Rhythms of Risk: Circadian Influences on Cardiac Electrophysiology and Drug-Induced Arrhythmias

Abstract

Visual Abstract

Get full access to this article

View all access options for this article.

References

Acosta

Falcone

Rajpurkar

Topol

(2022) Multimodal biomedical AI. Nat Med 28:1773-1784.

Black

D’Souza

Wang

Piggins

Dobrzynski

Morris

Boyett

(2019) Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms. Heart Rhythm 16:298-307.

Czeisler

Allan

Strogatz

Ronda

Sánchez

Ríos

Freitag

Richardson

Kronauer

(1986) Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Science 233:667-671.

Delisle

Prabhat

Burgess

Ono

Esser

Schroder

(2024) Circadian regulation of cardiac arrhythmias and electrophysiology. Circ Res 134:659-674.

Kane

(2024) ClinCalc DrugStats database. The top 300 of 2022. [accessed July 28, 2025]. https://clincalc.com/DrugStats/Top300Drugs.aspx.

Lévi

Zidani

Misset

(1997) Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy. Lancet 350:681-686.

Master

(1960) The role of effort and occupation (including physicians) in coronary occlusion. JAMA 174:942-948.

Qauli

Marcellinus

Setiawan

Zain

AFN

Pinandito

Lim

(2023) In silico assessment on TdP risks of drug combinations under CiPA paradigm. Sci Rep 13:2924.

Ruben

Smith

FitzGerald

Hogenesch

(2019) Dosing time matters. Science 365:547-549.

10.

Strauss

Gintant

Blinova

Vicente

Turner

Sager

(2019) Comprehensive In Vitro Proarrhythmia Assay (CiPA) update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA meeting. Ther Innov Regul Sci 53:519-525.

11.

Talamanca

Gobet

Naef

(2023) Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans. Science 379:478-483.

12.

Vatansever

Yang

Drelich

Kratch

Cho

Kempaiah

Hsu

Mellott

Tseng

C-TK

(2021) Bepridil is potent against SARS-CoV-2 in vitro. Proc Natl Acad Sci 118:e2012201118.

13.

Wei

Diekman

(2025) Dosing time of day impacts the safety of antiarrhythmic drugs in a computational model of cardiac electrophysiology. J Biol Rhythms 40:301-310.