We report a child presenting with intermittent ophthalmoplegia and fluctuating ptosis and facial weakness whose evaluation revealed no evidence of myasthenia gravis but did reveal hyperthyroidism secondary to Graves disease. Successful treatment of the child’s endocrinopathy resulted in complete resolution of his presenting symptoms. Children presenting with ophthalmoplegia and ptosis without proptosis should be evaluated for hyperthyroidism if no evidence of a myopathy or disorder of neuromuscular junction transmission is found.
MaoZFYangLXMoXA. Frequency of autoimmune diseases in myasthenia gravis: a systematic review. Int J Neurosci. 2011;121:121–129.
2.
OosterhuisHJ. Observations of the natural history of myasthenia gravis and the effect of thymectomy. Ann N Y Acad Sci. 1981;377:678–690.
3.
ChanWWongGWFanDSChengACLamDSNgJS. Ophthalmopathy in childhood Graves' disease. Br J Ophthalmol. 2002;86:740–742.
4.
WiersingaWMSmitTvan der GaagRMouritsMKoornneefL. Clinical presentation of Graves' ophthalmopathy. Ophthalmic Res. 1989;21:73–82.
5.
BeverCTJrAquinoAVPennASLovelaceRERowlandLP. Prognosis of ocular myasthenia. Ann Neurol. 1983;14:516–519.
6.
BossowskiATReddyVPerryLA. Clinical and endocrine features and long-term outcome of Graves' disease in early childhood. J Endocrinol Invest. 2007;30:388–392.
AcunaOMAthannassakiIPaysseEA.Association between thyroid-stimulating immunoglobulin levels and ocular findings in pediatric patients with Graves disease. Trans Am Ophthalmol Soc. 2007;105:146–150; discussion 150-151.
9.
EhaJPitzSPohlenzJ. Clinical features of pediatric Graves' orbitopathy. Int Ophthalmol. 2010;30:717–721.
10.
GrutersA. Ocular manifestations in children and adolescents with thyrotoxicosis. Exp Clin Endocrinol Diabetes. 1999;107(suppl 5): S172–S174.
11.
CrispMSLaneCHalliwellMWynford-ThomasDLudgateM. Thyrotropin receptor transcripts in human adipose tissue. J Clin Endocrinol Metab. 1997;82:2003–2005.
12.
PaschkeRVassartGLudgateM. Current evidence for and against the TSH receptor being the common antigen in Graves' disease and thyroid associated ophthalmopathy. Clin Endocrinol (Oxf). 1995;42:565–569.
13.
MarinoMRicciardiRPincheraA. Mild clinical expression of myasthenia gravis associated with autoimmune thyroid diseases. J Clin Endocrinol Metab. 1997;82:438–443.
14.
NakamuraHUsaTMotomuraM. Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. J Endocrinol Invest. 2008;31:861–865.
15.
PerrildHLavardLBrock-JacobsenB. Clinical aspects and treatment of juvenile Graves' disease. Exp Clin Endocrinol Diabetes. 1997;105(suppl 4):55–57.
16.
WongGWChengPS. Increasing incidence of childhood Graves' disease in Hong Kong: a follow-up study. Clin Endocrinol (Oxf). 2001;54:547–550.
17.
PhillipsLH 2ndTornerJCAndersonMSCoxGM. The epidemiology of myasthenia gravis in central and western Virginia. Neurology. 1992;42:1888–1893.
18.
ChuHYShuSGMakSCChiCS. Graves' disease associated with myasthenia gravis: report of one case. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1992;33:457–461.
19.
GadientPBoltonJPuriV. Juvenile myasthenia gravis: three case reports and a literature review. J Child Neurol. 2009;24:584–590.
20.
KovesIHCameronFJKornbergAJ. Ocular myasthenia gravis and Graves disease in a 10-year-old child. J Child Neurol. 2009;24:615–617.