hydrocarbons in air soil and vegetation in the vicinity of an urban roadway." Sci. Total Environ.102(0):229-240.
1026.
Yoshikawa, T., Ruhr, L.P., Flory, W., et al. (1987). "Toxicity of polycyclic aromatic hydrocarbons: III. Effects of beta-naphtoflavone pretreatment on hepatotoxicity of compounds produced in the ozonation or NO2-nitration of phenanthrene and pyrene in rats." Vet. Hum. Toxicol.29:113-117.
1027.
Zhao, X.L., et al. (1990). "Effects of benzo(a)pyrene on the humoral immunity of mice exposed by single intraperitoneal injection." Chinese J. Prevent. Med.24(4):220-222.
1028.
Zhao, Z.H., Quan, W.Y., and Tian, D.H. (1990). "Urinary 1-hydroxypyrene as an indicator of human exposure to ambient polycyclic aromatic hydrocarbons in a coal-burning environment ." Sci. Total Environ.92:145-154.
1029.
Zijlstra, J.A., and Vogel, E.W. (1984). "Mutagenecity of 7,12-dimethylbenz[a]anthracene and some other aromatic mutagens in Drosophila melanogaster." Mutat. Res.125:243-261.
